Abelmoschus manihot

Common Names: sunset muskmallow

Ethnobotanical Studies

Clinical Trials

Efficacy of Combined Abelmoschus manihot and Irbesartan for Reduction of Albuminuria in Patients With Type 2 Diabetes and Diabetic Kidney Disease: A Multicenter Randomized Double-Blind Parallel Controlled Clinical Trial.

Zhao J et al (2022).
Diabetes Care.
DOI:
10.2337/dc22-0607
PubMed:
35613364

Studies

Antidiabetic Potential of Abelmoschus manihot Flower Extract: In Vitro and Intracellular Studies.

Summary

Scientist's hangover shortcut: Medic flower extracts showed potent anti-diabetic effects by inhibiting enzymes, reducing oxidative stress, and protecting beta-cell function. Further research needed for potential diabetes management.

Diabetes
Wang SW et al (2024).
Medicina (Kaunas).
DOI:
10.3390/medicina60081211
PubMed:
39202492

Fabrication of Abelmoschus manihot gum/pullulan/magnesium L-ascorbate green composite packaging film and its excellent performance in preserving fresh-cut carrots.

Tan KB et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.134546
PubMed:
39116972

Total extracts from Abelmoschus manihot (L.) alleviate radiation-induced cardiomyocyte ferroptosis via regulating redox imbalances mediated by the NOX4/xCT/GPX4 axis.

Xu Z et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118582
PubMed:
39009325

Integrative physiological, transcriptomic, and metabolomic analysis of Abelmoschus manihot in response to Cd toxicity.

Wu M et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2024.1389207
PubMed:
38916029

Optimization of Flavonoid Extraction from Abelmoschus manihot Flowers Using Ultrasonic Techniques: Predictive Modeling through Response Surface Methodology and Deep Neural Network and Biological Activity Assessment.

Phytochemistry
Sun Z et al (2024).
Molecules.
DOI:
10.3390/molecules29112610
PubMed:
38893486

Total flavone of Abelmoschus manihot regulates autophagy through the AMPK/mTOR signaling pathway to treat intestinal fibrosis in Crohn's disease.

Gastroenterology
Zhang D et al (2024).
J Gastroenterol Hepatol.
DOI:
10.1111/jgh.16560
PubMed:
38803139

A single-cell profile reveals the transcriptional regulation responded for Abelmoschus manihot (L.) treatment in diabetic kidney disease.

Summary

HKC, from Abelmoschus manihot, treats diabetic kidney disease. Key flavonoids in HKC include rutin, hyperoside, and quercetin. Important for DKD treatment.

Diabetes
Wu C et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155642
PubMed:
38759315

Extraction and In Vitro Skincare Effect Assessment of Polysaccharides Extract from the Roots of Abelmoschus manihot (L.).

Wang J et al (2024).
Molecules.
DOI:
10.3390/molecules29092109
PubMed:
38731598

Enzyme-assisted ultrasonic extraction of total flavonoids and extraction polysaccharides in residue from Abelmoschus manihot (L).

Summary

Scientists used enzyme-assisted ultrasonic extraction to extract flavonoids and polysaccharides from Abelmoschus manihot. This method showed higher yields and increased concentrations of important flavonoids compared to traditional extraction methods, making it an efficient and environmentally friendly option.

Phytochemistry
Chu Q et al (2024).
Ultrason Sonochem.
DOI:
10.1016/j.ultsonch.2024.106815
PubMed:
38484470

Identification of the main flavonoids of Abelmoschus manihot (L.) medik and their metabolites in the treatment of diabetic nephropathy.

Summary

HKC, a Chinese medicine made from abelmoschus extracts, shows potential in treating diabetic nephropathy. Flavonoids in HKC were identified and their metabolism studied in diabetic mice, providing insights for improving DN treatment.

DiabetesPhytochemistry
Diao Z et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1290868
PubMed:
38313075

Efficacy and safety of Abelmoschus manihot capsule combined with ACEI/ARB on diabetic kidney disease: a systematic review and meta analysis.

Summary

Abelmoschus Manihot capsule combined with RASI is more effective in treating DKD than RASI alone, with fewer adverse reactions. More high-quality RCTs with large sample sizes needed for conclusive evidence.

Diabetes
Tan Y et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1288159
PubMed:
38249351

The flower of Abelmoschus manihot (L.) medik exerts antioxidant effects by regulating the Nrf2 signalling pathway in scald injury.

Immunology
Song Y et al (2023).
Wound Repair Regen.
DOI:
10.1111/wrr.13146
PubMed:
38151814

The pharmacological mechanism of Abelmoschus manihot in the treatment of chronic kidney disease.

Review
Wei C et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e22017
PubMed:
38058638

Identification of SSR markers through bulk segregant analysis and inheritance of resistance to yellow vein mosaic disease in okra (Abelmoschus esculentus L. Moench).

Singh G et al (2023).
Virusdisease.
DOI:
10.1007/s13337-023-00844-9
PubMed:
38046067

Effects of total flavones of Abelmoschus manihot (L.) on the treatment of diabetic nephropathy via the activation of solute carriers in renal tubular epithelial cells.

Diabetes
Yu H et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.115899
PubMed:
37984306

Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review.

Summary

Hyperoside is a natural compound found in many plants. It has many beneficial effects, including anti-inflammatory, antidepressant, and antioxidant properties. This review provides a summary of its characteristics, potential uses, and effectiveness, helping in the development of new drugs and maximizing its potential.

Review Immunology
Wang K et al (2023).
J Inflamm Res.
DOI:
10.2147/JIR.S418222
PubMed:
37854313

Mechanism of Abelmoschus manihot L. in the Treatment of Contrast-Induced Nephropathy on the Basis of Network Pharmacology Analysis.

Review
Xu Z et al (2022).
Front Nephrol.
DOI:
10.3389/fneph.2022.834513
PubMed:
37675022

Huangkui capsule attenuates diabetic kidney disease through the induction of mitophagy mediated by STING1/PINK1 signaling in tubular cells.

Diabetes
Zhu Z et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154975
PubMed:
37517171

Inhibition of ferroptosis of renal tubular cells with total flavones of Abelmoschus manihot alleviates diabetic tubulopathy.

Diabetes
Wang MZ et al (2023).
Anat Rec (Hoboken).
DOI:
10.1002/ar.25123
PubMed:
36440653

The Effectiveness and Safety of Abelmoschus manihot in Treating IgA Nephropathy: A Systematic Review and Meta-Analysis.

Review
Jia Q et al (2022).
Evid Based Complement Alternat Med.
DOI:
10.1155/2022/9730753
PubMed:
36248420

Total extract of Abelmoschus manihot L. alleviates uric acid-induced renal tubular epithelial injury via inhibition of caspase-8/caspase-3/NLRP3/GSDME signaling.

Ding Z et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.907980
PubMed:
36052125

Effects of Abelmoschus manihot Flower Extract on Enhancing Sexual Arousal and Reproductive Performance in Zebrafish.

Chang CC et al (2022).
Molecules.
DOI:
10.3390/molecules27072218
PubMed:
35408615

Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m(6)A Modification-Mediated NLRP3-Inflammasome Activation and PTEN/PI3K/Akt Signaling.

Liu BH et al (2021).
Front Pharmacol.
DOI:
10.3389/fphar.2021.667644
PubMed:
34335245

Abelmoschus manihot for Diabetic Nephropathy: A Systematic Review and Meta-Analysis.

Diabetes
Shi L et al (2019).
Evid Based Complement Alternat Med.
DOI:
10.1155/2019/9679234
PubMed:
31118973

Efficacy and safety of Flos Abelmoschus manihot (Malvaceae) on type 2 diabetic nephropathy: A systematic review.

Summary

Study found that Flos Abelmoschus manihot can improve symptoms of diabetic nephropathy. Consider using this plant for potential treatment of type 2 diabetes-related kidney damage.

Meta-Analysis Diabetes
Chen YZ et al (2015).
Chin J Integr Med.
DOI:
10.1007/s11655-014-1891-6
PubMed:
25491537