Achillea millefolium

Common Names: bloodwort, carpenter's weed, common yarrow, milenrama, milfoil, western yarrow, yarrow

Ethnobotanical Studies

Boreal Forest, Canada

Uses: Cough, cold and sore throat, Cough, cold and sore throat, Dermatological infections, Dermatological infections, Diabetes, Fever, Gastro-intestinal disorders, Gynaecological problems, Haemorrhages, Haemorrhages, Headache, Headache, Injuries, Injuries, Musculoskeletal disorders, Musculoskeletal disorders, Nutritional disorders, Odontological problems, Ophthalmological disorders, Poisoning, Poisoning, Pregnancy, child birth, puerperium, Respiratory system disorders, Urinary system disorders
DOI:
10.1186/1746-4269-8-7
PubMed:
22289509

Studies

Total Mineral Content in Raw Materials of Ten Medicinal Plants from Roadside Biotopes of Voronezh Oblast.

Dyakova NA et al (2024).
Dokl Biol Sci.
DOI:
10.1134/S0012496624701126
PubMed:
39128956

The Influence of Functional Composite Coatings on the Properties of Polyester Films before and after Accelerated UV Aging.

Mizielińska M et al (2024).
Materials (Basel).
DOI:
10.3390/ma17133048
PubMed:
38998133

Design of chitosan colon delivery micro/nano particles for an Achillea millefolium extract with antiproliferative activity against colorectal cancer cells.

Summary

Researchers designed micro/nanoparticles using chitosan to encapsulate a yarrow extract with anticancer properties. Spray-drying microparticles showed high encapsulation efficiency and effective release of phenolic compounds, making them a promising vehicle for delivering potential cancer-fighting agents to the colon.

CancerGastroenterology
Siles-Sánchez MLN et al (2024).
Drug Deliv.
DOI:
10.1080/10717544.2024.2372285
PubMed:
38952133

Mitigation of salinity stress in yarrow (Achillea millefolium L.) plants through spermidine application.

Alijani S et al (2024).
PLoS One.
DOI:
10.1371/journal.pone.0304831
PubMed:
38923971

Herbal oral care products for the prevention of ventilator-associated pneumonia: A systematic review and network meta-analysis of randomised trials.

Meta-Analysis
Li S, Huang Y and Xie H (2024).
PLoS One.
DOI:
10.1371/journal.pone.0304583
PubMed:
38848351

Structural and Functional Characterization of Medicinal Plants as Selective Antibodies towards Therapy of COVID-19 Symptoms.

Summary

Researchers investigated medicinal plants as potential therapies for COVID-19, using quantum sensing methods to analyze their interactions with COVID protein. Results suggest these plants could be effective against COVID-19 symptoms, aiding drug design efforts.

COVID-19
Mollaamin F et al (2024).
Antibodies (Basel).
DOI:
10.3390/antib13020038
PubMed:
38804306

Ethnomedicinal Plants and Herbal Preparations Used by Rural Communities in Tehsil Hajira (Poonch District of Azad Kashmir, Pakistan).

Ethnobotany
Jabeen T et al (2024).
Plants (Basel).
DOI:
10.3390/plants13101379
PubMed:
38794449

CDI crosslinked chitosan/poly (vinyl alcohol) electrospun nanofibers loaded with Achillea millefolium and Viola extract: A promising wound dressing.

Marjani ME, HMTShirazi R and Mohammadi T (2024).
Carbohydr Polym.
DOI:
10.1016/j.carbpol.2024.122117
PubMed:
38670768

The Effect of Essential Oils from Asteraceae Plants on Behavior and Selected Physiological Parameters of the Bird Cherry-Oat Aphid.

Czerniewicz P, Sytykiewicz H and Chrzanowski G (2024).
Molecules.
DOI:
10.3390/molecules29071673
PubMed:
38611952

Comparative Phytoprofiling of Achillea millefolium Morphotypes: Assessing Antioxidant Activity, Phenolic and Triterpenic Compounds Variation across Different Plant Parts.

ImmunologyPhytochemistry
Raudone L et al (2024).
Plants (Basel).
DOI:
10.3390/plants13071043
PubMed:
38611571

Novel bioactive extract from yarrow obtained by the supercritical antisolvent-assisted technique inhibits lipid metabolism in colorectal cancer.

CancerGastroenterology
Gómez de Cedrón M et al (2024).
Front Bioeng Biotechnol.
DOI:
10.3389/fbioe.2024.1256190
PubMed:
38576446

Revolutionizing Wound Healing: Unleashing Nanostructured Lipid Carriers Embodied with Herbal Medicinal Plant.

Jain A, Yadav S and Khan J (2024).
Curr Pharm Biotechnol.
DOI:
10.2174/0113892010287720240322060706
PubMed:
38566386

Correction: Villalva et al. Antioxidant, Anti-Inflammatory, and Antibacterial Properties of an Achillea millefolium L. Extract and Its Fractions Obtained by Supercritical Anti-Solvent Fractionation against Helicobacter pylori. Antioxidants 2022, 11, 1849.

Immunology
Villalva M et al (2024).
Antioxidants (Basel).
DOI:
10.3390/antiox13030306
PubMed:
38539917

HPLC analysis, genotoxic and antioxidant potential of Achillea millefolium L. and Chaerophyllum villosum Wall ex. Dc.

Immunology
Adil M et al (2024).
BMC Complement Med Ther.
DOI:
10.1186/s12906-024-04344-1
PubMed:
38365652

Safety and hemostatic effect of Achillea millefolium L. in localized bleeding.

Bagheri A et al (2024).
Hepatol Forum.
DOI:
10.14744/hf.2022.2022.0041
PubMed:
38283274

Biological Potential and Therapeutic Effectiveness of Artemetin from Traditional to Modern Medicine: An Update on Pharmacological Activities and Analytical Aspects.

Patel K and Patel DK (2024).
Recent Adv Antiinfect Drug Discov.
DOI:
10.2174/0127724344266027231215105620
PubMed:
38275071

The anti-inflammatory and anti-apoptotic effects of Achillea millefolium L. extracts on Clostridioides difficile ribotype 001 in human intestinal epithelial cells.

Summary

Researchers investigated the effects of Achillea millefolium extracts on the growth of C. difficile and its inflammatory and apoptosis-inducing properties. These extracts show potential as alternative medicines against CDI, a common healthcare-acquired infection.

GastroenterologyImmunology
Raeisi H et al (2024).
BMC Complement Med Ther.
DOI:
10.1186/s12906-024-04335-2
PubMed:
38218845

Potential of herbaceous plant species for copper (Cu) accumulation.

Asare MO et al (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-023-31579-1
PubMed:
38114695

Achillea millefolium: Mechanism of action, pharmacokinetic, clinical drug-drug interactions and tolerability.

Review
Farasati Far B, Behzad G and Khalili H (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e22841
PubMed:
38076118

Herb and Flowers of Achillea millefolium subsp. millefolium L.: Structure and Histochemistry of Secretory Tissues and Phytochemistry of Essential Oils.

Phytochemistry
Konarska A et al (2023).
Molecules.
DOI:
10.3390/molecules28237791
PubMed:
38067521

Ultra High-Performance Liquid Chromatography-Mass Spectrometry and Self-established Database Analysis of Chinese Herbal Medicine Components.

Phytochemistry
Gao Y et al (2023).
J Vis Exp.
DOI:
10.3791/66091
PubMed:
37982527

Guaianolide-type sesquiterpene lactones from Achillea millefolium L. and their anti-inflammatory activity.

Summary

Seventeen new compounds, millefoliumines A-Q, were found in Achillea millefolium plants from Xinjiang, China. Millefoliumine G showed promise as an anti-inflammatory agent by reducing NO release and pro-inflammatory cytokine levels. Implications for drug development.

Immunology
Li H et al (2023).
Phytochemistry.
DOI:
10.1016/j.phytochem.2023.113894
PubMed:
37839587

Antimicrobial and anti-aflatoxigenic activities of nanoemulsions based on Achillea millefolium and Crocus sativus flower extracts as green promising agents for food preservatives.

Summary

Nanoemulsions made from natural extracts can potentially be used as antimicrobial and anti-aflatoxigenic agents, making them effective for food preservation and safety. However, more research is needed to understand their mechanism of action.

Antimicrobial
Abu Safe FA et al (2023).
BMC Microbiol.
DOI:
10.1186/s12866-023-03033-2
PubMed:
37805450

Composition and Biological Activity of the Essential Oils from Wild Horsemint, Yarrow, and Yampah from Subalpine Meadows in Southwestern Montana: Immunomodulatory Activity of Dillapiole.

Immunology
Schepetkin IA et al (2023).
Plants (Basel).
DOI:
10.3390/plants12142643
PubMed:
37514257

Reply to Frański, R.; Beszterda-Buszczak, M. Comment on "Villalva et al. Antioxidant, Anti-Inflammatory, and Antibacterial Properties of an Achillea millefolium L. Extract and Its Fractions Obtained by Supercritical Anti-Solvent Fractionation against Helicobacter pylori. Antioxidants 2022, 11, 1849".

Immunology
Villalva M et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12071384
PubMed:
37507923

Nontarget catches of traps with chemical lures may refer to the flower-visitation, probable pollination, and feeding of bush crickets (Ensifera: Tettigoniidae).

Nagy A et al (2023).
Ecol Evol.
DOI:
10.1002/ece3.10249
PubMed:
37415641

Comment on Villalva et al. Antioxidant, Anti-Inflammatory, and Antibacterial Properties of an Achillea millefolium L. Extract and Its Fractions Obtained by Supercritical Anti-Solvent Fractionation against Helicobacter pylori. Antioxidants 2022, 11, 1849.

Immunology
Frański R and Beszterda-Buszczak M (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12061226
PubMed:
37371956

Nesting biology and phylogenetic relationships of the parasitoid-hunting wasp Lindenius pygmaeus armatus (Vander Linden, 1829) (Hymenoptera: Crabronidae).

Olszewski P et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-36019-1
PubMed:
37316508

Common yarrow (Achillea millefolium) essential oil and main components as potential repellents and acaricides against Ixodes scapularis and Dermacentor variabilis (Acari: Ixodidae) ticks.

Phytochemistry
Pickett LJ et al (2023).
Exp Appl Acarol.
DOI:
10.1007/s10493-023-00782-7
PubMed:
36905473

Aqueous extract of Achillea millefolium significantly affects mesenchymal stem cell renewal and differentiation in a dose dependent manner.

Asadi F et al (2022).
J Stem Cells Regen Med.
DOI:
10.46582/jsrm.1802006
PubMed:
36713795

Cytotoxic, Phytotoxic and Insecticidal Potential of Achillea millefolium L. and Chaerophyllum villosum wall. ex dc.

Adil M et al (2023).
Braz J Biol.
DOI:
10.1590/1519-6984.262479
PubMed:
36700584

Investigation of some endophytic fungi from five medicinal plants with growth promoting ability on maize (Zea mays L.).

Hatamzadeh S et al (2022).
J Appl Microbiol.
DOI:
10.1093/jambio/lxac015
PubMed:
36626729

Electrospun polycaprolactone nanofibers functionalized with Achillea millefolium extract yield biomaterial with antibacterial, antioxidant and improved mechanical properties.

Radisavljevic A et al (2022).
J Biomed Mater Res A.
DOI:
10.1002/jbm.a.37481
PubMed:
36571468

Chlorine-containing guaianolide sesquiterpenoids from Achillea millefolium L. with inhibitory effects against LPS-induced NO release in BV-2 microglial cells.

Li H et al (2023).
Phytochemistry.
DOI:
10.1016/j.phytochem.2022.113567
PubMed:
36549383

The Influence of Freeze-Dried Alcohol-Water Extracts from Common Yarrow (Achillea millefolium L.) and German Chamomile (Matricaria chamomilla L.) on the Properties of Elastomer Vulcanizates.

Aleksieiev A et al (2022).
Int J Mol Sci.
DOI:
10.3390/ijms232315048
PubMed:
36499374

Investigating the anti-tumoral effect of yarrow (Achillea milllefolium) on the mice in which ehrlich solid tumor is created.

Cancer
Bağcı Uzun G et al (2022).
Med Oncol.
DOI:
10.1007/s12032-022-01917-3
PubMed:
36472705

Traditional Ethnobotanical Knowledge of the Central Lika Region (Continental Croatia)-First Record of Edible Use of Fungus Taphrina pruni.

Ethnobotany
Vitasović-Kosić I et al (2022).
Plants (Basel).
DOI:
10.3390/plants11223133
PubMed:
36432861

In Vitro Bioactivities of Food Grade Extracts from Yarrow (Achillea millefolium L.) and Stinging Nettle (Urtica dioica L.) Leaves.

Mannila E et al (2023).
Plant Foods Hum Nutr.
DOI:
10.1007/s11130-022-01020-y
PubMed:
36370293

In vitro evaluation of the effects of methanolic plant extracts on the embryonation rate of Ascaridia galli eggs.

Poulopoulou I et al (2022).
Vet Res Commun.
DOI:
10.1007/s11259-022-09958-9
PubMed:
35727416

Comparative Studies on Essential Oil and Phenolic Content with In Vitro Antioxidant, Anticholinesterase, Antimicrobial Activities of Achillea biebersteinii Afan. and A. millefolium subsp. millefolium Afan. L. Growing in Eastern Turkey.

AntimicrobialPhytochemistry
Toplan GG et al (2022).
Molecules.
DOI:
10.3390/molecules27061956
PubMed:
35335326

Effects of Achillea millefolium on cisplatin induced ocular toxicity: an experimental study.

Okkay U et al (2021).
Cutan Ocul Toxicol.
DOI:
10.1080/15569527.2021.1919137
PubMed:
34180746

Achillea millefolium alleviates testicular damage in paclitaxel-intoxicated rats via attenuation of testicular oxido-inflammatory stress and apoptotic responses.

Immunology
Okkay U et al (2021).
Andrologia.
DOI:
10.1111/and.14028
PubMed:
33650701

Achillea millefolium L. and Achillea biebersteinii Afan. Hydroglycolic Extracts-Bioactive Ingredients for Cosmetic Use.

Gaweł-Bęben K et al (2020).
Molecules.
DOI:
10.3390/molecules25153368
PubMed:
32722270

Pharmacognosy, Phytochemistry and Pharmacological Properties of Achillea millefolium L.: A Review.

Review Phytochemistry
Ali SI, Gopalakrishnan B and Venkatesalu V (2017).
Phytother Res.
DOI:
10.1002/ptr.5840
PubMed:
28618131

Safety Assessment of Achillea millefolium as Used in Cosmetics.

Review
Becker LC et al (2016).
Int J Toxicol.
PubMed:
27913788

Minireview on Achillea millefolium Linn.

Review
Akram M et al (2013).
J Membr Biol.
PubMed:
23959026

Final report on the safety assessment of Yarrow (Achillea millefolium) Extract.

Review
(2001).
Int J Toxicol.
PubMed:
11558643