Achillea wilhelmsii, a common supplement in Persian medicine, has shown anti-inflammatory, anti-spasmodic, and antibacterial properties in studies, but lacks controlled clinical trial evaluation for gastrointestinal disorders.
The study aimed to investigate how a plant extract called Achillea wilhelmsii affects seizures induced by pentylenetetrazole (PTZ), a compound that can cause seizures. Nitric oxide (NO) is known to play a role in epilepsy, so the researchers wanted to see if NO was involved in the effects of the plant extract on seizures. The researchers found that the plant extract reduced the severity and frequency of seizures, potentially by reducing the levels of NO. This study suggests that A. wilhelmsii may have potential as a treatment for epilepsy, but more research would be needed to confirm this.