Achyranthes aspera

Common Names: devil's horsewhip

Ethnobotanical Studies

Studies

Targeting Endoplasmic Reticulum Stress by Natural and Chemical Compounds Ameliorates Cisplatin-Induced Nephrotoxicity: A Review.

Review
Mashayekhi-Sardoo H et al (2024).
Biol Trace Elem Res.
DOI:
10.1007/s12011-024-04351-w
PubMed:
39212819

Investigating the Endophyte Actinomycetota sp. JW0824 Strain as a Potential Bioinoculant to Enhance the Yield, Nutritive Value, and Chemical Composition of Different Cultivars of Anise (Pimpinella anisum L.) Seeds.

Mahmoud AM et al (2024).
Biology (Basel).
DOI:
10.3390/biology13080553
PubMed:
39194491

Clinical and microbial evaluation of mouthwash containing Achyranthes aspera and Trachyspermum ammi: A randomized controlled non-inferiority trial.

Kumar RS et al (2024).
J Oral Biol Craniofac Res.
DOI:
10.1016/j.jobcr.2024.06.006
PubMed:
39055999

Elucidating the phytoremediation potentials and ecophysiological mechanisms of indicator plants in the industrial polluted region.

Ejaz U et al (2024).
J Environ Manage.
DOI:
10.1016/j.jenvman.2024.121821
PubMed:
39018846

In silico Screening and in vitro Cytotoxicity Study of Achyranthes aspera Phytochemicals Against Oral Cancer: A Possible Step towards the Development of Anti-cancer Agents.

Cancer
Israr J et al (2024).
Comb Chem High Throughput Screen.
DOI:
10.2174/0113862073289916240503051643
PubMed:
38994626

Herbal Treatments for Obesity: A Review.

Summary

TL;DR: Obesity is linked to many health issues. FDA-approved drugs have side effects. Herbal plants like Berberis vulgaris and Aloe vera are effective and safe alternatives. Consider using them for cost-effective and novel treatments.

Obesity
Gasmi A et al (2024).
Curr Med Chem.
DOI:
10.2174/0109298673287491240315055726
PubMed:
38509683

Ethnoveterinary medicinal plants and their utilization by the people of Soro District, Hadiya Zone, southern Ethiopia.

Ethnobotany
Hankiso M et al (2024).
J Ethnobiol Ethnomed.
DOI:
10.1186/s13002-024-00651-6
PubMed:
38389077

Protective effect of Achyranthes aspera against compound 48/80, histamine and ovalbumin-induced allergic disorders in murine model.

Kaushik A et al (2024).
Mol Biol Rep.
DOI:
10.1007/s11033-023-09137-2
PubMed:
38270668

Analysis of Achyranthes aspera leaf extract and acute toxicity study on fingerlings of Nile tilapia, Oreochromis niloticus.

Mandefro B et al (2023).
Biochem Biophys Rep.
DOI:
10.1016/j.bbrep.2023.101624
PubMed:
38225992

Application of microscopy and spectroscopy in investigating anti-cancer potential of Achyranthes aspera L. leaves.

Summary

The research investigated the anticancer potential of Achyranthes aspera leaves. The extracts exhibited antioxidant, antimitotic, and antiproliferative activities, suggesting their potential use as an anti-cancer agent.

Cancer
Bashir H et al (2024).
Microsc Res Tech.
DOI:
10.1002/jemt.24495
PubMed:
38205658

Evaluation of phytochemical, antibacterial, thrombolytic, anti-inflammatory, and cytotoxicity profile of Achyranthes aspera aerial part extracts.

Summary

Achyranthes aspera extracts (ME-E and AQ-E) were analyzed for phytochemicals, antibacterial, thrombolytic, anti-inflammatory, and cytotoxicity activities. ME-E exhibited higher phytochemicals, superior antibacterial and thrombolytic activities, moderate anti-inflammatory activity, and dose-dependent cytotoxicity, suggesting potential biomedical applications.

ImmunologyPhytochemistry
Ha HA et al (2023).
Environ Res.
DOI:
10.1016/j.envres.2023.117802
PubMed:
38043891

Clinical Effects of Subgingivally Delivered Achyranthes Aspera Gel in Chronic Periodontitis: A Clinical and Microbiological Study.

Soorgani NR et al (2023).
J Pharm Bioallied Sci.
DOI:
10.4103/jpbs.jpbs_656_22
PubMed:
37654350

In Vitro Antibacterial, Cytotoxicity and Wound Healing Activities of Methanol and Aqueous Extracts from Achyranthes aspera.

Venkadassalapathy SD et al (2023).
J Pharm Bioallied Sci.
DOI:
10.4103/jpbs.jpbs_175_23
PubMed:
37654304

The protective role of Achyranthes aspera extract against cisplatin-induced nephrotoxicity by alleviating oxidative stress, inflammation, and PANoptosis.

Summary

Study investigated the protective effects of Achyranthes aspera on renal dysfunction. Findings offer insights into its potential therapeutic benefits and could guide further research for developing new treatment options.

Immunology
Lin SY et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117097
PubMed:
37648176

Four New Flavonoid C-Glycosides Isolated from Achyranthes aspera and Their Nitric Oxide Production Inhibitory Activities.

Phytochemistry
Lan HTT et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202300853
PubMed:
37409765

In Silico Screening and Validation of Achyranthes aspera as a Potential Inhibitor of BRAF and NRAS in Controlling Thyroid Cancer.

Summary

Genetic variations in thyroid cancer, called SNPs, can help diagnose, predict outcomes, and develop personalized treatments for patients with this common endocrine tumor.

CancerEndocrinology
Alamri A et al (2023).
Anticancer Agents Med Chem.
DOI:
10.2174/1871520623666230607125258
PubMed:
37287303

Systematic review on the anxiolytic and hypnotic effects of flower extracts in in vivo pre-clinical studies published from 2010 to 2020.

Summary

Researchers conducted a systematic review of scientific articles published between 2010 and 2020 that evaluated the anxiolytic, sedative, and/or hypnotic effects of flower extracts in pre-clinical animal models. They found that some flower extracts have an anxiolytic effect comparable to diazepam, but their therapeutic utility in anxiety disorders needs more investigation. The study compiled the characteristics of anxiety studies in animal models, evaluated locomotor activity, and the hypnotic effect of the extracts. The study revealed that matricaria chamomilla had a sedative effect, and 23 other flower plants had anxiolytic effects. However, more reliable behavioral tests and better experimental designs are needed to obtain more conclusive evidence with clinical significance.

Review Neuroscience
Meneses C et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7830
PubMed:
37039741

Characterization and comparison of polysaccharides from Achyranthes bidentata, Cyathula officinalis and Achyranthes aspera by saccharides mapping.

Si H et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115272
PubMed:
36739718

Achyranthes aspera ameliorates stress induced depression in mice by regulating neuroinflammatory cytokines.

Summary

Researchers investigated the effects of Linn. on depressive symptoms in mice with chronic unpredictable mild stress-induced depression. Linn. is a well-known nerve tonic in traditional Indian medicine. The study aimed to determine if it had similar antidepressant effects in animals. The findings suggest that Linn. may have potential as an alternative treatment for certain psychiatric disorders.

ImmunologyNeuroscience
Gawande D et al (2022).
J Tradit Complement Med.
DOI:
10.1016/j.jtcme.2022.06.001
PubMed:
36325246

Morphological and physiological changes induced by Achyranthes aspera-mediated silver nanocomposites in Aedes aegypti larvae.

Sharma A et al (2022).
Front Physiol.
DOI:
10.3389/fphys.2022.1031285
PubMed:
36311240

COVID-19 patient with B cell lymphoma co-morbidity managed with co-administration of ayurvedic formulation.

Summary

A 47-year-old male with chronic kidney disease and B Cell Lymphoma successfully recovered from COVID-19 using a poly-herbal ayurvedic formulation and integrated approach while in home quarantine. The patient had recently finished chemotherapy, making treatment challenging; however, he tolerated the intervention and recovered symptomatically without respiratory complications. Ayurvedic herbs have demonstrated anti-viral and immunomodulatory effects in in vitro studies, and this case supports their potential efficacy in real-world patients when combined with Ayurvedic epistemology. Early diagnosis by RT-PCR and early use of Ayurvedic interventions may be essential for successful recovery.

COVID-19Cancer
Dilip Pandkar P, Deshmukh SR and Sachdeva V (2022).
J Ayurveda Integr Med.
DOI:
10.1016/j.jaim.2022.100632
PubMed:
35975131

Impact of dust accumulation on the physiological functioning of selected herbaceous plants of Delhi, India.

Chaurasia M et al (2022).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-022-21484-4
PubMed:
35729390

Effect of leaves and seeds of Achyranthes aspera as feed supplements on the immunological and stress parameters and related gene expressions of Asian catfish (Clarias batrachus).

Kumar N et al (2023).
Vet Res Commun.
DOI:
10.1007/s11259-022-09932-5
PubMed:
35507243

Systematical characterization and comparison of saponins in Achyranthes bidentata Blume and its three analogous species.

Phytochemistry
Wang Y et al (2022).
Phytochem Anal.
DOI:
10.1002/pca.3128
PubMed:
35490700

Multi-methodological approach for the Quality assessment of Senecionis scandentis Herba (Qianliguang) in the herbal market.

Ngai HL et al (2022).
PLoS One.
DOI:
10.1371/journal.pone.0267143
PubMed:
35421189

Evaluation of UV-B protective properties of leaves and seeds of Achyranthes aspera in Asian catfish Clarias batrachus (Linn.).

Sharma J et al (2022).
Photochem Photobiol Sci.
DOI:
10.1007/s43630-022-00222-2
PubMed:
35403962

Developmental Toxicity of Ethanolic Extracts of Leaves of Achyranthes aspera, Amaranthaceae in Rat Embryos and Fetuses.

Teshome D et al (2021).
J Exp Pharmacol.
DOI:
10.2147/JEP.S312649
PubMed:
34104006

Achyranthes aspera L. leaf extract induced anticancer effects on Dalton's Lymphoma via regulation of PKCα signaling pathway and mitochondrial apoptosis.

Cancer
Singh RK et al (2021).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2021.114060
PubMed:
33771640

Is it safe to consume traditional medicinal plants during pregnancy?

Review
Bernstein N et al (2021).
Phytother Res.
DOI:
10.1002/ptr.6935
PubMed:
33164294

Pharmacological repositioning of Achyranthes aspera as an antidepressant using pharmacoinformatic tools PASS and PharmaExpert: a case study with wet lab validation.

Goel RK et al (2018).
SAR QSAR Environ Res.
DOI:
10.1080/1062936X.2017.1408683
PubMed:
29256630

Anticonvulsant activity and acute neurotoxic profile of Achyranthes aspera Linn.

Summary

Achyranthes aspera Linn. (A. aspera) root powder is used in Indian traditional medicine to manage epilepsy. This study aims to investigate its efficacy. The experimenters conducted a study on rats and found that A. aspera root powder had anticonvulsant effects, reduced the frequency and duration of seizures, and improved memory function. These results suggest that A. aspera may be a promising natural alternative for managing epilepsy. However, further research is needed to confirm and understand its therapeutic mechanisms.

Neuroscience
Gawande DY et al (2017).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2017.03.018
PubMed:
28315457

Identification of candidate synovial membrane biomarkers after Achyranthes aspera treatment for rheumatoid arthritis.

Arthritis
Zheng W et al (2016).
Biochim Biophys Acta.
DOI:
10.1016/j.bbapap.2015.12.010
PubMed:
26724776