Achyranthes bidentata

Common Names: pig's knee

Ethnobotanical Studies

Studies

The functional identification and evaluation of endophytic bacteria sourced from the roots of tolerant Achyranthes bidentata to overcome monoculture problems of Rehmannia glutinosa.

Zeng C et al (2024).
Front Microbiol.
DOI:
10.3389/fmicb.2024.1399406
PubMed:
39081886

Phytochemical analysis and cardiovascular protective effect of four herbal medicines with functional food properties (Four Huaiqing Chinese Medicine).

Summary

Chinese herbs Libosch, Bl., Thunb, and Ramat have shown potential as functional food materials. Identified constituents are mainly flavones and aromatic compounds. They demonstrated significant effects in reducing cell injury markers and improving cell function. These herbs could be beneficial for reducing cell apoptosis and improving cell migration capacity.

CardiologyPhytochemistry
Li Y et al (2024).
Nat Prod Res.
DOI:
10.1080/14786419.2024.2381659
PubMed:
39069726

Characterization of the Components and Metabolites of Achyranthes Bidentata in the Plasma and Brain Tissue of Rats Based on Ultrahigh Performance Liquid Chromatography-High-Resolution Mass Spectrometry (UHPLC-HR-MS).

Summary

AR has potential pharmacological effects for hypertension and cerebral ischemia. Further research needed for validation and possible use in medical treatment.

NeurosciencePhytochemistry
Wu M et al (2024).
Molecules.
DOI:
10.3390/molecules29122840
PubMed:
38930905

Multi-microdialysis analytical system to monitor acetaminophen and its pharmacokinetic interaction with A. bidentata in rat blood, forelimb extensor muscle, brain striatum, and the knee joint cavity.

Summary

Researchers studied the transfer of acetaminophen into various parts of the body when used alone or with a traditional Chinese medicinal herb. Results show no significant difference in pharmacokinetics and suggest broad-range analgesic effects of acetaminophen.

Neuroscience
Sun CK et al (2024).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2024.116285
PubMed:
38878452

A graminan type fructan from Achyranthes bidentata prevents the kidney injury in diabetic mice by regulating gut microbiota.

Summary

A compound from Achyranthis bidentatae (ABPW1) protects against kidney damage and intestinal issues in diabetic mice by modulating gut microbiota and producing beneficial short chain fatty acids. Potential application for diabetic kidney disease prevention.

DiabetesGastroenterology
Si H et al (2024).
Carbohydr Polym.
DOI:
10.1016/j.carbpol.2024.122275
PubMed:
38823933

Achyranthes bidentata polysaccharide ameliorates type 2 diabetes mellitus by gut microbiota-derived short-chain fatty acids-induced activation of the GLP-1/GLP-1R/cAMP/PKA/CREB/INS pathway.

Summary

ABP polysaccharide improves gut microbiota in T2DM mice, increasing SCFAs and GLP-1 levels, activating GLP-1/INS pathway. Potential T2DM therapeutic candidate.

DiabetesGastroenterology
Xia T et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.132256
PubMed:
38729481

An exploratory metabolomic study reveals the Dipsacus asper-Achyranthes bidentate herb pair against osteoarthritis by modulating imbalance in polyunsaturated fatty acids and energy metabolism.

Hu C et al (2024).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2024.116196
PubMed:
38723559

Ecdysterone improves oxidative damage induced by acute ischemic stroke via inhibiting ferroptosis in neurons through ACSL4.

Summary

Researchers studied the effects of Ecdysterone from Achyranthes bidentata Blume on acute ischemic stroke (AIS). EDS shows antioxidant and anti-cerebral hypoxia properties, potentially improving AIS outcomes. This research may lead to new therapies for stroke patients.

CardiologyNeuroscience
Sun J et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118204
PubMed:
38679397

Purification of triterpenoid saponins and 25R/25S-inokosterone from Achyranthes bidentata Bl. by high-speed countercurrent chromatography coupled silver nitrate coordination.

Phytochemistry
Niu T et al (2024).
J Sep Sci.
DOI:
10.1002/jssc.202300901
PubMed:
38605456

Achyranthes bidentata Blume (Amaranthaceae): a review of its botany, traditional uses, phytochemistry, pharmacology, and toxicology.

Phytochemistry
Chen YR, Niu YS and Zhou HL (2024).
J Pharm Pharmacol.
DOI:
10.1093/jpp/rgae012
PubMed:
38600792

The Protective Effects of Ecdysterone on Cognitive Impairment through Regulating Akt/GSK-3β/Nrf2 Signaling Pathway and Oxidative Stress in Cognitive Mice Model and Aβ-Induced Cell Neurotoxicity.

Summary

Researchers studied how ecdysterone, a compound in Blume, can improve cognitive dysfunction in conditions like Alzheimer's by reducing oxidative stress through Nrf2 activation. This could lead to potential treatment options.

ImmunologyNeuroscience
Xing H et al (2024).
Front Biosci (Landmark Ed).
DOI:
10.31083/j.fbl2903109
PubMed:
38538266

Chemometric guided isolation of new triterpenoid saponins as acetylcholinesterase inhibitors from seeds of Achyranthes bidentata Blume.

Summary

Researchers identified new compounds in Achyranthes bidentata seeds, potentially useful for treating various health conditions. Compound 23 showed promising acetylcholinesterase inhibitory activity, indicating potential therapeutic value. This study highlights the importance of using chemometric approaches for phytochemical exploration.

NeurosciencePhytochemistry
Puri S et al (2024).
Fitoterapia.
DOI:
10.1016/j.fitote.2024.105925
PubMed:
38537885

Achyranthes bidentata polysaccharides improve cyclophosphamide-induced adverse reactions by regulating the balance of cytokines in helper T cells.

Lei YY et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.130736
PubMed:
38479672

Futoquinol improves Aβ(25-35) -induced memory impairment in mice by inhibiting the activation of p38MAPK through the glycolysis pathway and regulating the composition of the gut microbiota.

Gastroenterology
Zhang Y et al (2024).
Phytother Res.
DOI:
10.1002/ptr.8136
PubMed:
38330236

Highly Stereoselective Synthesis of Branched Fructooligosaccharides ABW90-1 and ABW50-1 from Achyranthes bidentata with Potent Antiosteoporosis Activities.

Li K et al (2024).
Org Lett.
DOI:
10.1021/acs.orglett.4c00092
PubMed:
38329784

Oligo/polysaccharides from Cyathula officinalis and Achyranthes bidentata: a review of structures and bioactivities.

Chai JH et al (2024).
J Pharm Pharmacol.
DOI:
10.1093/jpp/rgae007
PubMed:
38243389

Isolation of Calenduloside E from Achyranthes bidentata Blume and its effects on LPS/D-GalN-induced acute liver injury in mice by regulating the AMPK-SIRT3 signaling pathway.

Guo P et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155353
PubMed:
38241918

Inulin-like polysaccharide ABWW may impede CCl(4) induced hepatic stellate cell activation through mediating the FAK/PI3K/AKT signaling pathway in vitro & in vivo.

Dai X et al (2024).
Carbohydr Polym.
DOI:
10.1016/j.carbpol.2023.121637
PubMed:
38142102

Complete composition analysis of polysaccharides based on HPAEC-PAD coupled with quantitative analysis of multi-components by single marker.

Yan XH et al (2023).
Phytochem Anal.
DOI:
10.1002/pca.3296
PubMed:
37886810

Traditional Chinese Medicine in Osteoporosis Intervention and the Related Regulatory Mechanism of Gut Microbiome.

Summary

TCM can influence the gut microbiome to combat osteoporosis. This is because the gut microbiome affects inflammation, hormone levels, nutrient absorption, and bone mass. TCM herbs can regulate the gut microbiome and indirectly impact bone health. Puerarin specifically improves intestinal health and reduces inflammation caused by estrogen deficiency.

ArthritisGastroenterology
Li K et al (2023).
Am J Chin Med.
DOI:
10.1142/S0192415X23500866
PubMed:
37884447

Unraveling the potential mechanisms of the anti-osteoporotic effects of the Achyranthes bidentata-Dipsacus asper herb pair: a network pharmacology and experimental study.

Li T et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1242194
PubMed:
37849727

Identification of Meloidogyne species on traditional Chinese medicine plants in the Qinling mountain area of China and their aggressiveness to different medicinal herbs.

Pan S et al (2023).
Plant Dis.
DOI:
10.1094/PDIS-01-23-0148-RE
PubMed:
37849284

Beneficial effect and mechanism of natural resourced polysaccharides on regulating bone metabolism through intestinal flora: A review.

Summary

Certain polysaccharides can improve gut microbiota and regulate bone metabolism. Factors like molecular weight and composition influence effectiveness, enhancing bone health. This can guide treatment of bone metabolic disorders.

Review Gastroenterology
Zhou Y et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.127428
PubMed:
37838110

Efficacy evaluation and metabolomics analysis of raw and salt-processed Achyranthes bidentata Radix in zebrafish larvae for osteoporosis treatment.

Arthritis
Jiang E et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115774
PubMed:
37832477

Aralia saponin A isolated from Achyranthes bidentata Bl. ameliorates LPS/D-GalN induced acute liver injury via SPHK1/S1P/S1PR1 pathway in vivo and in vitro.

Phytochemistry
Zeng M et al (2023).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2023.110912
PubMed:
37699301

Anti-osteoporosis bioactivity evaluation in zebrafish model of raw and salt-processed Achyranthes bidentata followed by liquid chromatography-mass spectrometry analysis and correlation analysis.

ArthritisPhytochemistry
Yang Y et al (2023).
Biomed Chromatogr.
DOI:
10.1002/bmc.5742
PubMed:
37674471

Achyranthes bidentata polysaccharides alleviate endoplasmic reticulum stress in osteoarthritis via lncRNA NEAT1/miR-377-3p pathway.

Fu C et al (2022).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2022.113551
PubMed:
35988424

The Adjuvant Effects on Vaccine and the Immunomodulatory Mechanisms of Polysaccharides From Traditional Chinese Medicine.

Review Immunology
Wang D, Liu Y and Zhao W (2021).
Front Mol Biosci.
DOI:
10.3389/fmolb.2021.655570
PubMed:
33869288

A Systematic Pharmacology and In Vitro Study to Identify the Role of the Active Compounds of Achyranthes bidentata in the Treatment of Osteoarthritis.

Chen Z, Wu G and Zheng R (2020).
Med Sci Monit.
DOI:
10.12659/MSM.925545
PubMed:
32925869

Raw and salt-processed Achyranthes bidentata attenuate LPS-induced acute kidney injury by inhibiting ROS and apoptosis via an estrogen-like pathway.

Endocrinology
Wang S et al (2020).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2020.110403
PubMed:
32574970

Achyranthes bidentata polypeptides prevent apoptosis by inhibiting the glutamate current in cultured hippocampal neurons.

Pan RL et al (2020).
Neural Regen Res.
DOI:
10.4103/1673-5374.270317
PubMed:
31823889

Effects of Achyranthes bidentata alcohol on proliferation capacity of osteoblasts and miRNA in Runx2.

Hua S and Zhang X (2019).
Exp Ther Med.
DOI:
10.3892/etm.2019.7723
PubMed:
31410108

Effect of Achyranthes bidentata Blume on 3T3-L1 Adipogenesis and Rats Fed with a High-Fat Diet.

Oh SD et al (2014).
Evid Based Complement Alternat Med.
DOI:
10.1155/2014/158018
PubMed:
24963319