Aconitum carmichaeli

Ethnobotanical Studies

Studies

Modulation of cellular metabolism and alleviation of bacterial dysbiosis by Aconiti Lateralis Radix Praeparata in non-small cell lung cancer treatment.

Summary

Researchers studied the effects of Fuzi on NSCLC. Fuzi showed promise in inhibiting NSCLC cell growth and inducing apoptosis. Understanding its mechanism may lead to new treatments for this deadly cancer.

Cancer
Zhang W et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155099
PubMed:
38412665

Songorine ameliorates LPS-induced sepsis cardiomyopathy by Wnt/β-catenin signaling pathway-mediated mitochondrial biosynthesis.

Summary

Songorine (SGR), a natural product derived from Aconitum carmichaeli, improves cardiac function and reduces inflammation in septic cardiomyopathy (SCM) by activating the Wnt/β-catenin signaling pathway and promoting mitochondrial biosynthesis. SGR could be a potential treatment for SCM.

Cardiology
Chen M et al (2023).
Naunyn Schmiedebergs Arch Pharmacol.
DOI:
10.1007/s00210-023-02897-5
PubMed:
38133657

Higenamine exerts antidepressant effect by improving the astrocytic gap junctions and inflammatory response.

Summary

Researchers investigated the effects of higenamine, found in Fuzi herb, on depression. Higenamine improved the dysfunction of gap junctions between astrocytes and reduced neuroinflammation. This suggests higenamine may be a potential treatment for neuropsychiatric disorders, including depression.

ImmunologyNeuroscience
Yao J et al (2023).
J Affect Disord.
DOI:
10.1016/j.jad.2023.12.020
PubMed:
38101523

Structural feature-based strategy for the identification of diterpene alkaloids in Aconitum carmichaeli Debeaux.

Summary

Researchers used LC-MS to identify 230 diterpene alkaloids in raw Aconitum carmichaelii and 466 in fermented Aconitum carmichaelii, improving identification accuracy and discovering potential new compounds.

Phytochemistry
Liu Z et al (2023).
Fitoterapia.
DOI:
10.1016/j.fitote.2023.105761
PubMed:
38036079

Strip intercropping with local crops increased Aconitum carmichaeli yield and soil quality.

Liu C et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1147671
PubMed:
36938055

The mechanism of Renshen-Fuzi herb pair for treating heart failure-Integrating a cardiovascular pharmacological assessment with serum metabolomics.

Cardiology
Chen X et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.995796
PubMed:
36545315

Chemical profile, anti-hepatoma activity, anti-acetylcholinesterase and antioxidant activity of aerial part of Aconitum carmichaeli Debx.

Summary

Researchers extracted five different compounds from the aerial parts of Debx using different methods and tested their antioxidant, anti-AChE, and anti-hepatoma activities. The results showed that the extract eluted by 80% ethanol had the best anti-hepatoma activity and high antioxidant activity. The study suggests that Debx may have medicinal value as a natural medicine.

Neuroscience
Yu J et al (2022).
Nat Prod Res.
DOI:
10.1080/14786419.2022.2155821
PubMed:
36503283

Qualitative Profiling and Quantitative Analysis of Major Constituents in Jinmu-tang by UHPLC-Q-Orbitrap-MS and UPLC-TQ-MS/MS.

Jang S, Lee A and Hwang YH (2022).
Molecules.
DOI:
10.3390/molecules27227887
PubMed:
36432001

Ginseng total saponins and Fuzi total alkaloids exert antidepressant-like effects in ovariectomized mice through BDNF-mTORC1, autophagy and peripheral metabolic pathways.

Summary

Shenfu decoction (SFD) is a Chinese medicine that improves heart function. The main ingredients, ginseng and Fuzi, were studied for their effects on menopausal depression. Researchers found that the active components, ginseng total saponins and Fuzi total alkaloids, have antidepressant properties. This is the first study to show the effects of these ingredients on menopausal depression.

NeurosciencePhytochemistry
Jin Y et al (2022).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154425
PubMed:
36137328

Research Progress on the Mechanism of Reducing Toxicity and Increasing the Efficacy of Sini Decoction Compatibility.

Chen H et al (2022).
Chem Pharm Bull (Tokyo).
DOI:
10.1248/cpb.c22-00380
PubMed:
36123021

Efficacy and Safety of Shenfu Injection for Severe Pneumonia in the Elderly: A Systematic Review and Meta-Analysis Based on Western and Eastern Medicine.

Shi S et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.779942
PubMed:
36091817

Effects of N and P enrichment on plant photosynthetic traits in alpine steppe of the Qinghai-Tibetan Plateau.

Shen H et al (2022).
BMC Plant Biol.
DOI:
10.1186/s12870-022-03781-9
PubMed:
35964004

Glycyrrhiza uralensis promote the metabolism of toxic components of Aconitum carmichaeli by CYP3A and alleviate the development of chronic heart failure.

Cardiology
Ni L et al (2022).
PLoS One.
DOI:
10.1371/journal.pone.0270069
PubMed:
35759460

Filtration and qualification for target biomarkers of traditional Chinese medicine formula "fuzi lizhong decoction" acting on stomach ulcer by UPLC/Q-TOF MS.

Gastroenterology
Xin Y et al (2022).
Pak J Pharm Sci.
PubMed:
35642408

Study on extraction methods of polysaccharides from a processed product of Aconitum carmichaeli Debx.

Qiu K et al (2021).
RSC Adv.
DOI:
10.1039/d1ra03628a
PubMed:
35478822

SBT (Composed of Panax ginseng and Aconitum carmichaeli) and Stigmasterol Enhances Nitric Oxide Production and Exerts Curative Properties as a Potential Anti-Oxidant and Immunity-Enhancing Agent.

Han NR et al (2022).
Antioxidants (Basel).
DOI:
10.3390/antiox11020199
PubMed:
35204082

The toxicology and detoxification of Aconitum: traditional and modern views.

Review
Chan YT, Wang N and Feng Y (2021).
Chin Med.
DOI:
10.1186/s13020-021-00472-9
PubMed:
34315520

Variations of microbial community in Aconitum carmichaeli Debx. rhizosphere soilin a short-term continuous cropping system.

Fei X et al (2021).
J Microbiol.
DOI:
10.1007/s12275-021-0515-z
PubMed:
33779961

Chemical constituents in different parts of seven species of Aconitum based on UHPLC-Q-TOF/MS.

Chen LL et al (2021).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2020.113713
PubMed:
33160222

(1α,2β,3α,7α,11α,13β)-1,3,11-Triacet-oxy-2,13-bis-(benz-yloxy)-7-hydr-oxy-21-methyl-N,19-secohetisan-19-al.

Li SH, Zi TY and Wang XQ (2008).
Acta Crystallogr Sect E Struct Rep Online.
DOI:
10.1107/S1600536808019223
PubMed:
21203114