Aconitum carmichaelii

Common Names: Carmichael's monkshood

Ethnobotanical Studies

Studies

Specialized metabolites of the endophyte Annulohypoxylon areolatum hosted by Aconitum carmichaelii.

Wang CY et al (2024).
Phytochemistry.
DOI:
10.1016/j.phytochem.2024.114251
PubMed:
39178977

Pharmacokinetics, safety, and efficacy of Fuqi Guben Gao in the treatment of kidney-yang deficiency syndrome: a randomized, double-blind phase I trial.

Cao WY et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1351871
PubMed:
39015370

Pityriasis Rosea-Like Eruption following anti-fatigue traditional herbs: Aconitum carmichaelii Debx and Panax Ginseng suspected.

Zeng X et al (2024).
BMC Complement Med Ther.
DOI:
10.1186/s12906-024-04556-5
PubMed:
38951791

Involvement of autophagy in mesaconitine-induced neurotoxicity in HT22 cells revealed through integrated transcriptomic, proteomic, and m6A epitranscriptomic profiling.

Summary

Mesaconitine induces neurotoxicity by causing oxidative stress and mitochondrial damage, activating autophagy, and altering RNA methylation. Understanding these mechanisms enhances the safe use of aconitum in medicine.

Neuroscience
Lin X et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1393717
PubMed:
38939838

Benzoylaconine Protects Skeletal Muscle Against Ischemia-Reperfusion Injury Through Activation of IF1-Dependent AMPK/Nrf2 Axis.

Summary

Researchers identified Benzoylaconine (BAC) as a key compound in (Fuzi) used to treat pain and muscle ailments. BAC shows promise for pharmacological applications.

Cardiology
Cui Y et al (2024).
Drug Des Devel Ther.
DOI:
10.2147/DDDT.S456699
PubMed:
38882050

Research on quality marker based on the processing from Aconiti lateralis radix praeparata to Heishunpian.

Xue R et al (2024).
Phytochem Anal.
DOI:
10.1002/pca.3376
PubMed:
38797531

Comparative transcriptome revealed the molecular responses of Aconitum carmichaelii Debx. to downy mildew at different stages of disease development.

Genetics
Chen L et al (2024).
BMC Plant Biol.
DOI:
10.1186/s12870-024-05048-x
PubMed:
38664645

Investigation of the drug-drug interaction and incompatibility mechanism between Aconitum carmichaelii Debx and Pinellia ternata (Thunb.) Breit.

Ge M et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118212
PubMed:
38636577

HBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis.

Guo YJ et al (2024).
Acta Pharmacol Sin.
DOI:
10.1038/s41401-023-01206-3
PubMed:
38467717

The acute toxic effect of Chinese medicine Fuzi is exacerbated in kidney yang deficiency mice due to metabolic difference.

Jiang H et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118036
PubMed:
38460575

Comparative analysis of the organelle genomes of Aconitum carmichaelii revealed structural and sequence differences and phylogenetic relationships.

Zhang R et al (2024).
BMC Genomics.
DOI:
10.1186/s12864-024-10136-1
PubMed:
38454328

Evaluation of the effects of three different processing methods of aconite on rat metabolites based on high-coverage pseudotargeted metabolomics.

Wu H et al (2024).
J Sep Sci.
DOI:
10.1002/jssc.202300583
PubMed:
38234034

Unlocking the hidden potential: Enhancing the utilization of stems and leaves through metabolite analysis and toxicity assessment of various parts of Aconitum carmichaelii.

Zhou Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117693
PubMed:
38176669

Structural feature-based strategy for the identification of diterpene alkaloids in Aconitum carmichaeli Debeaux.

Summary

Researchers used LC-MS to identify 230 diterpene alkaloids in raw Aconitum carmichaelii and 466 in fermented Aconitum carmichaelii, improving identification accuracy and discovering potential new compounds.

Phytochemistry
Liu Z et al (2023).
Fitoterapia.
DOI:
10.1016/j.fitote.2023.105761
PubMed:
38036079

Virome Analysis of Aconitum carmichaelii Reveals Infection by Eleven Viruses, including Two Potentially New Species.

Yang J et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms242115558
PubMed:
37958540

Qishen granule attenuates doxorubicin-induced cardiotoxicity by protecting mitochondrial function and reducing oxidative stress through regulation of Sirtuin3.

Immunology
Zhang J et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117134
PubMed:
37714227

Bioactive polysaccharides in different plant parts of Aconitum carmichaelii.

Fu YP et al (2023).
J Sci Food Agric.
DOI:
10.1002/jsfa.12967
PubMed:
37670420

Discovery of deoxyandrographolide and its novel effect on vascular senescence by targeting HDAC1.

Lin Z et al (2023).
MedComm (2020).
DOI:
10.1002/mco2.338
PubMed:
37600507

Genetic diversity, plant growth promotion potential, and antimicrobial activity of culturable endophytic actinobacteria isolated from Aconitum carmichaelii Debeaux.

Antimicrobial
Zou L et al (2023).
J Appl Microbiol.
DOI:
10.1093/jambio/lxad185
PubMed:
37580141

Identification and quality evaluation of different processed products of Aconitum carmichaelii by ultra-high-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry and ultra-high-performance liquid chromatography-tandem mass spectrometry.

Phytochemistry
Wei N et al (2023).
J Sep Sci.
DOI:
10.1002/jssc.202300235
PubMed:
37387561

Discovery of effective combination from Renshen-Fuzi herbal pair against heart failure by spectrum-effect relationship analysis and zebrafish models.

Cardiology
Li CJ et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116832
PubMed:
37352946

Intra-articular delivery system of methotrexate for rheumatoid arthritis therapy: An in-suit thermosensitive comprehensive gel of polysaccharide from Aconitum carmichaelii Debx.

Arthritis
Zhang R et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.124822
PubMed:
37257527

Cardioprotective Effects of Aconite in Isoproterenol-Induced Myocardial Infarction in Rats.

Cardiology
Xing Z et al (2022).
Oxid Med Cell Longev.
DOI:
10.1155/2022/1090893
PubMed:
36600948

Processed lateral root of Aconitum carmichaelii Debx.: A review of cardiotonic effects and cardiotoxicity on molecular mechanisms.

Review
Zhang J et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.1026219
PubMed:
36324672

Aconitine: A review of its pharmacokinetics, pharmacology, toxicology and detoxification.

Review
Gao Y et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115270
PubMed:
35405250

Aconitum carmichaelii Debeaux: A systematic review on traditional use, and the chemical structures and pharmacological properties of polysaccharides and phenolic compounds in the roots.

Review Phytochemistry
Fu YP et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115148
PubMed:
35240238

First Report of Damping-Off Caused by Mucor circinelloides on Aconitum carmichaelii in China.

Cui L et al (2020).
Plant Dis.
DOI:
10.1094/PDIS-02-20-0359-PDN
PubMed:
32896215

Identification of Potential Biomarkers from Aconitum carmichaelii, a Traditional Chinese Medicine, Using a Metabolomic Approach.

Zhao D et al (2018).
Planta Med.
DOI:
10.1055/s-0043-121708
PubMed:
29076119