Acronychia pedunculata

Ethnobotanical Studies

Studies

Chemical Compositions, Molecular Docking, Anti-Inflammatory, and Anti-Cancer Effects of the Leaf Essential Oils Isolated from Three Species of the Rutaceae Family in Vietnam.

Summary

Three Rutaceae essential oils, A. pedunculata and E. lepta are strong anti-cancer, while E. lepta is highly anti-inflammatory. Potential medicines for cancer and inflammation.

CancerImmunology
Pham TV et al (2024).
Chem Biodivers.
DOI:
10.1002/cbdv.202401466
PubMed:
39230662

Prenylated Acetophenone Derivatives from the Leaves of Acronychia pedunculata and Their Anti-proliferative Activities.

Summary

Researchers identified 4 new compounds from Acronychia pedunculata leaves, 1 dimer and 3 monomers, along with 7 known analogues. Compound 5 showed strong anti-cancer effects with IC50 values from 0.24 to 5.3 μM against HCT-116, RKO, and SW480 cell lines.

Cancer
Yang ZZ et al (2024).
Chem Biodivers.
DOI:
10.1002/cbdv.202401027
PubMed:
39073310

In Silico Analysis of Selective Bioactive Compounds from Acronychia Pedunculata as a Potential Inhibitor of HER2 in Colorectal Cancer.

Summary

Researchers studied compounds from Acronychia pedunculata for potential inhibition of HER2 in colorectal cancer. 12 compounds showed promising properties for drug-likeness and oral bioavailability, with two compounds showing strong binding affinities to HER2. Further experimental validation is needed.

CancerGastroenterology
Ramya S et al (2024).
J Pharm Bioallied Sci.
DOI:
10.4103/jpbs.jpbs_570_23
PubMed:
38882725

Acrotrione B, a Prenylated and Highly Oxidized Xanthenoid with Antibacterial and Anti-proliferative Activities from the Roots of Acronychia pedunculata.

Cancer
Wisetsai A et al (2023).
Planta Med.
DOI:
10.1055/a-1953-0479
PubMed:
36302543

A new polyphenolic isoprenylated acetophenone dimer from the stem bark of Acronychia pedunculata (L.) Miq.

Nathabumroong S et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2021.1989680
PubMed:
34632889

Acroflavone A, a new prenylated flavone from the fruit of Acronychia pedunculata (L.) Miq.

Wisetsai A et al (2022).
Nat Prod Res.
DOI:
10.1080/14786419.2021.1938043
PubMed:
34126824

Acroquinolones A and B, two polyphenolic isoprenylated acetophenone-quinolone hybrids with anti-proliferative activities from Acronychia pedunculata (L.) Miq.

Cancer
Panyasawat P et al (2022).
Nat Prod Res.
DOI:
10.1080/14786419.2021.1922405
PubMed:
33960228

Acetophenones from Acronychia pedunculata and their Cancer Chemopreventive Activity.

Cancer
Ito C et al (2016).
Nat Prod Commun.
PubMed:
30807028

Acrofolione A and B, acetophenone dimers from Acronychia pendunculata, induce an apoptotic effect on human NALM-6 pre-B cell leukaemia cells.

Matsui T et al (2019).
J Pharm Pharmacol.
DOI:
10.1111/jphp.13035
PubMed:
30362134

Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones.

Svouraki A et al (2017).
J Nat Prod.
DOI:
10.1021/acs.jnatprod.6b01008
PubMed:
28240894

Acetophenones Isolated from Acronychia pedunculata and their Anti-proliferative Activities.

Cancer
Ito C et al (2016).
Nat Prod Commun.
PubMed:
26996027

Cytotoxic prenylated acetophenone dimers from Acronychia pedunculata.

Kouloura E et al (2012).
J Nat Prod.
DOI:
10.1021/np201007a
PubMed:
22708987

Acetophenone derivatives from Acronychia pedunculata.

Su CR et al (2003).
J Nat Prod.
PubMed:
12880321