Actaea racemosa

Common Names: black baneberry, black cohosh, black snakeroot

Ethnobotanical Studies

Studies

State-of-the-Art Review on Botanical Hybrid Preparations in Phytomedicine and Phytotherapy Research: Background and Perspectives.

Review
Panossian A, Lemerond T and Efferth T (2024).
Pharmaceuticals (Basel).
DOI:
10.3390/ph17040483
PubMed:
38675443

Hydroxy(phenyl)pyruvic acid reductase in Actaea racemosa L.: a putative enzyme in cimicifugic and fukinolic acid biosynthesis.

Jahn A and Petersen M (2024).
Planta.
DOI:
10.1007/s00425-024-04382-6
PubMed:
38549005

Plant-derived natural medicines for the management of osteoporosis: A comprehensive review of clinical trials.

Summary

This study reviewed clinical evidence on using herbal medicine to manage osteoporosis, which is a chronic skeletal disease causing low bone density and increased fracture risk.

Review Arthritis
Karimi SM, Bayat M and Rahimi R (2023).
J Tradit Complement Med.
DOI:
10.1016/j.jtcme.2023.08.001
PubMed:
38223808

Variation in Botanical Reference Materials: Similarity of Actaea racemosa Analyzed by Flow Injection Mass Spectrometry.

Harnly J and Upton R (2023).
J AOAC Int.
DOI:
10.1093/jaoacint/qsad137
PubMed:
38141206

Analysis of Safety Concerns on Herbal Products with Assumed Phytoestrogenic Activity.

Endocrinology
Tjeerdsma AM et al (2023).
Pharmaceuticals (Basel).
DOI:
10.3390/ph16081137
PubMed:
37631050

Modulation of the Proliferative Pathway, Neuroinflammation and Pain in Endometriosis.

Summary

Administration of the natural compound AR reduced the size and histological morphology of endometriosis lesions in an in vivo model. AR also reduced hyperproliferation, restored the impaired apoptosis pathway, and exhibited antioxidant, anti-inflammatory, and pain-reducing effects.

CancerEndocrinologyNeurosciencePain
Interdonato L et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241411741
PubMed:
37511500

Actaea racemosa L. Rhizome Protect against MPTP-Induced Neurotoxicity in Mice by Modulating Oxidative Stress and Neuroinflammation.

Summary

A natural compound found in L. rhizome may alleviate symptoms of Parkinson's disease (PD) by reducing oxidative stress and modulating inflammatory indicators involved in the disease, according to a study on an in vivo model. Mice with PD were treated with L. rhizome for seven days, and the treatment reduced the degeneration of dopaminergic neurons and improved motor and non-motor deficits. L. rhizome may offer a promising dietary supplement to improve brain health and slow the course and symptoms of PD.

ImmunologyNeuroscience
Cordaro M et al (2022).
Antioxidants (Basel).
DOI:
10.3390/antiox12010040
PubMed:
36670902

A cross-sectional clinical study in women to investigate possible genotoxicity and hematological abnormalities related to the use of black cohosh botanical dietary supplements.

Smith-Roe SL et al (2022).
Environ Mol Mutagen.
DOI:
10.1002/em.22516
PubMed:
36323641

Actæa Racemosa.

Bailey FH et al (1873).
South Med Rec.
PubMed:
36021393

Novel Evidence-Based Combination of Plant Extracts with Multitarget Mechanisms of Action for the Elimination of Hot Flashes during Menopause.

Endocrinology
Tsoumani M et al (2022).
Molecules.
DOI:
10.3390/molecules27041221
PubMed:
35209016

Working with the natural complexity: Selection and characterization of black cohosh root extract for use in toxicology testing.

Waidyanatha S et al (2022).
Food Chem Toxicol.
DOI:
10.1016/j.fct.2021.112769
PubMed:
34929352

Cimicifuga racemosa isopropanolic extract for menopausal symptoms: an observational prospective case-control study.

Guida M et al (2021).
Gynecol Endocrinol.
DOI:
10.1080/09513590.2021.1974381
PubMed:
34477029

Case of cholestatic drug-induced liver injury (DILI) associated with black cohosh.

Brar HS and Marathi R (2021).
BMJ Case Rep.
DOI:
10.1136/bcr-2020-240408
PubMed:
33962922

Validation and Optimization of qPCR Method for Identification of Actaea racemosa (Black Cohosh) NHPs.

Shanmughanandhan J et al (2021).
J AOAC Int.
DOI:
10.1093/jaoacint/qsaa167
PubMed:
33346838

Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms - an update on the evidence.

Meta-Analysis
Castelo-Branco C et al (2021).
Climacteric.
DOI:
10.1080/13697137.2020.1820477
PubMed:
33021111

Black Cohosh.

Review
(2020).
PubMed:
31643322

Black Cohosh.

Review
(2021).
PubMed:
30000840

Economical, Plain, and Rapid Authentication of Actaea racemosa L. (syn. Cimicifuga racemosa, Black Cohosh) Herbal Raw Material by Resilient RP-PDA-HPLC and Chemometric Analysis.

Bittner M et al (2016).
Phytochem Anal.
DOI:
10.1002/pca.2622
PubMed:
27690371

The safety of black cohosh (Actaea racemosa, Cimicifuga racemosa).

Review
Huntley A et al (2004).
Expert Opin Drug Saf.
PubMed:
15500420

Black cohosh.

Review
Kligler B et al (2003).
Am Fam Physician.
PubMed:
12887117