Aesculus hippocastanum

Common Names: horse chestnut

Ethnobotanical Studies

Studies

Escin induces cell death in human skin melanoma cells through apoptotic mechanisms.

Vejselova Sezer C et al (2024).
Toxicol Res (Camb).
PubMed:
39108844

Urban forest species selection for improvement of ecological benefits in Polish cities - The actual and forecast potential.

Kacprzak MJ et al (2024).
J Environ Manage.
PubMed:
38981262

Assessment of cancer risk and radiological effects from (210)Po and (210)Pb with consumption of wild medicinal herbal plants.

Summary

Plants can store chemicals and radioisotopes from their environment, like Po and Pb, which can be hazardous to human health. Understanding this can help protect against toxicity.

Moniakowska A and Strumińska-Parulska D (2024).
J Trace Elem Med Biol.
PubMed:
38626651

Aesculus hippocastanum extract and the main bioactive constituent β-escin as antivirals agents against coronaviruses, including SARS-CoV-2.

Summary

Summary: β-escin from Aesculus hippocastanum has anti-inflammatory effects and affects NF-κB signaling. It shows promising broad-spectrum antiviral activity against coronaviruses including SARS-CoV-2, with potential as a therapeutic option for respiratory virus outbreaks.

Peñaranda Figueredo FA et al (2024).
Sci Rep.
PubMed:
38494515

Esculin inhibits hepatic stellate cell activation and CCl(4)-induced liver fibrosis by activating the Nrf2/GPX4 signaling pathway.

Xu S et al (2024).
Phytomedicine.
PubMed:
38471319

Phytoremediation by trees as a nature-based solution for mitigating metal contamination in urban soils.

Solomun MK et al (2024).
Environ Sci Pollut Res Int.
PubMed:
38460033

Reduction of Post-Surgical Facial Edema Following Bromelain and Coumarin Intake in Traumatology: A Prospective Study with 100 Patients.

Consorti G et al (2024).
J Clin Med.
PubMed:
38398236

Deciphering the Molecular Mechanism of Escin against Neuropathic Pain: A Network Pharmacology Study.

Summary

Escin, found in , has anti-inflammatory properties. This study uses network pharmacology, molecular docking, and molecular dynamics to understand how escin can help with neuropathic pain.

Li X et al (2023).
Evid Based Complement Alternat Med.
PubMed:
37876856

β-Escin: An Updated Review of Its Analysis, Pharmacology, Pharmacokinetics, and Toxicity.

Wang Y et al (2023).
Am J Chin Med.
PubMed:
37865870

Phenolic-Based Discrimination between Non-Symptomatic and Symptomatic Leaves of Aesculus hippocastanum Infested by Cameraria ohridella and Erysiphe flexuosa.

Hanaka A et al (2023).
Int J Mol Sci.
PubMed:
37762372

Painful bruising: Gynecology, hematology, or just pill bias? A case report.

Villamor G, Winograd D and Baum JD (2023).
Case Rep Womens Health.
PubMed:
37719129

Escin avoids hemorrhagic transformation in ischemic stroke by protecting BBB through the AMPK/Cav-1/MMP-9 pathway.

Summary

Escin, found in Aesculus hippocastanum, stabilizes the blood-brain barrier to mitigate hemorrhagic transformation (HT) caused by recombinant tissue plasminogen activator (rt-PA). Important for safer use of rt-PA in clinical applications.

Sun X et al (2023).
Phytomedicine.
PubMed:
37716034

A Study on the Stability and Antimicrobial Efficacy of a Newly Modeled Teat Dip Solution Containing Chlorhexidine.

Summary

Scientists developed a new biocide for post-milking udder hygiene to reduce antibiotic usage for mastitis treatment. It showed stability and effectiveness against mastitis pathogens. Important for minimizing antimicrobial resistance and environmental contamination.

Kybartas M et al (2023).
Vet Sci.
PubMed:
37624297

Genetic rearrangements in Pseudomonas amygdali pathovar aesculi shape coronatine plasmids.

Nielsen TK et al (2023).
Infect Genet Evol.
PubMed:
37541538

New biofunctional effects of oleanane-type triterpene saponins.

Summary

Various triterpene saponins have shown potential benefits in the gastrointestinal tract, affecting alcohol and glucose levels, gastric emptying, transit, and mucosal lesions, with shared modes of action.

Matsuda H et al (2023).
J Nat Med.
PubMed:
37436646

Temporal variation of mycorrhization rates in a tree diversity experiment.

Heklau H et al (2023).
Ecol Evol.
PubMed:
37091560

Phytochemical Estimation and Therapeutic Amelioration of Aesculus hippocastanum L. Seeds Ethanolic Extract in Gastric Ulcer in Rats Possibly by Inhibiting Prostaglandin Synthesis.

Idris S, Mishra A and Khushtar M (2023).
Chin J Integr Med.
PubMed:
37079159

Comparison of Semen Aesculi species from different geographical origins and horse chestnut based on metabolomics and chemometrics analysis.

Wang WW et al (2023).
Phytochem Anal.
PubMed:
36843182

Invasion Genetics of the Horse-Chestnut Leaf Miner, Cameraria ohridella (Lepidoptera: Gracillariidae), in European Russia: A Case of Successful Involvement of Citizen Science in Studying an Alien Insect Pest.

Kirichenko NI et al (2023).
Insects.
PubMed:
36835686

Potential protective effect of escin from Aesculus hippocastanum extract against cyclophosphamide-induced oxidative stress on rat tissues.

Küçükkurt İ et al (2022).
Toxicol Res (Camb).
PubMed:
36337244

Analysis of the Anti-Inflammatory and Anti-Osteoarthritic Potential of Flonat Fast(®), a Combination of Harpagophytum Procumbens DC. ex Meisn., Boswellia Serrata Roxb., Curcuma longa L., Bromelain and Escin (Aesculus hippocastanum), Evaluated in In Vitro Models of Inflammation Relevant to Osteoarthritis.

Quarta S et al (2022).
Pharmaceuticals (Basel).
PubMed:
36297375

New HPLC pattern-oriented approach for quality control of enteric coated tablets containing aescin from Aesculus hippocastanum.

Hien HM, Hien PL and Hung TV (2023).
J Pharm Biomed Anal.
PubMed:
36283324

The Secondary Metabolites Profile in Horse Chestnut Leaves Infested with Horse-Chestnut Leaf Miner.

Materska M et al (2022).
Molecules.
PubMed:
36080239

Assessment of Antimicrobial Activity of Ethanolic and Aqueous Extracts of Aesculus hippocastanum L. (Horse Chestnut) Bark against Bacteria Isolated from Urine of Patients Diagnosed Positive to Urinary Tract Infections.

Konstantinovitch KY et al (2022).
Front Biosci (Schol Ed).
PubMed:
35730436

A nutraceutical formulation combined with sclerofoam-assisted laser treatment ameliorates chronic venous insufficiency.

Palmieri B et al (2022).
Lasers Med Sci.
PubMed:
35435595

Red Horse Chestnut and Horse Chestnut Flowers and Leaves: A Potential and Powerful Source of Polyphenols with High Antioxidant Capacity.

Bielarska AM et al (2022).
Molecules.
PubMed:
35408675

A comparison of herbarium and citizen science phenology datasets for detecting response of flowering time to climate change in Denmark.

Iwanycki Ahlstrand N, Primack RB and Tøttrup AP (2022).
Int J Biometeorol.
PubMed:
35235036

Aesculus hippocastanum L. extract differently modulates normal human dermal fibroblasts and cancer-associated fibroblasts from basal/squamous cell carcinoma.

Melegová N et al (2022).
Neoplasma.
PubMed:
34962824

Aesculus hippocastanum-Derived Extract β-Aescin and In vitro Antibacterial Activity.

Dahash SL et al (2021).
J Microsc Ultrastruct.
PubMed:
33850709

Aesculus hippocastanum L. as a Stabilizer in Hemp Seed Oil Nanoemulsions for Potential Biomedical and Food Applications.

Jarzębski M et al (2021).
Int J Mol Sci.
PubMed:
33477381

Phytochemical, ethanomedicinal and pharmacological applications of escin from Aesculus hippocastanum L. towards future medicine.

Idris S, Mishra A and Khushtar M (2020).
J Basic Clin Physiol Pharmacol.
PubMed:
32649293

Horse Chestnut.

Review
(2018).
PubMed:
31643542

Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties.

Review Immunology
Gallelli L et al (2019).
Drug Des Devel Ther.
PubMed:
31631970

Aesculus hippocastanum (Horse chestnut). Monograph.

Review
(2009).
Altern Med Rev.
PubMed:
19803552

Hemorrhoids and varicose veins: a review of treatment options.

Review
MacKay D et al (2001).
Altern Med Rev.
PubMed:
11302778