Common Names: crofton weed, Maui pamakani, Mexican devil, sticky snakeroot
Study investigated inflammation and liver metabolism changes caused by A. adenophora ingestion in goats. Results show altered metabolites and pathways related to inflammation, along with liver injury and histopathological changes. Important for understanding A. adenophora hepatotoxicity and further research on liver metabolite changes.
Ageratina adenophora has been used in traditional medicine globally for various therapeutic purposes. It treats cancer, pain, fever, infections, and digestive issues. The plant is utilized by different ethnic groups in India, Portugal, and Nigeria.
The study examined the toxic mechanisms of Ageratina adenophora (a invasive plant) using multiomics approach. The main toxic compounds were identified, and metabolites involved in amino acid and lipid metabolism were found. The plant induces liver inflammatory damage and affects nutrient metabolism and neuron conduction.