Ajuga decumbens

Ethnobotanical Studies

Clinical Trials

ZY5301 Tablet vs Placebo for Treatment of Chronic Pelvic Pain After Pelvic Inflammatory Disease: A Phase 2 Randomized Clinical Trial.

ZY5301 tablets from Ajuga decumbens are being tested for treating chronic pelvic pain caused by pelvic inflammatory disease. Important potential treatment for a major issue with no established cure.

Teng X et al (2024).
JAMA Netw Open.
DOI:
10.1001/jamanetworkopen.2024.23229
PubMed:
39042407

Studies

Discovery of Novel Neo-Clerodane Derivatives as Potent Dual-Functional Antiosteoporosis Agents through Targeting Peroxisome Proliferator-Activated Receptor-γ.

Peng X et al (2024).
J Med Chem.
DOI:
10.1021/acs.jmedchem.4c01377
PubMed:
39185622

Metabolome-microbiome insights into therapeutic impact of 8-O-acetylharpagide against breast cancer in a murine model.

Summary

8-O-acetylharpagide, a compound in Ajuga decumbens Thunb, reduces 4 T1 breast cancer growth in mice by regulating bile acid and arachidonic acid metabolism and altering gut microbiota. Promising for breast cancer treatment.

Cancer
Qian J et al (2024).
Biomed Chromatogr.
DOI:
10.1002/bmc.5880
PubMed:
38634147

Isolation, structural elucidation of new phytoecdysteroids from Ajuga decumbens Thunb.

Olatunde OZ, Yong J and Lu C (2022).
Steroids.
DOI:
10.1016/j.steroids.2022.109089
PubMed:
35843360

Ferroptosis Inhibitory Aromatic Abietane Diterpenoids from Ajuga decumbens and Structural Revision of Two 3,4-Epoxy Group-Containing Abietanes.

Review
Peng X et al (2022).
J Nat Prod.
DOI:
10.1021/acs.jnatprod.2c00352
PubMed:
35796002

New neo-Clerodane Diterpenoids Isolated from Ajuga decumbens Thunb., Planted at Pingtan Island of Fujian Province with the Potent Anticancer Activity.

Cancer
Zacchaeus Olatunde O, Yong J and Lu C (2023).
Anticancer Agents Med Chem.
DOI:
10.2174/1871520622666220620151225
PubMed:
35726426

Acetylharpagide Protects Mice from Staphylococcus Aureus-Induced Acute Lung Injury by Inhibiting NF-κB Signaling Pathway.

Immunology
Zhang Z et al (2020).
Molecules.
DOI:
10.3390/molecules25235523
PubMed:
33255656

Accurate position exchange of stamen and stigma by movement in opposite direction resolves the herkogamy dilemma in a protandrous plant, Ajuga decumbens (Labiatae).

Ye ZM et al (2019).
AoB Plants.
DOI:
10.1093/aobpla/plz052
PubMed:
31579102

Neo-clerodane diterpenes and phytoecdysteroids from Ajuga decumbens Thunb. and evaluation of their effects on cytotoxic, superoxide anion generation and elastase release in vitro.

Chen H et al (2018).
Fitoterapia.
DOI:
10.1016/j.fitote.2018.06.004
PubMed:
29894737

Ajuga decumbens stimulates mesenchymal stem cell differentiation and regenerates cartilage in a rabbit osteoarthritis model.

Sawada Y et al (2018).
Exp Ther Med.
DOI:
10.3892/etm.2018.5981
PubMed:
29725360

Evaluation of the efficacy of Ajuga decumbens extract supplement in individuals with knee discomfort associated with physical activity: A randomized, double-blind, placebo-controlled study.

Sawada Y et al (2017).
Exp Ther Med.
DOI:
10.3892/etm.2017.5064
PubMed:
29109757

A New Succinate Derivative from Ajuga decumbens.

Fan GX et al (2016).
Nat Prod Commun.
PubMed:
27396203

Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens Thunb extract in rats.

Wen B et al (2013).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2013.03.048
PubMed:
23545457

neo-Clerodane diterpenes from Ajuga decumbens and their inhibitory activities on LPS-induced NO production.

Sun Z et al (2012).
Fitoterapia.
DOI:
10.1016/j.fitote.2012.08.003
PubMed:
22917649

New glycosides from ajuga decumbens.

Phytochemistry
Takasaki M et al (1998).
J Nat Prod.
PubMed:
9748375