Common Names: cultivated garlic
Scientists are studying plant peptides for their ability to fight antibiotic-resistant bacteria, offering potential new solutions to antibiotic resistance.
Study documents medicinal plant use in study area by 84 informants. 46 plants identified, with Brassicaceae, Ranunculaceae, and Polygonaceae most abundant. Leaves most common plant part used. Threats identified. Involving local communities crucial for plant conservation.
Summary: Review of medicinal plants in the family for treating diabetes, particularly type II diabetes. Limited research, potential for new treatments targeting α-glucosidase enzyme. Important for discovering alternative therapies to manage diabetes.
Researchers found that in specific types of breast cancer, changes in SULT1E1 and HIF1α factors can impact estrogen levels and tissue damage. Testing drug combinations targeting SULT1E1 may offer protective benefits in breast cancer treatment.
Garlic compound allicin shows promise in treating cardiovascular diseases by reducing inflammation, oxidative stress, and apoptosis. Nanotechnology may enhance its effectiveness. Worth exploring for potential drug development.
Indian Garlic Essential Oil (GEO) rich in allyl sulfur compounds showed strong antibacterial, antibiofilm, and antioxidant properties. It disrupts bacterial cell membranes and inhibits growth effectively. Potential for use in food industry.
This review discusses how radiation exposure affects the brain and neurodegenerative diseases. Herbal medicines like Allium cepa and Centella asiatica show promise in protecting against neurological damage and may have potential in managing neurological illnesses.
Garlic antimicrobial peptide improved by chemical modification for better antifungal activity. Study explores structure-activity relationship and antifungal mechanism. Useful for developing new antifungal treatments.
Researchers optimized garlic mustard oil as an antifungal agent against fungal infections. GMM showed strong activity against fungi with potential for treating tropical infections. Benefits include effective inhibition of fungal growth and strong binding affinity to N-myristoyltransferase.
Study shows Mediterranean plant extracts effectively combat foodborne pathogens, particularly Allium spp. against B. cereus and S. aureus, and Thymus spp. against B. cereus. Results inform food safety measures and highlight potential natural alternatives to chemical additives for food preservation.
Garlic and Citrullus colocynthis improve male reproductive function in diabetes through antioxidant properties. Lowering doses may still be effective in achieving desired results without unwanted side effects.
Researchers found that nano-CeO reduced antibiotic-resistant genes in garlic plants, potentially limiting spread to humans. Effective use of nanomaterials could help control antibiotic resistance in agriculture. The study suggests a potential solution to prevent the spread of antibiotic resistance in plants.
Allicin, a compound in garlic, shows promise in combating various types of cancer by targeting key biological functions. Researchers should investigate its potential as a low-toxicity anticancer drug.
This study annotates genes involved in the biosynthesis of allicin in garlic. It identifies their locations in the genome, reveals their structure, and explores their evolution. It also suggests that one of the genes may be a pseudogene.
Black garlic has medicinal properties, including anti-inflammatory and anti-cancer effects. It reduces pro-inflammatory cytokines, scavenges free radicals, induces cell death, and inhibits cancer cell growth. It is a valuable source for therapy with fewer side effects and easier consumption than regular garlic.
This review explores the positive effects of using garlic as a dietary additive in poultry production. Garlic improves production parameters, intestinal health, immune response, and reduces oxidative stress and cholesterol levels. It also has antibacterial and antiparasitic activities.
Exposure to B[a]P increases breast cancer risk. Garlic compound DATS can block B[a]P-induced carcinogenesis in breast cells, reducing cell damage and promoting DNA repair. DATS has potential for breast cancer prevention.
Researchers explored the mechanism by which a homeopathic preparation of Allium sativum (garlic) counteracts the formation of foam cells caused by oxidized LDL (OxLDL), a major contributor to atherosclerosis. Understanding this mechanism could lead to potential therapeutic applications.
This study explores the use of medicinal plants in the Habru District of Ethiopia. The objective is to gather information on the plant species and traditional practices used by the local community to treat human ailments.
This study assessed the impact of garlic and oregano essential oil mixture on digestibility in sheep. Results showed that low levels of the mixture improved dry matter digestibility and nutrient intake. The essential oil mixture has the potential to improve fiber digestion and reduce antibiotic use in livestock.
This research examined the anthelmintic properties of tropical plant extracts compared to praziquantel. Alligator pepper and neem extracts were most potent, and Aframomum melegueta and praziquantel were effective against all parasite classes with a wide safety margin for the fish host.
This study investigated how natural compounds bind to PTP1B, a drug target for diabetes. The optimized compounds had good binding scores and the kaempferol compounds showed stability. The study identified potential targets and pathways for anti-PTP1B effects, aiding diabetes medication development.
Garlic supplementation improved kidney function and metabolic disorders in animal models of diabetic kidney disease. Research suggests that doses of 500mg/kg for 8-10 weeks were most effective, but further studies are required. (33 words)
Researchers developed a method to extract allicin from garlic and found it remains stable at low temperatures. In zebrafish studies, allicin showed antioxidant, anti-proliferative, apoptotic, and anti-angiogenic properties. This suggests allicin could be investigated as a potential anti-cancer agent.
This study compared the antioxidant and anticancer properties of different forms of garlic. Garlicin supplement had high antioxidant activity and fresh garlic extracts strongly inhibited lung cancer cell growth. The preparation and processing methods of garlic can impact its antioxidant benefits.
Scientists used RNA-seq to study the transcriptomic changes in garlic under drought stress. They identified key genes involved in fructan metabolism and found that drought stress induces fructan accumulation in garlic. This research provides insights for developing drought-tolerant garlic varieties.
This review analyzed the therapeutic effects of natural products on obesity. Several natural products, including coffee, green tea, garlic, and others, showed anti-obesity effects. Further research is needed for clinical use.
An aged black garlic extract with low doses of SAC lowers blood pressure in Grade I hypertensive individuals on medication. It increases nitric oxide and antioxidant capacity, reduces uric acid levels and ACE activity, without affecting inflammation or endothelial function.
Garlic and its bioactive compounds have been shown to have antiviral and immunomodulatory properties in poultry, decreasing viral loads, increasing antibody titres, and regulating gene expression. However, further research is needed to determine the optimal dose and administration of garlic for optimal effects.
Garlic has numerous health benefits including antioxidant, antifungal, antibacterial, antidiabetic, anti-inflammatory, anticancer, and antiviral effects. This study provides a mini-review on the chemistry and pharmacology of garlic for treating cardiovascular/heart-related diseases.
This study investigated the antimicrobial potential of uncooked and cooked garlic extracts. Cooking garlic decreases or eliminates its antimicrobial benefits, so consuming uncooked garlic is best for maximum effectiveness against bacteria and fungi.
The researchers addressed the problem of antibiotic-resistant microbes caused by antibiotic overuse. They found that nanotechnology offers a solution by enabling the synthesis of new, multifunctional compounds to combat these microbes. This research is crucial for reducing global mortality rates.
Garlic essential oil reduces dopamine/serotonin turnover rates, reverses depression in rats, inhibits inflammation, and promotes intestinal barrier function, potentially influencing depression-like behavior.
Review finds that plant-based drugs, particularly herbs, used as add-on therapy for COVID-19 show efficacy and safety, potentially enhancing the immune system for treating the virus. (37 words)
Scientists are exploring alternative treatments for colorectal cancer (CRC) due to the limitations of current chemotherapeutics. In this study, researchers investigated the potential anti-CRC effects of a medicinal plant, (). They analyzed the plant's bioactive compounds and identified key targets for CRC treatment. Gene set enrichment analysis revealed the biological processes and pathways that could potentially be restored in CRC. Molecular docking studies identified beta-sitosterol and alpha-bisabolene as compounds with the highest binding affinity for the key targets. Further experimental studies are needed to validate these findings. This research has the potential to contribute to the development of more effective and targeted CRC treatments.
This study notes that patients can suffer harm from using conventional and complementary medicines together. However, this harm can be avoided. The researchers emphasize the importance of healthcare professionals educating patients about safe practices when using CMs alongside conventional medicine.
This review article examines the potential of medicinal plants and vitamins in the prevention and treatment of diabetes mellitus (DM). Current research suggests that certain phytochemicals in medicinal plants and vitamins C, D, and E may possess anti-hypoglycemic activities and improve the health of diabetes patients. However, more research is needed in this area.
Garlic helps with obesity and muscle atrophy. Aged black garlic and aged black elephant garlic enhance muscle growth through Akt/mTOR/p70 signaling.
Garlic compounds have potential as cancer-fighting agents in colorectal cancer. Consuming garlic may help prevent colorectal cancer.
Garlic has shown protective effects in models of Parkinson's Disease (PD) due to its anti-Parkinsonian activity through targeting oxidative stress, mitochondrial damage, and neuroinflammation-related signaling. However, the major bioactive components of garlic present stability issues and some adverse effects. This review explores the therapeutic potential of garlic and its constituents in PD, the molecular mechanisms responsible for its benefits, and the associated limitations that need to be overcome for clinical use. Garlic has potential as a treatment for PD, but more research is needed to develop safer and more effective methods of delivery.
Researchers conducted a study to discover potential antiviral compounds from a natural plant source, screening 25 phytocompounds against the drug target 3CL protease by CB-dock. The best five compounds were Allicin, Diallyl Sulfide, Diallyl Disulfide, Diallyl Trisulfide, Ajoene, and Levamisole, which showed themselves as hit compounds. Further refining by screening filters represented Levamisole as a lead compound that may potentially treat SARS-CoV-2. However, more research must be done before determining their medicinal use.
Researchers are investigating various hypotheses on the pathology of Alzheimer's disease (AD), including the Amyloid beta and Tau hypotheses. New mechanisms like immune, endocrine, and vagus pathways are also being explored. Garlic possesses antioxidant properties due to its allicin content, and its beneficial effects on AD are being examined. Garlic's components, including allicin and S-allyl cysteine, show promise in their effects on amyloid beta, oxidative stress, tau protein, gene expression, and cholinesterase enzymes. While animal studies have been positive, further research on humans is needed to fully understand garlic's exact effects on AD.
This study investigated supplement use in Saudi Arabia during the COVID-19 pandemic and found that 87% of participants reported using at least one type of supplement. Vitamin C and D were the most commonly used, and females were more likely to use supplements than males. These findings show a high prevalence of supplement use during the pandemic and highlight the importance of understanding the impact of supplement usage on COVID-19 outcomes.
Scientists are exploring the use of phytochemicals from medicinal plants as potential therapies against SARS CoV-2 and other coronaviruses. They created a library of 110 phytochemicals from different plants and found that ashwagandha and shatavari contained steroidal saponins and alkaloids that could potentially inhibit the virus's hemagglutinin-acetylesterase (HE) glycoprotein receptor. Molecular docking and dynamics simulations suggest that these phytochemicals could mask the active site of the receptor, preventing viral entry into host cells. This approach has potential for developing therapies against future deadly coronaviruses.