Scientists found bioactive compounds in Alstonia scholaris leaves extracts, showing antibacterial properties. Methanol extract used for green synthesis of Cu-NPs revealed potential for biomedical applications.
Ayush-64, a herbal formulation, showed positive results in hamsters against COVID-19, preventing weight loss, reducing inflammation, and lung damage. Further research is needed to identify active compounds for future studies.
Researchers extracted total alkaloids from Alstonia solaris, a plant used in traditional medicine to treat respiratory diseases. These alkaloids have potential as asthma medications, but further research is required to understand their effectiveness and mechanism of action.
Review finds that plant-based drugs, particularly herbs, used as add-on therapy for COVID-19 show efficacy and safety, potentially enhancing the immune system for treating the virus. (37 words)
Researchers isolated (-)-Tetrahydroalstonine (THA) and studied its effect on protecting neurons from oxygen-glucose deprivation/re-oxygenation (OGD/R)-induced damage. They pre-treated primary cortical neurons with THA and found it increased cell viability. THA also ameliorated autophagic activity and lysosomal dysfunction, which were present at the early stage of OGD/R. Additionally, THA activated the Akt/mTOR pathway, which was suppressed after OGD/R induction. This study suggests that THA exhibits promising neuroprotective effects against OGD/R-induced neuronal injury through autophagy regulation via the Akt/mTOR pathway.