Ampelopsis grossedentata

Ethnobotanical Studies

Studies

Supplementation of Ampelopsis grossedentata extract contributes to the improvement of intestinal health in swine.

Summary

Study on vine tea extract (AGE) highlights its anti-inflammatory, antioxidant, and immune-boosting properties. It also improves gut health and microbiota. Relevant for potential medical and dietary applications.

Gastroenterology
Liu X et al (2024).
Front Vet Sci.
DOI:
10.3389/fvets.2024.1417309
PubMed:
39234174

Progress of Exosomal MicroRNAs and Traditional Chinese Medicine Monomers in Neurodegenerative Diseases.

Summary

Exosomes contain microRNAs crucial for intercellular communication in neurodegenerative diseases. Traditional Chinese medicine monomers show promise in treating these diseases by reducing oxidative stress, apoptosis, and inflammation. Study explores their potential synergy with modern therapies.

Review Neuroscience
Liang J et al (2024).
Phytother Res.
DOI:
10.1002/ptr.8322
PubMed:
39225243

Metabolome analysis of egg yolk and white following dietary supplementation with Ampelopsis grossedentata extract.

Li P et al (2024).
Poult Sci.
DOI:
10.1016/j.psj.2024.104110
PubMed:
39106697

Analysis of the role of dihydromyricetin derived from vine tea (Ampelopsis grossedentata) on multiple myeloma by activating STAT1/RIG-I axis.

Cancer
Jiang W and Zhou M (2024).
Oncol Res.
DOI:
10.32604/or.2024.043423
PubMed:
39055888

An integrated network pharmacology approach reveals that Ampelopsis grossedentata improves alcoholic liver disease via TLR4/NF-κB/MLKL pathway.

Immunology
Qiu P et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155658
PubMed:
38981149

Widely targeted metabolomic analysis reveals effects of yellowing process time on the flavor of vine tea (Ampelopsis grossedentata).

Qi S et al (2024).
Food Chem X.
DOI:
10.1016/j.fochx.2024.101446
PubMed:
38846795

A new insight into the key matrix components for aftertaste in Ampelopsis grossedentata (vine tea) infusion: From the intensity and duration of taste profiles using non-targeted metabolomics and molecular simulation.

Chen L et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.139236
PubMed:
38640537

Integration of network pharmacology, lipidomics, and transcriptomics analysis to reveal the mechanisms underlying the amelioration of AKT-induced nonalcoholic fatty liver disease by total flavonoids in vine tea.

GeneticsPhytochemistry
Du S et al (2024).
Food Funct.
DOI:
10.1039/d4fo00586d
PubMed:
38630029

Effect of dietary supplementation Ampelopsis grossedentata extract on growth performance and muscle nutrition of Megalobrama hoffmanni by gut bacterial mediation.

Gastroenterology
Yang Q et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e29008
PubMed:
38601588

Dihydromyricetin regulates RIPK3-CaMKII to prevent necroptosis in high glucose-stimulated cardiomyocytes.

Sun L et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e28921
PubMed:
38596141

Dihydromyricetin ameliorates hepatic steatosis and insulin resistance via AMPK/PGC-1α and PPARα-mediated autophagy pathway.

Yang Y et al (2024).
J Transl Med.
DOI:
10.1186/s12967-024-05060-7
PubMed:
38532480

LanGui tea, an herbal medicine formula, protects against binge alcohol-induced acute liver injury by activating AMPK-NLRP3 signaling.

Gu M et al (2024).
Chin Med.
DOI:
10.1186/s13020-024-00906-0
PubMed:
38439080

The effect of vine tea (Ampelopsis grossedentata) extract on fatigue alleviation via improving muscle mass.

Qi S et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117810
PubMed:
38266948

Exploring the Therapeutic Potential of Ampelopsis grossedentata Leaf Extract as an Anti-Inflammatory and Antioxidant Agent in Human Immune Cells.

Immunology
Chervet A et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms25010416
PubMed:
38203587

Chemical Constituents and α-Glucosidase Inhibitory, Antioxidant and Hepatoprotective Activities of Ampelopsis grossedentata.

Immunology
Luo QJ et al (2023).
Molecules.
DOI:
10.3390/molecules28247956
PubMed:
38138447

Hepatoprotective Effect of Tea Composite Solid Beverage on Alcohol-Caused Rat Liver Injury.

Tang Z et al (2023).
Foods.
DOI:
10.3390/foods12224126
PubMed:
38002184

Integrating multi-level interactive network and in vivo/vitro studies to explore the protective mechanism of Ampelopsis grossedentata in hyperuricemia.

Zhou QX et al (2023).
Fitoterapia.
DOI:
10.1016/j.fitote.2023.105718
PubMed:
37931719

Ampelopsis grossedentata Represents a New Host of the 16SrI Group of Phytoplasma Associated with Yellow Leaf Symptoms in China.

Cao L et al (2023).
Plant Dis.
DOI:
10.1094/PDIS-09-23-1820-PDN
PubMed:
37923979

China Medicinal Plants of the Ampelopsis grossedentata-A Review of Their Botanical Characteristics, Use, Phytochemistry, Active Pharmacological Components, and Toxicology.

Summary

This abstract summarizes the research progress of AG, a plant mainly found in China. It discusses its chemical components, therapeutic properties, and potential uses in various fields. This information can be useful for further research on AG.

Review Phytochemistry
Wu RR et al (2023).
Molecules.
DOI:
10.3390/molecules28207145
PubMed:
37894624

Research progress of dihydromyricetin in the treatment of diabetes mellitus.

Summary

Dihydromyricetin (DMY) is a compound found in Ampelopsis grossedentata that shows promise in treating diabetes mellitus (DM). It improves glucose and lipid metabolism, reduces inflammation and oxidative stress. The specific mechanisms and potential applications are still unclear.

Review Diabetes
Wang Z et al (2023).
Front Endocrinol (Lausanne).
DOI:
10.3389/fendo.2023.1216907
PubMed:
37732125

Exploring the Impact of Ampelopsis Grossedentata Flavonoids on Growth Performance, Ruminal Microbiota, and Plasma Physiology and Biochemistry of Kids.

Summary

This study found that supplementing Ampelopsis grossedentata flavonoids (AGF) in goat's diets improved rumen bacterial microbiome, plasma physiology, and growth performance. This has potential benefits for livestock growth and economic outcomes.

GastroenterologyPhytochemistry
Zhu J et al (2023).
Animals (Basel).
DOI:
10.3390/ani13152454
PubMed:
37570263

A comprehensive review of vine tea: Origin, research on Materia Medica, phytochemistry and pharmacology.

Summary

Vine tea has been consumed for centuries in China for various medicinal purposes. Leaves of Nekemias grossedentata are considered a new food resource.

Review Phytochemistry
Zeng T et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116788
PubMed:
37343650

Dihydromyricetin attenuates cisplatin-induced acute kidney injury by reducing oxidative stress, inflammation and ferroptosis.

Immunology
Xu Z et al (2023).
Toxicol Appl Pharmacol.
DOI:
10.1016/j.taap.2023.116595
PubMed:
37328118

Dihydromyricetin Inhibits M1 Macrophage Polarization in Atherosclerosis by Modulating miR-9-Mediated SIRT1/NF-κB Signaling Pathway.

Immunology
Yang Z et al (2023).
Mediators Inflamm.
DOI:
10.1155/2023/2547588
PubMed:
37234960

Dihydromyricetin promotes GLP-1 release and glucose uptake by STC-1 cells and enhances the effects of metformin upon STC-1 cells and diabetic mouse model.

Diabetes
Yao Y et al (2023).
Tissue Cell.
DOI:
10.1016/j.tice.2023.102108
PubMed:
37229936

Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway.

Cancer
Li X et al (2023).
J Biochem Mol Toxicol.
DOI:
10.1002/jbt.23328
PubMed:
36807944

Ampelopsin induces MDA-MB-231 cell cycle arrest through cyclin B1-mediated PI3K/AKT/mTOR pathway in vitro and in vivo.

Meng M et al (2023).
Acta Pharm.
DOI:
10.2478/acph-2023-0005
PubMed:
36692465

Dihydromyricetin Attenuates Diabetic Cardiomyopathy by Inhibiting Oxidative Stress, Inflammation and Necroptosis via Sirtuin 3 Activation.

CardiologyImmunology
Chen Y et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12010200
PubMed:
36671063

Identification of Hydroxylation Enzymes and the Metabolic Analysis of Dihydromyricetin Synthesis in Ampelopsis grossedentata.

Zhang S et al (2022).
Genes (Basel).
DOI:
10.3390/genes13122318
PubMed:
36553585

Dihydromyricetin ameliorates social isolation-induced anxiety by modulating mitochondrial function, antioxidant enzymes, and BDNF.

Summary

Chronic social isolation is a psychological stressor that can induce neurobehavioral changes associated with anxiety disorders. This study observed the effects of social isolation on mitochondrial function and antioxidative enzymes. Treatment with dihydromyricetin counteracted the changes induced by social isolation on antioxidative enzymes, autophagy, and the BDNF-TrkB signaling pathway. These findings help explain the anxiolytic effects of dihydromyricetin and highlight the importance of oxidative stress in the pathogenesis of anxiety.

Neuroscience
Al Omran AJ et al (2022).
Neurobiol Stress.
DOI:
10.1016/j.ynstr.2022.100499
PubMed:
36532369

Dihydromyricetin Attenuates Depressive-like Behaviors in Mice by Inhibiting the AGE-RAGE Signaling Pathway.

Huang J et al (2022).
Cells.
DOI:
10.3390/cells11233730
PubMed:
36496991

Dihydromyricetin inhibits Hepatitis B virus replication by activating NF-κB, MAPKs, and autophagy in HepG2.2.15 cells.

Wang X et al (2023).
Mol Biol Rep.
DOI:
10.1007/s11033-022-07971-4
PubMed:
36474061

Dihydromyricetin contributes to weight loss via pro-browning mediated by mitochondrial fission in white adipose.

Xiong X et al (2022).
Eur J Pharmacol.
DOI:
10.1016/j.ejphar.2022.175345
PubMed:
36283451

Study on effects of processing technology and storage on the composition of Ampelopsis grossedentata by untargeted metabolomics.

Ai J et al (2022).
Food Res Int.
DOI:
10.1016/j.foodres.2022.111867
PubMed:
36192987

Comprehensive analysis of dihydromyricetin metabolites in rats using ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry.

Phytochemistry
Jing X et al (2022).
J Sep Sci.
DOI:
10.1002/jssc.202200319
PubMed:
36062729

Vine Tea (Ampelopsis grossedentata) Extract Attenuates CCl(4) -Induced Liver Injury by Restoring Gut Microbiota Dysbiosis in Mice.

Gastroenterology
Li Y et al (2022).
Mol Nutr Food Res.
DOI:
10.1002/mnfr.202100892
PubMed:
35188709

Effects of dietary supplementation with Ampelopsis grossedentata extract on production performance and body health of hens.

Huang T et al (2022).
Trop Anim Health Prod.
DOI:
10.1007/s11250-022-03044-7
PubMed:
35015154

Social isolation induces neuroinflammation and microglia overactivation, while dihydromyricetin prevents and improves them.

Summary

Anxiety disorders are prevalent and costly in the U.S. Despite available treatments, many patients experience side-effects or resistance. The COVID-19 pandemic has exacerbated the issue. Dihydromyricetin (DHM), a flavonoid found in Ampelopsis grossedentata, has been shown to have anxiolytic properties in mouse models. The authors investigated the effect of short-term social isolation on the neuroimmune system and found evidence that the GABAergic system plays a role in modulating immune response. These findings may lead to new therapies for anxiety disorders.

ImmunologyNeuroscience
Al Omran AJ et al (2022).
J Neuroinflammation.
DOI:
10.1186/s12974-021-02368-9
PubMed:
34983568

Protective effect of dihydromyricetin on vascular smooth muscle cell apoptosis induced by hydrogen peroxide in rats.

Li W et al (2023).
Perfusion.
DOI:
10.1177/02676591211059901
PubMed:
34979825

Flavonoids in Ampelopsis grossedentata as covalent inhibitors of SARS-CoV-2 3CL(pro): Inhibition potentials, covalent binding sites and inhibitory mechanisms.

Summary

Researchers identified the key constituents in Ampelopsis grossedentata extract (AGE) responsible for inhibiting coronavirus 3C-like protease (3CL), a target for treating COVID-19. Flavonoid-rich fractions from AGE were found to strongly inhibit SARS-CoV-2-3CL, with dihydromyricetin, isodihydromyricetin, and myricetin identified as the most effective compounds. The researchers found that myricetin covalently binds to SARS-CoV-2-3CL at Cys300 and Cys44, while dihydromyricetin and isodihydromyricetin covalently bind at Cys300, suggesting that these compounds could be used to develop new antiviral agents.

COVID-19Phytochemistry
Xiong Y et al (2021).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2021.07.167
PubMed:
34333006

Effect of steam explosion pretreatment on the structure and bioactivity of Ampelopsis grossedentata polysaccharides.

Liu CY et al (2021).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2021.06.002
PubMed:
34166690

Dihydromyricetin attenuates D-galactose-induced brain aging of mice via inhibiting oxidative stress and neuroinflammation.

Summary

Researchers investigated the effects of dihydromyricetin (DMY), a natural product found in Ampelopsis grossedentata, on brain aging in mice. The study found that DMY showed strong neuroprotective effects, improved spatial cognition, alleviated damage of hippocampal neurons, and inhibited senescence of hippocampal neurons. Additionally, DMY modulated oxidative stress and inflammation-related senescence of hippocampal neurons. These findings suggest that DMY may be a potential treatment for brain aging-related diseases.

ImmunologyNeuroscience
Qian J et al (2021).
Neurosci Lett.
DOI:
10.1016/j.neulet.2021.135963
PubMed:
34022267