Andrographis paniculata

Ethnobotanical Studies

Clinical Trials

Efficacy of Andrographis paniculata extract treatment in mild to moderate COVID-19 patients being treated with favipiravir: A double-blind, randomized, placebo-controlled study (APFaVi trial).

Favipiravir is commonly used to treat COVID-19, but its effectiveness is uncertain. Andrographis paniculata extract has antiviral properties and could be a promising treatment for early-stage COVID-19.

Siripongboonsitti T et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155018
PubMed:
37625206

Studies

Terminalia bellirica and Andrographis paniculata dietary supplementation in mitigating heat stress-induced behavioral, metabolic and genetic alterations in broiler chickens.

Fayed RH et al (2024).
BMC Vet Res.
DOI:
10.1186/s12917-024-04233-2
PubMed:
39227945

Degradation of andrographolide in Andrographis paniculata over 1 year storage.

Ahammed MT et al (2024).
Phytochem Anal.
DOI:
10.1002/pca.3441
PubMed:
39205402

Ayurveda in the integrative management of bovine secondary recumbency-a case report.

R R and K U (2024).
J Ayurveda Integr Med.
DOI:
10.1016/j.jaim.2024.100962
PubMed:
39121784

Screening of ent-copalyl diphosphate synthase and metabolic engineering to achieve de novo biosynthesis of ent-copalol in Saccharomyces cerevisiae.

Li S et al (2024).
Synth Syst Biotechnol.
DOI:
10.1016/j.synbio.2024.06.005
PubMed:
39021361

Dehydroandrographolide ameliorates doxorubicin-mediated cardiotoxicity by regulating autophagy through the mTOR-TFEB pathway.

Duan Y et al (2024).
Chem Biol Interact.
DOI:
10.1016/j.cbi.2024.111132
PubMed:
38964637

A Diterpenoid of the Medicinal Plant Andrographis paniculata Targets Cutaneous TRPV3 Channel and Relieves Itch.

Kalinovskii AP et al (2024).
J Nat Prod.
DOI:
10.1021/acs.jnatprod.4c00626
PubMed:
38961616

Andrographolide exhibits antinociceptive effects in neuropathic rats via inhibiting class Ⅱ MHC associated response and regulating synaptic plasticity.

Ma L et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155823
PubMed:
38941815

Immobilization of biosynthesized gallium nanoparticles in Polyvinylpyrrolidone/Sodium alginate films: Potent bactericidal protection against food spoilage bacteria.

El-Sawaf AK et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.133438
PubMed:
38936583

Synthetic Modifications of Andrographolide Targeting New Potential Anticancer Drug Candidates: A Comprehensive Overview.

Summary

Review of synthetic modifications of andrographolide for cancer treatment. Identifies key positions for activity and highlights importance of lipophilic capacity in targeting interactions. Useful for future research in oncology drug development.

Review Cancer
Messire G et al (2024).
Molecules.
DOI:
10.3390/molecules29122884
PubMed:
38930949

Andrographolide targets EGFR to impede epithelial-mesenchymal transition in human breast cancer cells.

Cancer
Kaewpiboon C et al (2024).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2024.116267
PubMed:
38889579

Current Evidence on Molecular Mechanisms of Andrographolide in Cancer.

Summary

Andrographolide, a natural compound from Andrographis paniculata, shows promising anti-cancer properties, inhibiting multiple signaling pathways and causing anti-proliferative and apoptotic effects. It has no side effects and potential as a new cancer treatment, but more research is needed for full understanding and clinical application.

Cancer
Attri DC et al (2024).
Curr Med Chem.
DOI:
10.2174/0109298673295496240530100728
PubMed:
38867528

Andrographolide promotes lymphangiogenesis and lymphatic vessel remodeling to alleviate secondary lymphedema.

Yang K et al (2024).
Biochem Biophys Res Commun.
DOI:
10.1016/j.bbrc.2024.150179
PubMed:
38820623

Polymer Matrix and Manufacturing Methods in Solid Dispersion System for Enhancing Andrographolide Solubility and Absorption: A Systematic Review.

Review
Tipduangta P et al (2024).
Pharmaceutics.
DOI:
10.3390/pharmaceutics16050688
PubMed:
38794350

Anticancer diterpenes of African natural products: Mechanistic pathways and preclinical developments.

Summary

Researchers studied natural products from African biodiversity hotspots and found diterpenes with promising anticancer properties. Further research could lead to new cancer therapies.

Review Cancer
Bangay G et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155634
PubMed:
38718637

Study of andrographolide bioactivity against Pseudomonas aeruginosa based on computational methodology and biochemical analysis.

He L et al (2024).
Front Chem.
DOI:
10.3389/fchem.2024.1388545
PubMed:
38680458

Isolation, Characterization, and Expression Analysis of NAC Transcription Factor from Andrographis paniculata (Burm. f.) Nees and Their Role in Andrographolide Production.

Kumar R et al (2024).
Genes (Basel).
DOI:
10.3390/genes15040422
PubMed:
38674357

Mechanism of antimalarial action and mitigation of infection-mediated mitochondrial dysfunction by phyto-constituents of Andrographis paniculata ((Burm f.) Wall. ex Nees) in Plasmodium berghei-infected mice.

Olanlokun JO et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118241
PubMed:
38670400

Herbal Medicines for the Treatment of Active Ulcerative Colitis: A Systematic Review and Meta-Analysis.

Summary

A systematic review and meta-analysis found that certain herbal medicines can help with active ulcerative colitis, specifically (IN) for clinical response and (CL) for clinical remission and endoscopic response. More research is needed for larger scale studies and regulatory standards.

Meta-Analysis Gastroenterology
Iyengar P et al (2024).
Nutrients.
DOI:
10.3390/nu16070934
PubMed:
38612967

Nitrogen Sources Reprogram Carbon and Nitrogen Metabolism to Promote Andrographolide Biosynthesis in Andrographis paniculata (Burm.f.) Nees Seedlings.

Jian S et al (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25073990
PubMed:
38612797

Synergistic action of Hedyotis diffusa Willd and Andrographis paniculata in Nasopharyngeal Carcinoma: Downregulating AKT1 and upregulating VEGFA to curb tumorigenesis.

Ye C et al (2024).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2024.111866
PubMed:
38603854

Anti-inflammatory effect and pharmacokinetics of dehydroandrographolide, an active component of Andrographis paniculata, on Poly(I:C)-induced acute lung injury.

Immunology
Liu YG et al (2024).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2024.116456
PubMed:
38552441

Fluorescence 'turn-off-on' assays for neomycin sulphate and K(+) ions with orange-red fluorescent molybdenum nanoclusters.

Sadhu VA et al (2024).
Luminescence.
DOI:
10.1002/bio.4709
PubMed:
38491906

Andrographolide attenuates sepsis-induced acute kidney injury by inhibiting ferroptosis through the Nrf2/FSP1 pathway.

Zhang Y et al (2024).
Free Radic Res.
DOI:
10.1080/10715762.2024.2330413
PubMed:
38478853

Discovery of Pesticide Candidates from Natural Plant Products: Semisynthesis and Characterization of Andrographolide-Based Esters and Study of Their Pesticidal Properties and Toxicology.

Hao M et al (2024).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.3c06681
PubMed:
38468388

Inhibition of hepatocellular carcinoma cell proliferation through regulation of the cell cycle, AGE RAGE, and leptin signaling pathways by a compound formulation comprised of andrographolide, wogonin, and oroxylin a derived from Andrographis Paniculata(Burm.f.) Nees.

Gao S, Tan H and Gang J (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118001
PubMed:
38467318

Author Correction: Effect of activated carbon microstructure and adsorption mechanism on the efficient removal of chlorophyll a and chlorophyll b from Andrographis paniculata extract.

Liang D et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-55393-y
PubMed:
38459075

Andrographolide Improves ApoE4-Mediated Blood-Brain Barrier Injury by Alleviating Inflammation.

Summary

Andrographolide protects blood-brain barrier from ApoE4-induced injury by inhibiting inflammation and promoting tight junction proteins, potential treatment for Alzheimer's disease.

ImmunologyNeuroscience
Zhou X et al (2024).
Mol Neurobiol.
DOI:
10.1007/s12035-024-04088-6
PubMed:
38448724

In vitro effects of phytogenic feed additive on Piscirickettsia salmonis growth and biofilm formation.

Santibáñez N et al (2024).
J Fish Dis.
DOI:
10.1111/jfd.13913
PubMed:
38421380

Integrating Transcriptome and Chemical Analyses to Provide Insights into Biosynthesis of Terpenoids and Flavonoids in the Medicinal Industrial Crop Andrographis paniculate and Its Antiviral Medicinal Parts.

Summary

Researchers conducted chemical and transcriptome analyses on the medicinal plant to understand biosynthesis pathways of diterpene lactones and flavonoids. Results suggest potential treatment for SARS-CoV-2 and insight for industrial crop production and in vitro biosynthesis.

AntimicrobialGeneticsPhytochemistry
Yu K et al (2024).
Molecules.
DOI:
10.3390/molecules29040852
PubMed:
38398604

ApCPS2 contributes to medicinal diterpenoid biosynthesis and defense against insect herbivore in Andrographis paniculata.

Garg A et al (2024).
Plant Sci.
DOI:
10.1016/j.plantsci.2024.112046
PubMed:
38395069

Enhancing oral bioavailability of andrographolide using solubilizing agents and bioenhancer: comparative pharmacokinetics of Andrographis paniculata formulations in beagle dogs.

Songvut P et al (2024).
Pharm Biol.
DOI:
10.1080/13880209.2024.2311201
PubMed:
38351624

Effect of Andrographis paniculata supplementation during the transition period on colostrum yield, IgG, and postpartum complications in multiparous sows during tropical summer.

Tummaruk P et al (2024).
Anim Biosci.
DOI:
10.5713/ab.23.0190
PubMed:
38271976

Discovery of ent-labdane derivatives from Andrographis paniculata and their anti-inflammatory activity.

Summary

Scientists discovered andropanilide D as a potential anti-inflammatory treatment after testing compounds from Andrographis paniculata, suggesting its superior activity compared to dexamethasone and andrographolide.

Immunology
Yu Y et al (2024).
Phytochemistry.
DOI:
10.1016/j.phytochem.2024.113986
PubMed:
38219853

Comparative effectiveness of biorational pesticides for management of Phenacoccus solenopsis Tinsley and Paracoccus marginatus Williams & Granara de Willink in Gymnema sylvestre (Retz.) R.Br. ex Sm.

Kadanakuppe Thammayya S et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e23648
PubMed:
38187271

Andrographolide inhibits Burkitt's lymphoma by binding JUN and CASP3 proteins.

Zeng J et al (2023).
Cancer Chemother Pharmacol.
DOI:
10.1007/s00280-023-04626-4
PubMed:
38148335

Harmonizing international quality standards for Andrographis paniculata: A comparative analysis of content determination methods across pharmacopeias.

Ruan LJ et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115924
PubMed:
38142499

One-Pot Solvothermal Synthetic Route of a Zinc Oxide Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposite: An Advanced Material with a Novel Anticancer Theranostic Approach.

Summary

A study developed a eco-friendly method to synthesize zinc oxide nanoparticles on graphene oxide. The resulting materials showed dose-dependent cytotoxicity and induced apoptosis in cancer cell lines. This suggests the potential of these materials for developing new cancer treatments.

Cancer
Kanth Kadiyala N et al (2023).
ACS Omega.
DOI:
10.1021/acsomega.3c06082
PubMed:
38107885

Antidiabetic property of fractions and pure compounds from Andrographis paniculata.

Summary

Andrographis paniculata fractions improved glucose uptake in adipocytes and contained potential antidiabetic chemicals. Andrographolide and 14-deoxyandrographolide showed promise for type 2 diabetes treatment.

Diabetes
Bokshi B, Chen H and Ung AT (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2023.2294115
PubMed:
38099351

Functionalized Phytochemicals-Embedded Carbon Dots Derived from Medicinal Plant for Bioimaging Application.

Annisa WD et al (2023).
ACS Appl Bio Mater.
DOI:
10.1021/acsabm.3c00575
PubMed:
38096155

Evaluation of Andrographis paniculata-supplemented Diet on the reproductive indices of Plasmodium berghei-infected mice.

Adedayo BC et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117558
PubMed:
38092319

Effect of activated carbon microstructure and adsorption mechanism on the efficient removal of chlorophyll a and chlorophyll b from Andrographis paniculata extract.

Liang D et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-42011-6
PubMed:
38081867

Ethanol extract of Andrographis paniculata alleviates aluminum-induced neurotoxicity and cognitive impairment through regulating the p62-keap1-Nrf2 pathway.

Summary

This study explores the potential neuroprotective effects of Andrographis paniculata (AP) in an aluminum-induced model of Alzheimer's disease (AD). AP reduces cognitive impairments, amyloid-β protein deposition, and activates autophagy through the p62-Keap1-Nrf2 pathway, suggesting its potential as a therapeutic intervention.

Neuroscience
Ma J et al (2023).
BMC Complement Med Ther.
DOI:
10.1186/s12906-023-04290-4
PubMed:
38057817

Identification and characterization of major bioactive compounds from Andrographis paniculata (Burm. f.) extracts showed multi-biomedical applications.

Chau TP et al (2023).
Environ Res.
DOI:
10.1016/j.envres.2023.117763
PubMed:
38029828

Assessment of antidiabetic, anti-inflammatory, antioxidant and anticancer activity competence of methonolic extracts of Trianthema ortulacastrum and Andrographis paniculata.

Summary

Methanol extracts from Andrographis paniculata have more beneficial compounds and higher antioxidant, antidiabetic, and anti-inflammatory activities compared to Trianthema portulacastrum. A. paniculata extract is worth exploring for potential biomedical applications.

CancerDiabetesImmunology
Wadaan MA, Baabbad A and Farooq Khan M (2023).
Environ Res.
DOI:
10.1016/j.envres.2023.117764
PubMed:
38029820

Assessment of multi-biomedical efficiency of Andrographis paniculata shoot extracts through in-vitro analysis and major compound identification.

Chau TP et al (2023).
Environ Res.
DOI:
10.1016/j.envres.2023.117779
PubMed:
38029817

Exploring the potential of Andrographis paniculata for developing novel HDAC inhibitors: an in silico approach.

Das D et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2281635
PubMed:
37969010

Inhibitory efficiency of Andrographis paniculata extract on viral multiplication and nitric oxide production.

Siridechakorn I et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-46249-y
PubMed:
37957171

Andrographolide Attenuates Oxidized LDL-Induced Activation of the NLRP3 Inflammasome in Bone Marrow-Derived Macrophages and Mitigates HFCCD-Induced Atherosclerosis in Mice.

Immunology
Chen CC et al (2023).
Am J Chin Med.
DOI:
10.1142/S0192415X23500933
PubMed:
37930331

Andrographis paniculata (Burm. f.) Nees extract ameliorates insulin resistance in the insulin-resistant HepG2 cells via GLUT2/IRS-1 pathway.

Ningsih S et al (2023).
Arch Physiol Biochem.
DOI:
10.1080/13813455.2023.2273221
PubMed:
37878369

Andrographolide Attenuates Inflammation Due to Intra-Abdominal Sepsis by Enhancing Bacterial Clearance in Mice.

Immunology
Yu L et al (2023).
J Inflamm Res.
DOI:
10.2147/JIR.S422342
PubMed:
37822531

Efficacy of Andrographis paniculata spray in acute pharyngitis: A randomized controlled trial.

Okonogi R, Thampanya V and Okonogi S (2023).
Drug Discov Ther.
DOI:
10.5582/ddt.2023.01053
PubMed:
37821383

"Andrographolide, Diterpenoid constituent of Andrographis paniculata: Review on Botany, Phytochemistry, Molecular docking analysis, and Pharmacology".

Summary

Andrographis paniculata (kalmegh), known as "king of bitters," has diterpenoid lactone derivatives that provide therapeutic effects. Through botany, phytochemistry, and pharmacological studies, this review highlights its potential as a valuable therapeutic herb in various diseases.

Review Phytochemistry
Gonde DP, Bhole BK and Kakad KS (2023).
Ann Pharm Fr.
DOI:
10.1016/j.pharma.2023.10.001
PubMed:
37813330

An in-vitro evaluation of antifungal, anti-lungcancer (A549), and anti-hyperglycemic activities potential of Andrographis paniculata (Burm. f.) flower extract.

Summary

Andrographis paniculata flower extract shows promise as an antifungal agent, inhibiting lung cancer cell growth and exhibiting anti-diabetic properties. Its bioactive compounds make it suitable for biomedical applications.

AntimicrobialDiabetes
Phuong TN et al (2023).
Environ Res.
DOI:
10.1016/j.envres.2023.117249
PubMed:
37783331

Andrographolide Induces ROS-Mediated Cytotoxicity, Lipid Peroxidation, and Compromised Cell Integrity in Saccharomyces cerevisiae.

Phetruen T, van Dam B and Chanarat S (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12091765
PubMed:
37760068

Decoding the mechanism of andrographolide to combat hepatocellular carcinoma: a network pharmacology integrated molecular docking and dynamics approach.

Dixit N et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2256866
PubMed:
37728545

Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity.

Summary

Scientists discovered three new compounds, called andropanilides A-C, from a plant called Andrographis paniculata. Andropanilide A showed promising anti-inflammatory properties by reducing the expression of pro-inflammatory molecules. This research may lead to the development of new drugs to treat inflammation-related diseases.

Immunology
Yu Y et al (2023).
Nat Prod Bioprospect.
DOI:
10.1007/s13659-023-00394-z
PubMed:
37713002

Comparative pharmacokinetics and safety evaluation of high dosage regimens of Andrographis paniculata aqueous extract after single and multiple oral administration in healthy participants.

Songvut P et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1230401
PubMed:
37663270

An Andrographis paniculata Burm. Nees extract standardized for three main Andrographolides prevents house dust mite-induced airway inflammation, remodeling, and hyperreactivity by regulating Th1/Th2 gene expression in mice.

GeneticsImmunology
Sulaiman I et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117082
PubMed:
37652197

Plant Growth Regulator- and Elicitor-Mediated Enhancement of Biomass and Andrographolide Production of Shoot Tip-Culture-Derived Plantlets of Andrographis paniculata (Burm.f.) Wall. (Hempedu Bumi).

Patuhai A et al (2023).
Plants (Basel).
DOI:
10.3390/plants12162953
PubMed:
37631165

The Effects of Andrographis paniculata (Burm.F.) Wall. Ex Nees and Andrographolide on Neuroinflammation in the Treatment of Neurodegenerative Diseases.

Summary

This review discusses the potential of the natural compound Ap and its constituent Andro in modulating neurodegeneration and neuroinflammation, which are major causes of neurodegenerative diseases.

Review Neuroscience
Bosco F et al (2023).
Nutrients.
DOI:
10.3390/nu15153428
PubMed:
37571363

Assessment of the Phytochemical Profile, Antioxidant Capacity, and Hepatoprotective Effect of Andrographis paniculata against CCl(4)-Induced Liver Dysfunction in Wistar Albino Rats.

ImmunologyPhytochemistry
Ali SK et al (2023).
Medicina (Kaunas).
DOI:
10.3390/medicina59071260
PubMed:
37512069

Creep in nitroimidazole inhibitory concentration among the Entamoeba histolytica isolates causing amoebic liver abscess and screening of andrographolide as a repurposing drug.

Singh A et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-39382-1
PubMed:
37500681

Effects of atmospheric dust particles on common medicinal plants in an industrial area of West Bengal, India.

Majee CK, Ali SY and Padhy PK (2023).
Environ Monit Assess.
DOI:
10.1007/s10661-023-11573-3
PubMed:
37477710

Endophytic fungus Colletotrichum sp. AP12 promotes growth physiology and andrographolide biosynthesis in Andrographis paniculata (Burm. f.) Nees.

Xu D et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1166803
PubMed:
37469772

Cytotoxic and Anti-Inflammatory Activity of 3,19-Isopropylidene-/Arylidene-Andrographolide Analogs.

Immunology
Van Chien T et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202300420
PubMed:
37466261

Real-time monitoring of biofilm growth identifies andrographolide as a potent antifungal compound eradicating Candida biofilms.

Summary

Scientists discovered that conventional antifungal drugs do not effectively combat biofilms formed by highly resistant fungi. However, they found that andrographolide, a natural compound, can both inhibit fungi growth and biofilm formation, indicating its potential as a treatment for drug-resistant fungal infections.

Antimicrobial
Žiemytė M et al (2023).
Biofilm.
DOI:
10.1016/j.bioflm.2023.100134
PubMed:
37396463

Andrographis paniculata methanol extract suppresses the phosphorylation of ETV6‑NTRK3.

Chi HT et al (2023).
Biomed Rep.
DOI:
10.3892/br.2023.1630
PubMed:
37383677

Efficacy and Safety of Add-On Plant-Based Drugs for COVID-19 Patients: A Review of the Randomized Control Trials.

Summary

Review finds that plant-based drugs, particularly herbs, used as add-on therapy for COVID-19 show efficacy and safety, potentially enhancing the immune system for treating the virus. (37 words)

Review COVID-19
Diantini A, Febriyanti RM and Levita J (2023).
Infect Drug Resist.
DOI:
10.2147/IDR.S417727
PubMed:
37361940

Identification of Andrographolide as a novel FABP4 inhibitor for osteoarthritis treatment.

Yang K et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154939
PubMed:
37354697

Shenlian extract protected ox-LDL-loaded macrophages against ER stress by promoting LAL-LXRα mediated cholesterol flux.

Immunology
Nie CX et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116721
PubMed:
37315648

HPTLC Stability Indicating Analytical Method of Andrographolide and 5-fluorouracil with Network Pharmacology Analysis against Cancer.

Summary

Combining herbal drugs with chemotherapeutic drugs shows promise in reducing side effects and improving efficacy. One such herbal compound, Andrographolide, has been found to have anti-cancer properties. Researchers have developed a combination nanoformulation with Andrographolide and the chemotherapeutic drug 5-fluorouracil to enhance oral absorption and bioavailability. This research highlights the potential for more effective and tolerable cancer treatments.

Cancer
Malik Z et al (2023).
Comb Chem High Throughput Screen.
DOI:
10.2174/1386207326666230609104038
PubMed:
37303181

Antidepressant evaluation of Andrographis paniculata Nees extract and andrographolide in chronic unpredictable stress zebrafish model.

Summary

Researchers investigated the anti-depressive properties of Andrographis paniculata extract and andrographolide in a zebrafish model of chronic unpredictable stress. Both compounds showed a reduction in freezing duration compared to the stressed, untreated group, and andrographolide also decreased cortisol levels and increased activity. The study confirms the potential of zebrafish as a model for researching antidepressant drugs and suggests further investigation of andrographolide's cellular and molecular effects.

Neuroscience
Aldurrah Z et al (2023).
Comp Biochem Physiol C Toxicol Pharmacol.
DOI:
10.1016/j.cbpc.2023.109678
PubMed:
37301417

De Novo Transcriptome Profiling for the Generation and Validation of Microsatellite Markers, Transcription Factors, and Database Development for Andrographis paniculata.

Genetics
Singh R et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24119212
PubMed:
37298166

Toxicological safety assessment of AP-Bio®, a standardized extract of Andrographis paniculata in Sprague Dawley rats.

Murugan SK et al (2023).
J Appl Toxicol.
DOI:
10.1002/jat.4501
PubMed:
37269249

Andrographis paniculata (Burm.f.) Nees Alleviates Methotrexate-Induced Hepatotoxicity in Wistar Albino Rats.

Parthasarathy M and Prince SE (2023).
Life (Basel).
DOI:
10.3390/life13051173
PubMed:
37240818

Potential Plant-Based New Antiplasmodial Agent Used in Papua Island, Indonesia.

Review
Indradi RB et al (2023).
Plants (Basel).
DOI:
10.3390/plants12091813
PubMed:
37176870

Andrographolide induced ferroptosis in multiple myeloma cells by regulating the P38/Nrf2/HO-1 pathway.

Summary

Andrographis paniculata is a functional food used in Asia. Andrographolide (Andro), derived from it, has potent anticancer properties. This study shows that Andro induces ferroptosis (iron-dependent cell death) in multiple myeloma cells through the P38/Nrf2/HO-1 pathway, suggesting a potential treatment for the disease.

Cancer
Li W et al (2023).
Arch Biochem Biophys.
DOI:
10.1016/j.abb.2023.109622
PubMed:
37172672

Exogenous γ-aminobutyric acid (GABA) alleviates nitrogen deficiency by mediating nitrate uptake and assimilation in Andrographis paniculata seedlings.

Summary

A study on Andrographis paniculata showed that exogenous GABA improved plant growth under low nitrogen conditions. GABA increased N assimilation and protein synthesis in plants, and up-regulated the activities and expression of N metabolic enzymes. GABA also increased the accumulation of α-ketoglutarate and malate for NO assimilation. N isotopic tracing and NRTs transcription showed that GABA up-regulated NRT2.4 and NRT3.2 to increase NO uptake. Primidone, an inhibitor of GABA receptor, impeded the effects of GABA on plant growth and N accumulation. The results suggest that GABA acts as a signal to up-regulate NRTs via its receptor and promote NO assimilation to alleviate N deficiency in A. paniculata.

Neuroscience
Huang XJ et al (2023).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2023.107700
PubMed:
37086691

The effects and mechanisms of the anti-COVID-19 traditional Chinese medicine, Dehydroandrographolide from Andrographis paniculata (Burm.f.) Wall, on acute lung injury by the inhibition of NLRP3-mediated pyroptosis.

Summary

Dehydroandrographolide (Deh) is a compound found in Andrographis paniculata that has been shown to have potent anti-inflammatory and antioxidant properties. Its potential use in medicine warrants further exploration.

COVID-19
Pu Z et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154753
PubMed:
37084628

Greater efficiency of polyherbal drug encapsulated biosynthesized chitosan nano-biopolymer on diabetes and its complications.

Diabetes
Revathi G et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.124445
PubMed:
37060982

The effect of Andrographis paniculata water extract on palliative management of metastatic esophageal squamous cell carcinoma-A phase II clinical trial.

Chiu PW et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7815
PubMed:
37042309

Evaluations of Andrographolide-Rich Fractions of Andrographis paniculata with Enhanced Potential Antioxidant, Anticancer, Antihypertensive, and Anti-Inflammatory Activities.

CancerImmunology
Adiguna SP et al (2023).
Plants (Basel).
DOI:
10.3390/plants12061220
PubMed:
36986909

The Potential Chemopreventive Effect of Andrographis paniculata on 1,2-Dimethylhydrazine and High-Fat-Diet-Induced Colorectal Cancer in Sprague Dawley Rats.

CancerGastroenterology
Subarmaniam T et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24065224
PubMed:
36982300

In vitro antioxidant and anti-diabetic analysis of Andrographis echioides and Andrographis paniculata ethanol extract.

Diabetes
Shreya Reddy CS et al (2022).
Bioinformation.
DOI:
10.6026/97320630018337
PubMed:
36909701

The standardized Jamu pahitan, an Indonesian antidiabetic formulation, stimulating the glucose uptake and insulin secretion in the in-vitro models.

Diabetes
Hartanti D et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e14018
PubMed:
36873515

Antidiabetic effects of Andrographis paniculata supplementation on biochemical parameters, inflammatory responses, and oxidative stress in canine diabetes.

DiabetesImmunology
Suemanotham N et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1077228
PubMed:
36865924

Efficacy and safety of AP-Bio®(KalmCold®) in participants with uncomplicated upper respiratory tract viral infection (common cold) - A phase III, double-blind, parallel group, randomized placebo-controlled trial.

Raj JP et al (2023).
Complement Ther Med.
DOI:
10.1016/j.ctim.2023.102934
PubMed:
36842634

Effect of andrographolide and deep eutectic solvent extracts of Andrographis paniculata on human coronavirus organ culture 43 (HCoV-OC43).

Summary

Andrographis paniculata has shown potential for treating coronaviruses, but no antiviral activity has been found against the human coronavirus HCoV-OC43 from the plant's extracts or andrographolide.

COVID-19
Komaikul J et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154708
PubMed:
36805485

Synthesis, characterization, and assessment of chitosan-nanomatrix enriched with antifungal formulation against biodeterioration of active ingredients of selected herbal raw materials.

Antimicrobial
Gupta V, Singh PP and Prakash B (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.123684
PubMed:
36791939

Andrographolide nanophytosomes exhibit enhanced cellular delivery and pro-apoptotic activities in HepG2 liver cancer cells.

Cancer
Neamatallah T et al (2023).
Drug Deliv.
DOI:
10.1080/10717544.2023.2174209
PubMed:
36762548

Quantification and Standardization of Andrographolide in Andrographis Paniculata Samples by Validated RP-HPLC and HPTLC Methods.

Jana SN et al (2023).
J Chromatogr Sci.
DOI:
10.1093/chromsci/bmad004
PubMed:
36748260

Andrographis paniculata and Andrographolide - A Snapshot on Recent Advances in Nano Drug Delivery Systems against Cancer.

Review Cancer
Deshmukh R et al (2024).
Curr Drug Deliv.
DOI:
10.2174/1567201820666230203115752
PubMed:
36740794

An improved strategy for identification and annotation of easily in-sourced dissociation diterpene lactones from plant natural products: Taking Andrographis paniculata (Burm. f.) as an example.

Review
Wu X et al (2023).
Rapid Commun Mass Spectrom.
DOI:
10.1002/rcm.9483
PubMed:
36718976

Red-to-blue colorimetric probe based on biomass carbon dots for smartphone-integrated optosensing of Cu(II) and L-cysteine.

Zhang D et al (2023).
Spectrochim Acta A Mol Biomol Spectrosc.
DOI:
10.1016/j.saa.2022.122285
PubMed:
36592594

Potency of Origanum vulgare and Andrographis paniculata extracts on growth performance in poultry.

Jahja EJ et al (2022).
Vet Anim Sci.
DOI:
10.1016/j.vas.2022.100274
PubMed:
36505504

Exploring multifunctional components from Andrographis paniculata by affinity ultrafiltration with three molecular targets.

Feng H, Chen G and Guo M (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2022.134515
PubMed:
36240559

Andrographis paniculata Dosage Forms and Advances in Nanoparticulate Delivery Systems: An Overview.

Review
Raman S, Murugaiyah V and Parumasivam T (2022).
Molecules.
DOI:
10.3390/molecules27196164
PubMed:
36234698

Estrogen receptor potentially stable conformations from molecular dynamics as a structure-based pharmacophore model for mapping, screening, and identifying ligands-a new paradigm shift in pharmacophore screening.

Endocrinology
Shanmugarajan D and David C (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2022.2074543
PubMed:
35543232

Dealkenylation of neoandrographolide, a phytochemical from Andrographis paniculata stimulates FXR (Farnesoid X Receptor) and enhances gallstone dissolution.

Phytochemistry
Sharma R, Kumar K and Tanvi K (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2022.2048078
PubMed:
35253613

In silico molecular docking study of Andrographis paniculata phytochemicals against TNF-α as a potent anti-rheumatoid drug.

Tarachand SP et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2022.2037463
PubMed:
35147481

Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches.

Review
Zeng B et al (2022).
Phytother Res.
DOI:
10.1002/ptr.7324
PubMed:
34818697

Safety evaluation of an antimalarial herbal product from Andrographis paniculata (AS201-01) in healthy volunteers.

Widyawaruyanti A et al (2021).
J Basic Clin Physiol Pharmacol.
DOI:
10.1515/jbcpp-2020-0381
PubMed:
34171938

Andrographis paniculata (Burm. F) Wall ex Nees: Antiviral properties.

Review Antimicrobial
Jadhav AK and Karuppayil SM (2021).
Phytother Res.
DOI:
10.1002/ptr.7145
PubMed:
33929758

Andrographis paniculata (Burm.f.) Nees: Traditional uses, phytochemistry, pharmacological properties and quality control/quality assurance.

Review Phytochemistry
Kumar S, Singh B and Bajpai V (2021).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2021.114054
PubMed:
33831465

Immunoprotective potential of Ayurvedic herb Kalmegh (Andrographis paniculata) against respiratory viral infections - LC-MS/MS and network pharmacology analysis.

Banerjee S et al (2021).
Phytochem Anal.
DOI:
10.1002/pca.3011
PubMed:
33167083

Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide.

Dai Y et al (2019).
Crit Rev Food Sci Nutr.
DOI:
10.1080/10408398.2018.1501657
PubMed:
30040451