Angelica sinensis

Ethnobotanical Studies

Studies

Nanocrystal hydroxyapatite carrying traditional Chinese medicine for osteogenic differentiation.

Xue B et al (2024).
Colloids Surf B Biointerfaces.
DOI:
10.1016/j.colsurfb.2024.114186
PubMed:
39226849

Elucidation of AsANS controlling pigment biosynthesis in Angelica sinensis through hormonal and transcriptomic analysis.

Summary

Researchers studied how purpleness is controlled in Angelica sinensis for commercial value. They found abscisic acid and key genes regulate anthocyanin production. Overexpressing AsANS increased purpleness, providing insights for breeding.

Endocrinology
Arshad KT et al (2024).
Physiol Plant.
DOI:
10.1111/ppl.14500
PubMed:
39221482

Ligustilide alleviates oxidative stress during renal ischemia-reperfusion injury through maintaining Sirt3-dependent mitochondrial homeostasis.

Summary

Researchers explored the potential of Ligustilide (LIG) to protect mitochondrial function and potentially ameliorate renal ischemia-reperfusion injury during transplantation. Understanding LIG's targets and mechanisms is important for improving patient outcomes.

CardiologyImmunology
Xia K et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155975
PubMed:
39216302

Angelica sinensis polysaccharide facilitates chondrogenic differentiation of adipose-derived stem cells via MDK-PI3K/AKT signaling cascade.

Li Y et al (2024).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2024.117349
PubMed:
39191028

The phthalide compound tokinolide B from Angelica sinensis exerts anti-inflammatory effects through Nur77 binding.

Summary

Nur77 controls inflammation and is a potential target for treating inflammatory diseases. Angelica sinensis contains compounds that reduce inflammation. Important for developing anti-inflammatory therapies.

Immunology
Xia Y et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155925
PubMed:
39173278

Ligustilide Inhibits the PI3K/AKT Signalling Pathway and Suppresses Cholangiocarcinoma Cell Proliferation, Migration, and Invasion.

Wu Y et al (2024).
Recent Pat Anticancer Drug Discov.
DOI:
10.2174/0115748928332384240812060751
PubMed:
39171465

Treating chronic atrophic gastritis: identifying sub-population based on real-world TCM electronic medical records.

Wang YM et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1444733
PubMed:
39170704

Targeting non-classical autophagy-dependent ferroptosis and the subsequent HMGB1/TfR1 feedback loop accounts for alleviating solar dermatitis by senkyunolide I.

Dermatology
Wei Q et al (2024).
Free Radic Biol Med.
DOI:
10.1016/j.freeradbiomed.2024.08.004
PubMed:
39117049

A refined formula derived from Jiawei-Xiaoyao pill exerts rapid antidepressant-like effects in LPS-induced depression by reducing neuroinflammation and restoring neuroplasticity signaling.

Summary

Researchers studied the Jiawei-Xiaoyao Pill for depression treatment. It acts quickly due to a synergistic effect of Gardeniae Fructus and other herbs. Identifying this refined formula is crucial for quality control of the pill.

Neuroscience
Wu Z et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118647
PubMed:
39094756

Identification Analysis of Angelicae sinensis radix and Angelicae pubescentis radix Based on Quantized "Digital Identity" and UHPLC-QTOF-MS(E) Analysis.

Wang XR et al (2024).
J Am Soc Mass Spectrom.
DOI:
10.1021/jasms.4c00254
PubMed:
39092573

Antioxidant and anti-inflammatory effects of different ratios and preparations of Angelica sinensis and chuanxiong rhizoma extracts.

Immunology
Zhang M et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118559
PubMed:
39002825

Network pharmacology analysis of the regulatory effects and mechanisms of ALAE on sow reproduction in vivo and in vitro.

Zhao L et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118525
PubMed:
38992402

Angelica sinensis polysaccharides promote extramedullary stress erythropoiesis via ameliorating splenic glycolysis and EPO/STAT5 signaling-regulated macrophages.

Summary

Angelica sinensis polysaccharides (ASP) protect against anemia induced by chemotherapy, promote extramedullary erythropoiesis, and improve glycolysis via PI3K/Akt/HIF2α signaling. ASP enhances splenic macrophage activity, erythroid progenitor expansion, and erythroid differentiation, making it a promising treatment for stress anemia.

Immunology
Sun N et al (2024).
J Mol Histol.
DOI:
10.1007/s10735-024-10219-z
PubMed:
38969952

Bioinspired chitosan based functionalization of biomedical implant surfaces for enhanced hemocompatibility, antioxidation and anticoagulation potential: an in silico and in vitro study.

Hassan S et al (2024).
RSC Adv.
DOI:
10.1039/d4ra00796d
PubMed:
38952927

Ameliorative effect of vanillic acid against scopolamine-induced learning and memory impairment in rat via attenuation of oxidative stress and dysfunctional synaptic plasticity.

Summary

Vanillic acid (VA) from Angelica sinensis plant improved learning and memory in rats induced with Alzheimer's-like symptoms by Scopolamine (SCOP). VA shows potential for treating Alzheimer's disease by protecting against cognitive decline and synaptic damage.

Immunology
Choi GY et al (2024).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2024.117000
PubMed:
38941895

Exploring the role of Chinese herbal medicine in the long-term management of postoperative ovarian endometriotic cysts: a systematic review and meta-analysis.

Summary

Ovarian endometriotic cysts are a major issue for women's health, impacting quality of life and fertility. Traditional Chinese medicine, specifically herbal medicine, shows promise in treating and preventing this condition.

Endocrinology
Ding D et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1376037
PubMed:
38910886

Elucidating the mechanism of action of Radix Angelica sinensis (Oliv.) Diels and Radix Astragalus mongholicus Bunge ultrafiltration extract on radiation-induced myocardial fibrosis based on network pharmacology and experimental research.

Summary

RAS-RA, a key compound in traditional Chinese medicine, showed promise in treating radiation-induced myocardial fibrosis by targeting inflammation and the PI3K/AKT/mTOR pathway. It improved cardiac function, reduced collagen deposition, and protected liver and kidney functions. This study highlights RAS-RA's potential as a therapeutic agent for RIMF.

Cardiology
Ren C et al (2024).
Eur J Pharm Sci.
DOI:
10.1016/j.ejps.2024.106794
PubMed:
38788908

Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Radix Rehmanniae Praeparata - Angelica Sinensis - Radix Achyranthis Bidentatae in Treating Knee Osteoarthritis.

Liu L et al (2024).
Drug Des Devel Ther.
DOI:
10.2147/DDDT.S455006
PubMed:
38765877

Angelica sinensis polysaccharide suppresses the Wnt/β-catenin-mediated malignant biological behaviors of breast cancer cells via the miR-3187-3p/PCDH10 axis.

Summary

ASP from Angelica sinensis inhibits breast cancer progression by regulating miR-3187-3p and PDCH10, suppressing Wnt/β-catenin signaling pathway. Potential treatment target for BC.

Cancer
Cai Y et al (2024).
Biochem Pharmacol.
DOI:
10.1016/j.bcp.2024.116295
PubMed:
38762145

Clinical remission of moderate generalized myasthenia gravis through exclusive use of Buzhong Yiqi decoction: A case report.

Qiu H et al (2024).
Explore (NY).
DOI:
10.1016/j.explore.2024.05.004
PubMed:
38744568

Angelica sinensis polysaccharide combined with cisplatin reverses cisplatin resistance of ovarian cancer by inducing ferroptosis via regulating GPX4.

Summary

Angelica sinensis polysaccharide (ASP) reverses cisplatin resistance in ovarian cancer cells by suppressing GPX4 expression. ASP in combination with cisplatin shows promise in overcoming drug resistance.

CancerEndocrinology
Guo W et al (2024).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2024.116680
PubMed:
38703506

The angelica Polysaccharide: a review of phytochemistry, pharmacology and beneficial effects on systemic diseases.

Summary

APS extracted from Angelica sinensis has various pharmacological effects, including promoting blood circulation and enhancing immunity. Different extraction methods and sites significantly impact its efficacy. Understanding these factors can improve APS application in disease treatment.

Review Phytochemistry
Shen J et al (2024).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2024.112025
PubMed:
38677093

Three types of enzymes complete the furanocoumarins core skeleton biosynthesis in Angelica sinensis.

Wang K et al (2024).
Phytochemistry.
DOI:
10.1016/j.phytochem.2024.114102
PubMed:
38641144

Ligustilide covalently binds to Cys703 in the pre-S1 helix of TRPA1, blocking the opening of channel and relieving pain in rats with acute soft tissue injury.

Summary

Researchers explored the analgesic properties of Ligustilide from Angelica sinensis and Ligusticum chuanxiong. Understanding TRP channels' involvement in pain relief could lead to improved treatments for dysmenorrhea, migraines, and arthritis.

Pain
Zhang K et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118217
PubMed:
38641072

Rapid and accurate quality evaluation of Angelicae Sinensis Radix based on near-infrared spectroscopy and Bayesian optimized LSTM network.

Bai L et al (2024).
Talanta.
DOI:
10.1016/j.talanta.2024.126098
PubMed:
38640523

Integrated transcriptomic and metabolomic analysis reveals the regulation mechanism of early bolting and flowering in two cultivars of Angelica sinensis.

Zhu C et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e28636
PubMed:
38576577

Research on the brewing technology of Dangshen Huangjiu with low biogenic amines and high functional factors.

Gao Y et al (2024).
J Sci Food Agric.
DOI:
10.1002/jsfa.13503
PubMed:
38563388

Discovery of a Potent Antiosteoporotic Drug Molecular Scaffold Derived from Angelica sinensis and Its Bioinspired Total Synthesis.

Zou J et al (2024).
ACS Cent Sci.
DOI:
10.1021/acscentsci.3c01414
PubMed:
38559293

Characterizing the pathogenicity and mycotoxin production capacity of Fusarium spp. causing root rot of Angelica sinensis in China.

Mu R et al (2024).
Plant Dis.
DOI:
10.1094/PDIS-10-23-2178-RE
PubMed:
38549274

Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from Angelica sinensis, Ligusticum chuanxiong, and Peaonia lactiflora.

Bak SB et al (2024).
Toxicol Res.
DOI:
10.1007/s43188-024-00227-2
PubMed:
38525135

Therapeutic potential of Angelica sinensis in addressing organ fibrosis: A comprehensive review.

Review
Zhi X et al (2024).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2024.116429
PubMed:
38490157

Traditional Chinese Medicine Shi-Bi-Man ameliorates psoriasis via inhibiting IL-23/Th17 axis and CXCL16-mediated endothelial activation.

Dermatology
Zhang C et al (2024).
Chin Med.
DOI:
10.1186/s13020-024-00907-z
PubMed:
38429819

Screening of polysaccharides from the differently processed products of Angelica sinensis with the best liver protection effect on chicken and the intervention mechanism study based on tandem mass tag proteomics and multiple reaction monitoring approach.

Li CC et al (2024).
Biomed Chromatogr.
DOI:
10.1002/bmc.5840
PubMed:
38402901

Levistilide A Exerts a Neuroprotective Effect by Suppressing Glucose Metabolism Reprogramming and Preventing Microglia Polarization Shift: Implications for Parkinson's Disease.

Summary

Levistilide A (LA) from Angelica sinensis decreases inflammation in microglia, protects neurons, and modulates glucose metabolism in Parkinson's disease, showing therapeutic promise.

Neuroscience
Zhang M et al (2024).
Molecules.
DOI:
10.3390/molecules29040912
PubMed:
38398662

Ligustilide inhibits Purkinje cell ferritinophagy via the ULK1/NCOA4 pathway to attenuate valproic acid-induced autistic features.

Summary

Researchers investigated the potential of Ligustilide (LIG) in treating autism-like symptoms. LIG, extracted from herbs, may be effective in neurological disorders, but its impact on autism remains unknown. This study explores its therapeutic potential for ASD.

Neuroscience
Zhou L et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155443
PubMed:
38394737

Angelica sinensis polysaccharides modified selenium nanoparticles for effective prevention of acute liver injury.

Xu Y et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.130321
PubMed:
38382780

Angelica Sinensis Polysaccharide-Based Nanoparticles for Liver-Targeted Delivery of Oridonin.

Sun H et al (2024).
Molecules.
DOI:
10.3390/molecules29030731
PubMed:
38338476

Fingerprint analysis of dang-gui-Si-Ni decoction and its anticoagulant activity in vivo-in vitro.

Li Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117890
PubMed:
38336186

Longitudinal Distribution Map of the Active Components and Endophytic Fungi in Angelica sinensis (Oliv.) Diels Root and Their Potential Correlations.

Sun Y et al (2024).
Metabolites.
DOI:
10.3390/metabo14010048
PubMed:
38248851

Anti-platelet aggregation activities of different grades of Angelica sinensis and their therapeutic mechanisms in rats with blood deficiency: insights from metabolomics and lipidomics analyses.

Shen X et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1230861
PubMed:
38235114

Degradation of Angelica sinensis polysaccharide: Structures and protective activities against ethanol-induced acute liver injury.

Zhang Y et al (2024).
Carbohydr Polym.
DOI:
10.1016/j.carbpol.2023.121745
PubMed:
38220331

Volatile oil of Angelica sinensis Radix improves cognitive function by inhibiting miR-301a-3p targeting Ppp2ca in cerebral ischemia mice.

Summary

Researchers investigated the effects of Angelica Sinensis Radix (ASR) and its volatile oil (VOASR) on cognitive impairment. ASR is a Chinese medicine used for pain relief and menstrual regulation, while VOASR showed promise in improving cognitive function. Understanding their mechanisms could aid in developing treatments for cognitive impairments.

CardiologyNeuroscience
Zhao J et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117621
PubMed:
38154524

A real-world data analysis-based study of Chinese medicine treatment patterns after breast cancer surgery.

Summary

The study analyzed breast cancer patients' clinical data after surgery and found that liver depression and spleen deficiency syndrome was common. Common TCM combinations were identified, aiding prescription decision-making post-surgery.

Cancer
Hu L et al (2023).
Medicine (Baltimore).
DOI:
10.1097/MD.0000000000036642
PubMed:
38115283

Z-Ligustilide Combined with Cisplatin Reduces PLPP1-Mediated Phospholipid Synthesis to Impair Cisplatin Resistance in Lung Cancer.

Summary

Z-ligustilide+cisplatin combination inhibits phospholipid synthesis by upregulating PLPP1, inducing cell cycle arrest and apoptosis in cisplatin-resistant lung cancer cells by inhibiting AKT activation. Potential promising approach for cisplatin-resistant tumors.

Cancer
Geng P et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms242317046
PubMed:
38069368

Ligustilide prevents thymic immune senescence by regulating Thymosin β15-dependent spatial distribution of thymic epithelial cells.

Xu X et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155216
PubMed:
38061285

Taohong Siwu decoction reduces acute myocardial ischemia-reperfusion injury by promoting autophagy to inhibit pyroptosis.

Summary

TSD is a traditional Chinese medicine used to improve blood circulation. Its effects on heart injury caused by lack of blood supply and subsequent reperfusion have not been studied in terms of autophagy and pyroptosis.

Cardiology
Yang Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117515
PubMed:
38042386

Integrating genomic and multiomic data for Angelica sinensis provides insights into the evolution and biosynthesis of pharmaceutically bioactive compounds.

Li S et al (2023).
Commun Biol.
DOI:
10.1038/s42003-023-05569-5
PubMed:
38001348

Protective effect of Angelica sinensis polysaccharide on pregnant rats suffering from iron deficiency anemia via regulation of the hepcidin-FPN1 axis.

Zhang Y et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.128016
PubMed:
37967601

Synergistic inhibition of glioblastoma multiforme through an in-silico analysis of luteolin and ferulic acid derived from Angelica sinensis and Cannabis sativa: Advancements in computational therapeutics.

Suhail M et al (2023).
PLoS One.
DOI:
10.1371/journal.pone.0293666
PubMed:
37943817

Identification of chemical components and rat serum metabolites in Danggui Buxue decoction based on UPLC-Q-TOF-MS, the UNIFI platform and molecular networks.

Lv Y et al (2023).
RSC Adv.
DOI:
10.1039/d3ra04419j
PubMed:
37942447

Chemical composition analysis of Angelica sinensis (Oliv.) Diels and its four processed products by ultra-high-performance liquid chromatography coupled with quadrupole-orbitrap mass spectrometry combining with nontargeted metabolomics.

Phytochemistry
Wang K et al (2023).
J Sep Sci.
DOI:
10.1002/jssc.202300473
PubMed:
37933715

Using ultra-performance liquid chromatography with linear ion trap-electrostatic field orbitrap mass spectrometry, network pharmacology, and molecular docking to explore the constituent targets and action mechanisms of decoction of Angelica sinensis, Zingiberis Rhizoma Recens, and Mutton in the treatment of diarrhea-predominant irritable bowel syndrome.

Phytochemistry
Liu Z et al (2023).
J Pharm Pharmacol.
DOI:
10.1093/jpp/rgad076
PubMed:
37832514

Role of senkyunolide I in the promotion of neural stem/progenitor cell proliferation via the Akt/β-catenin pathway.

Wang M et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.115683
PubMed:
37832402

Antifungal mechanism of Angelica sinensis essential oil against Penicillium roqueforti and its application in extending the shelf life of bread.

Summary

Researchers found that Angelica sinensis essential oil (ASEO) inhibits the growth of Penicillium roqueforti by affecting the cell membrane, signaling pathways, steroid synthesis, and inducing cell apoptosis. ASEO also extends bread shelf life, making it a potential food and agricultural product preservative.

AntimicrobialPhytochemistry
Gao Q et al (2023).
Int J Food Microbiol.
DOI:
10.1016/j.ijfoodmicro.2023.110427
PubMed:
37827052

Insights into the Mechanism of Supramolecular Self-Assembly in the Astragalus membranaceus-Angelica sinensis Codecoction.

Liang P et al (2023).
ACS Appl Mater Interfaces.
DOI:
10.1021/acsami.3c09494
PubMed:
37791782

Molecular networking unveils anti-SARS-CoV-2 constituents from traditionally used remedies.

Summary

Plants and fungi have historically been used for treating infections, including viruses. Some of these natural products have shown promise in fighting SARS-CoV-2 and related conditions, when approved therapeutics are limited.

COVID-19
Wasilewicz A et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117206
PubMed:
37783406

Angelica sinensis polysaccharides ameliorated 5-Fluorouracil-induced damage of early B cell progenitors by alleviating oxidative stress of IL-7 producing mesenchymal stem and progenitor cells.

Immunology
Xiao H et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.115599
PubMed:
37783150

Comparative study on Angelica sinensis after different processing with yellow rice wine in color, aromas, chemical components, and antioxidant activities.

Immunology
Zhang ZT et al (2023).
Food Chem X.
DOI:
10.1016/j.fochx.2023.100822
PubMed:
37780300

Preparation and evaluation of Angelica sinensis polysaccharide-modified chitosan sponge for acute liver injury protection.

Wang K et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.127126
PubMed:
37778573

Protective effect of ethyl ferulate against hypoxic injury in retinal cells and retinal neovascularization in an oxygen-induced retinopathy model.

Xue R et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155097
PubMed:
37778248

A Chinese medicine called Danggui Longhui may be a new clinically relevant clozapine inducer: Two case reports identified by therapeutic drug monitoring.

Jia F et al (2023).
Schizophr Res.
DOI:
10.1016/j.schres.2023.09.026
PubMed:
37775404

Quality evaluation of Angelica Sinensis Radix dispensing granules by integrating microvascular activity and chemical analysis.

Li WJ et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117236
PubMed:
37769884

Screening potential treatments for mpox from Traditional Chinese Medicine by using a data-driven approach.

Li L et al (2023).
Medicine (Baltimore).
DOI:
10.1097/MD.0000000000035116
PubMed:
37713907

Ligustilide enhances pregnancy outcomes via improvement of endometrial receptivity and promotion of endometrial angiogenesis in rats.

He D et al (2023).
J Nat Med.
DOI:
10.1007/s11418-023-01739-1
PubMed:
37698739

Correction to "Anti-phytopathogenic activity and the mechanisms of phthalides from Angelica sinensis (Oliv.) Diels.

(2023).
Pest Manag Sci.
DOI:
10.1002/ps.7731
PubMed:
37649324

The efficacy and mechanism of Angelica sinensis (Oliv.) Diels root aqueous extract based on RNA sequencing and 16S rDNA sequencing in alleviating polycystic ovary syndrome.

Summary

Researchers investigated the effects of Angelica sinensis root on PCOS symptoms. It may help alleviate menstrual disorders, reproductive dysfunction, anovulation, hyperandrogenism, and insulin resistance. Consider using it for treating PCOS in your lab.

EndocrinologyGenetics
Gao Y et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155013
PubMed:
37639812

Angelica sinensis polysaccharide improves mitochondrial metabolism of osteoarthritis chondrocytes through PPARγ/SOD2/ROS pathways.

Ni S et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7979
PubMed:
37632225

The serum lipidomics reveal the action mechanism of Danggui-Yimucao herbal pair in abortion mice.

Bai FY et al (2023).
Biomed Chromatogr.
DOI:
10.1002/bmc.5717
PubMed:
37580977

Angelica sinensis polysaccharide ameliorates nonalcoholic fatty liver disease via restoring estrogen-related receptor α expression in liver.

Summary

Angelica sinensis polysaccharide (ASP) regulates liver fat accumulation by altering gut microbiota and increasing propionate and butyrate levels. It can be used to prevent nonalcoholic fatty liver disease (NAFLD).

Endocrinology
Luo L et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7982
PubMed:
37563852

Carbon Quantum Dots Derived from Herbal Medicine as Therapeutic Nanoagents for Rheumatoid Arthritis with Ultrahigh Lubrication and Anti-inflammation.

Summary

Scientists have developed two new nanoagents derived from herbal medicine that have shown promising results in treating rheumatoid arthritis by improving joint lubrication and reducing inflammation.

ArthritisImmunology
Qiang R et al (2023).
ACS Appl Mater Interfaces.
DOI:
10.1021/acsami.3c06188
PubMed:
37535012

Senkyunolide B exhibits broad-spectrum antifungal activity against plant and human pathogenic fungi via inhibiting spore germination and destroying the mature biofilm.

Summary

Scientists studied the antifungal properties of phthalides, compounds found in Angelica sinensis. Understanding their effectiveness and mechanism could lead to new drugs for treating Aspergillus infection in immunocompromised patients.

Antimicrobial
Tan J et al (2023).
Pest Manag Sci.
DOI:
10.1002/ps.7696
PubMed:
37531560

Association of medicinal plant consumption with all-cause mortality and cognitive impairment in older adult: A large prospective cohort study.

Summary

This study examines the impact of consuming medicinal plants like Panax ginseng on overall mortality and cognitive impairment but lacks evidence from large-scale studies.

Neuroscience
Tao L et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154995
PubMed:
37516089

Comprehensive quality evaluation of two different geography originated Angelica sinensis Radix based on potential production area development and resource protection.

Zhou W et al (2023).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2023.107878
PubMed:
37480748

Comparative efficacy of Jaungo, a traditional herbal ointment, and a water-in-oil type non-steroidal moisturizer for radiation-induced dermatitis in patients with breast cancer: a prospective, randomized, single-blind, pilot study.

Summary

This study compared the effectiveness of Jaungo and a water-in-oil moisturizer in preventing radiation-induced dermatitis in breast cancer patients. Both treatments had similar efficacy and safety. Further research is needed.

CancerDermatology
Kim EH et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1216668
PubMed:
37469863

Novel pH-responsive E-selectin targeting natural polysaccharides hybrid micelles for diabetic nephropathy.

Summary

Researchers developed hybrid micelles loaded with Puerarin to treat diabetic nephropathy by targeting inflammatory and oxidative stress reactions in the kidney. promising strategy using natural polysaccharides.

Diabetes
Guo C et al (2023).
Nanomedicine.
DOI:
10.1016/j.nano.2023.102696
PubMed:
37394108

First Report of Fusarium solani and Fusarium oxysporum Causing Basal Stem Rot on Celery in China.

Wang R et al (2023).
Plant Dis.
DOI:
10.1094/PDIS-02-23-0230-PDN
PubMed:
37392030

Immuno-histologic and histomorphometric evaluation of Angelica sinensis adjunctive to ß-tricalcium phosphate in critical-sized class II furcation defects in dogs.

Eldeeb DW et al (2023).
BDJ Open.
DOI:
10.1038/s41405-023-00150-y
PubMed:
37353505

Magnetic graphitized carbon black based on crystal growth method combined with high-resolution mass spectrometry for screening of 300 pesticide residues in Radix Codonopsis and Angelica sinensis.

Zhang H et al (2023).
J Chromatogr B Analyt Technol Biomed Life Sci.
DOI:
10.1016/j.jchromb.2023.123788
PubMed:
37329779

Ligustilide, a novel SIRT1 agonist, alleviates lipopolysaccharide-induced acute lung injury through deacetylation of NICD.

Li G et al (2023).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2023.110486
PubMed:
37327514

Network pharmacology-based approach to research the effect and mechanism of Si-Miao-Yong-An decoction against thromboangiitis obliterans.

Zou J et al (2023).
Ann Med.
DOI:
10.1080/07853890.2023.2218105
PubMed:
37318081

Classification of Angelica species found in various foods using an LC-QTOF/MS-based metabolomics approach.

Ahn SJ et al (2023).
Food Addit Contam Part A Chem Anal Control Expo Risk Assess.
DOI:
10.1080/19440049.2023.2220827
PubMed:
37310353

Mechanism of ligusticum cycloprolactam against neuroinflammation based on network pharmacology and experimental verification.

Summary

Researchers have synthesized a derivative of ligustilide, a natural compound with anti-inflammatory properties, called ligusticum cycloprolactam (LIGc) to make it more stable. Using network pharmacological methods and experimental verification, they investigated the effects and mechanisms of ligustilide and LIGc on neuroinflammation. They identified four key targets of ligustilide that exert an anti-inflammatory effect, with the NF-κB signal pathway as the main signaling pathway. LIGc was found to downregulate the activation of the NF-κB signal pathway in BV2 cells induced by lipopolysaccharide and suppress the production of inflammatory cytokines, providing support for the development of anti-inflammatory drugs based on ligustilide or its derivatives.

Neuroscience
Gao J et al (2023).
Clin Exp Pharmacol Physiol.
DOI:
10.1111/1440-1681.13784
PubMed:
37308175

Colon-Targeting Angelica sinensis Polysaccharide Nanoparticles with Dual Responsiveness for Alleviation of Ulcerative Colitis.

Gastroenterology
Xu Y et al (2023).
ACS Appl Mater Interfaces.
DOI:
10.1021/acsami.3c02128
PubMed:
37233992

Angelica sinensis polysaccharides alleviate the oxidative burden on hematopoietic cells by restoring 5-fluorouracil-induced oxidative damage in perivascular mesenchymal progenitor cells.

Niu Y et al (2023).
Pharm Biol.
DOI:
10.1080/13880209.2023.2207592
PubMed:
37148130

Plant-beneficial Streptomyces dioscori SF1 potential biocontrol and plant growth promotion in saline soil within the arid and semi-arid areas.

Li X et al (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-023-27362-x
PubMed:
37145360

A liquid chromatography-time-of-flight/mass spectrometry method for analysis of pesticides and transfer behavior in Radix Codonopsis and Angelica sinensis decoctions.

Phytochemistry
Zhang H et al (2023).
Anal Methods.
DOI:
10.1039/d3ay00103b
PubMed:
37144343

Danggui Buxue decoction ameliorates mitochondrial biogenesis and cognitive deficits through upregulating histone H4 lysine 12 acetylation in APP/PS1 mice.

Summary

Danggui Buxue decoction (DBD), a traditional Chinese medicine consisting of Astragali Radix and Angelica Sinensis Radix, has been used to treat dementia. Researchers found that DBD can improve cognition deficits in neurodegenerative diseases by supplementing 'blood' and 'qi' levels. However, the mechanisms behind this effect are not well understood.

Neuroscience
Chai GS et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116554
PubMed:
37137453

Angelica sinensis polysaccharide extends lifespan and ameliorates aging-related diseases via insulin and TOR signaling pathways, and antioxidant ability in Drosophila.

Immunology
Tuo W et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.124639
PubMed:
37121419

Gut microbiota-based metabolites of Xiaoyao Pills (a typical Traditional Chinese medicine) ameliorate depression by inhibiting fatty acid amide hydrolase levels in brain.

Summary

XYPs are a commonly used Traditional Chinese Medicine (TCM) for treating depression. However, since they are taken orally, they may interact with gut bacteria and affect the therapeutic outcomes of TCMs. The chemical complexity of XYPs makes understanding their biological effects a challenge.

GastroenterologyNeuroscience
Zhang ZW et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116555
PubMed:
37100263

A comprehensive review of antitumor properties of Angelica species and their antitumor-responsible constituents and the underlying molecular mechanisms involved in tumor inhibition.

Review Cancer
Sabeel Z et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7841
PubMed:
37086188

Data mining-based analysis on medication rules of Chinese herbal medicine treating headache with blood stasis syndrome.

Liu GH et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e14996
PubMed:
37064440

Evaluation of the effect of ultrasonic pretreatment on vacuum far-infrared drying characteristics and quality of Angelica sinensis based on entropy weight-coefficient of variation method.

Zang Z et al (2023).
J Food Sci.
DOI:
10.1111/1750-3841.16566
PubMed:
37038306

Angelica Sinensis polysaccharide antagonizes 5-Fluorouracil-induced spleen injury and dysfunction by suppressing oxidative stress and apoptosis.

Immunology
Du K et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.114602
PubMed:
37018993

Bioinformatics and computational chemistry approaches to explore the mechanism of the anti-depressive effect of ligustilide.

Summary

Depression can lead to negative outcomes, and antidepressants can cause side effects. Ligustilide (LIG), a component in angelica sinensis, has been used to treat depression with fewer side effects. This study found that LIG interacts with multiple targets, including AKT1, MAPK14, and ESR1, and the pathways of PI3K/AKT and MAPK, to exert an anti-depressive effect. Molecular docking and dynamics simulations supported these findings. This study presents a new strategy to explore the molecular mechanisms of LIG in treating depression.

Neuroscience
Zhang K et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-32495-7
PubMed:
37012370

Improving Drying Characteristics and Physicochemical Quality of Angelica sinensis by Novel Tray Rotation Microwave Vacuum Drying.

Phytochemistry
Zang Z et al (2023).
Foods.
DOI:
10.3390/foods12061202
PubMed:
36981129

Study on the Hepatoprotective Effect Mechanism of Polysaccharides from Charred Angelica sinensis on the Layer Chickens Based on the Detection of the Intestinal Floras and Short-Chain Fatty Acids of Cecal Contents and Association Analysis.

Gastroenterology
Wu F et al (2023).
Vet Sci.
DOI:
10.3390/vetsci10030224
PubMed:
36977263

Levistolide A ameliorates fibrosis in chronic kidney disease via modulating multitarget actions in vitro and in vivo.

Aobulikasimu N et al (2023).
Life Sci.
DOI:
10.1016/j.lfs.2023.121565
PubMed:
36921687

First report of Fusarium tricinctum Species complex causing root rot of tobacco in China.

Qiu R et al (2023).
Plant Dis.
DOI:
10.1094/PDIS-12-22-2924-PDN
PubMed:
36916846

Multi-Function of a New Bioactive Secondary Metabolite Derived from Endophytic Fungus Colletotrichum acutatum of Angelica sinensis.

Yehia RS et al (2023).
J Microbiol Biotechnol.
DOI:
10.4014/jmb.2206.06010
PubMed:
36908276

Astragalus-cultivated soil was a suitable bed soil for nurturing Angelica sinensis seedlings from the rhizosphere microbiome perspective.

An ZG et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-30549-4
PubMed:
36854968

Comparative Analysis of Roots from Vicatia thibetica de Boiss and Angelica sinensis Based on Chemical Composition, Antioxidant, Nitrite-Scavenging and Enzyme Inhibition Activities.

Tang W, Chen Y and Guo F (2023).
Molecules.
DOI:
10.3390/molecules28041942
PubMed:
36838931

Isolation of the Main Pathogens Causing Postharvest Disease in Fresh Angelica sinensis during Different Storage Stages and Impacts of Ozone Treatment on Disease Development and Mycotoxin Production.

Xi J et al (2023).
Toxins (Basel).
DOI:
10.3390/toxins15020154
PubMed:
36828468

Morphology, Solid Structure and Antioxidant Activity in Vitro of Angelica sinensis Polysaccharide-Ce(IV).

Li K et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202200813
PubMed:
36792977

Elucidating the promising role of traditional Chinese medicine in neuroprotection against oxidative stress encompassing Alzheimer's disease.

Summary

Traditional Chinese Medicine (TCM) has shown potential in managing Alzheimer's disease (AD) by breaking the vicious cycle of oxidative stress and neurodegeneration. The active constituents of various herbs in TCM have a long history in managing oxidative stress and have highlighted therapeutic potential. Chinese herbs provide a multiple-target approach, which can target multiple pathways involved in AD, and untangle the issues in the current therapy regimen of AD. This review suggests that TCM is a promising candidate for breaking the vicious cycle of oxidative stress in AD therapy.

Review ImmunologyNeuroscience
Arora A et al (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-023-25800-4
PubMed:
36790717

Ligustilide Induces Apoptosis and Reduces Proliferation in Human Bladder Cancer Cells by NFκB1 and Mitochondria Pathway.

Cancer
Yin L et al (2023).
Chem Biol Drug Des.
DOI:
10.1111/cbdd.14207
PubMed:
36751909

[Determination of 101 pesticide residues in Platycodonis radix and extracts of Angelica sinensis by gel permeation chromatography-gas chromatography-ion trap mass spectrometry].

Phytochemistry
Zhang R et al (2023).
Se Pu.
DOI:
10.3724/SP.J.1123.2022.03042
PubMed:
36725714

Anti-phytopathogenic activity and the mechanisms of phthalides from Angelica sinensis (Oliv.) Diels.

Ding YY et al (2023).
Pest Manag Sci.
DOI:
10.1002/ps.7389
PubMed:
36721354

In situ analysis of volatile oil in Angelica sinensis roots by fluorescence imaging combined with mass spectrometry imaging.

Li Q et al (2023).
Talanta.
DOI:
10.1016/j.talanta.2023.124253
PubMed:
36630786

Identification of the metabolites of neocnidilide in rat, monkey and human liver microsomes by liquid chromatography coupled to benchtop Orbitrap mass spectrometry.

Phytochemistry
Xie T, Huang L and Wang C (2023).
Biomed Chromatogr.
DOI:
10.1002/bmc.5563
PubMed:
36484569

Analysis of 12 Chemical Compounds And Pattern Recognition of Different Parts of Angelicae Sinensis Radix by Liquid Chromatography-Tandem Mass Spectrometry And Chemometrics Methods.

Phytochemistry
Zhao SL et al (2023).
J Chromatogr Sci.
DOI:
10.1093/chromsci/bmac098
PubMed:
36478174

Compatibility between cold-natured medicine CP and hot-natured medicine AZ synergistically mitigates colitis mice through attenuating inflammation and restoring gut barrier.

Immunology
Li YY et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115902
PubMed:
36395977

Development of Colloidal Gold Immunochromatography and Reverse-Transcription Loop-Mediated Isothermal Amplification Assays to Detect Lychnis Mottle Virus.

Jin W et al (2023).
Plant Dis.
DOI:
10.1094/PDIS-08-22-1970-RE
PubMed:
36383991

Glutathione-modified graphene quantum dots as fluorescent probes for detecting organophosphorus pesticide residues in Radix Angelica Sinensis.

Mu XQ et al (2023).
Spectrochim Acta A Mol Biomol Spectrosc.
DOI:
10.1016/j.saa.2022.122021
PubMed:
36283209

Traditional uses, chemical compounds, pharmacological activities and clinical studies on the traditional Chinese prescription Yi-Gan San.

Review
Yang SY et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115859
PubMed:
36280017

Network pharmacology-based investigation of potential targets of astragalus membranaceous-angelica sinensis compound acting on diabetic nephropathy.

Diabetes
Dong Y, Zhao Q and Wang Y (2021).
Sci Rep.
DOI:
10.1038/s41598-021-98925-6
PubMed:
34593896

Overview of therapeutic potentiality of Angelica sinensis for ischemic stroke.

Summary

Researchers studied the use of Angelica sinensis in treating ischemic stroke, a disease caused by blood flow interruption that damages neurons. Chinese medicine, particularly Angelica sinensis, was found to be beneficial in the treatment and recovery of ischemic stroke. The study highlights the potential benefits of using Chinese medicine in treating neurological disorders.

CardiologyNeuroscience
Han Y et al (2021).
Phytomedicine.
DOI:
10.1016/j.phymed.2021.153652
PubMed:
34362631

Extraction, structure, pharmacological activities and drug carrier applications of Angelica sinensis polysaccharide.

Review
Nai J et al (2021).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2021.05.213
PubMed:
34090852

Polyethylenimine-coated PLGA nanoparticles-encapsulated Angelica sinensis polysaccharide as an adjuvant to enhance immune responses.

Gu P et al (2019).
Carbohydr Polym.
DOI:
10.1016/j.carbpol.2019.115128
PubMed:
31427012

Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury and cell death by suppressing oxidative stress and hepatic apoptosis in vivo and in vitro.

Cao P et al (2018).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2018.01.139
PubMed:
29415408