Annona muricata

Common Names: soursop

Ethnobotanical Studies

Studies

Soursop leaf extract and fractions protects against L-NAME-induced hypertension and hyperlipidemia.

Summary

Study showed leaf extracts have potential anti-hypertensive and antihyperlipidemic properties. Important for potential new treatments for high blood pressure and high cholesterol.

Cardiology
Nsor OO et al (2024).
Front Nutr.
DOI:
10.3389/fnut.2024.1437101
PubMed:
39171117

Deciphering Annona's Anticancer Potential: Comparative Analysis of Crude Extract Versus Nanoformulation on SCC-25 Oral Cancer Cells Through cell Viability, Apoptosis, Cell Cycle, ROS, and MMP Analysis.

Summary

Study found that Annona muricata has potential anticancer activity. Nano formulation of its extract showed promise against oral cancer cells. Important for potential cancer treatment development.

Cancer
Rekha M et al (2024).
J Maxillofac Oral Surg.
DOI:
10.1007/s12663-024-02184-7
PubMed:
39118929

Antioxidant and cytotoxicity screenings of ethyl acetate extract from Annona muricata leaves and its fractions.

Immunology
Ginting B et al (2024).
J Adv Pharm Technol Res.
DOI:
10.4103/JAPTR.JAPTR_470_23
PubMed:
38903553

Comprehensive Chemical Profiling and Mechanistic Insight into Anticancer Activity of Annona muricata Leaves Extract.

Summary

Scientists analyzed the impact of leaf extract from L. on cancer in male mice. Extract contains unique compounds, improved expression of genes related to cell death, and protected against liver cancer. Exciting potential for anticancer agents.

Cancer
Abdallah RH et al (2024).
Pharmaceuticals (Basel).
DOI:
10.3390/ph17050614
PubMed:
38794184

Potential Anti-Tumorigenic Properties of Diverse Medicinal Plants against the Majority of Common Types of Cancer.

Summary

Study shows natural products from plants have potential in cancer therapy. Phytochemicals regulate molecular pathways, offering chemo-preventive benefits. Literature review highlights medicinal plants' anticancer effects and mechanisms. Important for developing targeted treatments.

Review Cancer
Albahri G et al (2024).
Pharmaceuticals (Basel).
DOI:
10.3390/ph17050574
PubMed:
38794144

Untargeted metabolomics using UHPLC-Q-Orbitrap HRMS for identifying cytotoxic compounds on MCF-7 breast cancer cells from Annona muricata Linn leaf extracts as potential anticancer agents.

Cancer
Septaningsih DA et al (2024).
Phytochem Anal.
DOI:
10.1002/pca.3373
PubMed:
38708435

Exploring the antifungal potential of Annona muricata leaf extract-loaded hydrogel in treating vulvovaginal candidiasis.

Summary

Study developed innovative hydrogel containing Annona muricata extract to control Candida albicans in vulvovaginal candidiasis. Extract increased polymer interactions, decreased viscosity, and showed efficacy in reducing fungal burden and inflammation. Potential natural therapeutic option for treatment.

Antimicrobial
Campos LM et al (2024).
Colloids Surf B Biointerfaces.
DOI:
10.1016/j.colsurfb.2024.113919
PubMed:
38663311

Storage and time course effects on the quality of oil extracted from Phyllanthus amarus Schumach and Annona muricata Linn and their antidiabetic potentials.

Summary

Study evaluated storage effects on Schumach and Linn oil quality. Oils contain beneficial phytochemicals, lower rancidity, and inhibit enzymes linked to diabetes and oxidative stress. Consider incorporating these oils into your diet for health benefits.

Diabetes
Ogunjinmi OE et al (2024).
BioTechnologia (Pozn).
DOI:
10.5114/bta.2024.135641
PubMed:
38633891

Assessment of the changes in product characteristics, total ascorbic acid, total flavonoid content, total polyphenol content and antioxidant activity of dried soursop fruit tea (Annona muricata L.) during product storage.

ImmunologyPhytochemistry
Do YV et al (2024).
Food Sci Nutr.
DOI:
10.1002/fsn3.3949
PubMed:
38628185

Modification of the physicochemical, functional, biochemical and structural properties of a soursop seed (Annona muricata L.) protein isolate treated with high-intensity ultrasound.

Phytochemistry
López-Mártir KU et al (2024).
Ultrason Sonochem.
DOI:
10.1016/j.ultsonch.2024.106870
PubMed:
38579570

Anti-cancer effects of green synthesized gold nanoparticles using leaf extract of Annona muricata. L against squamous cell carcinoma cell line 15 through apoptotic pathway.

Summary

Researchers synthesized gold nanoparticles using plant leaf extracts as reducing and capping agents to create safer, targeted therapies for oral cancer. This could offer a promising, less toxic treatment option for tongue squamous cell carcinoma with poor prognosis, particularly in developing nations.

Cancer
Mary SJ et al (2024).
Dent Res J (Isfahan).
PubMed:
38476717

The effect of Annona muricata (Graviola) on the prevention of brain damage due to ionizing radiation in rats.

Summary

Ethanol extract of AM leaves may protect against brain damage from ionizing radiation in rats. AM decreased astrocyte and microglial reactions, inflammation, and edema compared to IR alone. AM reduced oxidative damage caused by IR.

Neuroscience
Elmas O et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e25932
PubMed:
38370260

Annona Muricata L. extract restores renal function, oxidative stress, immunohistochemical structure, and gene expression of TNF-α, IL-β1, and CYP2E1 in the kidney of DMBA-intoxicated rats.

GeneticsImmunology
Zeweil MM et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1348145
PubMed:
38362149

Silica/Annona muricata nano-hybrid: Synthesis and anticancer activity against breast cancer.

Summary

Silica nanoparticles extracted from sugarcane can be used as a targeted drug delivery system in biomedicine. The nanoparticles have a porous structure, high drug capacity, and low toxicity. They can slowly release drugs, have high binding affinity against tumor cells, and exhibit high cytotoxicity against breast cancer cells.

Cancer
Perinbarajan GK et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e25048
PubMed:
38322972

Duguetia confinis Engl. & Diels (Annonaceae) inhibitory and cytotoxic effects on breast adenocarcinoma growth both in vitro and in vivo.

Nkuimi OBK et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e24410
PubMed:
38317996

Antimutagenic and antitumor activities of a water-soluble fraction of soursop (syn Graviola, Annona muricata L.) fruit pulp.

Summary

This study analyzed the phenolic content and properties of soursop fruit pulp. It showed antioxidant and antimutagenic properties, as well as cytotoxicity against certain cancer cells. Soursop may have potential as a DNA chemopreventive and antitumor agent.

Cancer
Scharf RM et al (2024).
J Toxicol Environ Health A.
DOI:
10.1080/15287394.2024.2309335
PubMed:
38285000

Assessment of changes in product quality and antioxidant activity of dried soursop (Annona muricata L.) during product storage.

Immunology
Le TNQ et al (2023).
Food Chem X.
DOI:
10.1016/j.fochx.2023.101062
PubMed:
38259510

Optimization of Thermoultrasound Process of Soursop (Annona muricata) Nectar and Comparison of Its Physicochemical Properties and In Vitro Bioaccessibility of Antioxidants with Pasteurized Sample.

Phytochemistry
Zafra-Rojas QY et al (2023).
Food Technol Biotechnol.
DOI:
10.17113/ftb.61.04.23.8180
PubMed:
38205055

Overcoming multi drug resistance mediated by ABC transporters by a novel acetogenin- annonacin from Annona muricata L.

Manoharan JP, Palanisamy H and Vidyalakshmi S (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117598
PubMed:
38113989

Effect of Ethanol Extract of Soursop (Annona muricata L.) Stem Bark on Rat Liver Function.

Masykur et al (2023).
Pak J Biol Sci.
DOI:
10.3923/pjbs.2023.516.528
PubMed:
38110557

In silico studies on cytotoxicity and antitumoral activity of acetogenins from Annona muricata L.

Fallon Adido HE et al (2023).
Front Chem.
DOI:
10.3389/fchem.2023.1316779
PubMed:
38093819

Eco-friendly Cu/NiO nanoparticle synthesis: Catalytic potential in isatin-based chalcone synthesis for anticancer activity.

Summary

Isatin-based chalcones were synthesized using Cu/NiO nanoparticles as catalysts and showed potential as anticancer agents against MCF-7 cancer cells. Products 1 and 6 were particularly effective.

Cancer
Cahyana AH et al (2023).
MethodsX.
DOI:
10.1016/j.mex.2023.102471
PubMed:
38023319

Traditional medical practices for children in five islands from the Society archipelago (French Polynesia).

Chassagne F et al (2023).
J Ethnobiol Ethnomed.
DOI:
10.1186/s13002-023-00617-0
PubMed:
37853377

In ovo effect of Soursop (Annona muricata L.) leaf extract on hatching and post-hatch performance of Noiler chickens.

Kuka TT et al (2023).
Vet Anim Sci.
DOI:
10.1016/j.vas.2023.100311
PubMed:
37664412

Ethnomedicinal Uses, Phytochemistry, and Anticancer Potentials of African Medicinal Fruits: A Comprehensive Review.

Summary

This review explores the use of African fruits in traditional medicine and their potential as anticancer agents. It emphasizes the importance of further research and suggests that these fruits could provide valuable phytochemicals for anticancer studies.

Review CancerEthnobotanyPhytochemistry
Fakudze NT et al (2023).
Pharmaceuticals (Basel).
DOI:
10.3390/ph16081117
PubMed:
37631032

Assessing the Acute Toxicological Effects of Annona muricata Leaf Ethanol Extract on Rats: Biochemical, Histopathological, and Metabolomics Analyses.

Zubaidi SN et al (2023).
Toxics.
DOI:
10.3390/toxics11080688
PubMed:
37624193

Potential of Indonesian Herbal as an Anti-Cancer Therapy: A Systemic Review of in vitro Studies.

Summary

Researchers in Indonesia studied the use of natural ingredients from herbal plants as a potential therapy for cancer. With 6000 plant species used as herbal medicines in Indonesia, their findings could lead to effective treatments with fewer side effects.

Review Cancer
Permatasanti A and Hidayat W (2023).
Cancer Manag Res.
DOI:
10.2147/CMAR.S414457
PubMed:
37608914

LCMS/MS Phytochemical Profiling, Molecular, Pathological, and Immune-Histochemical Studies on the Anticancer Properties of Annona muricata.

Summary

The study identified 388 compounds in a tropical fruit extract, including potential new compounds. The extract showed anticancer properties in mice, improving abnormalities caused by cancer cells.

CancerPhytochemistry
Abdallah RH et al (2023).
Molecules.
DOI:
10.3390/molecules28155744
PubMed:
37570713

A Proteomic Study of the Bioactivity of Annona muricata Leaf Extracts in HT-1080 Fibrosarcoma Cells.

Marrero AD et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241512021
PubMed:
37569395

Effect of 4-Ethylbenzaldehyde from the Volatilome of Annona muricata on Meloidogyne incognita.

de Paula LL et al (2023).
Plant Dis.
DOI:
10.1094/PDIS-05-22-1075-RE
PubMed:
37552644

Investigations into Annona fruit consumption as a potential source of dietary higenamine intake in the context of sports drug testing.

Rubio A et al (2023).
Drug Test Anal.
DOI:
10.1002/dta.3558
PubMed:
37525530

Comparative anticancer effects of Annona muricata Linn (Annonaceae) leaves and fruits on DMBA-induced breast cancer in female rats.

Summary

This study compares the effects of fruit and leaves extracts of Annona muricata on breast cancer in rats, providing in vivo evidence for potential chemoprevention.

Cancer
Silihe KK et al (2023).
BMC Complement Med Ther.
DOI:
10.1186/s12906-023-04073-x
PubMed:
37454062

An evaluation of the quality of Annona muricata leaf products.

Jocelin Chan WJ et al (2023).
J Pharm Pharmacol.
DOI:
10.1093/jpp/rgad066
PubMed:
37440207

First report of Lasiodiplodia iraniensis causing crown rot on banana fruits in Brazil.

Silva DEMD et al (2023).
Plant Dis.
DOI:
10.1094/PDIS-10-22-2361-PDN
PubMed:
37392029

Annona muricata Leaf as an Anti-Cryptosporidial Agent: An In Silico Molecular Docking Analysis and In Vivo Studies.

El-Wakil ES et al (2023).
Pharmaceuticals (Basel).
DOI:
10.3390/ph16060878
PubMed:
37375825

Integrating Computational Methods in Network Pharmacology and In Silico Screening to Uncover Multi-targeting Phytochemicals against Aberrant Protein Glycosylation in Lung Cancer.

Summary

This work explores the potential of certain plant compounds to interact with cancer-associated glycoproteins. The researchers used computational methods and docking approaches to identify phytochemicals from selected plants with drug-like properties. They created a network to analyze the interactions between the compounds and glycoproteins. Several compounds, including α-pinene, cyanomaclurin, genistein, and quercetin, showed potential in binding to known cancer biomarkers. The researchers also performed cytotoxicity assays on plant extracts, finding that certain extracts had growth inhibitory activity against lung cancer cells. This research could help further understand the cytotoxic activities of these plant compounds.

Cancer
Grijaldo SJB et al (2023).
ACS Omega.
DOI:
10.1021/acsomega.2c07542
PubMed:
37332828

Annona muricate Extract Supplementation Contributes to Improve Aberrant Multi-Organ Energy Metabolism via Muscle-Brain Connectivity in Diabetic Mice.

Summary

This study investigated the effects of AM extract on the energy metabolism of T2DM mice. The extract increased insulin signaling in the skeletal muscle and hippocampus, and increased levels of myokines and neurotrophic factors. This suggests that AME may be a potential nutraceutical for improving energy metabolism and muscle-brain connectivity in T2DM.

DiabetesNeuroscience
Lee H, Kim SY and Lim Y (2023).
Nutrients.
DOI:
10.3390/nu15112559
PubMed:
37299522

Green synthesis of novel YMnO(3)-doped TiO(2) for enhanced visible-light- driven photocatalytic degradation of malachite green.

Yulizar Y et al (2023).
J Environ Manage.
DOI:
10.1016/j.jenvman.2023.118139
PubMed:
37285771

Antibiofilm potential of Annona muricata L. ethanolic extract against multi-drug resistant Candida albicans.

Campos LM et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116682
PubMed:
37263318

Ocurrence of Colletotrichum siamense Causing Leaf Spots on Soursop (Annona muricata) in Mexico.

Beltrán-Peña H et al (2023).
Plant Dis.
DOI:
10.1094/PDIS-03-23-0592-PDN
PubMed:
37261871

Effects of Annona muricata Extract on Trypsin, Cathepsin B and Collagenase Activities and Textural Changes in Chilled Macrobrachium rosenbergii.

Ibrahim A et al (2023).
Foods.
DOI:
10.3390/foods12091887
PubMed:
37174425

The anti-diarrheal and anti-inflammatory effects of hydroethanol extracts of ripe Annona muricata fruit pulp in Wistar rats using curative method.

Immunology
Okeke-Nwolisa BC et al (2023).
Int J Health Sci (Qassim).
PubMed:
37151748

Soursop (Annona muricata) Properties and Perspectives for Integral Valorization.

Review
Santos IL et al (2023).
Foods.
DOI:
10.3390/foods12071448
PubMed:
37048268

Comparative assessment of physicochemical, structural and functional properties of dietary fiber extracted from mango (Mangifera indica L.) and soursop (Annona muricata) peels.

Phytochemistry
Villacís-Chiriboga J et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.124116
PubMed:
36958454

Ethnobotanical Survey of Medicinal Plants Used in Breast Cancer Treatment by Traditional Health Practitioners in Central Uganda.

CancerEthnobotany
Lutoti S et al (2023).
J Multidiscip Healthc.
DOI:
10.2147/JMDH.S387256
PubMed:
36919184

Investigation of the chemical structure and analgesic and anti-inflammatory properties of polysaccharides that constitute the dietary fibers of soursop (Annona muricata) fruit.

Summary

This study analyzed the structure and biological activity of dietary fibers from soursop fruits. The soluble fibers promoted pain relief and reduced inflammation in mice. These findings could have potential health benefits.

ImmunologyPain
Lopes Leivas C et al (2023).
Food Res Int.
DOI:
10.1016/j.foodres.2023.112588
PubMed:
36914320

Influence of Foliar Application of Hydrogen Peroxide on Gas Exchange, Photochemical Efficiency, and Growth of Soursop under Salt Stress.

Capitulino JD et al (2023).
Plants (Basel).
DOI:
10.3390/plants12030599
PubMed:
36771685

Polysaccharides from Annona muricata leaves protect against cisplatin‑induced cytotoxicity in macrophages by alleviating mitochondrial dysfunction.

Immunology
Han JM et al (2023).
Mol Med Rep.
DOI:
10.3892/mmr.2022.12903
PubMed:
36453199

Nephroprotective plant species used in traditional Mayan Medicine for renal-associated diseases.

Review
Castañeda R et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115755
PubMed:
36181985

Yeasts from fermented Brazilian fruits as biotechnological tools for increasing phenolics bioaccessibility and improving the volatile profile in derived pulps.

Phytochemistry
de Lourdes Chaves Macêdo E et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2022.134200
PubMed:
36115231

Annona muricata as Possible Alternative in the Treatment of Hyperglycemia: A Systematic Review.

Review DiabetesGenetics
Martín Del Campo-Rayas P, Valdez Miramontes EH and Reyes Castillo Z (2022).
J Med Food.
DOI:
10.1089/jmf.2021.0058
PubMed:
35076315

Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity.

Cárdenas C et al (2021).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2021.112263
PubMed:
34626933

Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review.

Review Cancer
Rady I et al (2018).
Oxid Med Cell Longev.
DOI:
10.1155/2018/1826170
PubMed:
30151067

Emerging therapeutic potential of graviola and its constituents in cancers.

Review Cancer
Qazi AK et al (2018).
Carcinogenesis.
DOI:
10.1093/carcin/bgy024
PubMed:
29462271

Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities.

Review
Moghadamtousi SZ et al (2015).
Int J Mol Sci.
DOI:
10.3390/ijms160715625
PubMed:
26184167