Annona squamosa

Common Names: sugar apple, sweet sop

Ethnobotanical Studies

Studies

Phytochemical constituents, bioactivities, and applications of custard apple (Annona squamosa L.): A narrative review.

Summary

Researchers studied Annona squamosa L. for its nutritional content, medicinal properties, and industrial uses. It has various biological activities including cytotoxic, antidiabetic, and antioxidant effects. This review compiles data from 1990-2023 to provide a comprehensive understanding of its benefits.

Review Phytochemistry
Moussa AY et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.140363
PubMed:
39089196

Exploring the wound healing activity of phytosomal gel of Annona squamosa and Cinnamomum tamala leaves ethanolic extracts with antioxidant and antimicrobial activities in S aureus infected excision wound model.

Summary

Researchers combined ethanolic extracts of two plants to create a Polyherbal Ethanolic extract (PHEE) with antioxidant and antimicrobial properties. PHEE incorporated in a gel showed improved wound healing and reduced bacterial load in infected wounds, outperforming Povidone iodine ointment.

AntimicrobialImmunology
Khan AD et al (2024).
J Biomater Sci Polym Ed.
DOI:
10.1080/09205063.2024.2382540
PubMed:
39067021

Unveiling the Multifaceted Capabilities of Endophytic Aspergillus flavus Isolated from Annona squamosa Fruit Peels against Staphylococcus Isolates and HCoV 229E-In Vitro and In Silico Investigations.

Summary

Endophytic fungus from fruit peels produces compounds with potential antibacterial and antiviral properties. Strong activity against MRSA and biofilm formation, weak against Gram-negative bacteria. Promising antiviral activity against HCoV 229E. Molecular docking shows potential as drug targets.

COVID-19
Fathallah N et al (2024).
Pharmaceuticals (Basel).
DOI:
10.3390/ph17050656
PubMed:
38794226

Annona squamosa Fruit Extract Ameliorates Lead Acetate-Induced Testicular Injury by Modulating JAK-1/STAT-3/SOCS-1 Signaling in Male Rats.

Mobasher MA et al (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25105562
PubMed:
38791600

The Complete Genome Sequences of 12 Species of Plants from the Yucatan Peninsula, Mexico.

Genetics
Peña-Ramírez YJ et al (2024).
Biodivers Genomes.
DOI:
10.56179/001c.116283
PubMed:
38646443

Improvement effects of cyclic peptides from Annona squamosa on cognitive decline in neuroinflammatory mice.

Summary

Cyclic peptide Cylic(PIYAG) from Annona squamosa improves spatial memory, reduces inflammation markers, and passes through intestinal barrier. Potential for preventing cognitive decline.

Neuroscience
Li B et al (2023).
Food Sci Biotechnol.
DOI:
10.1007/s10068-023-01441-8
PubMed:
38585570

Cytotoxic naphtho- and benzofurans from an endophytic fungus Epicoccum nigrum Ann-B-2 associated with Annona squamosa fruits.

Elnaggar MS et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-55168-5
PubMed:
38418706

Empowering agricultural research: A comprehensive custard apple (Annona squamosa) disease dataset for precise detection.

Thite S et al (2024).
Data Brief.
DOI:
10.1016/j.dib.2024.110078
PubMed:
38317727

Larvicidal property and active compound profiling of Annona squamosa leaf extracts against two species of diptera, Aedes aegypti and Anopheles stephensi.

Dey P et al (2023).
J Vector Borne Dis.
DOI:
10.4103/0972-9062.383647
PubMed:
38174518

Selective and reliable fluorometric quantitation of anti-cancer drug in real plasma samples using nitrogen-doped carbon dots after MMIPs solid phase microextraction: Monitoring methotrexate plasma level.

Summary

Researchers synthesized a fluorescence probe for precise quantitation of methotrexate (MTX). The probe showed a wide detection range, high sensitivity, and selectivity. It was successfully applied for quantification of MTX in rabbit plasma samples, with potential for pharmaceutical applications.

Cancer
Alanazi AZ et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115862
PubMed:
37976985

Molecular networking unveils anti-SARS-CoV-2 constituents from traditionally used remedies.

Summary

Plants and fungi have historically been used for treating infections, including viruses. Some of these natural products have shown promise in fighting SARS-CoV-2 and related conditions, when approved therapeutics are limited.

COVID-19
Wasilewicz A et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117206
PubMed:
37783406

The Molluscicidal Activity of Green Synthesized Copper Oxide-Based Annona squamosa Seed Extract Nanoparticles on the Feeding Behavior, Biochemical, Molecular, and Immunohistochemical Alterations of Biomphalaria alexandrina Snails.

Hussein AAA et al (2023).
Biol Trace Elem Res.
DOI:
10.1007/s12011-023-03823-9
PubMed:
37648936

A novel heteropolysaccharide isolated from custard apple pulp and its immunomodulatory activity in mouse macrophages and dendritic cells.

Summary

A novel heteropolysaccharide (ASPA80-1) was isolated from custard apple pulp, and it showed significant activation of immune cells. It has potential for use in immunoenhancing functional foods.

Immunology
Huang C et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e18521
PubMed:
37554813

Low-dose of phenolic rich extract from Annona squamosa Linn leaves ameliorates insulin sensitivity and reduces body weight gain in HF diet-induced obesity.

Summary

This study examined the effects of an extract from Linn leaves on obesity-related metabolic abnormalities. The extract reduced body weight gain and improved insulin sensitivity, suggesting it could be a potential treatment for obesity-related diseases.

ObesityPhytochemistry
Alkhalidy H et al (2023).
Front Nutr.
DOI:
10.3389/fnut.2023.1146021
PubMed:
37538926

Investigations into Annona fruit consumption as a potential source of dietary higenamine intake in the context of sports drug testing.

Rubio A et al (2023).
Drug Test Anal.
DOI:
10.1002/dta.3558
PubMed:
37525530

The Apanteles adelinamoralesae species group (Hymenoptera, Braconidae) from Brazil, with descriptions of three new species reared from fruit borers(Lepidoptera, Depressariidae).

Shimbori EM et al (2023).
Zootaxa.
DOI:
10.11646/zootaxa.5277.2.5
PubMed:
37518316

In Vitro Effect on Plasmodium falciparum and In Vivo Effect on Plasmodium berghei of Annomaal, an Oily Fraction Obtained from the Seeds of Annona squamosa.

Sawant SS, Gabhe SY and Singh KK (2023).
Molecules.
DOI:
10.3390/molecules28145472
PubMed:
37513343

Effect of Annona squamosa leaf extract on human promyelocytic leukemia cells subjected to oxidative stress.

Summary

In this study, the researchers examined the impact of a specific plant extract on human promyelocytic leukemia cells. They wanted to determine if the extract could protect these cells from oxidative stress and damage. The results showed that the extract had antioxidative effects and could potentially offset damage caused by oxidative stress. This research is significant because it provides valuable insights into the potential therapeutic properties of the plant extract, specifically in relation to leukemia cells. By better understanding how this extract works, we can potentially develop more effective treatments for leukemia in the future.

CancerImmunology
Dilworth LL et al (2023).
J Complement Integr Med.
DOI:
10.1515/jcim-2023-0048
PubMed:
37247307

Anti-obesity potential of bioactive guided fractions of Annona squamosa linn. leaves extract: a combination of in-vitro, in-vivo and in-silico studies along with profiling of lead compounds by HPTLC MS-MS(n) method.

Summary

Bioactive fractions from [plant] show promise in reducing body weight and lipids in obese mice. Ascorbic acid and quercetin were identified in effective fractions, while stigmasterol and sitosterol exhibited strong binding to obesity-related receptors. Potential for anti-obesity treatment is suggested.

Obesity
Pratap Singh R and Pattnaik AK (2023).
3 Biotech.
DOI:
10.1007/s13205-023-03603-1
PubMed:
37188295

Seedless fruit in Annona squamosa L. is monogenic and conferred by INO locus deletion in multiple accessions.

Rodrigues BRA et al (2023).
Plant Reprod.
DOI:
10.1007/s00497-023-00464-9
PubMed:
37160783

Insecticidal Mechanism of Botanical Crude Extracts and Their Silver Nanoliquids on Phenacoccus solenopsis.

Madasamy M et al (2023).
Toxics.
DOI:
10.3390/toxics11040305
PubMed:
37112532

Transcriptome analysis reveals key metabolic pathways and gene expression involving in cell wall polysaccharides-disassembling and postharvest fruit softening in custard apple (Annona squamosa L.).

Genetics
Wang S et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.124356
PubMed:
37031786

Hydraulic trade-offs underlie enhanced performance of polyploid trees under soil water deficit.

Losada JM et al (2023).
Plant Physiol.
DOI:
10.1093/plphys/kiad204
PubMed:
37002827

Influence of methanolic extracts from seeds and pulp of Annona squamosa L. on osmotic and morphological fragility in human erythrocytes.

Leite DOD et al (2023).
Curr Res Toxicol.
DOI:
10.1016/j.crtox.2023.100103
PubMed:
36970244

Management of Oral Squamous Papilloma Using Annona squamosa (Custard Apple) Leaves: A Novel Case.

Yadav S et al (2023).
Cureus.
DOI:
10.7759/cureus.34806
PubMed:
36915838

Antioxidant, Immunostimulant, and Growth-Promoting Effects of Dietary Annona squamosa Leaf Extract on Nile Tilapia, Oreochromis niloticus, and Its Tolerance to Thermal Stress and Aeromonas sobria Infection.

Almarri SH et al (2023).
Animals (Basel).
DOI:
10.3390/ani13040746
PubMed:
36830534

Green Synthesis of Fluorescent Carbon Dots from Annona squamosa Leaves: Optical and Structural Properties with Bactericidal, Anti-inflammatory, Anti-angiogenesis Applications.

GeneticsImmunology
Vibhute A et al (2023).
J Fluoresc.
DOI:
10.1007/s10895-023-03159-6
PubMed:
36800043

Biogenic Synthesis of Fluorescent Carbon Dots (CDs) and Their Application in Bioimaging of Agricultural Crops.

Pete AM et al (2023).
Nanomaterials (Basel).
DOI:
10.3390/nano13010209
PubMed:
36616122

Green Biosynthesis of Silver Nanoparticles Using Annona glabra and Annona squamosa Extracts with Antimicrobial, Anticancer, Apoptosis Potentials, Assisted by In Silico Modeling, and Metabolic Profiling.

AntimicrobialCancer
Mokhtar FA et al (2022).
Pharmaceuticals (Basel).
DOI:
10.3390/ph15111354
PubMed:
36355526

Annona squamosa L. Extract-Loaded Niosome and Its Anti-Ehrlich Ascites' Carcinoma Activity.

Abd-Elghany AA et al (2022).
ACS Omega.
DOI:
10.1021/acsomega.2c03649
PubMed:
36340141

Evaluation of the skin protective effects of niosomal-entrapped annona squamosa against UVA irradiation.

Mohamad EA, Ahmed KA and Mohammed HS (2022).
Photochem Photobiol Sci.
DOI:
10.1007/s43630-022-00291-3
PubMed:
36030490

Comparison between Annona squamosa, Annona cherimolia and Annona atemoya ethanolic extracts extenuative impact against oxidative stress, inflammation and apoptosis in rat kidney induced by Ifosfamid.

Immunology
Abd-Elrazek A et al (2021).
Toxicol Res (Camb).
DOI:
10.1093/toxres/tfab078
PubMed:
34484686

Custard Apple (Annona squamosa L.) Leaves: Nutritional Composition, Phytochemical Profile, and Health-Promoting Biological Activities.

Review Phytochemistry
Kumar M et al (2021).
Biomolecules.
DOI:
10.3390/biom11050614
PubMed:
33919068