Common Names: wild celery
Researchers studied the effect of celery extract on lead-induced liver damage in rats. Celery extract lowered IL-6 and caspase 3 levels, showing potential as a protective agent against lead poisoning. This information could help develop treatments for lead toxicity.
Researchers explored the potential of 3-n-butylphthalide (NBP) in inhibiting ferroptosis, a cell death process linked to traumatic brain injury and neurodegenerative diseases. NBP, derived from Chinese celery, showed promising anti-ROS effects, suggesting potential for therapeutic development.
Various phytotherapy products, like garlic and green tea, have shown potential antihypertensive effects. Consider incorporating them into your treatment plan for hypertension to improve cardiovascular health.
Researchers studied the effect of synthetic compound NBP on PD rats with od dysfunction. Results may provide insights into PD mechanism and potential treatment for olfactory dysfunction.
NBP reduces brain damage in mice with stroke, improves neurological function, and decreases inflammation. Potential treatment for human ischemic stroke by targeting pyroptosis and neuroinflammation.
Researchers studied the potential of celery seed extract to prevent indomethacin-induced stomach ulcers in rats. This may lead to a new treatment or prevention approach for gastric ulcers.
Combining DL-3-n-butylphthalide (NBP) and dual antiplatelet therapy (DAPT) improves acute ischemic stroke in rats. It reduces neurological deficits, infarct area, and inflammation by suppressing the pyroptosis-inflammation pathway in brain tissues, especially in microglial cells.
This study investigated the potential of Apiaceae plants for treating cellulite. Extracts from Apium graveolens and Petroselinum crispum showed antioxidant activity, increased lipolysis, and decreased adipogenesis, making them promising for cellulite management.
A study found that consuming celery powder did not significantly improve cardiometabolic factors in individuals with type 2 diabetes. More research is needed.
Celery exosome-like nanovesicles (CELNs) have emerged as a promising option for drug delivery due to their high cellular uptake efficiency. Compared to other plant-derived nanovesicles, CELNs showed better tolerance and less toxicity as biotherapeutic roles in mice models. Encapsulating doxorubicin (DOX) into CELNs resulted in a more efficient treatment for tumors compared to conventional synthetic carriers like liposome, both in vitro and in vivo. This study highlights the potential of CELNs as a new-generation drug delivery carrier with distinct advantages.
DL-3-n-butylphthalide (NBP), derived from Apium graveolens seeds, has potential therapeutic effects for Parkinson's disease. Researchers established a rat model of the disease and found that NBP alleviated motor disturbance, prevented loss of dopaminergic neurons, reduced iron deposition in the substantia nigra and serum, and inhibited oxidative stress. The expression of iron metabolism-related proteins was altered by NBP treatment. These findings suggest that NBP mitigates Parkinson's disease by inhibiting iron deposition, oxidative stress, and ferroptosis in the substantia nigra.
Ischemic stroke is a major cause of morbidity and mortality, with few treatment options. Recombinant tissue plasminogen activator (rtPA) is the only FDA-approved drug, but its strict therapeutic window limits its use. Dl-3-n-Butylphthalide (NBP), a synthetic compound derived from seeds of the Apium graveolens plant, has shown promise in treating ischemic stroke in multiple clinical studies. NBP has multiple mechanisms of action, including anti-oxidant, anti-inflammatory, anti-apoptotic, and anti-thrombotic effects, as well as protecting mitochondria. This review highlights the potential of NBP as a powerful multi-target therapy for ischemic stroke.