Arctium lappa

Common Names: greater burrdock, greater burdock, woodland burdock, great burdock

Ethnobotanical Studies

Studies

Harnessing the power of Arctium lappa root: a review of its pharmacological properties and therapeutic applications.

Review
Shyam M and Sabina EP (2024).
Nat Prod Bioprospect.
DOI:
10.1007/s13659-024-00466-8
PubMed:
39162715

Therapeutic Effects of Arctiin on Alzheimer's Disease-like Model in Rats by Reducing Oxidative Stress, Inflammasomes and Fibrosis.

Summary

Arctiin from Arctium lappa L. shows potential in treating Alzheimer's with properties that combat cell growth, oxidative stress, and fat accumulation. Important for growing global AD prevalence.

ImmunologyNeuroscience
Almeaqli MT et al (2024).
Curr Alzheimer Res.
DOI:
10.2174/0115672050333388240801043509
PubMed:
39136502

Total Mineral Content in Raw Materials of Ten Medicinal Plants from Roadside Biotopes of Voronezh Oblast.

Dyakova NA et al (2024).
Dokl Biol Sci.
DOI:
10.1134/S0012496624701126
PubMed:
39128956

An integrated network pharmacology and molecular docking approach to reveal the role of Arctigenin against Cutibacterium acnes-induced skin inflammation by targeting the CYP19A1.

Immunology
Lu X et al (2024).
Chem Biol Drug Des.
DOI:
10.1111/cbdd.14598
PubMed:
39090783

Arctigenin from Burdock Root Exhibits Potent Antibacterial and Anti-Virulence Properties against Pseudomonas aeruginosa.

Koshak AE et al (2024).
J Microbiol Biotechnol.
DOI:
10.4014/jmb.2403.03003
PubMed:
39049476

Phytotherapeutic potential against MRSA: mechanisms, synergy, and therapeutic prospects.

He Q et al (2024).
Chin Med.
DOI:
10.1186/s13020-024-00960-8
PubMed:
38909250

NMR Metabolomics of Arctium lappa L., Taraxacum officinale and Melissa officinalis: A Comparison of Spontaneous and Organic Ecotypes.

Phytochemistry
Ambroselli D et al (2024).
Foods.
DOI:
10.3390/foods13111642
PubMed:
38890870

The conversion of monolignans to sesquilignans and dilignans is closely correlated to the regulation of Arctium lappa seed germination.

Zhao R et al (2024).
Planta.
DOI:
10.1007/s00425-024-04445-8
PubMed:
38795149

Potential Anti-Tumorigenic Properties of Diverse Medicinal Plants against the Majority of Common Types of Cancer.

Summary

Study shows natural products from plants have potential in cancer therapy. Phytochemicals regulate molecular pathways, offering chemo-preventive benefits. Literature review highlights medicinal plants' anticancer effects and mechanisms. Important for developing targeted treatments.

Review Cancer
Albahri G et al (2024).
Pharmaceuticals (Basel).
DOI:
10.3390/ph17050574
PubMed:
38794144

Integrated Mechanism of Immune Response Modulation by Arctium Lappa L. Fructans Based on Microbiome and Metabolomics Technologies.

Li L et al (2024).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.4c01299
PubMed:
38691768

Arctigenin induces activated HSCs quiescence via AMPK-PPARγ pathway to ameliorate liver fibrosis in mice.

Lv M et al (2024).
Eur J Pharmacol.
DOI:
10.1016/j.ejphar.2024.176629
PubMed:
38679116

Ethanolic extract of Arctium lappa leaves alleviates cerebral ischemia reperfusion-induced inflammatory injury via HDAC9-mediated NF-κB pathway.

Summary

Arctium lappa leaves may help treat ischemic stroke by reducing inflammatory response, potentially improving patient outcomes. Worth exploring further in lab research.

CardiologyImmunology
Wang M et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155599
PubMed:
38669967

Antidiabetic Properties of the Root Extracts of Dandelion (Taraxacum officinale) and Burdock (Arctium lappa).

Summary

Preclinical study on dandelion and burdock roots suggest potential antidiabetic properties. Burdock had higher antioxidant and hypoglycemic activity, dandelion had higher total polysaccharide. Further research needed for in vivo validation.

Diabetes
Zolotova D et al (2024).
Plants (Basel).
DOI:
10.3390/plants13071021
PubMed:
38611548

Non-cytotoxic nanomolar concentration of arctigenin protects neuronal cells from chemotherapy-induced ferroptosis by regulating SLC7A11-cystine-cysteine axis.

Summary

Arctigenin from Arctium lappa plant protects neurons from drug-induced neurotoxicity by preventing ferroptosis through activating SLC7A11-cystine-cysteine axis. Potential novel agent for neuroprotection.

CancerNeuroscience
Li Z et al (2024).
Biochem Biophys Res Commun.
DOI:
10.1016/j.bbrc.2024.149895
PubMed:
38593620

Comparison of Metabolic Profiles of Fruits of Arctium lappa, Arctium minus, and Arctium tomentosum.

Malaník M et al (2024).
Plant Foods Hum Nutr.
DOI:
10.1007/s11130-024-01175-w
PubMed:
38589624

The Biological Active Substances of Taraxacum officinale and Arctium lappa from the Siberian Federal District.

Frolova AS et al (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25063263
PubMed:
38542237

Extraction, structure and bioactivities of polysaccharide from root of Arctium lappa L.: A review.

Review
Li Z et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.131035
PubMed:
38518934

Arctigenin from Arctium lappa L. inhibits chikungunya virus by affecting its entry and replication.

Shukla S et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155491
PubMed:
38489894

The effect of aqueous extract of Arctium lappa root on the survival of Lactobacillus acidophilus La-5 and Bifidobacterium bifidum Bb-12 and sensorial and physicochemical properties of synbiotic yogurt.

Phytochemistry
Vanaki E et al (2023).
Food Sci Nutr.
DOI:
10.1002/fsn3.3919
PubMed:
38455177

Arctium lappa L. polysaccharides enhanced the therapeutic effects of nasal ectomesenchymal stem cells against liver fibrosis by inhibiting the Wnt/β-catenin pathway.

Xiang W et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.129670
PubMed:
38280697

Enhanced Chemoprevention of Prostate Cancer by Combining Arctigenin with Green Tea and Quercetin in Prostate-Specific Phosphatase and Tensin Homolog Knockout Mice.

Summary

Researchers tested the combination of arctigenin, green tea, and quercetin to enhance the anticancer effects on prostate cancer. They found a strong synergistic effect in vitro and significant inhibition of tumorigenesis in vivo. Clinical trials are needed to confirm efficacy in humans.

Cancer
Hao Q et al (2024).
Biomolecules.
DOI:
10.3390/biom14010105
PubMed:
38254705

An ethanolic extract of Arctium lappa L. leaves ameliorates experimental atherosclerosis by modulating lipid metabolism and inflammatory responses through PI3K/Akt and NF-κB singnaling pathways.

Immunology
Guo H et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117768
PubMed:
38253275

Analysis of Genes Associated with Feeding Preference and Detoxification in Various Developmental Stages of Aglais urticae.

Genetics
Xi O, Guo W and Hu H (2024).
Insects.
DOI:
10.3390/insects15010030
PubMed:
38249036

Acute and chronic toxicity in Sprague-Dawley rats of orally-administered total lignans from Arctii Fructus, a potential therapeutic drug for diabetes.

Summary

TLAF, a compound from Arctii Fructus, showed low toxicity in rats at 1,800 mg/kg for 26 weeks. It has potential for clinical treatment of diabetes.

DiabetesPhytochemistry
Mei J et al (2024).
Regul Toxicol Pharmacol.
DOI:
10.1016/j.yrtph.2023.105542
PubMed:
38070762

Preventive Effect of Arctium lappa Polysaccharides on Acute Lung Injury through Anti-Inflammatory and Antioxidant Activities.

Immunology
Lu N et al (2023).
Nutrients.
DOI:
10.3390/nu15234946
PubMed:
38068804

Arctium lappa L. roots inhibit the intestinal inflammation of dietary obese rats through TLR4/NF-κB pathway.

Summary

Long-term consumption of L. root powder (ARP) leads to weight loss. ARP inhibits pro-inflammatory cytokines, down-regulates genes involved in TLR4 complexes, and reduces inflammation in the colons of obese rats. ARP has potential in improving intestinal health and treating obesity.

GastroenterologyImmunologyObesity
Zeng F et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e21562
PubMed:
38027866

Effect of extraction methods on the chemical, structural, and rheological attributes of fructan derived from Arctium lappa L. roots.

de Marins AR et al (2024).
Carbohydr Polym.
DOI:
10.1016/j.carbpol.2023.121525
PubMed:
37985103

Immune regulation and inflammation inhibition of Arctium lappa L. polysaccharides by TLR4/NF-κB signaling pathway in cells.

Summary

Scientists extracted and purified polysaccharides from burdock roots, which showed antioxidant and anti-inflammatory effects in cells. It has potential as a functional food or nutraceutical to improve the immune system and treat intestinal inflammation.

Immunology
Zeng F et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.127700
PubMed:
37918584

Arctium lappa L. root polysaccharides ameliorate CCl(4)-induced acute liver injury by suppressing oxidative stress, inflammation and apoptosis.

Immunology
Xiang W et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2023.2272287
PubMed:
37867310

Systemic Review of Clot Retraction Modulators.

Review
Guilbeau A and Majumder R (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241310602
PubMed:
37445780

Exploring the Mechanism of Arctium Lappa L. Leaves in the Treatment of Alzheimer's Disease Based on Chemical Profile, Network Pharmacology and Molecular Docking.

Summary

Burdock leaves show potential in treating Alzheimer's Disease (AD) due to their bioactive ingredients. Chemical profiling and network pharmacology found 61 components and 792 targets, with 36 potential targets and four clinically significant targets identified. Therapeutic mechanisms involve the PI3K-Akt and AGE-RAGE signaling pathways.

Neuroscience
Mu SC et al (2023).
Adv Biol (Weinh).
DOI:
10.1002/adbi.202300084
PubMed:
37382195

Complete Mitogenome and Phylogenetic Analysis of the Carthamus tinctorius L.

Wu Z et al (2023).
Genes (Basel).
DOI:
10.3390/genes14050979
PubMed:
37239339

Evolutionary analysis of the OSCA gene family in sunflower (Helianthus annuus L) and expression analysis under NaCl stress.

Genetics
Shan F et al (2023).
PeerJ.
DOI:
10.7717/peerj.15089
PubMed:
37090105

Case study of clinical improvement of atopic dermatitis in a patient treated with herbal-based parapharmaceuticals.

Dermatology
Maraschio A, Wulhfard K and Monsellato L (2023).
J Complement Integr Med.
DOI:
10.1515/jcim-2023-0005
PubMed:
37043584

Preclinical Evidence that Arctigenin Effectively and Selectively Targets Clear Cell Renal Cell Carcinoma Via Suppressing EGFR and RhoA.

Liu D, Zhou G and Xu M (2023).
Nutr Cancer.
DOI:
10.1080/01635581.2023.2178920
PubMed:
36947006

Chemoproteomics reveals arctigenin as a phagophore-closure blocker via targeting ESCRT-I subunit VPS28.

Han J et al (2023).
Bioorg Chem.
DOI:
10.1016/j.bioorg.2023.106457
PubMed:
36907049

An Original Asteraceae Based Infused Drink Prevents Metabolic Syndrome in Fructose-Rat Model.

Idres AY et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12020340
PubMed:
36829899

Burdock-Derived Composites Based on Biogenic Gold, Silver Chloride and Zinc Oxide Particles as Green Multifunctional Platforms for Biomedical Applications and Environmental Protection.

Zgura I et al (2023).
Materials (Basel).
DOI:
10.3390/ma16031153
PubMed:
36770157

The burdock database: a multi-omic database for Arctium lappa, a food and medicinal plant.

Song Y et al (2023).
BMC Plant Biol.
DOI:
10.1186/s12870-023-04092-3
PubMed:
36759759

The therapeutic potential of arctigenin against multiple human diseases: A mechanistic review.

Review
Wang G et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154647
PubMed:
36628833

Anti-glutamatergic effects of three lignan compounds: arctigenin, matairesinol and trachelogenin - An ex vivo study on rat brain slices.

Summary

Arctigenin, a natural bioactive compound, was compared with matairesinol and trachelogenin in their effects on synaptic activity in rat brain slices. Arctigenin and trachelogenin were found to be more potent in inhibiting glutamate receptors and decreasing the amplitude of evoked potential early component in the rat brain than matairesinol. These results suggest that trachelogenin and arctigenin could be potential candidates for the development of neuroprotective drugs.

Neuroscience
Koech PK et al (2023).
Planta Med.
DOI:
10.1055/a-2005-5497
PubMed:
36592636

Visualizing the Spatial Distribution of Arctium lappa L. Root Components by MALDI-TOF Mass Spectrometry Imaging.

Li L et al (2022).
Foods.
DOI:
10.3390/foods11243957
PubMed:
36553700

Arctium lappa (Burdock): Insights from ethnopharmacology potential, chemical constituents, clinical studies, pharmacological utility and nanomedicine.

Review Ethnobotany
Yosri N et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2022.114104
PubMed:
36516694

Arctigenin mitigates insulin resistance by modulating the IRS2/GLUT4 pathway via TLR4 in type 2 diabetes mellitus mice.

Diabetes
Zhou Y et al (2023).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2022.109529
PubMed:
36481528

Abundant and diverse endophytic bacteria associated with medicinal plant Arctium lappa L. and their potential for host plant growth promoting.

Liu JQ et al (2022).
Antonie Van Leeuwenhoek.
DOI:
10.1007/s10482-022-01785-x
PubMed:
36284037

Ethanolic extract of root from Arctium lappa L ameliorates obesity and hepatic steatosis in rats by regulating the AMPK/ACC/CPT-1 pathway.

Obesity
Ma K et al (2022).
J Food Biochem.
DOI:
10.1111/jfbc.14455
PubMed:
36183168

Chromatographic fingerprint combined with quantitative analysis of multi-components by single-marker for quality control of total lignans from Fructus arctii by high-performance liquid chromatography.

Phytochemistry
Zhang JY et al (2022).
Phytochem Anal.
DOI:
10.1002/pca.3172
PubMed:
36131366

Arctium lappa leaves based on network pharmacology and experimental validation attenuate atherosclerosis by targeting the AMPK-mediated PPARG/LXRα pathway.

Wang M et al (2022).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2022.113503
PubMed:
36076592

Saccharides from Arctium lappa L. root reduce platelet activation and thrombus formation in a laser injury thrombosis mouse model.

Ruan Y et al (2022).
Exp Ther Med.
DOI:
10.3892/etm.2022.11274
PubMed:
35401796

Parasiticidal effects of Eclipta alba and Arctium lappa extracts against Ichthyophthirius multifiliis.

Leśniak P, Puk K and Guz L (2021).
Pol J Vet Sci.
DOI:
10.24425/pjvs.2021.139979
PubMed:
35179846

Arctium lappa L. roots ameliorates cerebral ischemia through inhibiting neuronal apoptosis and suppressing AMPK/mTOR-mediated autophagy.

Summary

Arctium lappa L. roots have been shown to possess pharmacological benefits and protect neurons from injury in previous studies. This current study investigates whether the roots can prevent cerebral ischemia and the underlying mechanism. The results suggest that Arctium lappa L. root extract can reduce cerebral ischemic injury in rats and provides neuroprotection through multiple mechanisms. This study highlights the potential therapeutic value of Arctium lappa L. roots for treatment of cerebral ischemia.

CardiologyNeuroscience
Yang Y et al (2021).
Phytomedicine.
DOI:
10.1016/j.phymed.2021.153526
PubMed:
33691269

Arctium lappa and Arctium tomentosum, Sources of Arctii radix: Comparison of Anti-Lipoxygenase and Antioxidant Activity as well as the Chemical Composition of Extracts from Aerial Parts and from Roots.

Skowrońska W et al (2021).
Plants (Basel).
DOI:
10.3390/plants10010078
PubMed:
33401685

Arctium lappa contributes to the management of type 2 diabetes mellitus by regulating glucose homeostasis and improving oxidative stress: A critical review of in vitro and in vivo animal-based studies.

Review Diabetes
Annunziata G et al (2019).
Phytother Res.
DOI:
10.1002/ptr.6416
PubMed:
31232489

Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L.

Review Immunology
Gao Q, Yang M and Zuo Z (2018).
Acta Pharmacol Sin.
DOI:
10.1038/aps.2018.32
PubMed:
29698388

Use of Arctium lappa Extract Against Acetaminophen-Induced Hepatotoxicity in Rats.

El-Kott AF and Bin-Meferij MM (2015).
Curr Ther Res Clin Exp.
DOI:
10.1016/j.curtheres.2015.05.001
PubMed:
26543508

Antitubercular activity of Arctium lappa and Tussilago farfara extracts and constituents.

Zhao J et al (2014).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2014.06.034
PubMed:
24955560

A review of the pharmacological effects of Arctium lappa (burdock).

Review
Chan YS et al (2011).
Inflammopharmacology.
DOI:
10.1007/s10787-010-0062-4
PubMed:
20981575