Common Names: marlberry
This study used a network pharmacology-based approach to investigate potential Traditional Chinese Medicine candidates as treatment targets for Alzheimer's disease (AD). Artificial Intelligence algorithms were employed to predict the bioactivity of the candidates and to explore the predicted results efficiently. The study showed that herbs Ardisia japonica, Ligusticum chuanxiong, Lippia nodiflora and Mirabilis jalapa might be a potential medicine formula for AD. Binding stability of the potential inhibitors was evaluated using 100 ns of MD simulation. This study elucidates new potential TCM approaches to treat AD.