Areca catechu

Common Names: betel palm

Ethnobotanical Studies

Clinical Trials

Salivary Areca and tobacco alkaloids for bioverification in the Betel Nut Intervention Trial.

The BENIT study aimed to help Pacific Islanders quit chewing a cancer-causing nut. This report shows the effectiveness of the intervention at day 22.

Franke AA et al (2023).
Drug Test Anal.
DOI:
10.1002/dta.3364
PubMed:
36057968

Studies

Optimizing Hard Carbon Anodes from Agricultural Biomass for Superior Lithium and Sodium Ion Battery Performance.

Naik PB et al (2024).
ChemSusChem.
DOI:
10.1002/cssc.202400970
PubMed:
39113614

1H-Pyrrole-2,5-dicarboxylic acid, a quorum sensing inhibitor from one endophytic fungus in Areca catechu L., acts as antibiotic accelerant against Pseudomonas aeruginosa.

Summary

PT22, a compound from an endophytic fungus, inhibits quorum sensing in multidrug-resistant bacteria, making antibiotics more effective against biofilm-forming pathogens like . Use of PT22 with gentamycin or piperacillin improves treatment outcomes and reduces antibiotic resistance.

Antimicrobial
Liu J et al (2024).
Front Cell Infect Microbiol.
DOI:
10.3389/fcimb.2024.1413728
PubMed:
39015339

Areca palm velarivirus 1 infection caused disassembly of chloroplast and reduction of photosynthesis in areca palm.

Cao X et al (2024).
Front Microbiol.
DOI:
10.3389/fmicb.2024.1424489
PubMed:
38939190

Inhibition of cortical synaptic transmission, behavioral nociceptive, and anxiodepressive-like responses by arecoline in adult mice.

Summary

Arecoline from Areca nut may alleviate pain, anxiety, and depression through muscarinic receptors in the anterior cingulate cortex. Potential future treatment for chronic pain and related disorders.

Pain
Chen QY et al (2024).
Mol Brain.
DOI:
10.1186/s13041-024-01106-5
PubMed:
38886822

Comprehensive insights into areca nut: active components and omics technologies for bioactivity evaluation and quality control.

Review
Sun Y et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1407212
PubMed:
38873426

Genome-wide identification of heavy-metal ATPases genes in Areca catechu: investigating their functionality under heavy metal exposure.

Genetics
Khan NM et al (2024).
BMC Plant Biol.
DOI:
10.1186/s12870-024-05201-6
PubMed:
38822228

Detection and identification of Bogia coconut syndrome phytoplasma from seed-associated tissues and seedlings of coconut (Cocos nucifera) and betel nut (Areca catechu).

Lu H et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-61916-4
PubMed:
38773154

First report of large-berry coffee (Coffea liberica) anthracnose caused by Colletotrichum kahawae in China.

Zhang H et al (2024).
Plant Dis.
DOI:
10.1094/PDIS-01-24-0039-PDN
PubMed:
38720534

Integrated transcriptomics and metabolomics analyses of the effects of bagging treatment on carotenoid biosynthesis and regulation of Areca catechu L.

Genetics
Zheng X et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2024.1364945
PubMed:
38628364

Association between habitual betel quid chewing and risk of adverse cardiovascular outcomes: A systematic review.

Summary

Betel quid chewing is linked to oral cancer in Asia-Pacific. Research examines if it also causes cardiovascular issues. Understanding this can lead to better health recommendations.

Review Cardiology
Itaki R and Taufa S (2024).
Trop Med Int Health.
DOI:
10.1111/tmi.13988
PubMed:
38556799

Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs.

Review
Sun H et al (2024).
Nutrients.
DOI:
10.3390/nu16050695
PubMed:
38474823

Predicting current and future climate suitability for arecanut (Areca catechu L.) in India using ensemble model.

Hebbar KB et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e26382
PubMed:
38420454

Gene co-expression network analysis in areca floral organ and the potential role of the AcMADS17 and AcMADS23 in transgenic Arabidopsis.

Genetics
Luo H et al (2024).
Plant Sci.
DOI:
10.1016/j.plantsci.2024.112049
PubMed:
38408509

Biological Effects and Biomedical Applications of Areca Nut and Its Extract.

Review
Tong T et al (2024).
Pharmaceuticals (Basel).
DOI:
10.3390/ph17020228
PubMed:
38399443

Towards a replacement therapy for stimulant betel quid dependence: A proof of concept study.

Osborne PG et al (2024).
Addict Biol.
DOI:
10.1111/adb.13371
PubMed:
38380696

Molecular mechanisms of macrophage immunomodulation mediated by Areca inflorescence polysaccharides based on RNA-seq analysis.

Summary

Areca inflorescence polysaccharide (AFP2a) activates macrophages and promotes immune responses through signaling pathways, revealing its potential as a natural immunomodulator.

GeneticsImmunology
Chen D et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.130076
PubMed:
38354932

First Report of Lasiodiplodia hormozganensis Causing Leaf Spot Disease on Areca catechu in China.

Zhang C et al (2024).
Plant Dis.
DOI:
10.1094/PDIS-10-23-2024-PDN
PubMed:
38240654

Development and application of mass spectrometric molecular networking for analyzing the ingredients of areca nut.

Zhao J et al (2024).
Mol Omics.
DOI:
10.1039/d3mo00232b
PubMed:
38224158

Supplementation of dietary areca nut extract modulates the growth performance, cecal microbiota composition, and immune function in Wenchang chickens.

Gastroenterology
Wang S et al (2023).
Front Vet Sci.
DOI:
10.3389/fvets.2023.1278312
PubMed:
38192720

Guideline for the Diagnosis and Clinical Management of Oral Submucous Fibrosis.

Society of Oral Medicine and Chinese Stomatological Association (2023).
Chin J Dent Res.
DOI:
10.3290/j.cjdr.b4784075
PubMed:
38126373

Impact of progressive and retrogressive land use changes on ecosystem multifunctionality: Implications for land restoration in the Indian Eastern Himalayan region.

Kurmi B et al (2023).
Sci Total Environ.
DOI:
10.1016/j.scitotenv.2023.169197
PubMed:
38101647

Integrated metabolomics and network pharmacology to reveal the mechanism of areca nut addiction.

Summary

Areca nut addiction mechanisms were explored using metabolomics and network pharmacology. Arecoline and G-protein coupled receptor signaling were identified as key factors, affecting dopamine and serotonin systems. The study also revealed a potential link between bile acids and addictive behavior, providing insights for interventions and treatment.

Neuroscience
Li M et al (2023).
Addict Biol.
DOI:
10.1111/adb.13352
PubMed:
38017647

Molecular Identification of 'Candidatus Phytoplasma malaysianum'-Related Strains Associated with Areca catechu Palm Yellow Leaf Disease and Phylogenetic Diversity of the Phytoplasmas within 16SrXXXII Group.

Yu SS et al (2023).
Plant Dis.
DOI:
10.1094/PDIS-11-23-2275-RE
PubMed:
37953232

The impact of main Areca Catechu root exudates on soil microbial community structure and function in coffee plantation soils.

Zhao S et al (2023).
Front Microbiol.
DOI:
10.3389/fmicb.2023.1257164
PubMed:
37928668

Phytohormones and candidate genes synergistically regulate fruitlet abscission in Areca catechu L.

Summary

Researchers studied the process of fruitlet abortion in Areca catechu, a plant with low yield due to frequent abscission. They analyzed hormone levels in abscised and non-abscised fruitlets to understand the physiological and molecular variations.

Genetics
Li J et al (2023).
BMC Plant Biol.
DOI:
10.1186/s12870-023-04562-8
PubMed:
37919647

Timing of oomycete-specific fungicide application impacts the efficacy against fruit rot disease in arecanut.

Balanagouda P et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1237795
PubMed:
37780514

Identification and molecular characterization of a novel member of the genus Totivirus from Areca catechu L.

Tan H et al (2023).
Arch Virol.
DOI:
10.1007/s00705-023-05867-7
PubMed:
37676322

Cohesion and Adhesion Performance of Tannin-Glyoxal Adhesives at Different Formulations and Hardener Types for Bonding Particleboard Made of Areca (Areca catechu) Leaf Sheath.

Anggini AW et al (2023).
Polymers (Basel).
DOI:
10.3390/polym15163425
PubMed:
37631482

Sampling locations and processing methods shape fungi microbiome on the surface of edible and medicinal Arecae semen.

Wei G et al (2023).
Front Microbiol.
DOI:
10.3389/fmicb.2023.1188986
PubMed:
37547678

Evaluation of Chemical Compositions and the Antioxidant and Cytotoxic Properties of the Aqueous Extract of Tri-Yannarose Recipe (Areca catechu, Azadirachta indica, and Tinospora crispa).

Immunology
Sanpinit S et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12071428
PubMed:
37507966

First Report of 16SrII Group Related Phytoplasma Associated with Areca Palm Yellow Leaf Disease on Areca catechu in China.

Lin Z et al (2023).
Plant Dis.
DOI:
10.1094/PDIS-03-23-0587-PDN
PubMed:
37467130

First Report of Anthracnose Caused by Colletotrichum ciggaro on Lonicera macranthoides Hand.-Mazz. in China.

Xiao J et al (2023).
Plant Dis.
DOI:
10.1094/PDIS-06-23-1057-PDN
PubMed:
37467123

Optimization of ultrasonic-assisted extraction of polyphenol from Areca nut (Areca catechu L.) seeds using response surface methodology and its effects on osteogenic activity.

Phytochemistry
Sun Y et al (2023).
Ultrason Sonochem.
DOI:
10.1016/j.ultsonch.2023.106511
PubMed:
37423070

Incredible Combination of Lifestyle Modification and Herbal Remedies for Polycystic Ovarian Syndrome Management.

Summary

Researchers reviewed the use of yoga and herbal remedies for polycystic ovarian syndrome (PCOS), a common hormonal disorder. These alternative therapies can help improve symptoms and quality of life, offering a holistic approach to PCOS management. Further research is needed to validate these findings.

Review Endocrinology
Balkrishna A et al (2023).
Evid Based Complement Alternat Med.
DOI:
10.1155/2023/3705508
PubMed:
37383339

Structural characterization of polysaccharide fractions in areca (Areca catechu L.) inflorescence and study of its immunological enhancement activity in vitro and in vivo.

Chen D et al (2023).
Food Res Int.
DOI:
10.1016/j.foodres.2023.113006
PubMed:
37330846

Areca catechu L. ameliorates chronic unpredictable mild stress-induced depression behavior in rats by the promotion of the BDNF signaling pathway.

Summary

Researchers studied the antidepressant effects of an Areca catechu fruit extract on rats under chronic unpredictable mild stress. They identified a potential underlying mechanism. These results suggest that ACL may be a promising treatment for depression.

Neuroscience
Yao C et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.114459
PubMed:
37245336

Systematic Analysis of NRAMP Family Genes in Areca catechu and Its Response to Zn/Fe Deficiency Stress.

Genetics
Zhou G et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24087383
PubMed:
37108545

Transcriptome and targeted metabolomic integrated analysis reveals mechanisms of B vitamin accumulation in Areca catechu nut development.

Genetics
Zhou G et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.124570
PubMed:
37100313

Areca Nut.

Review
(2023).
PubMed:
37043595

First report of Robbsia andropogonis causing bacterial leaf spot of bougainvilleas in Taiwan.

Hsu WY et al (2023).
Plant Dis.
DOI:
10.1094/PDIS-01-23-0099-PDN
PubMed:
36995768

UV-Visible-NIR camouflage textiles with natural plant based natural dyes on natural fibre against woodland combat background for defence protection.

Hossain MA et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-31725-2
PubMed:
36977725

Integrated Transcriptomic and Metabolomic Analyses Reveal the Molecular and Metabolic Basis of Flavonoids in Areca catechu L.

Phytochemistry
Lai J et al (2023).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.2c08864
PubMed:
36940468

Evaluation of aerial spraying application of multi-rotor unmanned aerial vehicle for Areca catechu protection.

Wang J et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1093912
PubMed:
36925752

Integrated metabolomic and transcriptomic analysis revealed the flavonoid biosynthesis and regulation in Areca catechu.

Yu D et al (2023).
Phytochem Anal.
DOI:
10.1002/pca.3216
PubMed:
36813748

Bio-inspired sustainable synthesis of novel SnS(2)/biochar nanocomposite for adsorption coupled photodegradation of amoxicillin and congo red: Effects of reaction parameters, and water matrices.

Gadore V, Mishra SR and Ahmaruzzaman M (2023).
J Environ Manage.
DOI:
10.1016/j.jenvman.2023.117496
PubMed:
36801688

Direct leaf-peeling method for areca protoplasts: a simple and efficient system for protoplast isolation and transformation in areca palm (Areca catechu).

Wang Y et al (2023).
BMC Plant Biol.
DOI:
10.1186/s12870-023-04048-7
PubMed:
36698067

Rapidly analyzing of ingredients during chewing and processing of areca nut using feature-based molecular networking.

Li M et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2022.135205
PubMed:
36638630

Antioxidant and Anti-Skin Aging Potential of Selected Thai Plants: In Vitro Evaluation and In Silico Target Prediction.

Chaikhong K et al (2022).
Plants (Basel).
DOI:
10.3390/plants12010065
PubMed:
36616194

Genome-Wide Identification of PIN and PILS Gene Families in Areca catechu and the Potential Role of AcPIN6 in Lateral Brace Root Formation.

Genetics
Wang Y et al (2022).
Plants (Basel).
DOI:
10.3390/plants12010033
PubMed:
36616161

The genome of Areca catechu provides insights into sex determination of monoecious plants.

Genetics
Zhou G et al (2022).
New Phytol.
DOI:
10.1111/nph.18471
PubMed:
36089819

Areca catechu L. and Anredera cordifolia (Ten) Steenis supplementation reduces faecal parasites and improves caecal histopathology in laying hens.

Murwani R, Kusumanti E and Naumova EN (2022).
Int J Vet Sci Med.
DOI:
10.1080/23144599.2022.2090732
PubMed:
35874604

Identifying new compounds with potential pharmaceutical and physiological activity in Areca catechu and Areca triandra via a non-targeted metabolomic approach.

Wu J et al (2021).
Phytochem Anal.
DOI:
10.1002/pca.3039
PubMed:
33619832

Is it safe to consume traditional medicinal plants during pregnancy?

Review
Bernstein N et al (2021).
Phytother Res.
DOI:
10.1002/ptr.6935
PubMed:
33164294

Pharmacology of Herbal Sexual Enhancers: A Review of Psychiatric and Neurological Adverse Effects.

Review
Brunetti P et al (2020).
Pharmaceuticals (Basel).
DOI:
10.3390/ph13100309
PubMed:
33066617

Areca catechu-From farm to food and biomedical applications.

Review
Salehi B et al (2020).
Phytother Res.
DOI:
10.1002/ptr.6665
PubMed:
32159263

Areca catechu (palm tree) nut chewing and seizures: An observational study.

Summary

Researchers conducted a study to examine the effects of chronic abuse of Areca catechu nut (doma, quid, paan) on people with epilepsy. The nut is the fourth most commonly abused psychoactive substance in the world. Results showed a significant increase in seizure frequency among those who abused the nut compared to those who did not. The study highlights the harmful effects of this popular substance and reinforces the importance of prevention and education efforts.

Neuroscience
Mateen FJ et al (2017).
Epilepsy Behav.
DOI:
10.1016/j.yebeh.2017.06.028
PubMed:
28732258

Herb-drug interactions.

Review
Fugh-Berman A et al (2000).
Lancet.
PubMed:
10675182