Common Names: sweet sagewort
PLWH in Uganda often use Artemisia annua and Moringa oleifera alongside ART. Study explores effects on CD4 count, viral load, and ARV interactions for better treatment decisions.
Artemisinin from Chinese herb used for malaria treatment; also shows promise for cancer treatment. Review discusses potential anticancer effects, mechanisms, and clinical trials, aiding future research.
Artemisinin shows potential for anti-diabetic and antioxidant effects by targeting the PI3K/AKT pathway. It inhibits enzymes related to hyperglycaemia and exhibits antioxidant properties without toxicity in zebrafish models. This suggests a promising therapy for diabetes and oxidative stress.
LIN and ATT, compounds from lotus and Artemisia, synergistically inhibit breast cancer cell growth and invasion by enhancing apoptosis and suppressing PI3K-AKT signaling. Promising potential for BC therapy.
Researchers found artesunate, a drug for severe malaria, enhances cell death in ovarian cancer when combined with navitoclax. This combo shows promising antineoplastic effects in both cell and animal models, hinting at a potential new treatment option for ovarian cancer.
Study explored how medicinal plant extract affects PI3K/Akt signaling in liver of diabetic mice. Understanding these mechanisms may improve diabetes treatment using natural remedies.
Research identified compounds in a Chinese medicine, L., with potential anticancer properties. Quercetin, a compound in L., inhibited endometrial cancer cell growth and migration by suppressing PTGS2 expression.
Polyphenols extracted from Korean L. enhance the anticancer effect of DTX in HCT116 cells by regulating p53 and other signaling pathways, leading to increased apoptotic cell death. This could improve DTX-containing chemotherapy for cancers with wild-type p53.
Researchers examined artemisinin derivatives as a potential anti-cancer treatment. These compounds induce cell death through ferroptosis by increasing iron levels and lipid peroxide accumulation. This study supports future clinical applications of these compounds in cancer treatment.
Artemisinin, an active compound from a Chinese herb, inhibits colorectal cancer cell growth by targeting microsomal prostaglandins synthase-2, reducing prostaglandin E biosynthesis. This discovery could lead to new treatments for colon cancer.
Combining polyphenols extracted from Korean L. with β-lapachone enhances its anticancer effect on colorectal cancer cells, particularly those resistant to oxaliplatin. This combination inhibits proteins associated with resistance and promotes DNA damage, making it a potential low-toxicity therapy for oxaliplatin-resistant cancer.
Scientists analyzed the AP2/ERF gene family in Zanthoxylum armatum leaves. Four genes were identified as potentially involved in terpenoid biosynthesis. Methyl jasmonate treatment led to increased terpenoid content. This research provides insights for understanding and manipulating terpenoid production in Z. armatum.
Essential oil from wild Artemisia from China was analyzed. It shows good antibacterial and antifungal activities against specific pathogens. This oil has potential applications in pharmaceutical and cosmetic industries.
Study aimed to investigate the gene structure, evolutionary history, and expression profile of the UVR8 or RCC1 genes in Artemisia annua, the major source of artemisinin. Understanding this could help optimize artemisinin production and light conditions for the plant.
This study used network pharmacology, molecular docking, and in vivo experiments to investigate the potential of Artemisia annua in treating acute myocardial infarction. It identified key targets and pathways and demonstrated the extract's positive effects on ventricular function and reducing fibrosis.
Scientists investigated the anticancer effects of rhein, a natural agent, in liver cancer. They identified its molecular targets and examined whether it can work with artemisinin derivatives to inhibit the disease. This research may lead to improved therapies for liver cancer.
The study found that extracts from Artemisia annua (sweet wormwood) have virucidal, antiviral, and antioxidant effects against COVID-19. Specific compounds from the plant show potential in inhibiting viral replication. Therefore, A. annua could be useful in fighting SARS-CoV-2 variants and future coronaviruses.
Artemisia annua extracts improved liver function and reduced oxidative stress in diabetic mice, showing comparable or greater antioxidant activity than metformin.
A study found that ethanol extracts from different species of L. contained monoterpenes and flavonoids. Cv. Smaragd killed Gram-positive bacteria, Cv. Tavrida targeted Gram-negative bacteria and fungi, and Cv. Novichok affected nicotine receptors.
Researchers manually corrected the genome annotation of Artemisia annua using transcriptome data. Incorrect gene information can affect structural, functional, and expression levels, as well as alternative splicing and gene function. Accurate annotation is crucial for future research on A. annua.
This study investigated the effects of different doses of L. water extract on broiler growth and intestinal indicators. AAWE improved growth performance and intestinal health in broilers. Care because it could be a potential feed additive.
A. annua, a Chinese medicinal herb, has shown promise in inhibiting the growth of cancer cells. This may lead to the development of alternative and perhaps more effective treatments for cancer.
This study investigates the role of chromatin structure in the production of artemisinin in Artemisia annua. Changes in chromatin organization were found to affect gene expression levels, leading to differences in artemisinin content. Understanding chromatin structure could provide insights into the mechanisms of artemisinin synthesis.
Scientists tested the effectiveness of Artemisia annua essential oil (EO) against rice weevils. Encapsulating the EO in chitosan/TPP or zeolite increased toxicity and fumigant persistence, making it an environmentally friendly solution for controlling the pests in storage.
Researchers used network pharmacology to investigate the effects of Qinghao Biejia decoction (QBD) against lung cancer and examined the anticancer impact of artemisinin B on H1299 cells. The study sheds light on the potential use of QBD and artemisinin B in treating non-small-cell lung cancer.
Researchers investigated the potential of the drug artesunate in treating intestinal mucositis, a common side effect of the chemotherapy drug 5-FU in colorectal cancer patients. Artesunate has shown effectiveness against various health conditions. This study aimed to find new treatments for 5-FU side effects.
In this study, scientists isolated a derivative of arteannuin B from a plant extract. This derivative inhibited the activity of the SARS-CoV-2 virus and a cancer enzyme. Understanding these activities can help develop treatments for malaria, COVID-19, and cancer.
Artesunate, extracted from Artemisia annua, reduces intestinal ischemia/reperfusion (II/R) induced lung injury in mice by targeting oxidative stress, inflammation, and apoptosis via AKT and HO-1 activation. Potential therapeutic candidate for II/R induced acute lung injury.
Researchers developed ZIF-DHA nanoparticles to enhance the anticancer properties of dihydroartemisinin (DHA) by improving its delivery to ovarian cancer cells and reducing cellular reactive oxygen species. The study suggests that ZIF-DHA nanoparticles could be a promising treatment for ovarian cancer. (40 words)
Artemisia annua, a medicinal plant used in Egyptian medicine, shows potential in improving testicular function, although the exact mechanism is still under investigation.
Oxidative stress plays a key role in Alzheimer's disease (AD), leading to cognitive dysfunction. A water-soluble extract of a traditional Chinese herbal medicine has been found to have strong anti-oxidant function and improves cognitive function in 3xTg AD mice. Using network pharmacology and experimental approaches, key genes and signaling pathways associated with oxidative stress were identified. The extract was found to have anti-oxidant/neuronal survival action against HO-induced damage, thus preventing cognitive decline and pathological changes in 3xTg mice. The findings suggest the potential of the extract as a therapy for AD.
Artemisia annua L. has a long history of treating fever caused by infectious diseases. It is commonly used as a tea infusion to combat viruses.
Artemisia annua Linné (AA) has antioxidant properties, but little is known about its effects on cognitive impairment. Researchers analyzed its potential in treating vascular dementia (VaD), the second most common type of dementia. There are currently no FDA-approved drugs for VaD. The findings show that AA may improve cognitive dysfunction by reducing oxidative stress and inflammation in the brain. Further studies are needed to explore the therapeutic potential of AA for VaD.
Studies suggest that compounds from Artemisia annua, a plant historically used to treat malaria, rheumatoid arthritis, and other illnesses, could have anti-severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) properties. In a search for peer-reviewed articles, 19 studies were examined and found that artemisinins demonstrated inhibitory properties against coronavirus-host proteins. The combination of A. annua's biological properties, action on different signaling pathways, and a multi-drug combined-therapy approach may help inhibit SARS-CoV-2 and assist in the treatment of coronavirus disease 2019 (COVID-19).