The researchers investigated the relationship between the immune memory of macrophages and histone modifications. They found that the polysaccharide of Asparagus cochinchinensis enhances macrophages' immune function, but it is unclear if this is linked to immune memory and histone modification.
Smilagenin, found in Chinese medicinal herbs, increases BDNF expression in brain cells, which is important for their growth and survival.
Researchers found three new compounds, aspacochinosides N (1), O (2), and P (3), and four known compounds in the roots of Asparagus cochinchinensis. They conducted experiments to evaluate their anti-inflammatory properties and found that compounds 2, 3, and 4 showed significant inhibition on NO production in LPS-induced BV-2 microglial cells. These results suggest that these compounds may have therapeutic potential for treating neuroinflammatory diseases.