Atalantia monophylla

Ethnobotanical Studies

Studies

Multi-Target Actions of Acridones from Atalantia monophylla towards Alzheimer's Pathogenesis and Their Pharmacokinetic Properties.

Summary

Ten compounds from were tested for their effectiveness in treating Alzheimer's disease. They were found to have strong antioxidant effects, inhibit the activity of acetylcholinesterase (AChE), prevent the aggregation of beta-amyloid (Aβ), and protect neurons. The researchers used computer modeling to predict the compounds' drug properties, and found that they were all favorable. The compounds work by inhibiting AChE activity and binding to specific regions of Aβ. One compound, citrusinine II, showed the best results in vitro and may provide protection against neuronal damage caused by Aβ toxicity and hydrogen peroxide.

Neuroscience
Takomthong P et al (2021).
Pharmaceuticals (Basel).
DOI:
10.3390/ph14090888
PubMed:
34577588

Atalantiaphyllines A-G, prenylated acridones from Atalantia monophylla DC. and their aromatase inhibition and cytotoxic activities.

Pailee P et al (2020).
Phytochemistry.
DOI:
10.1016/j.phytochem.2020.112525
PubMed:
33010534

New limonophyllines A-C from the stem of Atalantia monophylla and cytotoxicity against cholangiocarcinoma and HepG2 cell lines.

Sombatsri A et al (2018).
Arch Pharm Res.
DOI:
10.1007/s12272-018-1021-7
PubMed:
29546611

Green synthesis of silver nano particles from Atalantia monophylla (L) Correa leaf extract, their antimicrobial activity and sensing capability of H(2)O(2).

Antimicrobial
Mahadevan S, Vijayakumar S and Arulmozhi P (2017).
Microb Pathog.
DOI:
10.1016/j.micpath.2017.11.029
PubMed:
29170043

Ovicidal activity of Atalantia monophylla (L) Correa against Spodoptera litura Fab. (Lepidoptera: Noctuidae).

Baskar K et al (2012).
Asian Pac J Trop Biomed.
DOI:
10.1016/S2221-1691(13)60011-8
PubMed:
23593580