Atractylodes macrocephala

Ethnobotanical Studies

Studies

Polysaccharide of Atractylodes macrocephala Koidz alleviates NAFLD-induced hepatic inflammation in mice by modulating the TLR4/MyD88/NF-κB pathway.

Immunology
Chen J et al (2024).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2024.113014
PubMed:
39191120

Lingguizhugan decoction ameliorates cognitive impairment in AD-like mice by influencing the microbiome-gut-brain axis mediated by SCFAs.

Summary

Researchers studied Lingguizhugan decoction, a traditional Chinese herbal remedy, for its potential in treating Alzheimer's disease by influencing the gut-brain axis through gut microbiota modulation. This ancient remedy may offer novel therapeutic possibilities for AD.

GastroenterologyNeuroscience
Du L et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155942
PubMed:
39173279

Analyzing the defense response mechanism of Atractylodes macrocephala to Fusarium oxysporum through small RNA and degradome sequencing.

Genetics
Fan S et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2024.1415209
PubMed:
39104842

Polysaccharide extracted from Atractylodes macrocephala improves the spleen deficiency constipation in mice by regulating the gut microbiota to affect the 5-HT synthesis.

Summary

Researchers investigated the bioactive compounds in Atractylodes macrocephala to understand its medicinal benefits for gastrointestinal issues. Identifying these compounds may lead to improved treatment options for digestive disorders.

GastroenterologyNeuroscience
Chen L et al (2024).
Neurogastroenterol Motil.
DOI:
10.1111/nmo.14875
PubMed:
39077771

Traditional Chinese medicine combined with chemotherapy in the treatment of advanced non-small cell lung cancer: key drug screening and mechanism analysis.

Summary

Chinese medicine, when combined with other treatments, is effective in treating non-small cell lung cancer by reducing toxicity and increasing efficiency. Key components include Astragalus membranaceus, Wolfiporia cocos, and Atractylodes macrocephala, with potential therapeutic effects through AKT1 and EGFR targets.

Cancer
Tang Y et al (2024).
Naunyn Schmiedebergs Arch Pharmacol.
DOI:
10.1007/s00210-024-03310-5
PubMed:
39073415

Network pharmacology- and molecular docking-based exploration of the molecular mechanism underlying Jianpi Yiwei Recipe treatment of gastric cancer.

Summary

TCM is important in cancer treatment. Network pharmacology helps study interactions of TCM components, useful for understanding multi-pathway and multi-target effects.

CancerGastroenterology
Chen P and Wu HY (2024).
World J Gastrointest Oncol.
DOI:
10.4251/wjgo.v16.i7.2988
PubMed:
39072163

Atramacronoid A induces the PANoptosis-like cell death of human breast cancer cells through the CASP-3/PARP-GSDMD-MLKL pathways.

Summary

AM-A from Koidz induces unique cell death in breast cancer cells through specific pathways, showing potential as a lead compound for therapeutic development.

Cancer
Li JR et al (2024).
J Asian Nat Prod Res.
DOI:
10.1080/10286020.2024.2368841
PubMed:
38958645

Atractylenolide II combined with Interferon-γ synergistically ameliorates colorectal cancer progression in vivo and in vitro by blocking the NF-kB p65/PD-L1 pathway.

Summary

Koidz herbal medicine combined with IFN-γ inhibits CRC progression by regulating NF-kB p65/PD-L1 pathway. Effective against CRC cells and xenograft tumors in mice, shows potential for tumor immunotherapy.

CancerGastroenterology
Wu Y et al (2024).
J Cancer.
DOI:
10.7150/jca.96647
PubMed:
38947390

Rapid Mold Detection in Chinese Herbal Medicine Using Enhanced Deep Learning Technology.

Zhu T et al (2024).
J Med Food.
DOI:
10.1089/jmf.2024.k.0004
PubMed:
38919153

Integrating Network Pharmacology and Experimental Validation to Decipher the Mechanism of Action of Astragalus-Atractylodes Herb Pair in Treating Hepatocellular Carcinoma.

Liang Y et al (2024).
Drug Des Devel Ther.
DOI:
10.2147/DDDT.S459593
PubMed:
38882048

Transcriptome Analysis Reveals the Biocontrol Mechanism of Endophytic Bacterium AM201, Rhodococcus sp., against Root Rot Disease of Atractylodes macrocephala.

Genetics
Gao X et al (2024).
Curr Microbiol.
DOI:
10.1007/s00284-024-03742-5
PubMed:
38856763

Pharmacokinetic study and neuropharmacological effects of Atractylenolide Ⅲ to improve cognitive impairment via PI3K/AKT/GSK3β pathway in intracerebroventricular-streptozotocin rats.

Summary

Researchers studied the effects of ATL III, a compound in Chinese herb Atractylodes macrocephala Koidz, on neuroinflammation and oxidative stress in relation to Alzheimer's disease. Results suggest potential therapeutic benefits.

Neuroscience
Liu G et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118420
PubMed:
38838925

Study on regulating AQP1, AQP3, AQP4, 5-HT, NOS1 in slow transit constipation rats by Liqi Tongbian mixture.

Summary

Tongbian TCM helps with constipation by regulating water transfer in the colon through AQP3. Contains unique herbs like Atractylodes macrocephala and Astragalus membranaceus. Important for treating slow transit constipation.

Neuroscience
Liu M et al (2024).
Adv Clin Exp Med.
DOI:
10.17219/acem/175808
PubMed:
38819938

Prescription Data Mining and Network Pharmacology Study of 1152 Patients with Rectal Prolapse Using Traditional Chinese Medicine.

Zhang M et al (2024).
Curr Comput Aided Drug Des.
DOI:
10.2174/0115734099288156240517114206
PubMed:
38798220

*The traditional Chinese medicine processing change chemical composition and pharmacological effectiveness: Taking Atractylodes macrocephala Koidz. and honey bran-fried Atractylodes macrocephala Koidz. as examples.

Review
Hao Y et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155739
PubMed:
38797027

Atramacrolodes A-D (1-4), Four Undescribed Eudesmane-Type Sesquiterpenes from the Rhizome of Atractylodes macrocephala.

Li B et al (2024).
Chem Biodivers.
DOI:
10.1002/cbdv.202400817
PubMed:
38775105

Clinical remission of moderate generalized myasthenia gravis through exclusive use of Buzhong Yiqi decoction: A case report.

Qiu H et al (2024).
Explore (NY).
DOI:
10.1016/j.explore.2024.05.004
PubMed:
38744568

Atractylenolide-I Alleviates Hyperglycemia-Induced Heart Developmental Malformations through Direct and Indirect Modulation of the STAT3 Pathway.

Summary

Atractylenolide-I from Baizhu herb may prevent congenital heart defects in infants of mothers with gestational diabetes. Potential for new preventive and therapeutic treatments.

CardiologyDiabetesImmunology
Wang M et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155698
PubMed:
38728919

Rhizoma Alismatis Decoction improved mitochondrial dysfunction to alleviate SASP by enhancing autophagy flux and apoptosis in hyperlipidemia acute pancreatitis.

Zhang R et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155629
PubMed:
38677271

The effects of Atractylodes macrocephala extract BZEP self-microemulsion based on gut-liver axis HDL/LPS signaling pathway to ameliorate metabolic dysfunction-associated fatty liver disease in rats.

Gastroenterology
Li B et al (2024).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2024.116519
PubMed:
38663104

Cycasin derivative: a potential embryotoxic component of Atractylodes macrocephala rhizome for limb malformation.

Xie H et al (2024).
Toxicol Res (Camb).
DOI:
10.1093/toxres/tfae057
PubMed:
38623091

The anti-hyperlipidemia effect of Atractylodes macrocephala Rhizome increased HDL via reverse cholesterol transfer.

Li B et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e28019
PubMed:
38560167

Effects of Designed Herbal Formula on Growth Performance, Blood Indices, Organ Traits, and Cecum Microbiology in Broilers.

Sun Y et al (2024).
Vet Sci.
DOI:
10.3390/vetsci11030107
PubMed:
38535841

Polysaccharide of Atractylodes macrocephala Koidz alleviates LPS-induced proliferation, differentiation inhibition and excessive apoptosis in chicken embryonic myogenic cells.

Fu M et al (2024).
Vet Med Sci.
DOI:
10.1002/vms3.1412
PubMed:
38504633

Atractylenolide II Suppresses Glycolysis and Induces Apoptosis by Blocking the PADI3-ERK Signaling Pathway in Endometrial Cancer Cells.

Summary

Atractylenolide II (AT-II) inhibits endometrial cancer cell growth and glycolysis, induces apoptosis by blocking PADI3-ERK pathway. AT-II may be a potential novel therapy for endometrial cancer.

Cancer
Tian S et al (2024).
Molecules.
DOI:
10.3390/molecules29050939
PubMed:
38474453

The rhizomes of Atractylodes macrocephala Koidz improve gastrointestinal health and pregnancy outcomes in pregnant mice via modulating intestinal barrier and water-fluid metabolism.

Gastroenterology
Chenxing W et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117971
PubMed:
38403003

Polysaccharide from Atractylodes macrocephala Koidz Binding with Zinc Oxide Nanoparticles as a Novel Mucosal Immune Adjuvant for H9N2 Inactivated Vaccine.

Liu X et al (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25042132
PubMed:
38396809

Atractylodes macrocephala III suppresses EMT in cervical cancer by regulating IGF2BP3 through ETV5.

Summary

ATL III, a compound in Atractylodes macrocephala, inhibits migration and invasion of cervical cancer cells by regulating IGF2BP3 through ETV5. This has potential implications for cervical cancer treatment.

Cancer
Wang M et al (2024).
J Cell Mol Med.
DOI:
10.1111/jcmm.18081
PubMed:
38358034

Mucosal immune responses and protective efficacy elicited by oral administration AMP-ZnONPs-adjuvanted inactivated H9N2 virus in chickens.

Liu X et al (2024).
Poult Sci.
DOI:
10.1016/j.psj.2024.103496
PubMed:
38330890

Efficacy and safety of traditional plant-based medicines for preventing chronic oxaliplatin-induced peripheral neurotoxicity in patients with colorectal cancer: A systematic review and meta-analysis with core herb contribution.

Summary

Researchers studied the use of traditional plant-based medicines to prevent nerve damage caused by chemotherapy. Results are unclear due to different medicine combinations and lack of understanding of their mechanisms.

Review CancerGastroenterologyNeuroscience
Han J et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117735
PubMed:
38211824

Atractylodes macrocephala-Paeonia lactiflora Class Formula for the Treatment of Irritable Bowel Syndrome: A Systematic Review With Meta-Analysis and Trial Sequential Analysis.

Review
Bai W et al (2023).
Cureus.
DOI:
10.7759/cureus.49997
PubMed:
38186470

Combination of Atractylenolide I, Atractylenolide III, and Paeoniflorin promotes angiogenesis and improves neurological recovery in a mouse model of ischemic Stroke.

Summary

Study investigated the effects of Atractylenolide I, Atractylenolide III, and Paeoniflorin on promoting angiogenesis after stroke. Findings could contribute to potential therapies for improving outcomes in stroke patients.

CardiologyNeuroscience
Li H et al (2024).
Chin Med.
DOI:
10.1186/s13020-023-00872-z
PubMed:
38178130

The surface morphology of Atractylodes macrocephala polysaccharide and its inhibitory effect on PCV2 replication.

Qi C et al (2023).
J Sci Food Agric.
DOI:
10.1002/jsfa.13246
PubMed:
38148571

The rhizomes of Atractylodes macrocephala relieve loperamide-induced constipation in rats by regulation of tryptophan metabolism.

Qin LL et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117637
PubMed:
38135226

The Mechanism of Core Chinese Medicine Combination in Treating Salivation.

Wang Y and Zhang Y (2023).
Stud Health Technol Inform.
DOI:
10.3233/SHTI230899
PubMed:
38007798

Simultaneous Analysis of Hydrophobic Atractylenolides, Atractylon and Hydrophilic Sugars in Bai-Zhu Using a High-Performance Liquid Chromatography Column Tandem Technique.

Phytochemistry
Gu Z et al (2023).
Foods.
DOI:
10.3390/foods12213931
PubMed:
37959050

The compatibility rationality of Sijunzi decoction based on integrated analysis of tissue distribution and excretion characteristics in spleen deficiency syndrome rats.

Dong B et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117376
PubMed:
37918551

Effects of Yu-Ping-Feng polysaccharides on animal growth performance and immune function: a review.

Review
Chu H et al (2023).
Front Vet Sci.
DOI:
10.3389/fvets.2023.1260208
PubMed:
37799408

Atractylodes macrocephala Koidz polysaccharide improves glycolipid metabolism disorders through activation of aryl hydrocarbon receptor by gut flora-produced tryptophan metabolites.

Gastroenterology
He Z et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.126987
PubMed:
37729987

Novel Psychopharmacological Herbs Relieve Behavioral Abnormalities and Hippocampal Dysfunctions in an Animal Model of Post-Traumatic Stress Disorder.

Park HR, Cai M and Yang EJ (2023).
Nutrients.
DOI:
10.3390/nu15173815
PubMed:
37686847

Tong-Xie-Yao-Fang promotes dendritic cells maturation and retards tumor growth in colorectal cancer mice with chronic restraint stress.

Summary

Researchers investigated the effect of Tong-Xie-Yao-Fang (TXYF), a traditional Chinese medicine formula, on colorectal cancer (CRC) accompanied by psychological stress. TXYF improved depression and reduced intestinal symptoms, suggesting its potential as an intervention for CRC patients with psychological stress.

CancerGastroenterology
Jiang Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117069
PubMed:
37619860

Effects of Traditional Chinese Herbal Feed Additive on Production Performance, Egg Quality, Antioxidant Capacity, Immunity and Intestinal Health of Laying Hens.

Summary

A Chinese herbal feed additive (TCM) improved egg production, quality, antioxidant capacity, immunity, and intestinal health in Roman laying hens compared to control and antibiotic groups.

GastroenterologyImmunology
Liu B et al (2023).
Animals (Basel).
DOI:
10.3390/ani13152510
PubMed:
37570319

An UPLC-MS/MS method for targeted analysis of microbial and host tryptophan metabolism after administration of polysaccharides from Atractylodes macrocephala Koidz. in ulcerative colitis mice.

Gastroenterology
Hu P et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115585
PubMed:
37523866

Ling-Gui-Qi-Hua formula alleviates left ventricular myocardial fibrosis in rats with heart failure with preserved ejection fraction by blocking the transforming growth factor-β1 /Smads signaling pathway.

Summary

The researchers studied the LGQH decoction, a traditional Chinese medicine formula, and found it has cardioprotective effects on heart failure. The active ingredients and anti-fibrotic mechanism are still unknown.

Cardiology
Shi Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116849
PubMed:
37385575

Potential application of Atractylodes macrocephala Koidz. as a natural drug for bone mass regulation: A review.

Review
Yu Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116718
PubMed:
37268258

Atractylenolide I ameliorates cancer cachexia through inhibiting biogenesis of IL-6 and tumour-derived extracellular vesicles.

CancerImmunology
Fan M et al (2022).
J Cachexia Sarcopenia Muscle.
DOI:
10.1002/jcsm.13079
PubMed:
36085573

Isolation, structure and bioactivity of polysaccharides from Atractylodes macrocephala: A review.

Review
Li X et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115506
PubMed:
35760256

Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial/macrophage polarization.

Immunology
Xue MT et al (2022).
CNS Neurosci Ther.
DOI:
10.1111/cns.13839
PubMed:
35403332

A Review of the Ethnopharmacology, Phytochemistry, Pharmacology, Application, Quality Control, Processing, Toxicology, and Pharmacokinetics of the Dried Rhizome of Atractylodes macrocephala.

Review Phytochemistry
Yang L et al (2021).
Front Pharmacol.
DOI:
10.3389/fphar.2021.727154
PubMed:
34803677

Atractylenolides (I, II, and III): a review of their pharmacology and pharmacokinetics.

Review
Deng M et al (2021).
Arch Pharm Res.
DOI:
10.1007/s12272-021-01342-6
PubMed:
34269984

Network Pharmacology-Based Strategy to Investigate the Pharmacologic Mechanisms of Atractylodes macrocephala Koidz. for the Treatment of Chronic Gastritis.

Yang S et al (2020).
Front Pharmacol.
DOI:
10.3389/fphar.2019.01629
PubMed:
32063848