Common Names: neem
TL;DR: Folklore plants like Azadirachta indica, Calendula officinalis, and Piper retrofractum have compounds that can combat Chikungunya Virus by inhibiting viral replication. Potential for new treatments.
Plant nanoemulsions from Durban Botanical Gardens were tested for antimicrobial properties against antibiotic-resistant gonorrhoea strains. Results show potential as a safer alternative treatment option.
Researchers identified natural products, such as salvinorin A and deacetylgedunin, as potential anti-SARS-CoV-2 agents using computational methods. These compounds show promise in inhibiting viral replication and cell entry, providing a potential supplement to vaccination efforts against COVID-19.
Researchers are looking into the use of the phytochemical nimbolide (found in Azadirachta indica) as a potential treatment for pancreatic cancer. Nimbolide has shown promising anticancer properties in preclinical studies, but further research is needed to determine its safety and effectiveness in human trials.
Researchers identified Cannabis sativa L. as a potent inhibitor of MRSA, with cannabidiol and Δ9-THC showing bactericidal action. This plant-based alternative may help combat antimicrobial resistance in bovine biofilm-associated MRSA infections.
Researchers studied medicinal plants used by indigenous communities in Bangladesh for helminth infections. Discovering phytochemicals with anthelmintic activity could lead to new drugs to combat drug-resistant helminthiases in underdeveloped regions.
Researchers identified potential anti-FtsZ compound Nimbiol from against drug-resistant pathogen . Nimbiol shows promise for developing novel therapeutics to combat antibiotic resistance.
Tosser scientists made silver nanoparticles with neem leaf extract, showing potent antifungal and anticancer properties. Useful in crop protection and cancer research. Pioneering inhibition of C. falcatum.
Two herbal-alcohol-based hand sanitizers, containing Zingiber officinale and Ocimum sanctum, were found to be more effective than alcohol-based sanitizers in reducing microbial load, inhibiting influenza A virus, and causing less irritation to the skin. HS2 was particularly effective against viruses and the sanitizers have a longer shelf life.
Scientists studied the use of environmentally-friendly nanoparticles as a potential therapy for diabetes. This could provide a cost-effective and sustainable treatment option for a global, life-threatening syndrome.
This research examined the anthelmintic properties of tropical plant extracts compared to praziquantel. Alligator pepper and neem extracts were most potent, and Aframomum melegueta and praziquantel were effective against all parasite classes with a wide safety margin for the fish host.
The compound azadiradione found in Neem seeds has shown potential in improving synaptic function by increasing expression of Ube3a, parvalbumin, and BDNF. This suggests a possible role in treating neuropsychiatric/neurodegenerative disorders.
Nimbolide, a compound from , kills harmful bacteria, fungi, and insects. It works by binding to specific proteins, making it a potential ingredient for biological pesticides.
This study developed eco-friendly food packaging films using O-CMC, pectin, and neem leaves. Neem improved tensile strength, exhibited antimicrobial activity, had low opacity, and showed complete biodegradability in 75 days. The films are potentially suitable for food packaging.
Plants and fungi have historically been used for treating infections, including viruses. Some of these natural products have shown promise in fighting SARS-CoV-2 and related conditions, when approved therapeutics are limited.
The researchers studied a compound called EAD from seed and found that it effectively suppressed the growth of neuroblastoma, a childhood tumor. EAD inhibited certain proteins (Enolase1 and HSP90) involved in neuroblastoma development, suggesting it could be a potential treatment.
They studied the use of medicinal plants for treating malaria in a region of Uganda where medical facilities are limited. Understanding local knowledge can help improve malaria management in the area.
Saudi scientists identify potential anti-epileptic compounds from local flora using network pharmacology and bioinformatics, supported by molecular docking experiments. This research informs future development of epilepsy treatments.
Neem tree extracts contain limonoids with potent medicinal properties. These compounds have been found to display anticancer effects by preventing cancer cell growth, inflammation, invasion, and drug resistance. Neem limonoids offer potential as natural compounds for cancer prevention and therapy.
This study examined air pollution in Bhubaneswar during COVID-19 lockdown. Traffic restrictions improved air quality and certain plant species were found to be sensitive to pollution.
A study investigates the potential protective effects of a neem-derived compound, DEA, against the harmful effects of BPA exposure. DEA reduced cell damage in N9 cells and improved antioxidant production in zebrafish larvae, suggesting its ability to mitigate oxidative stress and inflammation caused by BPA.
This abstract discusses the medicinal properties of Azadirachta indica A. Juss., a widely recognized plant used for treating various ailments across the world. The extracts of this plant have shown promising bioactivity in in vitro and in vivo experiments. Specifically, this research focuses on understanding and establishing the mode of action of the plant's anticancer components, given the significant impact of lung cancer as the leading cause of cancer-related deaths. The study aims to uncover the specific mechanisms through which this plant can potentially combat this deadly form of cancer.
The brain of neurodegenerative disease (ND) patients had increased levels of glutamate, causing damage to mitochondria and leading to neurotoxicity. A study investigated the neuroprotective effects of stigmasterol, a natural compound, against glutamate-induced neurotoxicity and found that stigmasterol restored mitochondrial function and reduced neurotoxicity. These findings suggest that stigmasterol may be a potential treatment for ND.
The leaves of Azadirachta indica L. and Melia azedarach L. were analyzed for their medicinal properties. Both extracts were rich in phenolic and flavonoid compounds. In vitro testing showed they had strong anti-SARS-CoV-2 activities with low IC50 values of 8.451 and 6.922 μg/mL, respectively. Both extracts also had significant antibacterial activities against both Gram-negative and positive bacterial strains. The extracts were safe with high CC50 values of 446.2 and 351.4 μg/ml, respectively, and high selectivity indices. Further in vivo investigation is needed to confirm their potential as a treatment for COVID-19 and antimicrobial purposes.
Researchers have observed a worldwide increase in the use of natural remedies, including Chinese herbal medicine and local plants, in response to COVID-19. This alternative approach to traditional medicine aims to strengthen immunity and prevent the spread of the disease. While the broader implications of these remedies and their effectiveness in treating COVID-19 remain unclear, these findings suggest the need for further exploration of alternative therapeutic solutions.
The search for alternatives to amyloid-β (Aβ) drugs for Alzheimer's disease (AD) has led to the NLRP3 inflammasome as a potential target. This inflammasome is involved in innate immunity and neuroinflammation, contributing to AD pathophysiology. Targeting the NLRP3 inflammasome may offer a new avenue for AD therapy.
The COVID-19 virus, caused by the coronavirus SARS-CoV-2, has become a global pandemic with new strains emerging rapidly. While vaccine candidates are being rapidly developed, medicinal plant extracts show potential for developing effective antiviral nanoparticles. This systematic review focuses on the neem plant as a suitable candidate for biosynthesis of anti-SARS-CoV-2 nanoparticles. 98 studies were screened and discussed the biomedical and antiviral properties of neem extracts that could be important in the design of potential anti-SARS-CoV-2 nanoformulations.
COVID-19 can cause multiple organ distress syndrome (MODS) and has high mortality rates in severe cases, especially in those with comorbidities like cardiovascular disease and diabetes. The involvement of the vascular endothelium (VE) is a plausible explanation for MODS, as the VE connects all target organs and systems. This study hypothesizes that the acetone-water extract of Neem plant leaves, which has been shown to prevent the binding of other pathogens to the VE, could prevent SARS-CoV-2 binding and therefore be an effective treatment for COVID-19. The extract is readily available, simple to prepare, and non-toxic, making it a promising therapeutic option. Clinical trials are needed to investigate its efficacy further.