Bauhinia championii

Ethnobotanical Studies

Studies

Bauhinia championii alleviates extracellular matrix degradation in IL-1β induced chondrocytes via miRNA-145-5p/TLR4/NF-κB axis.

Summary

The study investigated the effects of a herbal medicine, BCAE, on chondrocytes in osteoarthritis. BCAE promoted cell viability, reduced extracellular matrix degradation, and inhibited the TLR4/NF-κB signaling pathway, potentially protecting chondrocytes from degeneration.

Immunology
Lin J et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e19138
PubMed:
37664703

The kidney antifibrotic effects of 5,7,3',4',5'-pentamethoxyflavone from Bauhinia championii in streptozotocin-induced diabetic rats: in vivo and in vitro experiments.

Summary

Researchers investigated the antidiabetic effects of a flavonoid called 5,7,3',4',5'-pentamethoxyflavone isolated from Benth. (Fabaceae) and confirmed its potential as a treatment for diabetes.

Diabetes
Li J et al (2023).
Pharm Biol.
DOI:
10.1080/13880209.2023.2222773
PubMed:
37345554

Metabolomics reveals the intervention effect of Zhuang medicine Longzuantongbi granules on a collagen-induced arthritis rat model by using UPLC-MS/MS.

Arthritis
Yao L et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115325
PubMed:
35508204

Extracts of Bauhinia Championii Alleviate Acute Neuronal Injury After Ischemic Reperfusion by Improving Endoplasmic Reticulum Stress-Mediated Neuronal Apoptosis.

Summary

Scientists investigated whether extracts from the Bauhinia championii plant could prevent neuronal injury caused by cerebral ischemia/reperfusion (I/R), which currently lacks effective remedies and can result in lethal injury. BCEs have previously shown anti-oxidative and anti-hypoxia properties. The study's findings suggest that BCE may be a potential treatment for I/R-induced neuronal injury.

CardiologyNeuroscience
Huang M et al (2022).
Curr Med Sci.
DOI:
10.1007/s11596-022-2525-4
PubMed:
35220494

Dihydrokaempferol (DHK) ameliorates severe acute pancreatitis (SAP) via Keap1/Nrf2 pathway.

Liang X et al (2020).
Life Sci.
DOI:
10.1016/j.lfs.2020.118340
PubMed:
32860805

Partitioned Extracts of Bauhinia championii Induce G(0)/G(1) Phase Arrest and Apoptosis in Human Colon Cancer Cells.

Cancer
Chen YF et al (2020).
Am J Chin Med.
DOI:
10.1142/S0192415X20500366
PubMed:
32349516

Screen for Potential Candidate Alternatives of Sargentodoxa cuneata from Its Six Adulterants Based on Their Phenolic Compositions and Antioxidant Activities.

GeneticsPhytochemistry
Yang L et al (2019).
Int J Mol Sci.
DOI:
10.3390/ijms20215427
PubMed:
31683574

Apoptosis Effects of Dihydrokaempferol Isolated from Bauhinia championii on Synoviocytes.

Zhang Y et al (2018).
Evid Based Complement Alternat Med.
DOI:
10.1155/2018/9806160
PubMed:
30622621

A new polyoxygenated abietane diterpenoid from the rattans of Bauhinia championii (Benth.) Benth.

Hua LP et al (2018).
Nat Prod Res.
DOI:
10.1080/14786419.2018.1428594
PubMed:
29350072

Bauhinia championii Flavone Attenuates Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes by Improving Mitochondrial Dysfunction.

Cardiology
Liao P et al (2016).
Molecules.
PubMed:
27827932

Extracts of Bauhinia championii (Benth.) Benth. inhibit NF-<kappa>B-signaling in a rat model of collagen-induced arthritis and primary synovial cells.

Arthritis
Xu W et al (2016).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2016.03.035
PubMed:
26988564

Bauhinia championii flavone inhibits apoptosis and autophagy via the PI3K/Akt pathway in myocardial ischemia/reperfusion injury in rats.

Cardiology
Jian J et al (2015).
Drug Des Devel Ther.
DOI:
10.2147/DDDT.S92549
PubMed:
26604691

Effects of Bauhinia championii (Benth.) Benth. polysaccharides on the proliferation and cell cycle of chondrocytes.

Cai L et al (2013).
Mol Med Rep.
DOI:
10.3892/mmr.2013.1368
PubMed:
23503887