Belamcanda chinensis

Common Names: blackberry lily

Ethnobotanical Studies

Studies

Belamcanda chinensis extract inhibits non-small cell lung cancer proliferation and induces apoptosis via inhibiting the MAPK (Ras/Raf) and Akt pathways.

Summary

BCE from traditional Chinese medicine inhibits NSCLC cell growth by inducing apoptosis and blocking key signaling pathways, suggesting potential as a treatment for NSCLC, particularly in patients with Ras or Raf mutations.

CancerImmunology
Ma C et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e36032
PubMed:
39229537

Irilin D suppresses RANKL-induced osteoclastogenesis and prevents inflammation-induced bone loss by disrupting the NF-κB and MAPK signaling pathways.

Immunology
Gal M et al (2024).
Eur J Pharmacol.
DOI:
10.1016/j.ejphar.2024.176956
PubMed:
39209096

Efficient degradation and enhanced anticomplementary activity of Belamcanda chinensis (L.) DC. polysaccharides via trifluoroacetic acid treatment with different degrees.

Duan Y et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.134117
PubMed:
39084989

Herbal textual research of Belamcanda chinensis (L.) redouté and screening of quality-markers based on 'pharmacodynamics-substance'.

Review
Wang Z et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118324
PubMed:
38754643

An arabinose-rich heteropolysaccharide isolated from Belamcanda chinensis (L.) DC treats liver cancer by targeting FAK and activating CD40.

Summary

BCP80-2 polysaccharide from Belamcanda chinensis inhibits tumor growth, metastasis, and angiogenesis in zebrafish. It suppresses cell migration via FAK pathway and boosts immune response.

Cancer
Zhao Y et al (2024).
Carbohydr Polym.
DOI:
10.1016/j.carbpol.2024.121831
PubMed:
38388048

First report of Phaeosphaeria caricicola causing leaf spot on Belamcanda chinensis in China.

Tang Z et al (2024).
Plant Dis.
DOI:
10.1094/PDIS-06-23-1191-PDN
PubMed:
38197883

Sucrosephenylpropanoid esters and isoflavonoids isolated from Belamcanda chinensis roots and their potential anti-osteoclastogenic activity.

Ha MT et al (2023).
Bioorg Chem.
DOI:
10.1016/j.bioorg.2023.107066
PubMed:
38185009

Exploring Asthma Mechanism of Belamcanda Chinensis by "Dose-effect Weighted Coefficient" Network Pharmacology and Experiment Validation.

Summary

Belamcanda chinensis (BC), a traditional Chinese medicine, has anti-inflammatory and immune regulatory properties that can help counteract asthma, a serious and chronic inflammatory disease of the airways. This research is important for finding potential treatments for asthma.

Asthma
Zhang K et al (2023).
Comb Chem High Throughput Screen.
DOI:
10.2174/0113862073254607231107074015
PubMed:
38155401

Three rare nor-sesquiterpenoids with lipid-lowering activity from Belamcanda chinensis.

Qianshi Y et al (2023).
Org Biomol Chem.
DOI:
10.1039/d3ob01724a
PubMed:
38019684

Preparation and photothermal therapy of gold nanorods modified by Belamcanda chinensis (L.) DC polysaccharide.

Zhao Y et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.127854
PubMed:
37935290

Impact of tectoridin on the pharmacokinetics of florfenicol via targeting cytochrome P450 and P-glycoprotein of rats.

Zhang M et al (2023).
Xenobiotica.
DOI:
10.1080/00498254.2023.2261040
PubMed:
37781957

Study on quality difference between Belamcanda chinensis (L.) DC and Iris tectorum Maxim. based on chemical chromatogram analysis, biological activity evaluation and in vivo distribution rule.

Xiong H et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117091
PubMed:
37634753

Functional characterization and structural basis of a reversible glycosyltransferase involves in plant chemical defence.

Cheng W et al (2023).
Plant Biotechnol J.
DOI:
10.1111/pbi.14157
PubMed:
37581303

Cytotoxic Compounds from Belamcanda chinensis (L.) DC Induced Apoptosis in Triple-Negative Breast Cancer Cells.

Summary

A recent study identified several compounds isolated from a specific plant species. These compounds were tested for their effects on tumor cell growth and metastasis. One compound in particular showed significant activity against two different types of breast cancer cells. Further investigation revealed that this compound caused cell cycle arrest, mitochondrial damage, and cell apoptosis. These findings suggest that this compound could be a potential treatment for triple-negative breast cancer. More research is needed to fully evaluate its effectiveness.

Cancer
Guo YP et al (2023).
Molecules.
DOI:
10.3390/molecules28124715
PubMed:
37375271

Irigenin attenuates lipopolysaccharide-induced acute lung injury by inactivating the mitogen-activated protein kinase (MAPK) signaling pathway.

Liu D et al (2023).
Hum Exp Toxicol.
DOI:
10.1177/09603271231155098
PubMed:
36738242

Medicinal Importance, Pharmacological Activity and Analytical Aspects of Flavonoid 'Irisflorentin' from Belamcanda chinensis (L.) DC.

Patel DK et al (2023).
Curr Drug Res Rev.
DOI:
10.2174/2589977515666230202123308
PubMed:
36733196

[Identification, biological characterization, and fungicide screening of pathogens causing leaf spot of Belamcanda chinensis].

Yang YW et al (2022).
Zhongguo Zhong Yao Za Zhi.
DOI:
10.19540/j.cnki.cjcmm.20220810.102
PubMed:
36471928

Ultrasonic-assisted extraction, fatty acids identification of the seeds oil and isolation of chemical constituent from oil residue of Belamcanda chinensis.

Liu P et al (2022).
Ultrason Sonochem.
DOI:
10.1016/j.ultsonch.2022.106200
PubMed:
36265291

Comparison Analysis Based on Complete Chloroplast Genomes and Insights into Plastid Phylogenomic of Four Iris Species.

Genetics
Feng JL et al (2022).
Biomed Res Int.
DOI:
10.1155/2022/2194021
PubMed:
35937412

Isolation, Characterization and Anticomplementary Activity of Polysaccharides from the Rhizomes of Belamcanda chinensis (L.) DC.

Duan Y et al (2022).
Chem Biodivers.
DOI:
10.1002/cbdv.202200525
PubMed:
35841390

UGT1A1 and UGT1A9 Are Responsible for Phase II Metabolism of Tectorigenin and Irigenin In Vitro.

Li J, Xu Z and Gu J (2022).
Molecules.
DOI:
10.3390/molecules27134104
PubMed:
35807350

Anti-Nociceptive and Anti-Inflammatory Activities of the Ethyl Acetate Extract of Belamcanda chinensis (L.) Redouté in Raw 264.7 Cells in vitro and Mouse Model in vivo.

ImmunologyPain
He X et al (2022).
J Pain Res.
DOI:
10.2147/JPR.S353357
PubMed:
35502404

Dual-Directional Regulation of Belamcanda chinensis Extract on Ovalbumin-Induced Asthma in Guinea Pigs of Different Sexes Based on Serum Metabolomics.

Summary

This study found that extract improved asthma symptoms in guinea pigs by affecting immune mechanisms, inflammation, nerve metabolism, and energy metabolism. The treatment effects varied based on sex.

Asthma
Liu J et al (2022).
Evid Based Complement Alternat Med.
DOI:
10.1155/2022/5266350
PubMed:
35399628

New iridal-type triterpenoid analogues with 6/5/6-fused carbon skeleton from the rhizomes of Belamcanda chinensis.

Li J et al (2022).
Fitoterapia.
DOI:
10.1016/j.fitote.2021.105040
PubMed:
34968640

Isoflavones of Belamcanda chinensis.

Yamaki M et al (1990).
Planta Med.
PubMed:
17221435

Isoflavonoids from Belamcanda chinensis.

Phytochemistry
Ito H, Onoue S and Yoshida T (2001).
Chem Pharm Bull (Tokyo).
PubMed:
11558622