Berberis aristata

Ethnobotanical Studies

Kaski district, western Nepal

Uses: Extract from root bark is given to cure jaundice (Pahele).

DOI:: 10.3389/fphar.2022.1076351
PubMed:: 36605393

Gyirong Valley, Tibet, China

Uses: Fuelwood, used to burn; food: fruit, raw

DOI:: 10.1186/s13002-022-00565-1
PubMed:: 36401315

Clinical Trials

Berberis aristata combined with Silybum marianum on lipid profile in patients not tolerating statins at high doses.

Derosa G et al (2015).; Atherosclerosis.
DOI:: 10.1016/j.atherosclerosis.2014.12.043
PubMed:: 25577665

Effects of Berberis aristata/Silybum marianum association on metabolic parameters and adipocytokines in overweight dyslipidemic patients.

Derosa G et al (2013).; J Biol Regul Homeost Agents.
PubMed:: 24152839

Berberis aristata/Silybum marianum fixed combination on lipid profile and insulin secretion in dyslipidemic patients.

Derosa G et al (2013).; Expert Opin Biol Ther.
DOI:: 10.1517/14712598.2013.832751
PubMed:: 23971720

Studies

Berberine sensitizes immune checkpoint blockade therapy in melanoma by NQO1 inhibition and ROS activation.

Luo Z et al (2024).; Int Immunopharmacol.
DOI:: 10.1016/j.intimp.2024.113031
PubMed:: 39217888

Development of Daruharidra (Berberis aristata) Based Biogenic Cadmium Sulfide Nanoparticles: Their Implementation as Antibacterial and Novel Therapeutic Agents against Human Breast and Ovarian Cancer.

Summary

Researchers developed a green method to create small cadmium sulfide nanoparticles. This could have applications in medicine, bioimaging, and environmental remediation.

Cancer Endocrinology

Bhatnagar A and Mishra A (2024).; Curr Pharm Biotechnol.
DOI:: 10.2174/0113892010244977231108043554
PubMed:: 39034838

Exploring Anticancer Properties of Medicinal Plants against Breast Cancer by Downregulating Human Epidermal Growth Factor Receptor 2.

Summary

Various medicinal plants show promising anticancer activity against HER2-positive breast cancer cells by reducing HER2 expression, altering proteome profile, and containing multiple anticancer compounds. Potential innovative therapies for HER2-positive breast cancer.

Cancer

Gupta S et al (2024).; J Agric Food Chem.
DOI:: 10.1021/acs.jafc.3c07565
PubMed:: 38624258

Berberine: A natural modulator of immune cells in multiple sclerosis.

Summary

Berberine may have immunomodulatory effects on T cell subsets and dendritic cells, impacting cytokines involved in multiple sclerosis. Research suggests potential therapeutic benefits for treating MS.

Review Neuroscience

Yazdanpanah E et al (2024).; Immun Inflamm Dis.
DOI:: 10.1002/iid3.1213
PubMed:: 38477663

Evaluation of iso-quinoline alkaloids by RP-HPLC-PDA in different Berberis species collected from Western Himalayan Region.

Summary

This study analyzed eight species of the genus to identify their metabolic variation using RP-HPLC-PDA chromatography. The method successfully separated the markers jatrorrhizine, palmatine, and berberine. The study provides a useful tool for identifying and differentiating various species, which can be used as an alternative to the official drug .

Phytochemistry

Chaudhary MK et al (2024).; Nat Prod Res.
DOI:: 10.1080/14786419.2024.2314634
PubMed:: 38353142

Myco-synthesis of multi-twinned silver nanoparticles as potential antibacterial and antimalarial agents.

Kumar S et al (2024).; RSC Adv.
DOI:: 10.1039/d3ra07752g
PubMed:: 38174259

Antioxidant and antiarthritic potential of berberine: In vitro and in vivo studies.

Immunology

Jain S, Tripathi S and Tripathi PK (2023).; Chin Herb Med.
DOI:: 10.1016/j.chmed.2023.02.007
PubMed:: 38094017

Effect of dietary supplementation with a new nutraceutical formulation on cardiometabolic risk factors: a double-blind, placebo-controlled, randomized clinical study.

Fogacci F et al (2023).; Arch Med Sci Atheroscler Dis.
DOI:: 10.5114/amsad/166571
PubMed:: 38089157

Chitosan/alginate nanogel potentiate berberine uptake and enhance oxidative stress mediated apoptotic cell death in HepG2 cells.

Immunology

Singh N et al (2023).; Int J Biol Macromol.
DOI:: 10.1016/j.ijbiomac.2023.128717
PubMed:: 38081485

10.

Ethnopharmacologically important highly subsidized Indian medicinal plants: Systematic review on their traditional uses, phytochemistry, pharmacology, quality control, conservation status and future prospective.

Summary

This review provides updated information on thirteen medicinal plants prioritized by the Indian government. It covers traditional uses, phytochemistry, pharmacology, quality control, and conservation status. Useful for understanding their importance and developing conservation strategies.

Review Phytochemistry

Anmol et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.117385
PubMed:: 37951375

11.

HPLC-DAD fingerprinting coupled with chemometric analysis can successfully differentiate Indian Berberis species and its plant parts.

Bhardwaj D and Kaushik N (2023).; 3 Biotech.
DOI:: 10.1007/s13205-023-03644-6
PubMed:: 37396470

12.

Buccal spray of standardized Berberis aristata extract causes tumour regression, chemoprotection and downregulation of inflammatory mediators in oral cancer hamster model.

Summary

Berberis aristata (BA) is a plant described in Ayurveda for treating oral conditions. Oral cancer (OC) is a serious health issue with high recurrence rates. This study explores the potential use of BA as a natural therapy for OC. By focusing on natural products, we aim to find safer treatment options for this aggressive disease. The research highlights the significance of incorporating traditional remedies into modern medicine to combat oral cancer and improve patient outcomes.

Cancer Immunology

Tamane P, Mahadik K and Pokharkar V (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.116732
PubMed:: 37315644

13.

Evaluation of Wound Healing Potential of Root Bark Extract of Berberis Aristata and Molecular Docking Analysis of Berberis Phytoconstituents.

Shrivastav A, Kumar Mishra A and Kumar Gupta A (2023).; Curr Drug Discov Technol.
DOI:: 10.2174/1570163820666230221154851
PubMed:: 36824006

14.

Phytochemicals, Antioxidant, Anti-inflammatory Studies, and Identification of Bioactive Compounds Using GC-MS of Ethanolic Novel Polyherbal Extract.

Immunology Phytochemistry

Singh AK et al (2023).; Appl Biochem Biotechnol.
DOI:: 10.1007/s12010-023-04363-7
PubMed:: 36701094

15.

Complementary and alternative medicine for glycemic control of diabetes mellitus: A systematic review.

Review Diabetes Genetics

Setiyorini E et al (2022).; J Public Health Res.
DOI:: 10.1177/22799036221106582
PubMed:: 35911428

16.

Development of Synergy-Based Combination of Methanolic Extract of Andrographis paniculata and Berberis aristata Against E. coli and S. aureus.

Abass S et al (2022).; Curr Microbiol.
DOI:: 10.1007/s00284-022-02911-8
PubMed:: 35704102

17.

Berberis aristata DC Extract Counteracts the High Fat Diet-Induced Reproductive Toxicity in Female Wistar Rats via Modulating Oxidative Stress and Resistance to Leptin and Insulin.

Mushtaq F et al (2022).; Endocr Metab Immune Disord Drug Targets.
DOI:: 10.2174/1871530322666220429125241
PubMed:: 35579124

18.

Standardization of Berberis aristata DC and Nigella sativa L. Using HPTLC and GCMS and Their Antineoplasia Activity in 7,12-Dimethylbenz[a]anthracene-Induced Mouse Models.

Mazhar M and Agrawal SS (2021).; Front Pharmacol.
DOI:: 10.3389/fphar.2021.642067
PubMed:: 34916928

19.

Ayurveda in the management of infant hyperlipidemia: A case report.

Jadhav SS et al (2022).; J Ayurveda Integr Med.
DOI:: 10.1016/j.jaim.2021.08.010
PubMed:: 34844842

20.

Tree Turmeric: A Super Food and Contemporary Nutraceutical of 21st Century - A Laconic Review.

Review

Bhasin J et al (2022).; J Am Nutr Assoc.
DOI:: 10.1080/07315724.2021.1958104
PubMed:: 34757887

21.

The Combination of Berberine, Tocotrienols and Coffee Extracts Improves Metabolic Profile and Liver Steatosis by the Modulation of Gut Microbiota and Hepatic miR-122 and miR-34a Expression in Mice.

Gastroenterology

Cossiga V et al (2021).; Nutrients.
DOI:: 10.3390/nu13041281
PubMed:: 33924725

22.

Ethnomedicinal Plants Traditionally Used for the Treatment of Jaundice (Icterus) in Himachal Pradesh in Western Himalaya-A Review.

Review Ethnobotany

Raghuvanshi D et al (2021).; Plants (Basel).
DOI:: 10.3390/plants10020232
PubMed:: 33504029

23.

The effects of Berberis vulgaris L. and Berberis aristata L. in metabolic syndrome patients: a systematic and meta-analysis study.

Roshanravan B et al (2020).; Arch Physiol Biochem.
DOI:: 10.1080/13813455.2020.1828482
PubMed:: 33040642

24.

Berberine: A novel therapeutic strategy for cancer.

Review Cancer

Samadi P et al (2020).; IUBMB Life.
DOI:: 10.1002/iub.2350
PubMed:: 32735398

25.

Antipsoriatic and Anti-inflammatory Studies of Berberis aristata Extract Loaded Nanovesicular Gels.

Immunology

Nimisha et al (2017).; Pharmacogn Mag.
DOI:: 10.4103/pm.pm_210_17
PubMed:: 29142419

26.

Berberine and Its Role in Chronic Disease.

Review

Cicero AF and Baggioni A (2016).; Adv Exp Med Biol.
PubMed:: 27671811

27.

Phyto-chemical and pharmacological applications of Berberis aristata.

Review

Potdar D, Hirwani RR and Dhulap S (2012).; Fitoterapia.
PubMed:: 22808523