GeoBotanical: Biophytum sensitivum

1.

Molecular dynamics and docking studies on potentially active natural phytochemicals for targeting SARS-CoV-2 main protease.

Summary

Researchers discovered that three compounds, Aegelinosides B, Epicatechin, and Feruloyltyramine, from popular herbs are potential candidates for fighting SARS-CoV-2. These compounds were screened from 87 phytochemicals and identified based on their binding energy and structural stability through molecular dynamics analysis. Comparing to popular reference compounds, Aegelinosides B demonstrated the best result. Further drug-likeness and toxicity tests also support the effectiveness of these compounds. These findings may have implications for developing treatments against COVID-19.

COVID-19

Karakkadparambil Sankaran S and Nair AS (2022).; J Biomol Struct Dyn.
DOI:: 10.1080/07391102.2022.2107573
PubMed:: 35930306

2.

Comparative analysis of plastomes in Oxalidaceae: Phylogenetic relationships and potential molecular markers.

Li X et al (2021).; Plant Divers.
DOI:: 10.1016/j.pld.2021.04.004
PubMed:: 34485770

3.

Protective effect of ethyl acetate fraction of Biophytum sensitivum extract against sodium oxalate-induced urolithiasis in rats.

Pawar AT and Vyawahare NS (2017).; J Tradit Complement Med.
DOI:: 10.1016/j.jtcme.2016.12.012
PubMed:: 29034196

4.

Fabrication and characterization of biosilver nanoparticles loaded calcium pectinate nano-micro dual-porous antibacterial wound dressings.

Augustine R et al (2016).; Prog Biomater.
PubMed:: 27995588

5.

Diuretic activity of different extracts of Biophytum sensitivum (Linn.) DC.

Chandavarkar SK and Mamle Desai SN (2015).; Ayu.
DOI:: 10.4103/0974-8520.182758
PubMed:: 27313427

6.

Anti-urolithiatic activity of standardized extract of Biophytum sensitivum against zinc disc implantation induced urolithiasis in rats.

Pawar AT and Vyawahare NS (2015).; J Adv Pharm Technol Res.
DOI:: 10.4103/2231-4040.165017
PubMed:: 26605159

7.

Co-occurrence of tannin and tannin-less vacuoles in sensitive plants.

Fleurat-Lessard P et al (2016).; Protoplasma.
DOI:: 10.1007/s00709-015-0844-z
PubMed:: 26103934

8.

Modulating effect of Biophytum sensitivum extract on rats with acetic acid-induced ulcerative colitis.

Gastroenterology

Sakthivel KM and Guruvayoorappan C (2014).; Pharm Biol.
DOI:: 10.3109/13880209.2014.908396
PubMed:: 25243883

9.

Ethnobotanical study of Kani tribes in Thoduhills of Kerala, South India.

Ethnobotany

Xavier TF et al (2014).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2013.12.016
PubMed:: 24393788

10.

Extracellular signal-regulated kinase is a direct target of the anti-inflammatory compound amentoflavone derived from Torreya nucifera.

Immunology

Oh J et al (2013).; Mediators Inflamm.
DOI:: 10.1155/2013/761506
PubMed:: 23970815

11.

Effect of Biophytum sensitivum on streptozotocin and nicotinamide-induced diabetic rats.

Diabetes

Ananda PK et al (2012).; Asian Pac J Trop Biomed.
DOI:: 10.1016/S2221-1691(11)60185-8
PubMed:: 23569830

12.

Biophytum sensitivum: Ancient medicine, modern targets.

Sakthivel KM and Guruvayoorappan C (2012).; J Adv Pharm Technol Res.
DOI:: 10.4103/2231-4040.97279
PubMed:: 22837955

13.

Ethnobotany, phytochemistry and pharmacology of Biophytum sensitivum DC.

Ethnobotany Phytochemistry

Bharati AC and Sahu AN (2012).; Pharmacogn Rev.
DOI:: 10.4103/0973-7847.95893
PubMed:: 22654407

14.

Protective effect of Biophytum sensitivum (L.) DC on radiation-induced damage in mice.

Guruvayoorappan C and Kuttan G (2008).; Immunopharmacol Immunotoxicol.
DOI:: 10.1080/08923970802439480
PubMed:: 18951225

15.

Biophytum sensitivum (L.) DC inhibits tumor cell invasion and metastasis through a mechanism involving regulation of MMPs, prolyl hydroxylase, lysyl oxidase, nm23, ERK-1, ERK-2, STAT-1, and proinflammatory cytokine gene expression in metastatic lung tissue.

Cancer Genetics Immunology

Guruvayoorappan C and Kuttan G (2008).; Integr Cancer Ther.
DOI:: 10.1177/1534735407313744
PubMed:: 18292594

16.

Effect of Biophytum sensitivum on cell-mediated immune response in mice.

Guruvayoorappan C and Kuttan G (2007).; Immunopharmacol Immunotoxicol.
PubMed:: 18075848

17.

Immunomodulatory and antitumor activity of Biophytum sensitivum extract.

Cancer Immunology

Guruvayoorappan C and Kuttan G (2007).; Asian Pac J Cancer Prev.
PubMed:: 17477767

18.

Antioxidant potential of Biophytum sensitivum extract in vitro and in vivo.