Bixa orellana

Common Names: annatto, lipsticktree, roucou

Ethnobotanical Studies

Clinical Trials

Consumption of Eggs Alone or Enriched with Annatto (Bixa orellana L.) Does Not Increase Cardiovascular Risk in Healthy Adults-A Randomized Clinical Trial, the Eggant Study.

This study found that consuming two eggs a day or two eggs enriched with Annatto for eight weeks did not have adverse effects on cardiovascular risk markers in healthy adults.

Galvis Y et al (2023).
Nutrients.
DOI:
10.3390/nu15020369
PubMed:
36678239

Studies

Engineering Yarrowia lipolytica for Efficient Synthesis of Geranylgeraniol.

Wang K et al (2024).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.4c06749
PubMed:
39241196

Evaluation of the potential of annatto seed powder to reduce the formation of heterocyclic amines in charcoal-grilled and pan-fried beef patties.

de Moura Neves-Gonçalves T et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.141015
PubMed:
39216375

Effect of the Structural Modification of Plant Proteins as Microencapsulating Agents of Bioactive Compounds from Annatto Seeds (Bixa orellana L.).

Quintero Quiroz J et al (2024).
Foods.
DOI:
10.3390/foods13152345
PubMed:
39123536

Oil/Water Biphasic Solvent System for the Eco-Extraction and Cosmetic Formulation of Bixa orellana L.

Chambaud M et al (2024).
Plants (Basel).
DOI:
10.3390/plants13141940
PubMed:
39065467

Bixin, a New Atheroprotective Carotenoid Candidate, Prevents oxLDL-Induced Cytotoxicity and Mitochondrial Dysfunction in Macrophages: Involvement of the Nrf2 and NF-κB Pathways.

Immunology
Somacal S et al (2024).
Foods.
DOI:
10.3390/foods13132002
PubMed:
38998509

Development of topical silver nano gel formulation of Bixin: Characterization, and evaluation of anticancer activity.

Summary

Research developed a stable silver nanoparticle gel with bixin to potentially treat skin cancer. Could lead to more effective and stable plant-based anticancer treatments.

Cancer
Patil SS et al (2024).
Saudi Pharm J.
DOI:
10.1016/j.jsps.2024.102125
PubMed:
38933714

From Extraction to Stabilization: Employing a 2(2) Experimental Design in Developing Nutraceutical-Grade Bixin from Bixa orellana L.

Luna-Finkler CL et al (2024).
Foods.
DOI:
10.3390/foods13111622
PubMed:
38890850

Obtaining Bixin- and Tocotrienol-Rich Extracts from Peruvian Annatto Seeds Using Supercritical CO(2) Extraction: Experimental and Economic Evaluation.

Cárdenas-Toro FP et al (2024).
Foods.
DOI:
10.3390/foods13101549
PubMed:
38790850

One-step ultrasound-assisted recovery of yellow-orange-red natural coloring from defatted annatto seeds: A cleaner processing alternative.

Strieder MM et al (2024).
Ultrason Sonochem.
DOI:
10.1016/j.ultsonch.2024.106906
PubMed:
38776867

Potential use of bixin beyond function as a natural colourant in food and cosmetics.

Review
Takamoto RTO et al (2024).
Nat Prod Res.
DOI:
10.1080/14786419.2024.2350634
PubMed:
38726906

Ethanol-Based Extraction of Annatto (Bixa Orellana L.) and Characterization of the Bixin and Norbixin.

Aluko E et al (2024).
ACS Omega.
DOI:
10.1021/acsomega.3c10120
PubMed:
38680327

Sustainable appraisal of lipstick tree seeds (Bixa orellana)-based bixin natural orange colorant for green mordanted silk fabrics and wool yarns.

Yameen M et al (2024).
Sci Prog.
DOI:
10.1177/00368504241242282
PubMed:
38614468

Exploring antioxidative, cytotoxic and neuropharmacological insights into Bixa orellana leaves: Experimental and in silico approaches.

Sarkar KK et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e27001
PubMed:
38468966

Gene structure and potential regulation of the lycopene cyclase genes in Bixa orellana L.

Genetics
Rivero-Manzanilla G et al (2023).
Physiol Mol Biol Plants.
DOI:
10.1007/s12298-023-01384-8
PubMed:
38076759

Chromatic and medicinal properties of six natural textile dyes: A review of eucalyptus, weld, madder, annatto, indigo and woad.

Review
Santiago D, Cunha J and Cabral I (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e22013
PubMed:
38034740

Plant age-dependent dynamics of annatto pigment (bixin) biosynthesis in Bixa orellana L.

de Godoy Machado KL et al (2023).
J Exp Bot.
DOI:
10.1093/jxb/erad458
PubMed:
37975812

Bixa orellana ethyl acetate fraction and its isolated compound ellagic acid attenuate the progression of MIA-induced osteoarthritis in rat knees.

Santiago LÂM et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.115644
PubMed:
37839112

Exploring bixin from Bixa orellana L. seeds: quantification and in silico insights into its anti-cancer potential.

Summary

Bixin, a pigment found in seed arils, has potential anti-cancer activity. It may inhibit BRAF, MMP9, TNF expression, enhance TP53 expression, and interact with skin cancer targets with low binding energy. Bixin is stable and shows promise for skin cancer treatment.

Cancer
Muthusamy K et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2268202
PubMed:
37837422

Therapeutic potential of bixin on inflammation: a mini review.

Summary

Bixin, found in the seeds of L., shows potential as a treatment for inflammatory-related diseases. It inhibits TLR4/NF-κB, PI3K/Akt, and TXNIP/NLRP3 mechanisms, suggesting it may ameliorate inflammation. Further clinical studies are needed to confirm its effectiveness and safety.

Review Immunology
Shadisvaaran S et al (2023).
Front Nutr.
DOI:
10.3389/fnut.2023.1209248
PubMed:
37781110

Effect of the Association of Fixed Oils from Abelmoschus esculentus (L.) Moench, Euterpe oleracea Martius, Bixa orellana Linné and Chronic SM(®) on Atherogenic Dyslipidemia in Wistar Rats.

Sales PF et al (2023).
Molecules.
DOI:
10.3390/molecules28186689
PubMed:
37764465

The role of bixin as antioxidant, anti-inflammatory, anticancer, and skin protecting natural product extracted from Bixa orellana L.

Summary

This review explores the medicinal properties of Bixa orellana L., specifically focusing on its main component, bixin. Bixin has anti-inflammatory, antioxidant, anticancer, and skin-protecting properties and can be extracted from the seeds of Bixa orellana L.

Review CancerImmunology
Ashraf A et al (2023).
Fitoterapia.
DOI:
10.1016/j.fitote.2023.105612
PubMed:
37454777

First Report of Pseudocercospora paraguayensis Causing Leaf Spots on Bixa orellana from Chinese Mainland.

Liu CY, Yang S and Liu YL (2023).
Plant Dis.
DOI:
10.1094/PDIS-05-23-1023-PDN
PubMed:
37386706

Exploration of the Production of Three Thiodiketopiperazines by an Endophytic Fungal Strain of Cophinforma mamane.

Pacheco-Tapia RG et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202201087
PubMed:
36919620

In vitro antimicrobial activity of Bixa orellana L . Leaves extract against anaerobic bacteria associated to bacterial vaginosis and Lactobacillus spp.

Antimicrobial
Marcas J et al (2022).
Rev Peru Med Exp Salud Publica.
DOI:
10.17843/rpmesp.2022.394.11978
PubMed:
36888802

Gene expression profile during seed development of Bixa orellana accessions varying in bixin pigment.

Cárdenas-Conejo Y et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1066509
PubMed:
36875614

Investigation on the effect of antimicrobial photodynamic therapy as an adjunct for management of deep caries lesions-study protocol for a randomized, parallel groups, controlled clinical trial.

Antimicrobial
Martins LFB et al (2023).
Trials.
DOI:
10.1186/s13063-023-07181-8
PubMed:
36870982

Intramuscular compatibility of an injectable anti-inflammatory nanodispersion from a standardized Bixa orellana oil (Chronic(®)): a toxicological study in Wistar rats.

Immunology
de Oliveira Carvalho H et al (2023).
Inflammopharmacology.
DOI:
10.1007/s10787-023-01162-8
PubMed:
36853419

Leaves of Moringa oleifera Are Potential Source of Bioactive Compound β-Carotene: Evidence from In Silico and Quantitative Gene Expression Analysis.

Muteeb G et al (2023).
Molecules.
DOI:
10.3390/molecules28041578
PubMed:
36838566

Dynamics of annatto pigment synthesis and accumulation in seeds of Bixa orellana L. revealed by integrated chemical, anatomical, and RNA-Seq analyses.

Genetics
Moreira VS et al (2023).
Protoplasma.
DOI:
10.1007/s00709-023-01842-w
PubMed:
36787048

Accumulation and decomposition of cultural residues of Theobroma grandiflorum, Paullinia cupana, Bixa orellana and forest in the southern region of Amazonas.

Paula EMB et al (2023).
Braz J Biol.
DOI:
10.1590/1519-6984.264237
PubMed:
36651448

Cytoprotective effect of Fridericia chica (Bonpl.) L.G. Lohmann extract associated with geranylgeraniol enriched-fraction from Bixa orellana L. on epithelial cells treated with bisphosphonate.

Machado Júnior RJ et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2022.2131782
PubMed:
36226767

Evaluation of Anticolitis and Antioxidant Properties of Bixa orellana (Bixaceae) Leaf Hydroethanolic Extract on Acetic Acid-Induced Ulcerative Colitis in Rats.

Gastroenterology
Fokam Tagne MA et al (2022).
Curr Ther Res Clin Exp.
DOI:
10.1016/j.curtheres.2022.100685
PubMed:
36212166

Ethyl Acetate Fraction of Bixa orellana and Its Component Ellagic Acid Exert Antibacterial and Anti-Inflammatory Properties against Mycobacterium abscessus subsp. massiliense.

Immunology
Moraes-Neto RN et al (2022).
Antibiotics (Basel).
DOI:
10.3390/antibiotics11060817
PubMed:
35740223

Gene expression analysis during the fruit development in dehiscent and indehiscent Bixa orellana L. accessions.

Tamayo-García R et al (2022).
Physiol Mol Biol Plants.
DOI:
10.1007/s12298-022-01180-w
PubMed:
35592485

Bixa orellana L. carotenoids: antiproliferative activity on human lung cancer, breast cancer, and cervical cancer cells in vitro.

Cancer
Kusmita L et al (2022).
Nat Prod Res.
DOI:
10.1080/14786419.2022.2036144
PubMed:
35133226

Bixa orellana L. (Achiote, Annatto) as an antimicrobial agent: A scoping review of its efficiency and technological prospecting.

Antimicrobial
Coelho Dos Santos D et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2021.114961
PubMed:
34968663

Heterologous expression of Bixa orellana cleavage dioxygenase 4-3 drives crocin but not bixin biosynthesis.

Frusciante S et al (2022).
Plant Physiol.
DOI:
10.1093/plphys/kiab583
PubMed:
34919714

Photodynamic therapy with Bixa orellana extract and LED for the reduction of halitosis: study protocol for a randomized, microbiological and clinical trial.

Gonçalves MLL et al (2018).
Trials.
DOI:
10.1186/s13063-018-2913-z
PubMed:
30373650

Achiote (Bixa orellana L.): a natural source of pigment and vitamin E.

Review
Raddatz-Mota D et al (2017).
J Food Sci Technol.
DOI:
10.1007/s13197-017-2579-7
PubMed:
28559632

Safety and efficacy of Bixa orellana (achiote, annatto) leaf extracts.

Review
Stohs SJ et al (2014).
Phytother Res.
DOI:
10.1002/ptr.5088
PubMed:
24357022