This study investigated the effects of Leontice leontopetalum and Bongardia chrysogonum on brain function in rats with induced seizures. The extracts were found to have antioxidant effects, decreasing oxidative stress and increasing levels of helpful proteins while reducing harmful ones. The GABAA receptor cell number was similar to that in healthy rats despite the seizures. This research suggests that these extracts could be useful in treating conditions involving brain seizures and oxidative stress.