Borago officinalis

Common Names: common borage

Ethnobotanical Studies

Marmilla Subregion, Sardinia, Italy

Uses: Intestinal laxative and purifying agent, diuretic

DOI:: 10.3390/plants11223165
PubMed:: 36432894

Ecuador

Uses: Anti-inflammatory, anti-flu, expectorant, febrifuge, to enhance blood circulation, sudorific, astringent, diuretic, anti-hypercholesterolemic, analgesic, antidiarrheal, antitussive and emmenagogue; to treat hepatic pain, conjunctivitis, burnings, headache, and coughs; to decrease disease relapses after recovery (locally known as recaída in Spanish); to cure gastrointestinal, respiratory, and renal-urological problems.

DOI:: 10.3390/plants11121590
PubMed:: 35736741

Studies

Effect of a polyherbal Unani formulation on left ventricular diastolic dysfunction in hypertensive patients - a randomized single blind placebo controlled clinical trial.

Khanum A et al (2024).; Drug Metab Pers Ther.
DOI:: 10.1515/dmpt-2024-0041
PubMed:: 39135328

Strength and functionalized borage biochar for effective elimination of nickel contamination: Insight into batch and dynamic flow mode treatment applications.

Tunali Akar S et al (2024).; Environ Res.
DOI:: 10.1016/j.envres.2024.119430
PubMed:: 38885826

Ultrastructure and development of the floral nectary from Borago officinalis L. and phytochemical changes in its secretion.

Phytochemistry

Gismondi A et al (2024).; Plant Sci.
DOI:: 10.1016/j.plantsci.2024.112135
PubMed:: 38797382

The Influence of Copper and Zinc on Photosynthesis and Phenolic Levels in Basil (Ocimum basilicum L.), Borage (Borago officinalis L.), Common Nettle (Urtica dioica L.) and Peppermint (Mentha piperita L.).

Phytochemistry

Adamczyk-Szabela D and Wolf WM (2024).; Int J Mol Sci.
DOI:: 10.3390/ijms25073612
PubMed:: 38612424

Effects of Various Nectar and Pollen Plants on the Survival, Reproduction, and Predation of Neoseiulus bicaudus.

Han Y et al (2024).; Insects.
DOI:: 10.3390/insects15030190
PubMed:: 38535385

Resilience of bumblebee foraging behavior despite colony size reduction.

Gérard M et al (2023).; Front Insect Sci.
DOI:: 10.3389/finsc.2022.1073380
PubMed:: 38468768

BORAGO OFFICINALIS L.: A REVIEW ON EXTRACTION, PHYTOCHEMICAL, AND PHARMACOLOGICAL ACTIVITIES.

Phytochemistry

Nabila S et al (2024).; Chem Biodivers.
DOI:: 10.1002/cbdv.202301822
PubMed:: 38426739

Improvement of biochemical and antioxidant responses of borage (Borago officinalis L.) under drought stress conditions with the use of vermicompost and zinc sulfate.

Summary

Zinc sulfate and vermicompost alleviate drought stress in Borage plants by increasing chlorophyll levels, improving water content, reducing cell damage, and increasing biomass.

Immunology

Behzadi Y et al (2023).; Physiol Mol Biol Plants.
DOI:: 10.1007/s12298-023-01363-z
PubMed:: 38222282

First Report of Clover yellow vein virus Infecting Senna septemtrionalis (Arsenic bush).

Hu H et al (2023).; Plant Dis.
DOI:: 10.1094/PDIS-01-23-0101-PDN
PubMed:: 37943510

10.

New Insights on Primary and Secondary Metabolite Contents of Seven Italian Wild Food Plants with Medicinal Applications: A Comparative Study.

Monari S et al (2023).; Plants (Basel).
DOI:: 10.3390/plants12183180
PubMed:: 37765345

11.

Nutraceutical Potential of Leafy Vegetables Landraces at Microgreen, Baby, and Adult Stages of Development.

Mallor C et al (2023).; Foods.
DOI:: 10.3390/foods12173173
PubMed:: 37685105

12.

Of mixed vegetables and cardiac arrhythmias - Digitalis purpurea confused with Borago officinalis: A case series of accidental digitoxin intoxications.

Summary

Two women ate vegetables from their garden, thinking one was borage but accidentally ate foxglove. They experienced severe symptoms and elevated digitoxin levels. Plant misclassifications can be dangerous.

Cardiology

Iraci F et al (2023).; J Cardiol Cases.
DOI:: 10.1016/j.jccase.2023.04.007
PubMed:: 37521578

13.

Pyrrolizidine alkaloids in borage (Borago officinalis): Comprehensive profiling and development of a validated LC-MS/MS method for quantification.

Phytochemistry

Sattler M et al (2023).; Talanta.
DOI:: 10.1016/j.talanta.2023.124425
PubMed:: 36924638

14.

Antimicrobial Activity of Catechol-Containing Biopolymer Poly[3-(3,4-dihydroxyphenyl)glyceric Acid] from Different Medicinal Plants of Boraginaceae Family.

Antimicrobial

Barbakadze V et al (2023).; Antibiotics (Basel).
DOI:: 10.3390/antibiotics12020285
PubMed:: 36830198

15.

Phenolic Profile and Comparison of the Antioxidant, Anti-Ageing, Anti-Inflammatory, and Protective Activities of Borago officinalis Extracts on Skin Cells.

Immunology Phytochemistry

Michalak M et al (2023).; Molecules.
DOI:: 10.3390/molecules28020868
PubMed:: 36677923

16.

Effectiveness of Borage plus syrup on COVID-19 patients in intensive care units.

Summary

In this study, researchers investigated the potential benefits of using a traditional plant, Borage, in combination with syrup (BPS) in severe COVID-19 patients in an ICU setting. Borage is a good source of gamma-linolenic acid (GLA). The study aimed to find a possible curative treatment for COVID-19 patients, who still have a high mortality rate globally.

COVID-19

Hashemian SM et al (2022).; Front Nutr.
DOI:: 10.3389/fnut.2022.975937
PubMed:: 36458163

17.

Neuroprotective Profile of Edible Flowers of Borage (Borago officinalis L.) in Two Different Models: Caenorhabditis elegans and Neuro-2a Cells.

Summary

A study aimed to evaluate the benefits of fresh borage flower extract, commonly used in culinary, on antioxidant, neuroprotective, and anti-aging properties. The extract was obtained using ethanol as a solvent and had high amounts of polyunsaturated fatty acids. In vitro assays showed promising antioxidant activity. The extract was also subjected to oxidative stress, resulting in better responses to mitochondrial activity, redox state, and antioxidant enzymes. The study concluded that the extract has potential antioxidant properties without causing toxicity, supporting its benefits in living organisms.

Neuroscience

Moliner C et al (2022).; Antioxidants (Basel).
DOI:: 10.3390/antiox11071244
PubMed:: 35883735

18.

The complete plastome of Nonea vesicaria (L.) Rchb. (Boraginaceae), the first chloroplast genome belonging to the Nonea genus.

Genetics

Carvalho Leonardo I et al (2022).; Mitochondrial DNA B Resour.
DOI:: 10.1080/23802359.2022.2095233
PubMed:: 35874278

19.

Evaluation of Borage (Borago officinalis L.) Genotypes for Nutraceutical Value Based on Leaves Fatty Acids Composition.

Genetics

Montaner C et al (2021).; Foods.
DOI:: 10.3390/foods11010016
PubMed:: 35010142

20.

The Effect of Borage (Borago officinalis) Extract on Growth Performance and Immune System of Broilers at High-Density Conditions.

Salehifar E and Sobhanirad S (2022).; J Appl Anim Welf Sci.
DOI:: 10.1080/10888705.2021.2021653
PubMed:: 34979832

21.

A study on the nutritional characteristics of some plants and their effects on ruminal microbial fermentation and protozoa population.

Kazemi M, Moheghi MM and Tohidi R (2021).; AMB Express.
DOI:: 10.1186/s13568-021-01338-x
PubMed:: 34936064

22.

The effect of Borago officinalis on the signaling pathway of the NLRP3 inflammasome complex, TLR4 and some inflammatory cytokines in type II diabetic patients with acute respiratory distress syndrome.

Immunology

Yue Y, Jin F and Yue X (2021).; Cell Mol Biol (Noisy-le-grand).
DOI:: 10.14715/cmb/2021.67.3.28
PubMed:: 34933712

23.

Where Is the Honey Bee Queen Flying? The Original Case of a Foraging Queen.

Floris I et al (2021).; Insects.
DOI:: 10.3390/insects12111035
PubMed:: 34821834

24.

Haploid Plant Production in Borage (Borago officinalis L.) by Anther Culture.

Genetics

Abdollahi MR, Eshaghi ZC and Seguí-Simarro JM (2021).; Methods Mol Biol.
DOI:: 10.1007/978-1-0716-1331-3_15
PubMed:: 34270074

25.

A Validated, Rapid and Cost-Efficient HPTLC Method for Quantification of Gamma-Linolenic Acid in Borage Oil and Evaluation of Antioxidant Activity.

Kawish SM et al (2022).; J Chromatogr Sci.
DOI:: 10.1093/chromsci/bmab059
PubMed:: 34080615

26.

Potential Use of Hyssopus officinalis and Borago officinalis as Curing Ingredients in Pork Meat Formulations.

Zając M et al (2020).; Animals (Basel).
DOI:: 10.3390/ani10122327
PubMed:: 33297565

27.

Protective Effects of Borago officinalis (Borago) on Cold Restraint Stress-Induced Gastric Ulcers in Rats: A Pilot Study.

Gastroenterology

Di Cerbo A et al (2020).; Front Vet Sci.
DOI:: 10.3389/fvets.2020.00427
PubMed:: 32984407

28.

Phytochemical characterization of Borago officinalis L. and Centaurea cyanus L. during flower development.

Phytochemistry

Fernandes L et al (2019).; Food Res Int.
DOI:: 10.1016/j.foodres.2019.05.014
PubMed:: 31285027

29.

Do recent research studies validate the medicinal plants used in British Columbia, Canada for pet diseases and wild animals taken into temporary care?

Review

Lans C et al (2019).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2019.02.030
PubMed:: 30772483

30.

Borage.

Review

(2021).
PubMed:: 30000849

31.

Anti-Inflammatory Drugs and Herbs with Special Emphasis on Herbal Medicines for Countering Inflammatory Diseases and Disorders - A Review.

Review Immunology

Yatoo MI et al (2018).; Recent Pat Inflamm Allergy Drug Discov.
DOI:: 10.2174/1872213X12666180115153635
PubMed:: 29336271

32.

Effect of Borago Officinalis Extract on Moderate Persistent Asthma: A Phase two Randomized, Double Blind, Placebo-Controlled Clinical Trial.

Summary

Clinical trial examined the effect of Borago officinalis on moderate asthma. It shows potential for treating allergic disorders by suppressing TNF-alpha and delivering gamma-linolenic acid.

Asthma

Mirsadraee M et al (2016).; Tanaffos.
PubMed:: 28210282

33.

Cancer Prevention and Health Benefices of Traditionally Consumed Borago officinalis Plants.

Cancer

Lozano-Baena MD et al (2016).; Nutrients.
DOI:: 10.3390/nu8010048
PubMed:: 26797631

34.

Officinalioside, a new lignan glucoside from Borago officinalis L.

Samy MN et al (2016).; Nat Prod Res.
DOI:: 10.1080/14786419.2015.1088540
PubMed:: 26382913