Brucea javanica

Ethnobotanical Studies

Studies

Brucea javanica Seed Oil Emulsion and Shengmai Injections Improve Peripheral Microcirculation in Treatment of Gastric Cancer.

Summary

Researchers studied the effects of two herbal injections on blood flow in gastric cancer patients. YDZI and SMI may improve circulation, potentially aiding in GC treatment.

CancerGastroenterology
Quan L et al (2024).
Chin J Integr Med.
DOI:
10.1007/s11655-024-4103-z
PubMed:
39225883

Yadanziolide A Inhibits Proliferation and Induces Apoptosis of Hepatocellular Carcinoma via JAK-STAT Pathway: A Preclinical Study.

Lin L and Chen Q (2024).
Biology (Basel).
DOI:
10.3390/biology13070528
PubMed:
39056720

Intraperitoneal administration of doxorubicin-encapsulated Brucea javanica oil nanoemulsion against malignant ascites.

Dai J et al (2024).
Eur J Pharm Biopharm.
DOI:
10.1016/j.ejpb.2024.114422
PubMed:
39033885

The quassinoids bruceines A-M: pharmacology, mechanism of action, synthetic advance, and pharmacokinetics-a review.

Review
Hop NQ and Son NT (2024).
Naunyn Schmiedebergs Arch Pharmacol.
DOI:
10.1007/s00210-024-03281-7
PubMed:
38985315

Effectiveness and safety of brucea javanica oil assisted TACE versus TACE in the treatment of liver cancer: a systematic review and meta-analysis of randomized controlled trials.

Cancer
Wu ZH et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1337179
PubMed:
38974037

Brusatol improves the efficacy of an anti-mouse-PD-1 antibody via inhibiting programmed cell death 1 ligand 1 expression in a murine head and neck squamous cell carcinoma model.

Wu Y et al (2024).
Arch Oral Biol.
DOI:
10.1016/j.archoralbio.2024.106043
PubMed:
38968906

Combination of Brucea javanica oil emulsion and Aidi injection associated with the long‑term survival of a patient with colon cancer and lung metastases post‑chemotherapy: A case report.

Summary

Two plant-derived products, BJOE and ADI, show promise in treating CRC with limited options, allowing a patient with resectable lung metastases to achieve >5 years progression-free survival. More research needed, but offers hope for future treatments.

CancerGastroenterology
Song J et al (2024).
Oncol Lett.
DOI:
10.3892/ol.2024.14494
PubMed:
38895054

Decrease in GPSM2 mediated by the natural product luteolin contributes to colon adenocarcinoma treatment and increases the sensitivity to fluorouracil.

Gastroenterology
Yang C et al (2024).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2024.116847
PubMed:
38823277

Study on the Mechanism of Yadanzi Oil in Treating Lung Cancer Based on Network Pharmacology and Molecular Docking Technology.

Cancer
Liu Z et al (2024).
ACS Omega.
DOI:
10.1021/acsomega.3c10105
PubMed:
38708221

Brusatol hinders the progression of bladder cancer by Chac1/Nrf2/SLC7A11 pathway.

Summary

Brusatol from Brucea javanica inhibits bladder cancer growth by inducing ferroptosis through the Chac1/Nrf2/SLC7A11 pathway, showing promise as a potential antineoplastic drug.

Cancer
Yu XI et al (2024).
Exp Cell Res.
DOI:
10.1016/j.yexcr.2024.114053
PubMed:
38663476

Bruceantinol works as a CDK2/4/6 inhibitor to inhibit the growth of breast cancer cells.

Summary

BOL from Brucea javanica inhibits breast cancer cell growth by targeting CDK2/4/6 and activating ERK. Potential anti-breast cancer treatment option.

Cancer
Sun L et al (2024).
Chem Biol Interact.
DOI:
10.1016/j.cbi.2024.110999
PubMed:
38608999

Molecular networking-based mass spectral identification of Brucea javanica (L.) Merr. metabolites and their selective binding affinities for dengue virus enzymes.

Yousof NSAM et al (2024).
Fitoterapia.
DOI:
10.1016/j.fitote.2024.105955
PubMed:
38604259

KLF4 suppresses anticancer effects of brusatol via transcriptional upregulating NCK2 expression in melanoma.

Cancer
Li X et al (2024).
Biochem Pharmacol.
DOI:
10.1016/j.bcp.2024.116197
PubMed:
38583810

Cytotoxicity and Apoptosis Studies of Brucein D against T24 Bladder Cancer Cells.

Summary

Tossers isolated Brucein D from Brucea javanica fruit and showed it can kill bladder cancer cells by causing apoptosis. Good for potential cancer treatment.

Cancer
Nandana PI et al (2024).
Asian Pac J Cancer Prev.
DOI:
10.31557/APJCP.2024.25.3.921
PubMed:
38546074

Traditional Chinese medicine for gastric cancer: An evidence mapping.

Summary

Chinese Medicine has potential benefits for gastric cancer treatment, improving survival, myelosuppression, and immune function. More rigorous studies are needed, but integrating these interventions into clinical care may be beneficial.

CancerGastroenterology
Dai Z et al (2024).
Phytother Res.
DOI:
10.1002/ptr.8155
PubMed:
38517014

Improving cellular uptake and synergetic anti-tumor effects of magnolol and Brucea javanica oil through self-microemulsion.

Summary

Researchers found that combining magnolol and betulinic acid oil improved their anti-tumor effects, but their low solubility and stability hindered oral bioavailability. This could lead to new methods for cancer treatment.

Cancer
Zhang H et al (2024).
Drug Dev Ind Pharm.
DOI:
10.1080/03639045.2024.2329730
PubMed:
38466185

Bruceantinol targeting STAT3 exerts promising antitumor effects in in vitro and in vivo osteosarcoma models.

Summary

Bruceantinol (BOL) from Brucea javanica inhibits growth and metastasis of osteosarcoma cells by binding to STAT3, showing promise as a therapeutic agent for OS.

CancerImmunology
Miao J et al (2024).
Mol Carcinog.
DOI:
10.1002/mc.23714
PubMed:
38426797

Brusatol's anticancer activity and its molecular mechanism: a research update.

Summary

Brusatol (BT), from a Chinese herb, shows promising anti-cancer and anti-inflammatory properties. This review highlights its potential for treating various diseases, including leukemia and malaria.

Cancer
Xi W et al (2024).
J Pharm Pharmacol.
DOI:
10.1093/jpp/rgae017
PubMed:
38394388

Effect of Brucea javanica Oil on the Toxicity of β-Cypermethrin Emulsifiable Concentrate Formulation.

Wu J et al (2024).
ACS Appl Mater Interfaces.
DOI:
10.1021/acsami.3c16384
PubMed:
38373060

A review of Brucea javanica: metabolites, pharmacology and clinical application.

Review
Chen J et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1317620
PubMed:
38371913

Brucea javanica derived exosome-like nanovesicles deliver miRNAs for cancer therapy.

Summary

Exosome-like nanovesicles from B. javanica (BF-Exos) delivered microRNAs to cancer cells, slowing growth and metastasis. BF-Exos also inhibited angiogenesis. Promising for TNBC treatment.

Cancer
Yan G et al (2024).
J Control Release.
DOI:
10.1016/j.jconrel.2024.01.060
PubMed:
38295998

Bruceine B Displays Potent Antimyeloma Activity by Inducing the Degradation of the Transcription Factor c-Maf.

Li H et al (2023).
ACS Pharmacol Transl Sci.
DOI:
10.1021/acsptsci.3c00222
PubMed:
38230274

Discovery of bi-4-methoxycarbonyl-2-quinolone and evaluation of its anti-inflammatory and anti-cancer activity in vitro.

Summary

A new alkaloid compound with anti-inflammatory and anti-cancer properties was discovered, along with six known alkaloids, holding promise for potential therapeutic applications in inflammation and cancer treatment.

CancerImmunology
Wang W et al (2024).
Nat Prod Res.
DOI:
10.1080/14786419.2024.2303606
PubMed:
38217490

Efficacy and safety of Chinese medicine injections in combination with docetaxel and cisplatin for non-small cell lung cancer: a network meta-analysis.

Summary

This meta-analysis found that several Chinese herbal injections combined with docetaxel and cisplatin showed promising effectiveness in treating non-small cell lung cancer. Further research is required for confirmation.

Review Cancer
Wen L et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1277284
PubMed:
38146464

Current status of Complementary and Alternative Medicine Interventions in the Management of Pancreatic Cancer - An Overview.

Summary

CAM options such as medical cannabis, plants, fungi, and herbal formulas, particularly from traditional Chinese or Japanese medicine, show promise in treating pancreatic cancer. They may improve quality of life and be a useful addition to conventional therapy.

Review Cancer
Tarasiuk A, Mirocha G and Fichna J (2023).
Curr Treat Options Oncol.
DOI:
10.1007/s11864-023-01146-4
PubMed:
38079061

Brucea Javanica Oil Emulsion Injection inhibits proliferation of pancreatic cancer via regulating apoptosis-related genes.

Summary

This study investigated the anti-tumor effects of Brucea Javanica Oil Emulsion Injection (BJOEI) on pancreatic cancer. They found that BJOEI inhibited tumor growth and induced cell apoptosis by regulating apoptosis-related genes, particularly PPARG. BJOEI may have potential therapeutic effects for pancreatic cancer.

CancerGenetics
Wu Y et al (2023).
Am J Cancer Res.
PubMed:
38058798

Bruceine D suppresses CAF-promoted TNBC metastasis under TNF-α stimulation by inhibiting Notch1-Jagged1/NF-κB(p65) signaling.

Summary

TNBC has limited treatment options and poor prognosis. CAFs in the tumor microenvironment contribute to metastasis. Developing therapies targeting TNF-α and other key factors could improve outcomes for TNBC patients.

CancerImmunology
Chen H et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154928
PubMed:
38043386

Brucine D restrains colorectal cancer tumorigenesis and autophagy by downregulating circ_0068464.

Summary

Bruceine D (BD) from Brucea javanica inhibits colorectal cancer (CRC) cell proliferation, invasion, and autophagy, while promoting apoptosis. This is mediated by BD's regulation of the circ_0068464/miR-520h/ATG5 axis, suggesting potential as a CRC treatment.

CancerGastroenterology
Yang Y et al (2023).
Chem Biol Drug Des.
DOI:
10.1111/cbdd.14407
PubMed:
38040413

Brusatol enhances MEF2A expression to inhibit RCC progression through the Wnt signalling pathway in renal cell carcinoma.

Wang T et al (2023).
J Cell Mol Med.
DOI:
10.1111/jcmm.17972
PubMed:
37859585

Brucea javanica oil inhibits tongue squamous cell invasion and metastasis by regulating miR-138-EZH2 pathway.

Summary

Brucea javanica oil (BJO) inhibits tongue squamous cell carcinoma (TSCC) invasion and metastasis by up-regulating miR-138 and down-regulating EZH2, Slug, p-ERK1/2, and Vimentin through the miR-138-EZH2 pathway. This suggests a potential therapeutic strategy for TSCC.

Cancer
Jiang L et al (2023).
J Stomatol Oral Maxillofac Surg.
DOI:
10.1016/j.jormas.2023.101611
PubMed:
37619672

Identification of the Brucea javanica Constituent Brusatol as a EGFR-Tyrosine Kinase Inhibitor in a Cell-Free Assay.

Suwattanasophon C et al (2023).
ACS Omega.
DOI:
10.1021/acsomega.3c02931
PubMed:
37576644

Inhibition of Hepatitis B Virus (HBV) replication and antigen expression by Brucea javanica (L.) Merr. oil emulsion.

Qin B et al (2023).
Front Cell Infect Microbiol.
DOI:
10.3389/fcimb.2023.1193775
PubMed:
37560319

In silico study of phytochemicals contained in Brucea javanica in inhibiting the InhA enzyme as antituberculosis.

Sulistyowaty MI et al (2023).
J Public Health Afr.
DOI:
10.4081/jphia.2023.2518
PubMed:
37492543

Bruceine D Acts as a Potential Insecticide by Antagonizing 20E-EcR/USP Signal Transduction.

Chen D et al (2023).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.3c02275
PubMed:
37478461

Exploring the Mechanism of Brucea Javanica against Ovarian Cancer based on Network Pharmacology and the Influence of Luteolin on the PI3K/AKT Pathway.

Summary

Researchers studied the Chinese herbal medicine Brucea javanica for ovarian cancer treatment. Its effectiveness and mechanism were unknown, but if proven effective, it could offer new treatment options for this frequently diagnosed cancer.

CancerEndocrinology
Zhu J et al (2023).
Comb Chem High Throughput Screen.
DOI:
10.2174/1386207326666230627114111
PubMed:
37366364

Intrapleural injection of brucea javanica oil emulsion provided a long-term benefits in patient with malignant pleural effusion from pleural mesothelioma: A case report.

Zhou H et al (2023).
Explore (NY).
DOI:
10.1016/j.explore.2023.06.001
PubMed:
37286465

Network meta-analysis of 8 types of traditional Chinese medicine injection combined with chemotherapy in colorectal cancer treatment.

Summary

Researchers compared 8 traditional Chinese medicine injections with chemotherapy for treating colorectal cancer, using network meta-analysis to find the best approach and enhance outcomes.

Review CancerGastroenterology
Gao W and Zhang K (2023).
J Cancer Res Clin Oncol.
DOI:
10.1007/s00432-023-04892-y
PubMed:
37246189

Application of a Novel Multicomponent Nanoemulsion to Tumor Therapy Based on the Theory of "Unification of Drugs and Excipients".

Cancer
Li Q et al (2023).
Pharm Dev Technol.
DOI:
10.1080/10837450.2023.2196330
PubMed:
36971746

Comparative efficacy and safety of Chinese medicine injections combined with capecitabine and oxaliplatin chemotherapies in treatment of colorectal cancer: A bayesian network meta-analysis.

Cancer
Liu S, Zhang K and Hu X (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.1004259
PubMed:
36523501

[Research progress in chemical constituents, pharmacological activity, and quality markers of Bruceae Fructus].

Xu SY et al (2022).
Zhongguo Zhong Yao Za Zhi.
DOI:
10.19540/j.cnki.cjcmm.20220604.201
PubMed:
36472022

Investigation on the efficiency of Brucea javanica oil emulsion injection with chemotherapy for treating malignant pleural effusion: A meta-analysis of randomized controlled trials.

Cancer
Shi R et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.998218
PubMed:
36188623

Brucea javanica oil emulsion significantly improved the effect of anti-programmed cell death protein-1 immunotherapy.

Meng J et al (2022).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154446
PubMed:
36182799

Bruceine D may affect the phenylpropanoid biosynthesis by acting on ADTs thus inhibiting Bidens pilosa L. seed germination.

Tong Y et al (2022).
Ecotoxicol Environ Saf.
DOI:
10.1016/j.ecoenv.2022.113943
PubMed:
35999761

Brucea javanica Oil Emulsion Promotes Autophagy in Ovarian Cancer Cells Through the miR-8485/LAMTOR3/mTOR/ATG13 Signaling Axis.

Cancer
Wang Y et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.935155
PubMed:
35959437

Brujavanoids A-U, structurally diverse apotirucallane-type triterpenoids from Brucea javanica and their anti-inflammatory effects.

Immunology
Hu ZF et al (2022).
Bioorg Chem.
DOI:
10.1016/j.bioorg.2022.106012
PubMed:
35830756

Efficacy and safety of Brucea javanica oil emulsion injection as adjuvant therapy for cancer: An overview of systematic reviews and meta-analyses.

Review Cancer
Chen J et al (2022).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154141
PubMed:
35598523

A New C22-Quassinoid with Anti-Pancreatic Adenocarcinoma Activity from Seeds of Brucea javanica.

Yang CB et al (2022).
Chem Biodivers.
DOI:
10.1002/cbdv.202101004
PubMed:
35514039

Hyperthermia-sensitive liposomes containing brucea javanica oil for synergistic photothermal-/chemo-therapy in breast cancer treatment.

Cancer
Huang Y et al (2023).
Curr Drug Deliv.
DOI:
10.2174/1567201819666220411115632
PubMed:
35410599

Major Constituents From Brucea javanica and Their Pharmacological Actions.

Review
Zhang J et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.853119
PubMed:
35370639

Brusatol inhibits the growth of renal cell carcinoma by regulating the PTEN/PI3K/AKT pathway.

Wang T et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115020
PubMed:
35066068

Phytochemical and biological activities of an anticancer plant medicine: Brucea javanica.

Review CancerPhytochemistry
Zhao L et al (2014).
Anticancer Agents Med Chem.
PubMed:
24066797