Caesalpinia sappan

Common Names: sappanwood

Ethnobotanical Studies

Studies

The efficacy of topically applied Sappan wood (Caesalpinia sappan L.) ethanol extract during incision wound healing in albino rats.

Sucita RE et al (2024).
Open Vet J.
DOI:
10.5455/OVJ.2024.v14.i7.5
PubMed:
39175965

Brazilin cream from Caesalpinia sappan inhibit periodontal disease: in vivo study.

Sugiaman VK et al (2024).
PeerJ.
DOI:
10.7717/peerj.17642
PubMed:
38978754

Antioxidant, antiglycation, and antibacterial of copper oxide nanoparticles synthesized using Caesalpinia Sappan extract.

Immunology
Sasarom M et al (2024).
Drug Discov Ther.
DOI:
10.5582/ddt.2024.01030
PubMed:
38945877

Pharmaceutical activity of sappan wood extract (Caesalpinia sappan L.) for treating Escherichia coli infection in piglets.

Chukiatsiri K, Tippaya K and Ngasaman R (2024).
Open Vet J.
DOI:
10.5455/OVJ.2024.v14.i4.4
PubMed:
38808290

Anti-pancreatic cancer activity of cassane diterpenoids isolated from the seeds of Caesalpinia sappan mediated by autophagy activation via ROS/AMPK/mTORC1 pathway.

Summary

Researchers isolated new cassane diterpenoids from Caesalpinia sappan seeds. Compound 4 showed anti-cancer activity against pancreatic cancer cells by inducing autophagy through the ROS/AMPK/mTORC1 pathway. This suggests potential for 4 as a therapy for pancreatic cancer.

Cancer
Su J et al (2024).
Phytochemistry.
DOI:
10.1016/j.phytochem.2024.114105
PubMed:
38657886

Tetracyclic homoisoflavanoid (+)-brazilin: a natural product inhibits c-di-AMP-producing enzyme and Streptococcus mutans biofilms.

Rojas EM et al (2024).
Microbiol Spectr.
DOI:
10.1128/spectrum.02418-23
PubMed:
38591917

Article review: Brazilin as potential anticancer agent.

Summary

Brazilin, a compound in traditional herbal medicine, shows promise as an anti-cancer agent with cytotoxic effects on various cancers and iron-chelating abilities. This research suggests brazilin could be a future chemo-preventive and anticancer treatment.

Review Cancer
Raptania CN et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1355533
PubMed:
38515856

Immune response enhancement by dietary supplementation with Caesalpinia sappan extract in weaned pigs challenged with porcine reproductive and respiratory syndrome virus.

Arjin C et al (2024).
BMC Vet Res.
DOI:
10.1186/s12917-024-03911-5
PubMed:
38515094

Effects of Dietary Supplementation with Caesalpinia sappan Linn. Extract for Promoting Flock Health and Performance in Late-Phase Laying Hens.

Longchuphon M et al (2024).
Animals (Basel).
DOI:
10.3390/ani14030515
PubMed:
38338157

Effective constituents and protective effect of Mudan granules against Schwann cell injury.

Shi Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117692
PubMed:
38176668

Ethyl acetate extracted from the chinese medicinal plant Caesalpinia sappan L alleviates gustatory response in diabetes mellitus rats.

Summary

EtOAc extracts of C. sappan have a beneficial effect on taste-regulatory peptides in vallate papillae and the hypothalamus, suggesting their potential in controlling diseases and possibly improving gustatory response in diabetes mellitus.

Diabetes
Cao X, Cui L and Yang W (2023).
Histol Histopathol.
DOI:
10.14670/HH-18-676
PubMed:
37997936

Effects of Encapsulation of Caesalpinia sappan L. with Cyclodextrins for Bovine Mastitis.

Chaisri W et al (2023).
AAPS PharmSciTech.
DOI:
10.1208/s12249-023-02687-5
PubMed:
37964017

In Vitro Synergistic Inhibitory Effects of Plant Extract Combinations on Bacterial Growth of Methicillin-Resistant Staphylococcus aureus.

Jeong JY et al (2023).
Pharmaceuticals (Basel).
DOI:
10.3390/ph16101491
PubMed:
37895962

Brazilin from Caesalpinia sappan L. as a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitor: Pharmacophore-Based Virtual Screening, In Silico Molecular Docking, and In Vitro Studies.

Iqbal M et al (2023).
Adv Pharmacol Pharm Sci.
DOI:
10.1155/2023/5932315
PubMed:
37860715

Sappanone A Alleviates the Severity of Carbon Tetrachloride-Induced Liver Fibrosis in Mice.

Qi J et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12091718
PubMed:
37760020

A Comprehensive Review on Bioactive Compounds Found in Caesalpinia sappan.

Review
Vij T et al (2023).
Molecules.
DOI:
10.3390/molecules28176247
PubMed:
37687076

Analytical determination, antioxidant and anti-inflammatory activities of Bhamrung-Lohit a traditional Thai medicine.

Summary

Researchers studied traditional Thai medicine BRL, assessing its antioxidant and anti-inflammatory properties and developing a new analytical method. Results provide health benefits insights and a reliable analysis method.

Immunology
Panchakul C et al (2023).
Res Pharm Sci.
DOI:
10.4103/1735-5362.378091
PubMed:
37614616

Biosynthesis of copper oxide nanoparticles using Caesalpinia sappan extract: In vitro evaluation of antifungal and antibiofilm activities against Candida albicans.

Summary

The researchers used Caesalpinia sappan extract to synthesize copper oxide nanoparticles (CuONPs) and investigated the effects of pH on their properties. CuONPs synthesized at pH 10 and 12 showed positive results against Candida albicans, suggesting potential use in treating fungal infection and biofilms.

Antimicrobial
Sasarom M et al (2023).
Drug Discov Ther.
DOI:
10.5582/ddt.2023.01032
PubMed:
37612046

Moisturized and non-irritating hand gel based on sappan wood (Caesalpinia sappan l.) and limau citrus peel (Citrus amblycarpa (hassk.) ochse) extracts.

Sari DY et al (2023).
J Public Health Afr.
DOI:
10.4081/jphia.2023.2509
PubMed:
37492550

Identification and pathogenicity of multidrug-resistant Elizabethkingia miricola isolated from farmed American bullfrogs Rana catesbeiana in China with in vitro screening of herbal antimicrobial agents.

Antimicrobial
Liu F et al (2023).
J Aquat Anim Health.
DOI:
10.1002/aah.10185
PubMed:
37334434

Guided Isolation of New Cytotoxic Cassane Diterpenoids from Caesalpinia sappan.

Jin Y et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202300211
PubMed:
37014182

Brazilein inhibits epithelial-mesenchymal transition (EMT) and programmed death ligand 1 (PD-L1) expression in breast cancer cells.

Cancer
Wudtiwai B et al (2023).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2023.109988
PubMed:
36933493

Brazilin from Caesalpinia sappan inhibits viral infection against PRRSV via CD163(ΔSRCR5) MARC-145 cells: an in silico and in vitro studies.

Arjin C et al (2022).
Sci Rep.
DOI:
10.1038/s41598-022-26206-x
PubMed:
36517668

Sappanone A Aggrandises Ionising Radiation-induced Damage in Oral Epithelial Cells.

Zhao XF et al (2022).
Chin J Dent Res.
DOI:
10.3290/j.cjdr.b3628117
PubMed:
36479890

Inhibitory Effects of Selected Medicinal Plants on Bacterial Growth of Methicillin-Resistant Staphylococcus aureus.

Jung IG et al (2022).
Molecules.
DOI:
10.3390/molecules27227780
PubMed:
36431886

Caesalpinia sappan Linn. Ameliorates Allergic Nasal Inflammation by Upregulating the Keap1/Nrf2/HO-1 Pathway in an Allergic Rhinitis Mouse Model and Nasal Epithelial Cells.

Immunology
Pyun BJ et al (2022).
Antioxidants (Basel).
DOI:
10.3390/antiox11112256
PubMed:
36421442

Ethyl acetate extract of Caesalpinia sappan L. for the treatment of atherosclerosis in ApoE(-/-) mice and its mechanism.

Liu Z et al (2022).
Mol Omics.
DOI:
10.1039/d2mo00254j
PubMed:
36367369

Protective role of Caesalpinia sappan extract and its main component brazilin against blue light-induced damage in human fibroblasts.

Park JI et al (2022).
J Cosmet Dermatol.
DOI:
10.1111/jocd.15354
PubMed:
36057446

Brazilein as an alternative pigment: Isolation, characterization, stability enhancement and food applications.

Review Genetics
Ngamwonglumlert L and Devahastin S (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2022.133898
PubMed:
35969994

Comparison between patch test results of natural dyes and standard allergens in batik workers with occupational contact dermatitis.

Dermatology
Diana EDN et al (2022).
Cutan Ocul Toxicol.
DOI:
10.1080/15569527.2022.2077751
PubMed:
35771736

Development of Intelligent Gelatin Films Incorporated with Sappan (Caesalpinia sappan L.) Heartwood Extract.

Cardiology
Romruen O et al (2022).
Polymers (Basel).
DOI:
10.3390/polym14122487
PubMed:
35746061

Brazilin: Biological activities and therapeutic potential in chronic degenerative diseases and cancer.

Review Cancer
Nava-Tapia DA et al (2022).
Pharmacol Res.
DOI:
10.1016/j.phrs.2021.106023
PubMed:
34883212

Protective Effects of Caesalpinia sappan Linn. and Its Bioactive Compounds on Cardiovascular Organs.

Review Cardiology
Syamsunarno MRA, Safitri R and Kamisah Y (2021).
Front Pharmacol.
DOI:
10.3389/fphar.2021.725745
PubMed:
34603037

Activity Screening of the Herb Caesalpinia sappan and an Analysis of Its Antitumor Effects.

Cancer
Li Y et al (2021).
Evid Based Complement Alternat Med.
DOI:
10.1155/2021/9939345
PubMed:
34257693