Common Names: grass, hashish, hemp, marijuana, Mary Jane, pot
A trial examined the effects of CBD on cognitive and psychomotor function in healthy college students. Results showed increased attention lapse duration and slight improvement in auditory reaction time with CBD. However, larger trials are needed to fully comprehend CBD's impact on cognition.
CBD may be a safer and effective adjunctive therapy for schizophrenia, with antipsychotic, anxiolytic, and neuroprotective effects. Research is needed to fully understand its potential benefits and interactions with traditional antipsychotics.
Researchers studied the role of cannabidiol (CBD) in treating neurodegenerative disorders through its antioxidant, anti-inflammatory, and neuroprotective properties. CBD shows promise in inhibiting protein aggregation, free radicals, and neuroinflammation, making it a potential therapeutic option for conditions like Alzheimer's and Parkinson's.
CBD has potential anti-cancer, anti-inflammatory, and pain-relieving properties, but more research is needed to understand its therapeutic effects on oral mucositis.
Lebanese scientists studied how cannabis extracts from Cannabis sativa can help treat arthritis, diabetes, and cancer. Knowing this can help us find new natural remedies for these illnesses.
Study extracted and analyzed hemp essential oil (HEO) components, showing potential anti-tumor and anti-neuropathic pain effects. HEO reduced inflammatory cytokines and inhibited tumor growth in mice models, suggesting potential in cancer treatment and medicinal development of hemp.
Researchers tested 5 minor cannabinoids in mice for pain relief and cannabimimetic behaviors. Findings show potential differences between compounds and sexes, warranting further investigation into therapeutic benefits of minor cannabinoids. Significant for understanding effects of lesser-studied compounds in marijuana.
CBD interacts with D1-like dopamine receptors in the hippocampus to reduce METH-seeking behavior. This suggests CBD may be a potential treatment for methamphetamine addiction.
Researchers studied four strains of that were causing diseases in hemp plants. The strains had genome sizes between 42.8 and 44.4 Mb and contained approximately 16,500 genes. Understanding these strains can help improve management of diseases in hemp crops.
CBD improves cognition and activates microglia shift in AD model mice. It enhances gut barrier, reduces toxic metabolites, and lowers LPS levels, suggesting a potential therapeutic role in AD.
Researchers identified Cannabis sativa L. as a potent inhibitor of MRSA, with cannabidiol and Δ9-THC showing bactericidal action. This plant-based alternative may help combat antimicrobial resistance in bovine biofilm-associated MRSA infections.
Cannabidiol (CBD) from Cannabis sativa L. shows neuroprotective effects on CNS diseases via interactions with endocannabinoid system and 5-HT receptor, offering potential treatment for epilepsy, Parkinson's, and multiple sclerosis. Further research needed for stronger evidence.
Researchers developed a synthetic polymer nano-system for delivering CBD to improve its effectiveness in treating neuroinflammation. This system shows promising results in restoring mitochondrial function in cells after ischemic events. Worth considering for preclinical studies.
Study shows CBD from Cannabis sativa protects brain from I/R injury in heart. Potential neuroprotective and therapeutic benefits. Worth exploring for organ damage prevention.
CBD, found in Cannabis sativa, induces cell death in colorectal cancer cells. It activates the MAPK pathway, leading to apoptosis, paraptosis, and autophagy. This suggests that CBD could be a potential treatment for colorectal cancer.
The researchers investigated the antimicrobial effect of cannabidiol (CBD) on Mycobacterium tuberculosis (TB). CBD exhibited antimicrobial activity against TB and reduced intracellular bacteria in infected cells without toxicity to human cells. This suggests that CBD could be a potential treatment for TB.
CBD from Cannabis sativa has potential for delaying aging and treating Alzheimer's disease (AD). This article explores the correlation between cellular senescence, aging, and AD, and summarizes the role and mechanisms of CBD in preventing aging and treating AD.
Researchers identified expression patterns in ethylene-related genes (ERGs) associated with sexual determination in Cannabis sativa. They proposed a new pattern called karyotype concordant (KC) expression and found that ERGs related to sexual plasticity are widespread. This could inform regulation decisions for sexual plasticity in the plant.
This study identified three prenylflavonoids from leaves that show potential against SARS-CoV-2. The compounds have structural similarities to a ligand of the virus' Papain-Like Protease and successfully bind to its active pocket. Further research is needed to confirm their effectiveness and safety.
Study on HIIT + hemp seed in sedentary males: ↑ TT, SHBG, antioxidant capacity, ↓ oxidative stress. Potential benefits for exercise performance and overall health.
Researchers analyzed cannabinoids using gas chromatography, a common technique. Cannabinoids have properties similar to those in Cannabis sativa. This study may help in the analysis of cannabinoids in various substances.
Cannabinoids from Cannabis sativa have therapeutic potential for CNS diseases. This review summarizes their effects in cellular, animal, and human trials, suggesting their use for neurological disorders.
This study developed a method to analyze and quantify 15 cannabinoids in cannabis. The method was sensitive, selective, reproducible, and accurate, making it useful for determining these compounds in cannabis plant materials and cannabis-based products.
Researchers developed biparental populations of Cannabis sativa to study powdery mildew (PM) susceptibility. They identified a major QTL on chromosome 1 and smaller QTLs on four other chromosomes, suggesting a mutated MLO susceptibility gene that could be used to develop resistant cultivars. (42 words)
Researchers obtained an enriched fraction of polyphenols from non-psychoactive hemp and evaluated its potential as a therapeutic product against colorectal cancer. Promising antiproliferative activity was observed, suggesting further investigation is warranted.
Recent preclinical studies suggest that THC-containing cannabis extracts have limited effectiveness and are associated with side effects. Therefore, it is important to focus on targeting channels and receptors other than cannabinoid CB1 receptors to improve the treatment of chronic neuropathic pain.
Researchers investigated the impact of different solvents on extracting beneficial compounds from Cannabis sativa L. This study is important for understanding which extraction method is best suited for obtaining cannabinoids, which have health benefits.
Scientists developed a method to separate and analyze carboxylated phytocannabinoids, their derivatives, and investigated chiral analysis and racemization parameters. It aids in understanding different Cannabis varieties.
This study found that hemp seed oil (HSO) improved depression-like behavior in rats by regulating hormone levels and neurotransmitter function. It suggests that HSO may have potential as a natural antidepressant.
CBD, a compound found in cannabis plants, has powerful antiviral properties against Zika virus and other viruses. It also modulates the immune response and affects cellular membranes, making it a potential treatment option for viral outbreaks.
This study examined the effects of combining codeine, tramadol, and Cannabis sativa on the brain function of rats. The results showed that prolonged administration of these substances suppressed cognitive function and enzyme activities, leading to neurotoxicity.
Scientists seized a suspicious powder labeled as "nutmeg" but it smelled like cannabis. They tested it using chemicals and cannabis DNA to confirm it was actually cannabis. This highlights the need for proper regulation and identification of cannabis products.
Researchers analyzed the accuracy of cannabinoid labels in commercial hemp products. This is important because incorrect labeling affects consumers' ability to make informed decisions about their usage.
This study analyzed data from middle-aged adults and found that a history of monthly cannabis use >1 year before a heart attack was not associated with a heart attack, except when cannabis was not used within the past month.
Researchers have found that cannabinoids, compounds derived from the Cannabis sativa plant, have anti-cancer effects and could be potential treatments for gynecological cancers. Non-psychoactive cannabinoids show promise in treating ovarian cancer, but more research is needed.
Hemp seed proteins have hypoglycemic effects. Researchers found six potential hypoglycemic peptides through enzymatic hydrolysis. In animal experiments, these peptides reduced blood glucose levels, showing promise for treating hyperglycemia.
This review discusses the potential therapeutic benefits of using kratom and cannabis compounds together for chronic pain. More research is needed to understand their effectiveness.
Cannabinoids from L. show antiviral effects against SARS-CoV-2 variants. Cannabidiolic acid (CBDA) is the most active compound, but its instability led researchers to develop a more effective CBDA methyl ester. It effectively neutralized all variants and could be a potential COVID-19 drug.
Cannabis sativa L. has been used medicinally for centuries, but research on its effects and properties was limited until its recent legalization in many countries.
Terpenoid compounds found in Cannabis sativa plants, specifically the delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), have already shown central and peripheral activities in treating brain diseases like Alzheimer's and multiple sclerosis. In this study, we examined the effects of CBD- and THC-rich oils on aluminum (Al)-induced toxicity using the zebrafish model. We measured behavioral biomarkers and biochemical markers related to neurotoxicity. The results showed that the oils increased the activity of the enzyme acetylcholinesterase, which helped the cholinergic nervous system combat Al toxicity. These findings suggest that CBD- and THC-based oils may protect against neurological and antioxidant impairment caused by Al intoxications, and could have potential in preventing related conditions.
CBD reduced anxiety, pain hypersensitivity, and anhedonic behavior in mice with a partner in chronic pain. It also reversed chronic pain-induced anxiety and improved withdrawal thresholds, grooming behavior, and the partner's symptoms. CBD may help alleviate pain-related symptoms in individuals and their close contacts.
Researchers used a metabolomics approach to identify potential biomarkers in Alzheimer's disease (AD) rats treated with Streptozotocin. They found that primary bile acid biosynthesis and taurine and hypotaurine metabolism were significantly correlated with AD rats, and key enzymes affecting these pathways were verified at the protein level. In rats treated with a high dose of PHS (from Cannabis sativa), the levels of certain key enzymes were restored. This study shows that PHS has a protective effect on AD by regulating bile acid biosynthesis and taurine/hypotaurine metabolism.
Recreational use of certain cannabinoid agonists in herbal blends can cause cardiovascular events. JWH-073 may have greater vascular adverse effects than Δ-THC.
Traumatic brain injury can have debilitating consequences, with even mild injuries leaving approximately 20% of patients with persistent symptoms. Current pharmaceutical interventions have not improved outcomes after TBI. Research has focused on the endocannabinoid system and the therapeutic benefits of cannabis, including cannabinoids and terpenes. Cannabinoids interact with neurons, microglia, and astrocytes, exerting anti-inflammatory and neuroprotective effects that are desirable for TBI management. This review comprehensively appraises the scientific literature on phytocannabinoids, synthetic and endogenous cannabinoids, and terpenes in TBI and other neurological conditions.
This article discusses the historical relevance of the approval of cannabidiol (CBD) for epilepsy treatment. Unlike its related compound, marijuana's Δ9-tetrahydrocannabinol, CBD does not have any euphorigenic or withdrawal effects at anticonvulsant doses. CBD also has anti-inflammatory properties. Though CBD's anticonvulsant properties were suggested in a few studies in rodent seizure models, social and regulatory pressures kept it from being clinically implemented. However, CBD was approved for the orphan disease Dravet syndrome in 2018 after its efficacy was established in randomized, placebo-controlled trials in children. The article suggests that CBD's approval is a key driver of a new discovery strategy for epilepsy treatment in the 21st century.
This study looked at the effects of two major cannabinoids, delta-9-tetrahydrocannabinol and cannabidiol, on brain metabolites using human and animal studies. The researchers found evidence that these cannabinoids may alter brain metabolite levels in distinct ways from each other, but more research is needed. Understanding these effects could help improve the design of future studies of cannabinoids on brain metabolites.