Researchers have found that a specific polysaccharide, called α-1,6-galactan, derived from the chanterelle mushroom, can improve memory and reduce the harmful buildup of amyloid plaques in Alzheimer's disease (AD) mice. By reducing the molecular weight of the polysaccharide, its absorption and solubility are improved, leading to better results. The study suggests that these effects are due to the polysaccharide's anti-neuroinflammatory properties. This research may contribute to the development of new treatments for AD using natural polysaccharides.
Researchers investigated the neuroprotective properties of Cantharellus cibarius polysaccharides fractions in models of neurodegeneration. The fractions were tested for their influence on neuron viability and antioxidant capacity using various tests. The studies revealed that two tested fractions (CC2a, CC3) had a beneficial effect on neuron viability and outgrowth, as well as demonstrated antioxidant capacity, effectively countering negative changes induced by glutamatergic system activators. These findings suggest that the investigated compounds could be developed for a safe and effective strategy for treating neurodegenerative diseases.