Cardiospermum halicacabum

Common Names: balloonvine, love in a puff

Ethnobotanical Studies

Studies

Evaluation of Cardiospermum halicacabum on Bone Morphogenetic Protein-2 (BMP2) mRNA Expression in Osteoblast Cells.

Genetics
Zuvairiya U, R P and Palati S (2024).
Cureus.
DOI:
10.7759/cureus.60292
PubMed:
38872645

Design, optimization, and evaluation of topical gel of Cardiospermum halicacabum and Ricinus communis L. leaves extract for the treatment of rheumatoid arthritis.

Arthritis
Ojha C, Sharma P and Jain V (2024).
J Biomater Sci Polym Ed.
DOI:
10.1080/09205063.2024.2340872
PubMed:
38613797

Constructing indicator species distribution models to study the potential invasion risk of invasive plants: A case of the invasion of Parthenium hysterophorus in China.

Liu J et al (2023).
Ecol Evol.
DOI:
10.1002/ece3.10672
PubMed:
37920769

Antibacterial, antifungal, and antioxidant competence of Cardiospermum halicacabum based nanoemulsion and characterized their physicochemical properties.

Summary

This research evaluated two types of nanoemulsions, CHE-NE-A and CHE-NE-B, for their potential as drug carriers. CHE-NE-A showed better drug release, antioxidant activity, antibacterial activity, and antifungal activity compared to CHE-NE-B. It may be considered as a useful drug carrier.

AntimicrobialImmunologyPhytochemistry
Sayanam RRA et al (2023).
3 Biotech.
DOI:
10.1007/s13205-023-03703-y
PubMed:
37520341

Purification, biochemical characterization, and DPP-IV and α-amylase inhibitory activity of Berberine from Cardiospermum halicacabum.

Naik S et al (2022).
J Mol Recognit.
DOI:
10.1002/jmr.2983
PubMed:
35852019

Ethnomedical, phytochemical and pharmacological insights on an Indian medicinal plant: The balloon vine (Cardiospermum halicacabum Linn.).

Review Phytochemistry
Elangovan A et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115143
PubMed:
35227784

Virtual screening of natural products inspired in-house library to discover potential lead molecules against the SARS-CoV-2 main protease.

Summary

Researchers have identified four potential inhibitors of the SARS-CoV-2 Main protease, an important protein for viral replication. The ligands were evaluated based on docking scores, predicted binding energies, and in silico ADME analysis. One of the top ligands is a natural product from Andrographis nallamalayana, which exhibited a high binding energy close to clinical candidates Boceprevir and GC376. The lead molecules also showed stable interactions with the viral protease during replicated MD simulations. These findings provide a promising opportunity for developing drug candidates to combat COVID-19.

COVID-19
Garg A et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2022.2027271
PubMed:
35043750

In vitro study of the antioxidant, antiproliferative, and anthelmintic properties of some medicinal plants of Kokrajhar district, India.

CancerImmunology
Swargiary A, Roy MK and Verma AK (2021).
J Parasit Dis.
DOI:
10.1007/s12639-021-01410-0
PubMed:
34789998

Design of a Nasal Spray Based on Cardiospermum halicacabum Extract Loaded in Phospholipid Vesicles Enriched with Gelatin or Chondroitin Sulfate.

Casula E et al (2021).
Molecules.
DOI:
10.3390/molecules26216670
PubMed:
34771079

Antioxidant and Antiinflammatory Effects of Epilobium parviflorum, Melilotus officinalis and Cardiospermum halicacabum Plant Extracts in Macrophage and Microglial Cells.

Immunology
Merighi S et al (2021).
Cells.
DOI:
10.3390/cells10102691
PubMed:
34685671

Comparison of characteristics and biocompatibility of green synthesized iron oxide nanoparticles with chemical synthesized nanoparticles.

Dowlath MJH et al (2021).
Environ Res.
DOI:
10.1016/j.envres.2021.111585
PubMed:
34181925

Cardiospermum halicacabum in atopic dermatitis: Clinical evidence based on phytotherapic approach.

Dermatology
Fai D et al (2020).
Dermatol Ther.
DOI:
10.1111/dth.14519
PubMed:
33169921

Seed dormancy of Cardiospermum halicacabum (Sapindaceae) from three precipitation zones in Sri Lanka.

Thusithana V et al (2021).
Plant Biol (Stuttg).
DOI:
10.1111/plb.13189
PubMed:
32989855

Quantitative analysis of medicinal plants used to treat musculoskeletal ailments by non-institutionally trained siddha practitioners of Virudhunagar district, Tamil Nadu, India.

Esakkimuthu S et al (2021).
J Ayurveda Integr Med.
DOI:
10.1016/j.jaim.2018.11.005
PubMed:
31003860

Antifungal activity of Cardiospermum halicacabum L. (Sapindaceae) against Trichophyton rubrum occurs through molecular interaction with fungal Hsp90.

Antimicrobial
Gaziano R et al (2018).
Drug Des Devel Ther.
DOI:
10.2147/DDDT.S155610
PubMed:
30034223

Evaluation of Aqueous Leaf Extract of Cardiospermum halicacabum (L.) on Fertility of Male Rats.

Peiris LD, Dhanushka MA and Jayathilake TA (2015).
Biomed Res Int.
DOI:
10.1155/2015/175726
PubMed:
26064883

Pharmacognostical evaluation of Cardiospermum halicacabum Linn. leaf and stem.

Zalke AS et al (2013).
Anc Sci Life.
DOI:
10.4103/0257-7941.134561
PubMed:
25161325

Repellent properties of Cardiospermum halicacabum Linn. (Family: Sapindaceae) plant leaf extracts against three important vector mosquitoes.

Govindarajan M and Sivakumar R (2012).
Asian Pac J Trop Biomed.
DOI:
10.1016/S2221-1691(12)60105-1
PubMed:
23569979

Protective effect of Cardiospermum halicacabum leaf extract on glycoprotein components on STZ-induced hyperglycemic rats.

Diabetes
Veeramani C et al (2012).
Asian Pac J Trop Med.
DOI:
10.1016/S1995-7645(12)60178-3
PubMed:
23199710

Cardiospermum halicacabum ethanol extract inhibits LPS induced COX-2, TNF-alpha and iNOS expression, which is mediated by NF-kappaB regulation, in RAW264.7 cells.

Immunology
Sheeba MS and Asha VV (2009).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2009.04.020
PubMed:
19393729