Carthamus tinctorius

Common Names: safflower

Ethnobotanical Studies

Clinical Trials

Safflower (Carthamus tinctorius L.) oil could improve abdominal obesity, blood pressure, and insulin resistance in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled clinical trial.

Safflower has been used in traditional medicine for metabolic disorders. It has anti-hypercholesterolemic and antioxidant effects, but its protective effects against Metabolic Syndrome need further research.

Ruyvaran M et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2021.114590
PubMed:
34487844

Studies

Carthamus tinctorius L. inhibits hepatic fibrosis and hepatic stellate cell activation by targeting the PI3K/Akt/mTOR pathway.

Dong Z et al (2024).
Mol Med Rep.
DOI:
10.3892/mmr.2024.13314
PubMed:
39219289

Elucidating hydroxysafflor yellow A's multi-target mechanisms against alcoholic liver disease through integrative pharmacology.

Yu HC et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155956
PubMed:
39216301

Biochar application affected biochemical properties, yield and nutrient content of safflower under water stress.

Ghaedi M et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-71131-w
PubMed:
39215054

XueBiJing injection improves the symptoms of sepsis-induced acute lung injury by mitigating oxidative stress and ferroptosis.

Immunology
Zou F et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118732
PubMed:
39181287

Influence of furcellaran and safflower oil concentration on the properties of model emulgel systems.

Stępień A et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.134751
PubMed:
39173801

Safflower Alleviates Pulmonary Arterial Hypertension by Inactivating NLRP3: A Combined Approach of Network Pharmacology and Experimental Verification.

Summary

Study explores how safflower treats pulmonary arterial hypertension. Fill gaps in knowledge on mechanisms behind safflower's effectiveness. Relevant for developing treatments for PAH.

Cardiology
Ding S et al (2024).
Clin Respir J.
DOI:
10.1111/crj.13826
PubMed:
39155275

Systematic Review of Preclinical Studies on the Efficacy and Mechanisms of Herbal Medicines in Post-Myocardial Infarction Heart Failure with Reduced Ejection Fraction.

Summary

Researchers reviewed studies of traditional herbal medicines on heart failure with reduced ejection fraction in rodent models. Common herbs showed positive effects on heart function, but more research is needed to understand timing of treatment for optimal results.

Review Cardiology
Yun S et al (2024).
Medicina (Kaunas).
DOI:
10.3390/medicina60071101
PubMed:
39064530

Safflower cake as an ingredient for a composite flour development towards a circular economy: extrusion versus conventional mixing.

Amadeu CAA et al (2024).
Food Res Int.
DOI:
10.1016/j.foodres.2024.114609
PubMed:
39059893

Efficacy of Astragalus membranaceus-Carthamus tinctorius in cerebral ischemia/reperfusion injury: Insights from metabolomics and mass spectrometry imaging.

Summary

AC combo is effective in treating brain injury. Studying brain metabolism is key to understanding injury mechanisms and AC benefits. More research needed for in-depth understanding.

Cardiology
Zhao D et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155881
PubMed:
39059267

Absorption enhancement of peach kernel oil on hydroxysafflor yellow A in safflower extracts and its mechanisms.

Ye T et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.140218
PubMed:
38964104

Genetic Gain and Inbreeding in Different Simulated Genomic Selection Schemes for Grain Yield and Oil Content in Safflower.

Zhao H et al (2024).
Plants (Basel).
DOI:
10.3390/plants13111577
PubMed:
38891385

α-Glucosidase, butyrylcholinesterase and acetylcholinesterase inhibitory activities of phenolic compounds from Carthamus tinctorius L. flowers: In silico and in vitro studies.

Summary

Scientists found seven metabolites in L. flowers with potential benefits for Alzheimer's disease and hyperglycemia. Compounds showed promising inhibitory effects on key enzymes and antioxidant activity. Worth exploring for potential therapeutic applications.

NeurosciencePhytochemistry
Alotaibi JAM et al (2024).
Saudi Pharm J.
DOI:
10.1016/j.jsps.2024.102106
PubMed:
38831925

Quercetin improves the protection of hydroxysafflor yellow a against cerebral ischemic injury by modulating of blood-brain barrier and src-p-gp-mmp-9 signalling.

Summary

HSYA and Quer from a plant protect the blood-brain barrier in stroke, improving outcomes and reducing neural damage. They target specific proteins for potential treatment benefits.

Neuroscience
Li X et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e31002
PubMed:
38803916

Niaodukang mixture inhibits micro-inflammation in CKD rats by enhancing MiR-146a levels in enterogenous exosomes.

Immunology
Liu L et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118318
PubMed:
38754642

Safflower protein as a potential plant protein powder: optimization of extraction and spray-drying process parameters and determination of physicochemical and functional properties.

Phytochemistry
Korkmaz F et al (2024).
J Sci Food Agric.
DOI:
10.1002/jsfa.13561
PubMed:
38717249

Integrated Proteomics and Metabolomics of Safflower Petal Wilting and Seed Development.

Vincent D, Reddy P and Isenegger D (2024).
Biomolecules.
DOI:
10.3390/biom14040414
PubMed:
38672431

Dried tangerine peel polysaccharide (DTPP) alleviates hepatic steatosis by suppressing TLR4/MD-2-mediated inflammation and endoplasmic reticulum stress.

Immunology
Wang L et al (2024).
Bioorg Chem.
DOI:
10.1016/j.bioorg.2024.107369
PubMed:
38640721

Chinese herbal medicine bath therapy for psoriasis vulgaris using topical calcipotriol as the comparator: A systematic review with meta-analysis and association rule analysis.

Summary

Researchers compared CHM bath therapy to topical calcipotriol for psoriasis vulgaris. CHM may be as effective as calcipotriol with added benefits from herb combinations. Consider CHM as an alternative treatment for psoriasis.

Review Dermatology
Wang J et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118166
PubMed:
38621466

Investigation into safflower injection as a prophylactic treatment for retinal vein occlusion in a rabbit model.

Li J, Guo Z and Wu J (2024).
Sci Rep.
DOI:
10.1038/s41598-024-58734-z
PubMed:
38580804

CSM-CROPGRO model to simulate safflower phenological development and yield.

Afzal O et al (2024).
Int J Biometeorol.
DOI:
10.1007/s00484-024-02662-0
PubMed:
38538982

Naodesheng decoction regulating vascular function via G-protein-coupled receptors: network analysis and experimental investigations.

Chen S et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1355169
PubMed:
38533257

Investigating the therapeutic effects and mechanisms of Carthamus tinctorius L.-derived nanovesicles in atherosclerosis treatment.

Yang R et al (2024).
Cell Commun Signal.
DOI:
10.1186/s12964-024-01561-6
PubMed:
38475787

Uncovering the Role of Hydroxycinnamoyl Transferase in Boosting Chlorogenic Acid Accumulation in Carthamus tinctorius Cells under Methyl Jasmonate Elicitation.

Liu Z et al (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25052710
PubMed:
38473957

Co-treatment with the seed of Carthamus tinctorius L. and the aerial part of Taraxacum coreanum synergistically suppresses Aβ(25-35)-induced neurotoxicity by altering APP processing.

Summary

Co-treatment with L. and aerial part of shows neuroprotective effects, increasing cell viability, inhibiting ROS production, downregulating BACE and APP, and decreasing Bax expression, suggesting potential for Alzheimer's disease prevention.

Neuroscience
He MT, Kim JH and Cho EJ (2023).
Food Sci Nutr.
DOI:
10.1002/fsn3.3768
PubMed:
38455162

Hydroxysafflor Yellow A Exerts Neuroprotective Effects by Inhibiting Protein Carbonyl Formation in Cerebral Ischemia-Reperfusion Injury.

Summary

HSYA from Carthamus tinctorius protects against cerebral ischemia-reperfusion injury by reducing protein carbonylation, improving neurological function, and enhancing antioxidant capacity through ONOO- scavenging and suppressing protein oxidation.

CardiologyNeuroscience
Zhao R et al (2024).
Altern Ther Health Med.
PubMed:
38430158

Chemical components with antibacterial properties found in sanchen powder from traditional Tibetan medicine.

Zhao Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117981
PubMed:
38417599

Growth performance, meat quality and hematological parameters of broiler chickens fed safflower seed.

Rathaur A et al (2024).
Trop Anim Health Prod.
DOI:
10.1007/s11250-024-03927-x
PubMed:
38411734

Enriched biochars with silicon and calcium nanoparticles mitigated salt toxicity and improved safflower plant performance.

Ghassemi-Golezani K, Mousavi SA and Farhangi-Abriz S (2024).
Int J Phytoremediation.
DOI:
10.1080/15226514.2024.2321167
PubMed:
38411090

Antibacterial, ROS scavenging and angiogenesis promoting ε-polylysine/gelatin based hydrogel containing CTLP to regulate macrophages for pressure ulcer healing.

Immunology
Lin P et al (2024).
Biofabrication.
DOI:
10.1088/1758-5090/ad2d2e
PubMed:
38408382

Synergistic effects of vermicompost and mycorrhizal inoculation on arsenic tolerance and phytostabilization in safflower (Carthamus tinctorius L.).

Salari H, Amooaghaie R and Mozafari H (2024).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-024-32515-7
PubMed:
38400962

Hydroxysafflor Yellow A and Tenuigenin Exhibit Neuroprotection Effects Against Focal Cerebral Ischemia Via Differential Regulation of JAK2/STAT3 and SOCS3 Signaling Interaction.

Summary

Combining natural compounds in Chinese medicine, hydroxysafflor yellow A (HSYA) and tenuigenin (TEN), shows promise in treating ischemic stroke by improving various aspects of brain function and suppressing cell apoptosis. This combination modulates signaling pathways, leading to synergistic effects against stroke.

CardiologyImmunology
Yu L et al (2024).
Mol Neurobiol.
DOI:
10.1007/s12035-023-03896-6
PubMed:
38214838

Effective constituents and protective effect of Mudan granules against Schwann cell injury.

Shi Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117692
PubMed:
38176668

Danhong formula alleviates endothelial dysfunction and reduces blood pressure in hypertension by regulating MicroRNA 24 - Phosphatidylinositol 3-Kinase-Serine/Threonine Kinase- Endothelial Nitric Oxide Synthase axis.

Summary

Researchers studied the antihypertensive effects of a Chinese medicine, Danhong Formula (DHF), to understand how it improves endothelial dysfunction and reduces high blood pressure, benefiting cardiovascular health.

Cardiology
Yang X et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117615
PubMed:
38163560

Metagenomic sequencing revealed the regulative effect of Danshen and Honghua herb pair on the gut microbiota in rats with myocardial ischemia injury.

Summary

DHHP, a Chinese herb pair, relieves myocardial ischemia in rats by regulating gut microbiota. It improves diversity and increases beneficial bacteria while reducing harmful bacteria, offering potential for MI treatment.

CardiologyGastroenterology
Du SB et al (2024).
FEMS Microbiol Lett.
DOI:
10.1093/femsle/fnad133
PubMed:
38100390

Elevated atmospheric CO(2) concentration mitigates salt damages to safflower: Evidence from physiological and biochemical examinations.

Vaghar M, Eshghizadeh HR and Ehsanzadeh P (2024).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2023.108242
PubMed:
38070243

The mechanism of Semen Persicae-Flos Carthami in treating hypertrophic scar: A study based on network pharmacological analysis and in vitro experiments.

Li X et al (2024).
Chem Biol Drug Des.
DOI:
10.1111/cbdd.14412
PubMed:
38056934

Uncovering Mechanism and Efficacy of Salvia Miltiorrhiza-Safflower in Cerebral Ischemia-Reperfusion Injury.

Summary

This study investigates the molecular regulation and therapeutic effectiveness of the Danshen-Honghua herb pair for cerebral ischemia (CI). By identifying common targets and pathways, it suggests that DH may activate the TNF-α/JNK signaling pathway for CI treatment.

Cardiology
Zhang Y et al (2024).
Neuroscience.
DOI:
10.1016/j.neuroscience.2023.11.021
PubMed:
38036060

Whole-genome and genome-wide association studies improve key agricultural traits of safflower for industrial and medicinal use.

Genetics
Chen J et al (2023).
Hortic Res.
DOI:
10.1093/hr/uhad197
PubMed:
38023481

Optimized Separation of Carthamin from Safflower by Macroporous Adsorption Resins and Its Protective Effects on PC12 Cells Injured by OGD/R via Nrf2 Signaling Pathway.

Zhang X et al (2023).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.3c05285
PubMed:
37997370

Genome-Wide Identification and Characterization of the bHLH Gene Family and Its Response to Abiotic Stresses in Carthamus tinctorius.

Genetics
Tan Z et al (2023).
Plants (Basel).
DOI:
10.3390/plants12213764
PubMed:
37960120

Plant Extracts as Skin Care and Therapeutic Agents.

Review
Michalak M et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms242015444
PubMed:
37895122

Identification and Characterization of CtUGT3 as the Key Player of Astragalin Biosynthesis in Carthamus tinctorius L.

Ren C et al (2023).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.3c05117
PubMed:
37870279

Carthamus tinctorius L. Seed and Taraxacum coreanum Attenuate Oxidative Stress Induced by Hydrogen Peroxide in SH-SY5Y Cells.

Summary

The combination of CTS and TC herbal medicines effectively protected SH-SY5Y cells from oxidative stress, increasing cell survival and reducing LDH release and apoptosis. The combination also inhibited NO and ROS generation and up-regulated antioxidant enzymes and Bcl-2 protein expression while down-regulating Bax expression. This suggests that using CTS and TC together could be beneficial for preventing and treating neurodegenerative diseases caused by oxidative stress.

Immunology
He MT et al (2023).
Foods.
DOI:
10.3390/foods12193617
PubMed:
37835271

DIA-based serum proteomics revealed the protective effect of modified siwu decoction against hypobaric hypoxia.

Tu B et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117303
PubMed:
37827297

Regulation of dormancy break and germination of safflower seeds: the role of GA3, light and cold temperatures.

Silva BNP et al (2023).
Braz J Biol.
DOI:
10.1590/1519-6984.270354
PubMed:
37820205

Genome-wide identification and comprehensive analysis of WRKY transcription factor family in safflower during drought stress.

Genetics
Song X et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-44340-y
PubMed:
37805641

[Effect of sowing dates on physiological characteristics, yield, and quality of Carthamus tinctorius].

Ma B et al (2023).
Zhongguo Zhong Yao Za Zhi.
DOI:
10.19540/j.cnki.cjcmm.20230511.101
PubMed:
37802838

Quercetin inhibits mesothelial-mesenchymal transition and alleviates postoperative peritoneal adhesions by blocking the TGF-β1/PI3K/AKT pathway.

Li G et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117242
PubMed:
37777024

Experimental and in silico evaluation of Carthamus tinctorius L. oil emulgel: a promising treatment for bacterial skin infections.

Saeed J et al (2023).
Front Cell Infect Microbiol.
DOI:
10.3389/fcimb.2023.1253095
PubMed:
37731820

Modeling hormesis using multivariate nonlinear regression in plant biology: A comprehensive approach to understanding dose-response relationships.

Amorim DJ et al (2023).
Sci Total Environ.
DOI:
10.1016/j.scitotenv.2023.167041
PubMed:
37730055

Safflower (Carthamus tinctorius L.) crop adaptation to residual moisture stress: conserved water use and canopy temperature modulation are better adaptive mechanisms.

Manikanta C et al (2023).
PeerJ.
DOI:
10.7717/peerj.15928
PubMed:
37719114

Carbon Quantum Dots Derived from Herbal Medicine as Therapeutic Nanoagents for Rheumatoid Arthritis with Ultrahigh Lubrication and Anti-inflammation.

Summary

Scientists have developed two new nanoagents derived from herbal medicine that have shown promising results in treating rheumatoid arthritis by improving joint lubrication and reducing inflammation.

ArthritisImmunology
Qiang R et al (2023).
ACS Appl Mater Interfaces.
DOI:
10.1021/acsami.3c06188
PubMed:
37535012

Metabolomics reveals the effects of hydroxysafflor yellow A on neurogenesis and axon regeneration after experimental traumatic brain injury.

Summary

Hydroxysafflor yellow A (HSYA) in safflower may treat traumatic brain injuries, a critical condition with limited treatment options, leading to potential new therapies.

Neuroscience
Hu E et al (2023).
Pharm Biol.
DOI:
10.1080/13880209.2023.2229379
PubMed:
37416997

Control of Listeria monocytogenes in a fresh cheese using aromatic and medicinal plants and enterocin: a comparative study.

Ananou S et al (2023).
Lett Appl Microbiol.
DOI:
10.1093/lambio/ovad076
PubMed:
37401169

Simultaneous Analysis of 53 Pesticides in Safflower (Carthamus tinctorius L.) by Using LC-MS/MS Coupled with a Modified QuEChERS Technique.

Song W et al (2023).
Toxics.
DOI:
10.3390/toxics11060537
PubMed:
37368637

Safflor Yellow A Protects Beas-2B Cells Against LPS-Induced Injury via Activating Nrf2.

Chen LS and Zheng DS (2023).
Rev Bras Farmacogn.
DOI:
10.1007/s43450-023-00409-3
PubMed:
37363713

The Cardioprotective Effects and Mechanisms of Astragalus-Safflower Herb Pairs on Coronary Heart Disease Identified by Network Pharmacology and Experimental Verification.

Summary

This study explores how Huang Qi and Hong Hua, Chinese herbal remedies for coronary heart disease, work together and their potential benefits.

Cardiology
Yuan Y, Liu H and Meng Q (2023).
Front Biosci (Landmark Ed).
DOI:
10.31083/j.fbl2805094
PubMed:
37258471

Complete Mitogenome and Phylogenetic Analysis of the Carthamus tinctorius L.

Wu Z et al (2023).
Genes (Basel).
DOI:
10.3390/genes14050979
PubMed:
37239339

The mechanism of action of safflower total flavonoids in the treatment of endometritis caused by incomplete abortion based on network pharmacology and 16S rDNA sequencing.

Phytochemistry
Chen Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116639
PubMed:
37201664

Hydroxysafflor yellow A attenuates allergic response of ovalbumin induced allergic rhinitis via Nrf2/HO-1 and inflammatory signaling pathways.

Immunology
Ma Q et al (2023).
Environ Toxicol.
DOI:
10.1002/tox.23783
PubMed:
37195255

Effects of Genotype and Climate on Productive Performance of High Oleic Carthamus tinctorius L. under Rainfed Conditions in a Semi-Arid Environment of Sicily (Italy).

Genetics
Licata M et al (2023).
Plants (Basel).
DOI:
10.3390/plants12091733
PubMed:
37176792

Effect of Jiawei Tongqiao Huoxue decoction in basilar artery dolichoectasia mice through yes-associated protein/transcriptional Co-activator with PDZ-binding motif pathway.

Liu FX et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116599
PubMed:
37149070

Distinct Effects of Seed Coat and Flower Colors on Metabolite Contents and Antioxidant Activities in Safflower Seeds.

Immunology
Li W et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12040961
PubMed:
37107336

Evolutionary analysis of the OSCA gene family in sunflower (Helianthus annuus L) and expression analysis under NaCl stress.

Genetics
Shan F et al (2023).
PeerJ.
DOI:
10.7717/peerj.15089
PubMed:
37090105

The mechanism of peach kernel and safflower herb-pair for the treatment of liver fibrosis based on network pharmacology and molecular docking technology: A review.

Review
Huang L et al (2023).
Medicine (Baltimore).
DOI:
10.1097/MD.0000000000033593
PubMed:
37083803

Phylogenomic investigation of safflower (Carthamus tinctorius) and related species using genotyping-by-sequencing (GBS).

Sardouei-Nasab S et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-33347-0
PubMed:
37069212

Optimization of green extraction process with natural deep eutectic solvent and comparative in vivo pharmacokinetics of bioactive compounds from Astragalus-Safflower pair.

Jin L et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154814
PubMed:
37062134

Plants and Other Materials Used for Dyeing in the Present Territory of Poland, Belarus and Ukraine according to Rostafiński's Questionnaire from 1883.

Köhler P, Bystry A and Łuczaj Ł (2023).
Plants (Basel).
DOI:
10.3390/plants12071482
PubMed:
37050108

Systematic review on the anxiolytic and hypnotic effects of flower extracts in in vivo pre-clinical studies published from 2010 to 2020.

Summary

Researchers conducted a systematic review of scientific articles published between 2010 and 2020 that evaluated the anxiolytic, sedative, and/or hypnotic effects of flower extracts in pre-clinical animal models. They found that some flower extracts have an anxiolytic effect comparable to diazepam, but their therapeutic utility in anxiety disorders needs more investigation. The study compiled the characteristics of anxiety studies in animal models, evaluated locomotor activity, and the hypnotic effect of the extracts. The study revealed that matricaria chamomilla had a sedative effect, and 23 other flower plants had anxiolytic effects. However, more reliable behavioral tests and better experimental designs are needed to obtain more conclusive evidence with clinical significance.

Review Neuroscience
Meneses C et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7830
PubMed:
37039741

Automated glycan assembly of highly branched heptadecasaccharide repeating unit of arabinogalactan polysaccharide HH1-1 from Carthamus tinctorius.

Sabbavarapu NM and Seeberger PH (2023).
Chem Commun (Camb).
DOI:
10.1039/d3cc00687e
PubMed:
37013411

Hydroxysafflor yellow A protects against colitis in mice by suppressing pyroptosis via inhibiting HK1/NLRP3/GSDMD and modulating gut microbiota.

Gastroenterology
Chen J et al (2023).
Toxicol Appl Pharmacol.
DOI:
10.1016/j.taap.2023.116494
PubMed:
37001609

Quality Changes of Cold-Pressed Black Cumin (Nigella sativa L.), Safflower (Carthamus tinctorius L.), and Milk Thistle (Silybum marianum L.) Seed Oils during Storage.

Tarasevičienė Ž et al (2023).
Plants (Basel).
DOI:
10.3390/plants12061351
PubMed:
36987040

Solid lipid nanoparticles cyclodextrin-decorated incorporated into gellan gum-based dry floating in situ delivery systems for controlled release of bioactive compounds of safflower (Carthamus tinctorius. L): A proof of concept study in biorelevant media.

Permana AD et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.124084
PubMed:
36940768

High interspecific competitiveness of the invasive plant Xanthium italicum Moretti severely reduces the yield and quality of Carthamus tinctorius L.

Ma X, Hou M and Ma M (2023).
Sci Rep.
DOI:
10.1038/s41598-023-31101-0
PubMed:
36922573

Isolation of Lead Resistant Bacteria from Spent Mushroom Compost and Their Impact on Growth and Biochemical Parameters of Safflower.

Shahin S, Mohammadi-Sichani M and Rezayatmand Z (2023).
Curr Microbiol.
DOI:
10.1007/s00284-022-03153-4
PubMed:
36920625

Active substances and molecular mechanisms of the anti-myocardial ischemia effects of Carthami flos by network pharmacology and in vitro experiments.

Cardiology
Zhang S et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e13877
PubMed:
36895345

Identification of a secondary Q-marker in high-quality ecotypes of Carthamus tinctorius L. and exploration of the target preference.

Zeng T et al (2023).
Food Funct.
DOI:
10.1039/d2fo02596e
PubMed:
36852499

Hydroxysafflor yellow a confers neuroprotection against acute traumatic brain injury by modulating neuronal autophagy to inhibit NLRP3 inflammasomes.

Summary

Hydroxysafflor yellow A (HSYA) is a compound found in Carthamus tinctorius L. that has been shown to protect against neurological diseases, including traumatic brain injury (TBI). The methods and mechanisms behind HSYA's neuroprotective effects are not entirely understood.

Neuroscience
Lai Z et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116268
PubMed:
36842723

Network pharmacology and bioinformatics study on the treatment of renal fibrosis with persicae semen-carthami flos drug pair.

Wang J et al (2023).
Medicine (Baltimore).
DOI:
10.1097/MD.0000000000032946
PubMed:
36827014

Effects of Temperature and Salt Stress on the Expression of delta-12 Fatty Acid Desaturase Genes and Fatty Acid Compositions in Safflower.

Genetics
Li D et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24032765
PubMed:
36769084

Combination of Radix Astragali and Safflower Promotes Angiogenesis in Rats with Ischemic Stroke via Silencing PTGS2.

Summary

Radix astragali-safflower (AS) has been used for centuries in China to treat patients with ischemic stroke (IS). In this study, network pharmacology was used to uncover the mechanism of AS in treating IS. AS was shown to promote angiogenesis, which was associated with PTGS2 silence. Middle cerebral artery occlusion/reperfusion (MCAO/R) model rats were then treated with AS and showed improved cerebral infarct volume, neurological and histopathological damage, inhibition of cell apoptosis, and increased levels of PDGF-BB, EPO, and TGF-β1. AS was found to promote angiogenesis in MCAO/R rats by reversing the down-regulation of VEGF and promoting the expression of CD31. The protective mechanism of AS for IS involves PTGS2 silence.

CardiologyGeneticsNeuroscience
Xu S et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24032126
PubMed:
36768450

Qingrequzhuo capsule alleviated methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice through regulating gut microbiota, enhancing gut tight junction and inhibiting the activation of TLR4/NF-κB signaling pathway.

GastroenterologyImmunology
Lv S et al (2023).
Front Endocrinol (Lausanne).
DOI:
10.3389/fendo.2022.1106875
PubMed:
36743916

Indistinct assessment of the quality of traditional Chinese medicine in precision medicine exampling as safflower.

Zhou Y et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115277
PubMed:
36736110

Development of Solid Lipid Nanoparticle-Loaded Polymeric Hydrogels Containing Antioxidant and Photoprotective Bioactive Compounds of Safflower (Carthamus tinctorius L.) for Improved Skin Delivery.

Aanisah N et al (2023).
Langmuir.
DOI:
10.1021/acs.langmuir.2c02754
PubMed:
36701815

The Carthamus tinctorius L. and Lepidium apetalum Willd. Drug Pair Inhibits EndMT through the TGFβ1/Snail Signaling Pathway in the Treatment of Myocardial Fibrosis.

Cardiology
Zhou Z et al (2023).
Evid Based Complement Alternat Med.
DOI:
10.1155/2023/6018375
PubMed:
36686974

Purification, Characterization and Bioactivities of Polysaccharides Extracted from Safflower (Carthamus tinctorius L.).

Wang Q et al (2023).
Molecules.
DOI:
10.3390/molecules28020596
PubMed:
36677653

Safflower (Carthamus tinctorius L.) Response to Cadmium Stress: Morpho-Physiological Traits and Mineral Concentrations.

Tunçtürk M et al (2023).
Life (Basel).
DOI:
10.3390/life13010135
PubMed:
36676083

Genome-Wide Identification of MADS-Box Family Genes in Safflower (Carthamus tinctorius L.) and Functional Analysis of CtMADS24 during Flowering.

Genetics
Wang Y et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24021026
PubMed:
36674539

Molecular Characterization of a Stereoselective and Promiscuous Flavanone 3-Hydroxylase from Carthamus tinctorius L.

Sui S et al (2023).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.2c07202
PubMed:
36633228

The safflower MBW complex regulates HYSA accumulation through degradation by the E3 ligase CtBB1.

Hong Y et al (2023).
J Integr Plant Biol.
DOI:
10.1111/jipb.13444
PubMed:
36598461

Sesquiterpenoids from the Florets of Carthamus tinctorius (Safflower) and Their Anti-Atherosclerotic Activity.

Li L et al (2022).
Nutrients.
DOI:
10.3390/nu14245348
PubMed:
36558507

An image dataset of diverse safflower (Carthamus tinctorius L.) genotypes for salt response phenotyping.

Genetics
Thoday-Kennedy E et al (2022).
Data Brief.
DOI:
10.1016/j.dib.2022.108787
PubMed:
36506801

The rising status of edible seeds in lifestyle related diseases: A review.

Review
Kakkar S, Tandon R and Tandon N (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2022.134220
PubMed:
36137389

Carthamus tinctorius L.: A natural neuroprotective source for anti-Alzheimer's disease drugs.

Summary

Alzheimer's disease (AD) is a neurodegenerative disease with complicated pathogenic processes including abnormal protein accumulation, oxidative stress, and inflammation. Cholinesterase inhibitors can somewhat alleviate AD symptoms, but new treatment options are needed.

Review Neuroscience
Liang Y and Wang L (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115656
PubMed:
36041691

Cloning and expression analysis of HY5 transcription factor gene of safflower in response to light signal.

Genetics
Xian B et al (2023).
Biotechnol Appl Biochem.
DOI:
10.1002/bab.2373
PubMed:
35695381

Hydroxysafflor yellow A, a natural compound from Carthamus tinctorius L with good effect of alleviating atherosclerosis.

Review
Xue X et al (2021).
Phytomedicine.
DOI:
10.1016/j.phymed.2021.153694
PubMed:
34403879

Pharmacological potential of the combination of Salvia miltiorrhiza (Danshen) and Carthamus tinctorius (Honghua) for diabetes mellitus and its cardiovascular complications.

Review CardiologyDiabetes
Orgah JO et al (2020).
Pharmacol Res.
DOI:
10.1016/j.phrs.2020.104654
PubMed:
31945473

Phytotherapy in treatment of Parkinson's disease: a review.

Summary

This review article discusses the potential of medicinal plants in treating Parkinson's disease (PD). PD is a neurological disorder that causes motor disorders such as tremors and stiffness. The article includes 12 plant-derived active ingredients and 18 herbal extracts that have been studied for their effects on PD. These compounds have been found to affect PD by targeting pathways associated with the pathogenesis of the disease. Some herbal extracts and active ingredients have shown positive effects in animal models of PD, but additional studies are needed to investigate potential active ingredients and mechanisms of action. This field offers numerous perspectives for future studies on plants and their bioactive compounds.

Review Neuroscience
Rabiei Z, Solati K and Amini-Khoei H (2019).
Pharm Biol.
DOI:
10.1080/13880209.2019.1618344
PubMed:
31141426