Catha edulis

Common Names: khat

Ethnobotanical Studies

Clinical Trials

Reducing Khat use among Somalis living in Kenya: a controlled pilot study on the modified ASSIST-linked brief intervention delivered in the community.

Widmann M et al (2022).
BMC Public Health.
PubMed:
36471268

Studies

The effects of khat (Catha edulis) use on the genitourinary system: A systematic review and meta-analysis.

Review
Ahmed F et al (2024).
J Ethn Subst Abuse.
PubMed:
39092911

The Effects of Khat Chewing among Djiboutians: Dental Chemical Studies, Gingival Histopathological Analyses and Bioinformatics Approaches.

Mohamed Abdoul-Latif F et al (2024).
Bioengineering (Basel).
PubMed:
39061798

Impact of khat (Catha edulis) and oral contraceptive use on telomerase levels and tumor suppressor genes p53 and p21 in normal subjects and breast cancer patients.

Summary

Study found OC use, khat chewing increase telomerase, p53, p21 in breast cancer patients. OCs increase telomerase in controls. Khat chewing is protective. Combination decreases telomerase risk in BC patients.

Atroosh F et al (2024).
Sci Rep.
PubMed:
39013992

Catha edulis Leaves: Morphological Characterization and Anti-Inflammatory Properties in an In Vitro Model of Gastritis.

Magnavacca A et al (2024).
Plants (Basel).
PubMed:
38891346

Different Course And Management of Khat-Induced Autoimmune Hepatitis: Report On Three Cases.

Someili A et al (2024).
Eur J Case Rep Intern Med.
PubMed:
38846663

Current khat (Catha edulis F.) use among Ethiopian women and its association with anemia and underweight: A cross-sectional analysis from Ethiopian Demographic and Health Survey.

Amaha ND, Kifle MM and Mebrahtu SG (2024).
PLoS One.
PubMed:
38820499

Prevalence and associated factors of congenital anomalies in Ethiopia: A systematic review and meta-analysis.

Meta-Analysis
Mogess WN and Mihretie TB (2024).
PLoS One.
PubMed:
38687732

Synthetic Cathinones: Epidemiology, Toxicity, Potential for Abuse, and Current Public Health Perspective.

Review
Chen S, Zhou W and Lai M (2024).
Brain Sci.
PubMed:
38671986

Levels and Health Risk Assessments of Heavy Metals in Khat and Its Support Soil in Algesachi, Ilu Ababor, Ethiopia.

Damana S, Geletu AK and Keru IU (2024).
Environ Health Insights.
PubMed:
38628468

Individual and community-level factors associated with khat (Catha edulis) use among women of reproductive age in Halaba zone, South Ethiopia: a multilevel mixed effect analysis.

Wogayehu B et al (2024).
Front Psychiatry.
PubMed:
38439793

MnOx-Coffea arabica Husk and Catha edulis Leftover Biochar Nanocomposites for Removal of Methylene Blue from Wastewater.

Kochito J et al (2024).
ScientificWorldJournal.
PubMed:
38434937

Cyclodextrin-Enabled Enantioselective Complexation Study of Cathinone Analogs.

Dohárszky A et al (2024).
Molecules.
PubMed:
38398627

Metabolic profile of N-ethylhexedrone, N-ethylpentedrone, and 4-chloromethcathinone in urine samples by UHPLC-QTOF-HRMS.

Massano M et al (2024).
J Pharm Biomed Anal.
PubMed:
38309098

Magnitude and associated factors of chewing khat during pregnancy in Eastern Ethiopia, 2022: a mixed method cross-sectional study.

Wondemagegn AT et al (2023).
Pan Afr Med J.
PubMed:
38282772

Traditional homegardens change to perennial monocropping of khat (Catha edulis) reduced woody species and enset conservation and climate change mitigation potentials of the Wondo Genet landscape of southern Ethiopia.

Mellisse BT, Tolera M and Derese A (2023).
Heliyon.
PubMed:
38187286

Apparent Khat chewers exposure to DDT in Ethiopia and its potential toxic effects: A scoping review.

Review
Ali SA and Destaye AG (2023).
Regul Toxicol Pharmacol.
PubMed:
38142813

Clavulanic Acid Improves Memory Dysfunction and Anxiety Behaviors through Upregulating Glutamatergic Transporters in the Nucleus Accumbens of Mice Repeatedly Exposed to Khat Extract.

Summary

The scientists found that clavulanic acid, a β-lactam-containing compound, can improve memory impairment and anxiety-like behaviors caused by khat exposure in mice. This is achieved by upregulating GLT-1 in the nucleus accumbens. This suggests that β-lactam-containing compounds may be effective in reducing the negative effects of khat use.

Arab AO et al (2023).
Int J Mol Sci.
PubMed:
37958641

Perceived harms and protective behavioural strategies among khat chewers: a qualitative study in Jimma, Ethiopia.

Olani AB and Decorte T (2023).
Harm Reduct J.
PubMed:
37875920

The epidemiology of khat (catha edulis) chewing and alcohol consumption among pregnant women in Ethiopia: A systematic review and meta-analysis.

Wogayehu B et al (2023).
PLOS Glob Public Health.
PubMed:
37713384

Violence against housemaids in an Ethiopian town during the early phase of the COVID-19 pandemic: a cross-sectional study.

Summary

This study investigates violence against housemaids in Ethiopia during the COVID-19 pandemic. Understanding their experiences can help develop effective policies and programs to reduce this issue.

Adane M et al (2023).
BMC Womens Health.
PubMed:
37700265

Task-specific oromandibular dystonia secondary to chewing Khat (Catha edulis)- A series of 35 cases.

Wadia PM et al (2023).
Parkinsonism Relat Disord.
PubMed:
37619301

Prevalence, Antibiotic Resistance and Associated Factors of Neisseria gonorrhoeae Among Patients Attending Non-Profitable Private Clinics in Mekelle, Tigrai, Ethiopia.

Summary

This study aimed to determine the prevalence, antibiotic resistance, and risk factors of a common bacterial sexually transmitted disease in Tigrai, Ethiopia. This information is important for developing effective treatments and prevention strategies.

Kahsay AG et al (2023).
Infect Drug Resist.
PubMed:
37383604

Is chewing khat associated with mental health disorders? A scoping review of the content and quality of the current evidence base.

Review
Olani AB et al (2023).
Subst Abuse Treat Prev Policy.
PubMed:
37370160

Synthetic Cathinones and Neurotoxicity Risks: A Systematic Review.

Summary

Synthetic cathinones (SCs) are the second largest class of new psychoactive substances (NPS) monitored by the EU Early Warning System. They have similar structure to cathinone and cause various neurological events, including increased alertness, mild agitation, severe psychosis, hyperthermia, and death. A systematic literature search was conducted, and 76 studies were included in the present review, highlighting neurotoxic mechanisms and toxic effects on animals and humans. Adverse effects include encephalopathy, coma, convulsions, and hallucinogenic toxidromes, as well as excited/agitated delirium syndrome and serotonin syndrome. These findings suggest that synthetic cathinones pose a significant public health and forensic toxicology challenge.

Daziani G et al (2023).
Int J Mol Sci.
PubMed:
37047201

A Narrative Review of the Toxic Effects on Male Reproductive and Sexual Health of Chewing the Psychostimulant, Catha edulis (Khat).

Alzahrani MA et al (2023).
Med Sci Monit.
PubMed:
37002591

Role of nanohybrid NiO-Fe(3)O(4) in enhancing the adsorptive performance of activated carbon synthesized from Yemeni-Khat leave in removal of Pb (II) and Hg (II) from aquatic systems.

Alswat AA et al (2023).
Heliyon.
PubMed:
36967866

Adverse Effects of Chewing Khat (Catha edulis): A Community-based Study in Ethiopia.

Asfaw LS et al (2023).
Oman Med J.
PubMed:
36923946

Cathine and cathinone disposition kinetics and neurotransmitter profile in several organs of rats exposed to a single dose of Catha edulis (Vahl) Forssk. ex Endl. extract.

Summary

Researchers studied the effects of a stimulant plant called khat on rats. They gave the rats a single dose of the plant and then looked at how the two active ingredients, cathine and cathinone, were processed in the body. They also measured the levels of different neurotransmitters, which are chemicals that help transmit signals in the brain. The results will help us understand how khat affects the body and brain, which could be important for understanding its possible risks and benefits.

Alamir AM et al (2023).
Drug Metab Pers Ther.
PubMed:
36883753

Epidemiology of Khat (Catha edulis) Chewing in Ethiopia: A Systematic Review and meta-analysis.

Review
Ayano G et al (2022).
J Psychoactive Drugs.
PubMed:
36508190

Assessment of chromium contamination in the soil and khat leaves (Catha edulis Forsk) and its health risks located in the vicinity of tannery industries; A case study in Bahir Dar City, Ethiopia.

Alemu A and Tegegne A (2022).
Heliyon.
PubMed:
36506399

Substance use and substance use disorders in Africa: An epidemiological approach to the review of existing literature.

Review
Onaolapo OJ et al (2022).
World J Psychiatry.
PubMed:
36389088

Non Ischemic Cardiomyopathy in a 54-Year-Old Khat Consuming Yemeni Male Presenting with Worsening Exertional Dyspnea, T Wave Inversions in V5-V6 and Normal Coronary Artery Angiography.

Emeasoba EU et al (2022).
Am J Case Rep.
PubMed:
35787598

Protein-Ligand Identification and In Vitro Inhibitory Effects of Cathine on 11 Major Human Drug Metabolizing Cytochrome P450s.

Lim SYM et al (2022).
Int J Toxicol.
PubMed:
35658727

Impact of khat leaves on glycosylated haemoglobin and lipid profile in healthy individuals in Dire Dawa, Ethiopia.

Tekle Y et al (2022).
SAGE Open Med.
PubMed:
35492886

Khat (Catha Edulis Forsk) induced apoptosis and cytotoxicity in cultured cells: A scoping review.

Review
Al-Qadhi G et al (2021).
Heliyon.
PubMed:
34926848

Progress and Research Trends on Catha edulis (Vahl) Endl. (Catha edulis): A Review and Bibliometric Analysis.

Ye S et al (2021).
Front Pharmacol.
PubMed:
34867319

Traditional Somali Diaspora Medical Practices in the USA: A Scoping Review.

Ferdjallah A and Hassan M (2023).
J Relig Health.
PubMed:
34812997

Catha edulis Forsk and Ascorbic Acid Effects on Hematological Indices in Rat.

Leminie AA et al (2021).
J Blood Med.
PubMed:
34602828

Khat.

Review
(2018).
PubMed:
31644017

Khat (Catha edulis) and its oral health effects: An updated review.

Review
Al-Maweri SA, Warnakulasuriya S and Samran A (2018).
J Investig Clin Dent.
PubMed:
28834423

Khat (Catha edulis) and Obesity: A Scoping Review of Animal and Human Studies.

Review Obesity
Alshagga MA et al (2016).
Ann Nutr Metab.
PubMed:
27871070

Introduction to the special issue: the changing use and misuse of khat (Catha edulis)--tradition, trade and tragedy.

Odenwald M, Klein A and Warfa N (2010).
J Ethnopharmacol.
PubMed:
21115151