Catharanthus roseus

Common Names: Madagascar periwinkle

Ethnobotanical Studies

Studies

Morphology and Inheritance of Wavy Flower Form in Periwinkle (Catharanthus roseus (L.) G. Don).

Huang TH et al (2024).
Plants (Basel).
PubMed:
39204708

Influence of biochar amendment on removal of heavy metal from soils using phytoremediation by Catharanthus roseus L. and Chrysopogon zizanioides L.

Deka D et al (2024).
Environ Sci Pollut Res Int.
PubMed:
39196321

Exploring the potential of two Pseudomonas species to produce vincristine from vinblastine via biotransformation.

Srivastava G et al (2024).
Sci Rep.
PubMed:
39179785

Quantitative Single-Cell Mass Spectrometry Provides a Highly Resolved Analysis of Natural Product Biosynthesis Partitioning in Plants.

Vu AH et al (2024).
J Am Chem Soc.
PubMed:
39138868

Characterization of the ZCTs, a subgroup of Cys2-His2 zinc finger transcription factors regulating alkaloid biosynthesis in Catharanthus roseus.

Traverse KKF et al (2024).
Plant Cell Rep.
PubMed:
39115578

Bioprocessing of camptothecin from Alternaria brassicicola, an endophyte of Catharanthus roseus, with a strong antiproliferative activity and inhibition to Topoisomerases.

El-Hady NAAA et al (2024).
Microb Cell Fact.
PubMed:
39060918

Detection of vinblastine and related bioactive compounds from culture extracts of endophytic fungi of Catharanthus roseus.

Khan U and Gond SK (2024).
World J Microbiol Biotechnol.
PubMed:
39046545

Active-Site Oxygen Accessibility and Catalytic Loop Dynamics of Plant Aromatic Amino Acid Decarboxylases from Molecular Simulations.

Gou Y, Li T and Wang Y (2024).
Biochemistry.
PubMed:
39008055

Green Synthesis and Characterization of Zinc Oxide Nanoparticles Using Catharanthus roseus Extract: A Novel Approach.

Malaiappan S, P T P and Niveditha S (2024).
Cureus.
PubMed:
38883108

Unsaturated fatty acid, Nonacosenoic acid isolated from an endophyte Chaetomium nigricolor inhabiting the stem of Catharanthus roseus and its bioactivity.

Dhayanithy G et al (2024).
Fungal Biol.
PubMed:
38876540

Critical parameters for robust Agrobacterium-mediated transient transformation and quantitative promoter assays in Catharanthus roseus seedlings.

Cole-Osborn LF, Meehan E and Lee-Parsons CWT (2024).
Plant Direct.
PubMed:
38855128

FERONIA homologs in stress responses of horticultural plants: current knowledge and missing links.

Review
Huang X et al (2024).
Stress Biol.
PubMed:
38847988

Genome Characteristics of the Endophytic Fungus Talaromyces sp. DC2 Isolated from Catharanthus roseus (L.) G. Don.

Quan ND et al (2024).
J Fungi (Basel).
PubMed:
38786707

The role of the Golden2-like (GLK) transcription factor in regulating terpenoid indole alkaloid biosynthesis in Catharanthus roseus.

Cole-Osborn LF et al (2024).
Plant Cell Rep.
PubMed:
38743349

Crosstalk between melatonin and nitric oxide restrains Cadmium-induced oxidative stress and enhances vinblastine biosynthesis in Catharanthus roseus (L) G Don.

Nabaei M et al (2024).
Plant Cell Rep.
PubMed:
38735908

Identification of Metabolites from Catharanthus roseus Leaves and Stem Extract, and In Vitro and In Silico Antibacterial Activity against Food Pathogens.

Jamal QMS and Ahmad V (2024).
Pharmaceuticals (Basel).
PubMed:
38675411

Structural insights into the molecular mechanism of phytoplasma immunodominant membrane protein.

Liu CY et al (2024).
IUCrJ.
PubMed:
38656311

Efficient production of (S)-limonene and geraniol in Saccharomyces cerevisiae through the utilization of an Erg20 mutant with enhanced GPP accumulation capability.

Bernard A et al (2024).
Metab Eng.
PubMed:
38631459

Genome wide characterization and expression analysis of CrRLK1L gene family in wheat unravels their roles in development and stress-specific responses.

Gawande ND and Sankaranarayanan S (2024).
Front Plant Sci.
PubMed:
38595759

Plant cell wall-mediated disease resistance: Current understanding and future perspectives.

Review
Molina A et al (2024).
Mol Plant.
PubMed:
38594902

Discovery and characterization of two highly divergent variants of a novel potyvirus species infecting Madagascar periwinkle (Catharanthus roseus L.).

Alabi OJ et al (2024).
Plant Dis.
PubMed:
38568788

Vincarostine A, a novel anti-malarial trimeric monoterpenoid indole alkaloid from Catharanthus roseus.

Summary

Vincarostine A (1), a unique alkaloid from Catharanthus roseus, has potential as an anti-malarial drug. Its structure and stereocenters were determined using NMR and CD data.

Hirasawa Y et al (2024).
J Nat Med.
PubMed:
38564155

Modulating plant-soil microcosm with green synthesized ZnONPs in arsenic contaminated soil.

Rehman A et al (2024).
J Hazard Mater.
PubMed:
38555668

Molecular Identification and Phytochemical Analysis and Bioactivity Assessment of Catharanthus roseus Leaf Extract: Exploring Antioxidant Potential and Antimicrobial Activities.

Summary

Catharanthus roseus, a plant used in Indian medicine, contains bioactive compounds like vinblastine. Its DNA shows genetic diversity. Extracts show strong antioxidant and antibacterial properties. It has potential as a medicinal plant.

Arulvendhan V, Saravana Bhavan P and Rajaganesh R (2024).
Appl Biochem Biotechnol.
PubMed:
38526661

Catharanthus roseus-assisted bio-fabricated zinc oxide nanoparticles for promising antibacterial potential against Klebsiella pneumoniae.

Sultana S et al (2024).
Bioprocess Biosyst Eng.
PubMed:
38526617

An overview of the ameliorative efficacy of Catharanthus roseus extract against Cd(2+) toxicity: implications for human health and remediation strategies.

Review
Hashim M et al (2024).
Front Public Health.
PubMed:
38525339

Integration of cell differentiation and initiation of monoterpenoid indole alkaloid metabolism in seed germination of Catharanthus roseus.

Uzaki M et al (2024).
New Phytol.
PubMed:
38513692

Functional annotation of proteins in Catharanthus roseus shoot cultures under biogenic zinc nanotreatment.

Perveen S et al (2024).
Plant Mol Biol.
PubMed:
38459275

Comprehensive transcriptomic meta-analysis unveils new responsive genes to methyl jasmonate and ethylene in Catharanthusroseus.

Tabatabaeipour SN et al (2024).
Heliyon.
PubMed:
38449649

Halotolerant and plant growth-promoting endophytic fungus Aspergillus terreus CR7 alleviates salt stress and exhibits genoprotective effect in Vigna radiata.

Chauhan P et al (2024).
Front Microbiol.
PubMed:
38404598

On the traditional medicinal plants and plant-derived natural drugs used by indigenous people of Nagaland, India.

Review
Luikham S and Bhattacharyya J (2024).
Nat Prod Res.
PubMed:
38372281

A Cotyledon-based Virus-Induced Gene Silencing (Cotyledon-VIGS) approach to study specialized metabolism in medicinal plants.

Liu Y et al (2024).
Plant Methods.
PubMed:
38347628

Integrated transcriptomic and proteomic analyses uncover the early response mechanisms of Catharanthus roseus under ultraviolet-B radiation.

Zhong Z et al (2024).
J Photochem Photobiol B.
PubMed:
38330691

Genome-wide identification of GATA transcription factor family and the effect of different light quality on the accumulation of terpenoid indole alkaloids in Uncaria rhynchophylla.

Shao Y et al (2024).
Plant Mol Biol.
PubMed:
38329633

Evolution and diversification of carboxylesterase-like [4+2] cyclases in aspidosperma and iboga alkaloid biosynthesis.

DeMars MD 2nd and O'Connor SE (2024).
Proc Natl Acad Sci U S A.
PubMed:
38319969

A fused hybrid enzyme of 8-hydroxygeraniol oxidoreductase (8HGO) from Gardenia jasminoides and iridoid synthase (ISY) from Catharanthus roseus significantly enhances nepetalactol and iridoid production.

Liu H et al (2024).
Planta.
PubMed:
38319463

Bioprocessing of Epothilone B from Aspergillus fumigatus under solid state fermentation: Antiproliferative activity, tubulin polymerization and cell cycle analysis.

Summary

Researchers optimized the production of epothilone, a potent anticancer drug, by growing Aspergillus fumigatus on orange peels. The extracted epothilone showed activity against various cancer cells and caused growth arrest in HepG2 cells. This finding suggests a potential commercial source of epothilone.

El-Sayed ASA et al (2024).
BMC Microbiol.
PubMed:
38291363

An efficient grafting method for phytoplasma transmission in Catharanthus roseus.

Chang HC and Chen JC (2024).
Plant Methods.
PubMed:
38245775

Differential response of biochar in mitigating salinity stress in periwinkle (Catharanthus roseus L.) as an ornamental-medicinal plant species.

Mohammadi Kabari SF et al (2024).
Int J Phytoremediation.
PubMed:
38189302

Camptothecin bioprocessing from Aspergillus terreus, an endophyte of Catharanthus roseus: antiproliferative activity, topoisomerase inhibition and cell cycle analysis.

Summary

A strain of Aspergillus terreus in the medicinal plant Catharanthus roseus produces camptothecin (CPT), which exhibits anticancer and wound healing properties. Adding sterilized C. roseus leaves can restore CPT production, making A. terreus a potential source for industrial CPT production.

El-Sayed ASA et al (2024).
Microb Cell Fact.
PubMed:
38183118

Screening herbal extracts as biostimulant to increase germination, plant growth and secondary metabolite production in wheatgrass.

Yadav A, Singh S and Yadav V (2024).
Sci Rep.
PubMed:
38182633

First report of a 'Candidatus phytoplasma asteris' related strain (16SrI) associated with phyllody and witches'-broom symptom in Pisum sativum in Hisar, India.

Dhillon JS et al (2024).
Plant Dis.
PubMed:
38175654

Anti-oncogenic Potential and Inflammation Modulatory Response of Green Synthesized Biocompatible Silver Nanoparticles.

Shobha N et al (2023).
Chem Biodivers.
PubMed:
38156969

The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize.

Zhou LZ et al (2023).
Plant Cell.
PubMed:
38142229

Combination of Machine Learning and Empirical Computation for the Structural Validation of Trirosaline, a Natural Trimeric Monoterpene Indole Alkaloid from Catharanthus roseus.

Summary

Scientists found trirosaline, the first tris-ajmalicine-type monoterpene indole alkaloid and trimeric MIA, from a plant. Its structure was determined using analysis methods and its biosynthetic pathway was proposed. This expands knowledge of alkaloids and biosynthesis. (40 words)

Szwarc S et al (2023).
Org Lett.
PubMed:
38134219

Engineering Yarrowia lipolytica for the biosynthesis of geraniol.

Agrawal A, Yang Z and Blenner M (2023).
Metab Eng Commun.
PubMed:
38029016

Regulation of T16H subcellular localization for promoting its catalytic efficiency in yeast cells.

Cao J et al (2023).
Biotechnol Lett.
PubMed:
37971563

Genome-wide identification and characterization of wall-associated kinases, molecular docking and polysaccharide elicitation of monoterpenoid indole alkaloids in micro-propagated Catharanthus roseus.

Ahmed J et al (2023).
J Plant Res.
PubMed:
37962734

Synthesis, characterization and anti-breast cancer potential of an incensole acetate nanoemulsion from Catharanthus roseus essential oil; in silico, in vitro, and in vivo study.

Summary

Scientists found that incensole acetate (IA), a compound in essential oils, has potential anticancer activity. IA biosynthesized nanoemulsion showed cytotoxicity against breast cancer cells and improved indicators in a rat model, suggesting it has anticancer properties.

Nayila I et al (2023).
RSC Adv.
PubMed:
37928847

Exploring the mechanism of resistance to vincristine in breast cancer cells using transcriptome sequencing technology.

Summary

Scientists investigated the development of resistance to vincristine (VCR), a chemotherapy drug used for breast cancer treatment. By analyzing gene expression and splicing events, they identified changes in the VCR-resistant breast cancer cell line. This study lays the foundation for understanding VCR resistance and developing potential treatments.

Chen Y et al (2023).
Oncol Lett.
PubMed:
37920438

Temperature-induced lipocalin-mediated membrane integrity: Possible implications for vindoline accumulation in Catharanthus roseus leaves.

Mall M et al (2023).
Physiol Plant.
PubMed:
37882277

Genome-Wide Identification and Analysis of Catharanthus roseus Receptor-like Kinase 1-like Proteins in Eggplant.

Summary

This study identified and analyzed 32 receptor-like kinase 1-like (CrRLK1L) proteins in eggplant. These proteins are involved in plant growth, stress response, and interactions with pathogens. Understanding their functions can aid in improving eggplant growth, development, and resistance.

Ma W et al (2023).
Plants (Basel).
PubMed:
37836119

Fungal Elicitation Enhances Vincristine and Vinblastine Yield in the Embryogenic Tissues of Catharanthus roseus.

Tonk D et al (2023).
Plants (Basel).
PubMed:
37836112

The leaf idioblastome of the medicinal plant Catharanthus roseus reveals commitment with stress resistance and alkaloid metabolism.

Summary

The study found that protoplasts of C. roseus leaf idioblasts have a unique transcriptomic profile associated with stress protection and alkaloid accumulation. Understanding this profile could help increase the levels of anticancer drugs.

Guedes JG et al (2023).
J Exp Bot.
PubMed:
37804484

Catharanthus roseus (L.) G. Don counteracts the ampicillin resistance in multiple antibiotic-resistant Staphylococcus aureus by downregulation of PBP2a synthesis.

Summary

Researchers evaluated the mechanism by which an extract from the root of the medicinal plant (L.) G. Don reverses ampicillin resistance in . The extract caused DNA damage, reduced plasmid band intensities, and decreased the expression of PBP2a protein, making the bacteria susceptible to the antibiotic ampicillin.

Shil A et al (2023).
Open Life Sci.
PubMed:
37772260

Catalytic Site Constraints in the P450s Mediating Loganic Acid (7DLH) and Secologanic Acid Synthesis (SLAS) in Camptotheca.

Rao P et al (2023).
Biochemistry.
PubMed:
37656055

Vincristine-based nanoformulations: a preclinical and clinical studies overview.

Review
Shukla R, Singh A and Singh KK (2023).
Drug Deliv Transl Res.
PubMed:
37552393

UPLC-ESI-QTOF-MS assisted targeted metabolomics to study the enrichment of vinca alkaloids and related metabolites in Catharanthus roseus plants grown under controlled LED environment.

Nagy K et al (2023).
J Pharm Biomed Anal.
PubMed:
37542828

Selenium nanoparticles based on Amphipterygium glaucum extract with antibacterial, antioxidant, and plant biostimulant properties.

Summary

Scientists synthesized selenium nanoparticles from a plant extract and studied their chemical and biological properties. These nanoparticles have the potential to improve crop quality and yield while protecting against diseases caused by microorganisms.

Garza-García JJO et al (2023).
J Nanobiotechnology.
PubMed:
37537575

Evaluation of the impact of vindoline, an active components of Catharanthus roseus, on rat hepatic cytochrome P450 enzymes by using a cocktail of probe drugs.

Zhang Y et al (2023).
PLoS One.
PubMed:
37535556

Impact of Plant Symbiotic Endophytic Fungus, Aspergillus terreus on Insect Herbivore Spodoptera litura (Fabricius) (Lepidoptera: Noctuidae).

Singh S et al (2023).
Neotrop Entomol.
PubMed:
37530941

A near-complete genome assembly of Catharanthus roseus and insights into the biosynthesis of vinblastine and its high susceptibility to Huanglongbing pathogen.

Xu Z et al (2023).
Plant Commun.
PubMed:
37464741

Vindoline Exhibits Anti-Diabetic Potential in Insulin-Resistant 3T3-L1 Adipocytes and L6 Skeletal Myoblasts.

Summary

Vindoline, an alkaloid, was tested on insulin-resistant cells and dysfunctional adipocytes. Results showed it improved insulin resistance, suggesting it may be a potential treatment for obesity-induced type 2 diabetes.

Shijina BN et al (2023).
Nutrients.
PubMed:
37447192

Developing Sustainable Agriculture Systems in Medicinal and Aromatic Plant Production by Using Chitosan and Chitin-Based Biostimulants.

Review
Sun W et al (2023).
Plants (Basel).
PubMed:
37447031

Transcriptome-based identification and functional characterization of iridoid synthase involved in monotropein biosynthesis in blueberry.

Lawas LMF et al (2023).
Plant Direct.
PubMed:
37440931

Boosting Geranyl Diphosphate Synthesis for Linalool Production in Engineered Yarrowia lipolytica.

Taratynova MO et al (2023).
Appl Biochem Biotechnol.
PubMed:
37392322

Small RNA Profiling of Aster Yellows Phytoplasma-Infected Catharanthus roseus Plants Showing Different Symptoms.

Contaldo N et al (2023).
Genes (Basel).
PubMed:
37239473

Novel plant-derived exosome-like nanovesicles from Catharanthus roseus: preparation, characterization, and immunostimulatory effect via TNF-α/NF-κB/PU.1 axis.

Ou X et al (2023).
J Nanobiotechnology.
PubMed:
37210530

Phylogenomics of transcriptionally active AP2/ERF and bHLH transcription factors and study of their promoter regions in Nothapodytes nimmoniana (J.Graham) Mabb.

Godbole RC et al (2023).
Genome.
PubMed:
37163758

Bioefficacy of ursolic acid and its derivatives isolated from Catharanthus roseus (L) G. Don leaf against Aedes aegypti, Culex quinquefasciatus, and Anopheles stephensi larvae.

Kamatchi PAC et al (2023).
Environ Sci Pollut Res Int.
PubMed:
37133656

Pathogenicity and Transcriptomic Analyses of Two "Candidatus Liberibacter asiaticus" Strains Harboring Different Types of Phages.

Zheng Y et al (2023).
Microbiol Spectr.
PubMed:
37071011

Protective Effect of Hirsutidin against Rotenone-Induced Parkinsonism via Inhibition of Caspase-3/Interleukins-6 and 1β.

Shahid Nadeem M et al (2023).
ACS Omega.
PubMed:
37065035

mRNA transcriptome profiling of human hepatocellular carcinoma cells HepG2 treated with Catharanthus roseus-silver nanoparticles.

Azhar NA et al (2023).
World J Hepatol.
PubMed:
37034237

Biogenic Synthesis and Characterization of Silver Nanoparticles: Evaluation of Their Larvicidal, Antibacterial, and Cytotoxic Activities.

Mahalingam S et al (2023).
ACS Omega.
PubMed:
37033866

Biomass valorization of agriculture wastewater grown freshwater diatom Nitzschia sp. for metabolites, antibacterial activity, and biofertilizer.

Singh PK et al (2023).
Bioresour Technol.
PubMed:
36990328

Metabolomic responses to the mechanical wounding of Catharanthus roseus' upper leaves.

Chen Q et al (2023).
PeerJ.
PubMed:
36968002

Using 'sentinel' plants to improve early detection of invasive plant pathogens.

Lovell-Read FA et al (2023).
PLoS Comput Biol.
PubMed:
36730434

Synthesis and characterization of barium doped CaO heterogeneous nanocatalyst for the production of biodiesel from Catharanthus roseus seeds: Kinetics, optimization and performance evaluation.

M K et al (2023).
Environ Res.
PubMed:
36706901

Tabersonine, a natural NLRP3 inhibitor, suppresses inflammasome activation in macrophages and attenuate NLRP3-driven diseases in mice.

Xu HW et al (2023).
Acta Pharmacol Sin.
PubMed:
36627344

Improved protein glycosylation enabled heterologous biosynthesis of monoterpenoid indole alkaloids and their unnatural derivatives in yeast.

Shahsavarani M et al (2022).
Metab Eng Commun.
PubMed:
36569379

Engineering the Biosynthesis of Late-Stage Vinblastine Precursors Precondylocarpine Acetate, Catharanthine, Tabersonine in Nicotiana benthamiana.

Grzech D et al (2023).
ACS Synth Biol.
PubMed:
36516122

Identification of a second 16-hydroxytabersonine-O-methyltransferase suggests an evolutionary relationship between alkaloid and flavonoid metabolisms in Catharanthus roseus.

Lemos Cruz P et al (2023).
Protoplasma.
PubMed:
35947213

Transient Gene Expression in Catharanthus roseus Flower Petals Using Agroinfiltration.

Colinas M and Goossens A (2022).
Methods Mol Biol.
PubMed:
35732952

Molecular and biochemical characterization of Catharanthus roseus perivine-N(β)-methyltransferase.

Levac D, Flores PC and De Luca V (2022).
Phytochemistry.
PubMed:
35671807

Use of Catharanthus roseus Cell Cultures for the Synthesis of Metal Nanoparticles.

Osibe DA and Aoyagi H (2022).
Methods Mol Biol.
PubMed:
35508829

Induction of Catharanthus roseus Secondary Metabolites When Calotropis procera Was Used as Bio-Stimulant.

Abeed AHA et al (2021).
Plants (Basel).
PubMed:
34451668