Common Names: Madagascar periwinkle
Vincarostine A (1), a unique alkaloid from Catharanthus roseus, has potential as an anti-malarial drug. Its structure and stereocenters were determined using NMR and CD data.
Catharanthus roseus, a plant used in Indian medicine, contains bioactive compounds like vinblastine. Its DNA shows genetic diversity. Extracts show strong antioxidant and antibacterial properties. It has potential as a medicinal plant.
Researchers optimized the production of epothilone, a potent anticancer drug, by growing Aspergillus fumigatus on orange peels. The extracted epothilone showed activity against various cancer cells and caused growth arrest in HepG2 cells. This finding suggests a potential commercial source of epothilone.
A strain of Aspergillus terreus in the medicinal plant Catharanthus roseus produces camptothecin (CPT), which exhibits anticancer and wound healing properties. Adding sterilized C. roseus leaves can restore CPT production, making A. terreus a potential source for industrial CPT production.
Scientists found trirosaline, the first tris-ajmalicine-type monoterpene indole alkaloid and trimeric MIA, from a plant. Its structure was determined using analysis methods and its biosynthetic pathway was proposed. This expands knowledge of alkaloids and biosynthesis. (40 words)
Scientists found that incensole acetate (IA), a compound in essential oils, has potential anticancer activity. IA biosynthesized nanoemulsion showed cytotoxicity against breast cancer cells and improved indicators in a rat model, suggesting it has anticancer properties.
Scientists investigated the development of resistance to vincristine (VCR), a chemotherapy drug used for breast cancer treatment. By analyzing gene expression and splicing events, they identified changes in the VCR-resistant breast cancer cell line. This study lays the foundation for understanding VCR resistance and developing potential treatments.
This study identified and analyzed 32 receptor-like kinase 1-like (CrRLK1L) proteins in eggplant. These proteins are involved in plant growth, stress response, and interactions with pathogens. Understanding their functions can aid in improving eggplant growth, development, and resistance.
The study found that protoplasts of C. roseus leaf idioblasts have a unique transcriptomic profile associated with stress protection and alkaloid accumulation. Understanding this profile could help increase the levels of anticancer drugs.
Researchers evaluated the mechanism by which an extract from the root of the medicinal plant (L.) G. Don reverses ampicillin resistance in . The extract caused DNA damage, reduced plasmid band intensities, and decreased the expression of PBP2a protein, making the bacteria susceptible to the antibiotic ampicillin.
Scientists synthesized selenium nanoparticles from a plant extract and studied their chemical and biological properties. These nanoparticles have the potential to improve crop quality and yield while protecting against diseases caused by microorganisms.
Vindoline, an alkaloid, was tested on insulin-resistant cells and dysfunctional adipocytes. Results showed it improved insulin resistance, suggesting it may be a potential treatment for obesity-induced type 2 diabetes.