Caulophyllum thalictroides

Common Names: blue cohosh, caulophylle faux-pigamon, papoose-root, squaw-root

Ethnobotanical Studies

Boreal Forest, Canada

Uses: Dermatological infections, Gastro-intestinal disorders, Gynaecological problems, Mental disorders, Musculoskeletal disorders, Nervous system disorders, Pregnancy, child birth, puerperium, Respiratory system disorders, Urinary system disorders

DOI:: 10.1186/1746-4269-8-7
PubMed:: 22289509

Cherokee Nation

Uses: root decoction given as sedative and anticonvulsive; root taken internally to treat rheumatism

ISBN:: 0881924539

Studies

Non-targeted chemical analysis of consumer botanical products labeled as blue cohosh (Caulophyllum thalictroides), goldenseal (Hydrastis canadensis), or yohimbe bark (Pausinystalia yohimbe) by NMR and MS.

Summary

This study analyzed botanical dietary supplements using NMR and mass spectrometry to assess product quality and authenticity. Outliers were identified, and known constituents helped determine product authenticity. NMR and MS data provided similar and complementary results.

Phytochemistry

Quiroz-Delfi GO et al (2023).; Anal Bioanal Chem.
DOI:: 10.1007/s00216-023-05004-y
PubMed:: 37910202

Blue Cohosh.

Review

(2021).
PubMed:: 30000839

Heart Toxicity Related to Herbs and Dietary Supplements: Online Table of Case Reports. Part 4 of 5.

Review Cardiology

Brown AC et al (2018).; J Diet Suppl.
DOI:: 10.1080/19390211.2017.1356418
PubMed:: 28981338

Toxins in botanical dietary supplements: blue cohosh components disrupt cellular respiration and mitochondrial membrane potential.

Datta S et al (2014).; J Nat Prod.
DOI:: 10.1021/np400758t
PubMed:: 24328138

Adverse effects of herbal medicines: an overview of systematic reviews.

Review

Posadzki P, Watson LK and Ernst E (2013).; Clin Med (Lond).
PubMed:: 23472485

Primary constituents of blue cohosh: quantification in dietary supplements and potential for toxicity.

Review

Rader JI and Pawar RS (2013).; Anal Bioanal Chem.
DOI:: 10.1007/s00216-013-6783-7
PubMed:: 23420136

Anti-Inflammatory Effect of Triterpene Saponins Isolated from Blue Cohosh (Caulophyllum thalictroides).

Immunology Phytochemistry

Lee Y et al (2012).; Evid Based Complement Alternat Med.
DOI:: 10.1155/2012/798192
PubMed:: 22988475

Analytical methods for determination of magnoflorine and saponins from roots of Caulophyllum thalictroides (L.) Michx. using UPLC, HPLC and HPTLC.

Phytochemistry

Avula B et al (2011).; J Pharm Biomed Anal.
DOI:: 10.1016/j.jpba.2011.07.028
PubMed:: 21872415

Teratogenic effects of blue cohosh (Caulophyllum thalictroides) in Japanese medaka (Oryzias latipes) are probably mediated through GATA2/EDN1 signaling pathway.

Wu M et al (2010).; Chem Res Toxicol.
DOI:: 10.1021/tx100205a
PubMed:: 20707411

10.

Nicotinic plant poisoning.

Summary

Plants containing nicotinic and nicotinic-like alkaloids can be toxic to humans and have similar symptoms. This review focuses on the taxonomy and principal alkaloids of these plants, their mechanisms of toxicity, and how to manage poisoning. The study provides valuable information for healthcare professionals to identify and treat plant-related toxicities in patients.

Review Neuroscience

Schep LJ, Slaughter RJ and Beasley DM (2009).; Clin Toxicol (Phila).
DOI:: 10.1080/15563650903252186
PubMed:: 19778187

11.

Triterpene glycosides from the underground parts of Caulophyllum thalictroides.

Phytochemistry

Matsuo Y, Watanabe K and Mimaki Y (2009).; J Nat Prod.
DOI:: 10.1021/np900164b
PubMed:: 19449879

12.

Alkaloids and saponins as cytochrome P450 inhibitors from blue cohosh (Caulophyllum thalictroides) in an in vitro assay.

Phytochemistry

Madgula VL et al (2009).; Planta Med.
DOI:: 10.1055/s-0028-1112207
PubMed:: 19137500

13.

Alkaloids and saponins in dietary supplements of blue cohosh (Caulophyllum thalictroides).

Phytochemistry

Satchithanandam S et al (2008).; J AOAC Int.
PubMed:: 18376582

14.

Safety and efficacy of blue cohosh (Caulophyllum thalictroides) during pregnancy and lactation.

Review

Dugoua JJ et al (2008).; Can J Clin Pharmacol.
PubMed:: 18204101

15.

Characterization of the triterpene saponins of the roots and rhizomes of blue cohosh (Caulophyllum thalictroides).

Phytochemistry

Jhoo JW et al (2001).; J Agric Food Chem.
PubMed:: 11743794