Common Names: spadeleaf
Study on herbal medicine's impact on traumatic brain injury in rat model. Potential neuropharmacology treatment for TBI. Key for improving morbidity and mortality rates globally.
Researchers identified natural compounds from plants that can inhibit BACE1 enzyme, crucial in Alzheimer's development. Astilbin showed promise in altering BACE1 behavior, potentially managing Alzheimer's Disease.
This review discusses how radiation exposure affects the brain and neurodegenerative diseases. Herbal medicines like Allium cepa and Centella asiatica show promise in protecting against neurological damage and may have potential in managing neurological illnesses.
Researchers created Centella asiatica-derived nanovesicles (ADNVs) with anticancer properties through a simple process. ADNVs target diseases like cancer, show internalization in HepG2 cells, and impact metabolic pathways, suggesting their potential as effective anticancer agents.
Bacopa monnieri and Centella asiatica share neuroprotective mechanisms, supported by metabolomics and protein target prediction. Potential for memory enhancement and ROS reduction.
CQA found in coffee and Centella asiatica improves cognitive function in AD model mice. Study suggests potential benefits for reducing neuroinflammation, neuronal loss, and Aβ plaque burden.
Scientists found that oxidative stress and inflammation can worsen diabetes. Researchers are exploring plant-based treatments for diabetes with fewer side effects. This could lead to more effective and affordable medications.
Study explores antidepressant-like effects of C. asiatica compounds on zebrafish stress model. Madecassoside and asiaticoside show potential in reducing cortisol levels and behavior, offering new treatment possibilities for depression.
Madecassoside from Centella asiatica has antioxidant and anti-inflammatory properties in disease models. Its effects on white adipocytes and gene knockdown mechanisms need further study.
Researchers developed a nanocomposite of PLX/ZnO and CAE for diabetic wound healing. It promotes rapid healing, antimicrobial action, and cell proliferation, offering a promising treatment option for diabetic foot ulcers.
Study shows Centella-Asiatica extract and intermittent fasting protect brain from hypoxia-induced damage in zebrafish. Benefits include antioxidant, anti-inflammatory, and neuroprotective effects, along with improved mitochondrial function. Useful for stroke prevention research and potential clinical applications.
Scientists studied the effects of a water extract from an Ayurvedic plant on cognitive deficits, anxiety, and depression in aged mice. The extract improved cognition and reduced anxiety when administered in drinking water, while the effects were less significant when given in the diet.
Researchers conducted a comprehensive analysis of metabolome and transcriptome to understand triterpenoid saponin biosynthesis in leaves. They identified key candidate genes associated with synthesis and accumulation of triterpenoid saponins. This can lead to further research on molecular mechanisms in medicinal plants.
Researchers investigated the bioactivity of triterpenes in the ethanolic extract of Centella asiatica (SECA) and found potential benefits for treating Alzheimer's disease by reducing neuroinflammation and oxidative stress.
Scientists synthesized cerium oxide nanoparticles (CeONPs) from () leaf extract, known for neuroprotective properties. CeONPs showed antioxidant activity and protected human neuroblastoma cells from oxidative stress-induced damage and apoptosis. CeONPs could be valuable in treating neurodegenerative disorders.
Study investigated the effects of ECa 233 (Centella asiatica extract) on pain hypersensitivity caused by nerve injury during oral surgery. Important for managing post-operative orofacial pain.
PIMT protein repairs brain protein damage linked to aging. Mice without PIMT showed anxiety and cognitive issues, but treatment with MA reversed symptoms. MA could help treat anxiety and cognitive impairments in neurodegenerative diseases.
Scientists collected and characterized 26 pennywort accessions from Vietnam and Laos. They found that HUIB_CA20 and HUIB_CA27 were elite cultivars based on their high yield and phytochemical contents. Genetic diversity was also explored for breeding programs.
Centella asiatica (Centella) does not improve cognitive function or reduce disease burden in multiple sclerosis (MS) in mice. However, it does increase antioxidant gene expression and mitochondrial respiratory activity, suggesting potential benefits in MS patients.
Researchers developed an analytical method to accurately quantify 12 bioactive compounds in Centella asiatica (CA), a widely used culinary vegetable and medicinal herb. This method can support the standardization of CA products for clinical trials and confirm correct levels of CA phytochemical markers in preclinical diets.
Researchers investigated the pharmacological properties of asiaticoside, a bioactive component of Centella asiatica, and found it has various benefits including wound-healing, anti-inflammatory, antioxidant, and anti-tumor activities.
Researchers used deep learning and a graph-based system to study the immune system target NF-κB. They found nine molecules from Centella asiatica that could regulate NF-κB and need further investigation.
The study evaluated the phenolic content, antioxidants, and antibacterial properties of an ethanolic plant extract from Guilan, Iran. Hesperetin was the main phenolic compound. The extract showed strong antibacterial activity against specific bacteria. This suggests its potential use in cosmetics and pharmaceuticals.
Researchers developed a new, rapid method to detect bioactive compounds in Centella asiatica using high performance liquid chromatography coupled with tandem mass spectrometry. The method was found to be efficient, environmentally friendly, and sensitive. It can be used to determine four target compounds in herbs.
Researchers studied the use of asiatic acid (AA) in solid lipid nanoparticles (SLNs) delivered through the nose to enhance its penetration in the brain. AA has neuroprotective properties and may be beneficial in the early stages of Alzheimer's disease.
Asiaticoside (AS) reduced cognitive dysfunction and neuroinflammation in AD mice by inhibiting microglia activation and the p38 MAPK pathway, suggesting AS as a potential AD treatment.
Madecassoside (MAD) is a compound from Centella asiatica plant. It potentially reduces blood glucose levels in diabetic rats by protecting β-cells.
Review finds that plant-based drugs, particularly herbs, used as add-on therapy for COVID-19 show efficacy and safety, potentially enhancing the immune system for treating the virus. (37 words)
Summary: Centella asiatica, also known as Gotu Kola, is popular in South East and South East Asian communities for its nutritional and medicinal advantages. In addition to its traditional uses for memory enhancement and wound healing, this plant's phytochemicals have been well-studied for their neuroprotective, neuroregenerative, and antioxidant properties. This research highlights the potential of Centella asiatica in promoting brain health and fighting against oxidative stress, making it a valuable plant for further investigation and potential therapeutic applications.
The study found that ECa 233, a Centella asiatica extract, reduces inflammation and pain in mice with temporomandibular disorder (TMD). It may be a safe alternative treatment with maximum effectiveness at a dosage of 100 mg/kg.
Medicinal herbs have emerged as a promising therapy option for Parkinson's disease (PD). Zebrafish are a potentially cost-effective and efficient animal model for studying PD due to their molecular history and bioimaging properties. A review revealed that only six plants had been investigated as potential PD treatments using zebrafish, and only two - Centella asiatica and Bacopa monnieri - showed potential anti-PD activity. The study explores these plants' mechanisms of action and suggests accessible assays for further investigation.
Plant-based nootropics are natural drugs that can improve cognitive abilities through various mechanisms. They enhance erythrocyte plasticity, inhibit aggregation, and possess antioxidant activity that protects brain tissue from neurotoxicity. They induce the synthesis of neuronal proteins, nucleic acids, and phospholipids for constructing and repairing neurohormonal membranes. The study provides brief descriptions of representative species, their chemical composition, uses, dosages, and contraindications. These plant nootropics have potential therapeutic benefits for treating cognitive disorders, but must be taken at optimal doses for extended periods, and their psychoactive properties are produced by a synergistic combination of several compounds.
Madecassic acid (MDCA) is a natural compound with anti-inflammatory and other medicinal properties. A study investigated its potential as a drug against COVID-19. Computer simulations showed that MDCA could bind to several key proteins involved in the virus' infection process, including the spike protein and its receptors, with high affinity. MDCA also formed strong interactions with these proteins. This suggests that MDCA could be a promising multi-target drug to combat SARS-CoV-2, especially against mutant strains.
Scientists are exploring the potential of a medicinal plant extract from Centella asiatica (CA) as a solution for healthy aging. Past studies have shown that its key components exhibit anti-inflammatory, neuroprotective, and cognitive benefits, linked to the plant's antioxidant and mitoprotective properties. Mitochondrial dysfunction and oxidative stress play a significant role in aging and neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Researchers believe that CA could be an effective treatment for brain aging and neurodegenerative diseases based on its antioxidative and mitoprotective effects.