Centipeda minima

Common Names: spreading sneezeweed

Ethnobotanical Studies

Studies

Centipeda minima and 6-O-angeloylplenolin enhance the efficacy of immune checkpoint inhibitors in non-small cell lung cancer.

Summary

Chemotherapy drugs like cisplatin, gemcitabine, and pemetrexed boost immune checkpoint inhibitor efficacy in lung cancer, but low response rates and side effects hinder widespread use.

Cancer
Wang M et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155825
PubMed:
38968790

Arnicolide D Inhibits Proliferation and Induces Apoptosis of Osteosarcoma Cells through PI3K/Akt/mTOR Pathway.

Chen Z et al (2024).
Anticancer Agents Med Chem.
DOI:
10.2174/0118715206289595240105082138
PubMed:
38967079

Mechanistic prediction and validation of Brevilin A Therapeutic effects in Lung Cancer.

Summary

This study investigates Brevilin A, a component of Centipeda minima, in treating lung cancer using network pharmacology. Understanding its mechanisms could lead to promising new therapies.

Cancer
Wang R et al (2024).
BMC Complement Med Ther.
DOI:
10.1186/s12906-024-04516-z
PubMed:
38840248

Arnicolide D: a multi-targeted anticancer sesquiterpene lactone-preclinical efficacy and mechanistic insights.

Summary

Arnicolide D from Centipeda minima shows promising anticancer effects by inhibiting cell proliferation, inducing apoptosis, and suppressing metastasis. It targets key signaling pathways and displays broad-spectrum cytotoxicity, warranting further investigation for potential clinical use.

Review Cancer
Mangalpady SS et al (2024).
Naunyn Schmiedebergs Arch Pharmacol.
DOI:
10.1007/s00210-024-03095-7
PubMed:
38652277

Arnicolide C Suppresses Tumor Progression by Targeting 14-3-3θ in Breast Cancer.

Summary

Arnicolide C has promising antitumor effects in breast cancer by inhibiting cell proliferation, inducing apoptosis, and targeting 14-3-3θ protein. Further research needed on specific mechanism.

Cancer
Liu Z et al (2024).
Pharmaceuticals (Basel).
DOI:
10.3390/ph17020224
PubMed:
38399439

Identification of arnicolide C as a novel chemosensitizer to suppress mTOR/E2F1/FANCD2 axis in non-small cell lung cancer.

Summary

Researchers identified and examined the chemosensitizing effects of Centipeda minima extracts, revealing that it inhibits FANCD2 activity. Understanding how this works could lead to improved cancer treatments.

Cancer
Chen YF et al (2023).
Br J Pharmacol.
DOI:
10.1111/bph.16281
PubMed:
37926864

Brevilin A inhibits RANKL-induced osteoclast differentiation and bone resorption.

Wei J et al (2023).
In Vitro Cell Dev Biol Anim.
DOI:
10.1007/s11626-023-00783-1
PubMed:
37460875

Hair Growth Effect of DN106212 in C57BL/6 Mouse and Its Network Pharmacological Mechanism of Action.

Baek JY et al (2023).
Curr Issues Mol Biol.
DOI:
10.3390/cimb45060322
PubMed:
37367071

Brevilin A shows an anti-tumor role in prostate cancer via the lncRNA H19/miR-194/E2F3 signaling pathway.

Summary

Brevilin A, a natural compound, has been discovered to have anti-tumor properties in prostate cancer cells. In our study, we investigated the relationship between Brevilin A and the biological behaviors of these cells. We found that Brevilin A inhibited cell proliferation, migration, and invasion, and also promoted apoptosis. This was achieved by suppressing the expression of lncRNA H19 and E2F3, while increasing the level of miR-194. Furthermore, our experiments using a mouse model confirmed that Brevilin A had a tumor-repressing effect. Overall, Brevilin A shows promise as a potential treatment for prostate cancer.

Cancer
You P et al (2023).
Aging (Albany NY).
DOI:
10.18632/aging.204744
PubMed:
37253635

Centipeda minima Extract Inhibits Inflammation and Cell Proliferation by Regulating JAK/STAT Signaling in Macrophages and Keratinocytes.

Immunology
Ma Y et al (2023).
Molecules.
DOI:
10.3390/molecules28041723
PubMed:
36838711

Assessment of the Impacts of Centipeda minima (L.) on Cell Viability, and Osteogenic Differentiation of Mesenchymal Stem Cell Spheroids.

Lee HJ et al (2022).
Medicina (Kaunas).
DOI:
10.3390/medicina59010043
PubMed:
36676667

Brevilin A Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis and Reduces Th17 Differentiation in Psoriasis Patients.

Dermatology
Yen LJ et al (2022).
J Pers Med.
DOI:
10.3390/jpm12111888
PubMed:
36579613

Brevilin A Inhibits VEGF-Induced Angiogenesis through ROS-Dependent Mitochondrial Dysfunction.

Genetics
Wei B et al (2022).
Oxid Med Cell Longev.
DOI:
10.1155/2022/5888636
PubMed:
36567856

Arnicolide D Inhibits Oxidative Stress-Induced Breast Cancer Cell Growth And Invasion Through Apoptosis, Ferroptosis, And Parthanatos.

Cancer
Wen W et al (2022).
Anticancer Agents Med Chem.
DOI:
10.2174/1871520623666221208102021
PubMed:
36503456

Optimization of the Extraction Process and Antioxidant Activity of Polysaccharide Extracted from Centipeda minima.

Yang G et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202200626
PubMed:
36448941

Brevilin A enhances innate immunity and the resistance of oxidative stress in Caenorhabditis elegans via p38 MAPK pathway.

Zhu X et al (2022).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2022.109385
PubMed:
36330917

Two sesquiterpene lactones, arnicolide B and arnicolide C, isolated from Centipeda minima, exert anti-inflammatory effects in LPS stimulated RAW 264.7 macrophages via inactivation of the MAPK pathway.

Immunology
Wang G et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2022.2140659
PubMed:
36323306

Corrigendum to "Promising anticancer activities and mechanisms of action of active compounds from the medicinal herb Centipeda minima (L.) A. Braun & Asch" [Phytomedicine 106 (2022) 154397].

Cancer
Liu YQ and Zhou GB (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154472
PubMed:
36240607

Discovery of potential Q-marker of traditional Chinese medicine based on chemical profiling, chemometrics, network pharmacology, and molecular docking: Centipeda minima as an example.

Liu M et al (2022).
Phytochem Anal.
DOI:
10.1002/pca.3173
PubMed:
36117130

Promising anticancer activities and mechanisms of action of active compounds from the medicinal herb Centipeda minima (L.) A. Braun & Asch.

Review Cancer
Liu YQ and Zhou GB (2022).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154397
PubMed:
36084403

Recent Progress in Traditional Chinese Medicines and Their Mechanism in the Treatment of Allergic Rhinitis.

Review
Mao D et al (2022).
J Healthc Eng.
DOI:
10.1155/2022/3594210
PubMed:
35444784

Centipeda minima extract exerts antineuroinflammatory effects via the inhibition of NF-κB signaling pathway.

Summary

The plant Centipeda minima has been used in traditional Chinese medicine to treat various ailments. Recent studies show that the ethanol extract of C. minima has anti-bacterial, anti-arthritis, and anti-inflammatory properties, but its effects on neuroinflammation are unknown. No reports have been made on the mechanisms behind this.

ImmunologyNeuroscience
Li SY et al (2020).
Phytomedicine.
DOI:
10.1016/j.phymed.2019.153164
PubMed:
31954258

[Pharmacognostic identification of Centipeda minima].

Wu HZ et al (2009).
Zhong Yao Cai.
PubMed:
19504961