Chelidonium majus

Common Names: celandine

Ethnobotanical Studies

Studies

Alkaloids in Chelidonium majus L: a review of its phytochemistry, pharmacology and toxicology.

Summary

Researchers studied the alkaloids in L. plant, known for its medicinal properties. These alkaloids have various pharmacological effects including anti-microbial and anti-inflammatory properties. This review provides a basis for using L. in medicinal chemistry research.

Review Phytochemistry
Li XL et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1440979
PubMed:
39239653

Cardioprotective effect of chelidonic acid against doxorubicin-induced cardiac toxicity in rats.

Summary

Study shows CA protects against doxorubicin-induced heart damage. CA is a compound in celandine plant. Potential for new heart protection treatment.

Cardiology
Khairnar SI, Kulkarni YA and Singh K (2024).
Rev Port Cardiol.
DOI:
10.1016/j.repc.2024.06.003
PubMed:
39216530

The pollen quality of woody and herbaceous plants from the Chernobyl exclusion zone.

Makarenko ES, Volkova PY and Geras'kin SA (2024).
J Environ Radioact.
DOI:
10.1016/j.jenvrad.2024.107504
PubMed:
39038421

Novel Approaches for the Analysis and Isolation of Benzylisoquinoline Alkaloids in Chelidonium majus.

Summary

Tossers developed a supercritical fluid chromatography method to rapidly analyze and isolate benzylisoquinoline alkaloids in . This can aid in the development of new pharmaceuticals for gastrointestinal ailments.

Phytochemistry
Zwerger M et al (2024).
Planta Med.
DOI:
10.1055/a-2204-5686
PubMed:
38843792

A Hidden Cause of Hypertransaminasemia: Liver Toxicity Caused by Chelidonium Majus L.: Report of Two Cases of Herb-Induced Liver Injury and Literature Review.

Ciornolutchii V et al (2024).
Am J Ther.
DOI:
10.1097/MJT.0000000000001708
PubMed:
38820341

A Yellow Flower With Jaundice Power: Liver Injury Attributed to Greater Celandine.

Power S and Barritt AS 4th (2024).
ACG Case Rep J.
DOI:
10.14309/crj.0000000000001347
PubMed:
38682076

Integration of metabolomics and transcriptomics reveals the therapeutic mechanism underlying Chelidonium majus L. in the treatment of allergic asthma.

Summary

Study investigates mechanism of action of Chelidonium majus in relieving cough and asthma, important for potential use in modern medicine.

AsthmaGenetics
Wang R et al (2024).
Chin Med.
DOI:
10.1186/s13020-024-00932-y
PubMed:
38671520

The complete chloroplast genome sequence and phylogenetic relationship analysis of Eomecon chionantha, one species unique to China.

Genetics
Zhang Z et al (2024).
J Plant Res.
DOI:
10.1007/s10265-024-01539-y
PubMed:
38652407

Identification of Flavonoids, Antioxidant and Antiproliferative Activity of Aqueous Infusions of Calendula officinalis L., Chelidonium majus L., Teucrium chamaedrys L. and Alchemilla vulgaris L.

Summary

Study explores biopotential of medicinal herb infusions to meet increasing demand due to global changes. Important for future healthcare needs in face of climate crisis and COVID-19.

CancerImmunologyPhytochemistry
Bilušić T, Šola I and Čikeš Čulić V (2024).
Food Technol Biotechnol.
DOI:
10.17113/ftb.62.01.24.8175
PubMed:
38601959

Evaluation of the in vitro and in vivo antimicrobial activity of alkaloids prepared from Chelidonium majus L. using MRSA- infected C. elegans as a model host.

Summary

Researchers extracted alkaloids from Chelidonium majus L. and found they have strong antibacterial properties, particularly against MRSA. Alkaloids also extended the lifespan of C. elegans under stress through the DAF-2/DAF-16 pathway. This research could lead to new antibiotics and insights into immune responses.

AntimicrobialPhytochemistry
Qi J et al (2024).
Fitoterapia.
DOI:
10.1016/j.fitote.2024.105944
PubMed:
38580033

Identification of toxic Gelsemium elegans in processed food and honey based on real-time PCR analysis.

Wang G et al (2024).
Food Res Int.
DOI:
10.1016/j.foodres.2024.114188
PubMed:
38519193

Screening of Chelidonium majus isoquinoline alkaloids reveals berberine and chelidonine as selective ligands for the nuclear receptors RORβ and HNF4α, respectively.

Phytochemistry
Salehi S et al (2024).
Arch Pharm (Weinheim).
DOI:
10.1002/ardp.202300756
PubMed:
38501877

Romanian Wild-Growing Chelidonium majus-An Emerging Approach to a Potential Antimicrobial Engineering Carrier System Based on AuNPs: In Vitro Investigation and Evaluation.

Summary

Tl;dr: New nanotechnology using herbal products improves stability, toxicity, absorption, and release. In vitro studies show high dissolution and antioxidant potential, making it a promising antimicrobial and anti-inflammatory candidate with diverse applications.

Antimicrobial
Segneanu AE et al (2024).
Plants (Basel).
DOI:
10.3390/plants13050734
PubMed:
38475580

The Greater Celandine: Identification and Characterization of an Antimicrobial Peptide from Chelidonium majus.

Summary

Greater Celandine plant with potential for future antimicrobial drug development. Strong focus on structural and functional characterization of CM-AMP1 and its impact on bacterial proteomics under stress.

Antimicrobial
Sadecki PW et al (2024).
J Nat Prod.
DOI:
10.1021/acs.jnatprod.3c00939
PubMed:
38366995

Chemical characterization of three different extracts obtained from Chelidonium majus L. (Greater celandine) with insights into their in vitro, in silico and network pharmacological properties.

Terzic M et al (2024).
Fitoterapia.
DOI:
10.1016/j.fitote.2024.105835
PubMed:
38301936

Integrating bioinformatics and experimental models to investigate the mechanism of the chelidonine-induced mitotic catastrophe via the AKT/FOXO3/FOXM1 axis in breast cancer cells.

Summary

Chelidonine, an ingredient in Chelidonium majus, can trigger mitotic catastrophe in breast cancer (BC) cells. FOXO3 is a potential biomarker for BC prognosis, and chelidonine inhibits BC cell proliferation, induces M phase arrest, and weakens the AKT/FOXO3/FOXM1 axis, making it a promising treatment for BC.

Cancer
Li H et al (2023).
Biomol Biomed.
DOI:
10.17305/bb.2023.9665
PubMed:
37976368

Herbgenomics meets Papaveraceae: a promising -omics perspective on medicinal plant research.

Kielich N et al (2023).
Brief Funct Genomics.
DOI:
10.1093/bfgp/elad050
PubMed:
37952099

EVALUATION OF THE COMPLEX USE OF PLANT TEST-SYSTEMS TO DETERMINE THE NATURE AND INTENSITY OF THE MUTAGENIC BACKGROUND OF THE ENVIRONMENT.

Summary

Study evaluated the use of plant test-systems to identify the specific effects of mutagens on hereditary apparatus. Important for making informed decisions in the lab.

Genetics
Shvets LS et al (2023).
Pol Merkur Lekarski.
DOI:
10.36740/Merkur202303106
PubMed:
37589106

Chelidonine reduces IL-1β-induced inflammation and matrix catabolism in chondrocytes and attenuates cartilage degeneration and synovial inflammation in rats.

Summary

Chelidonine, extracted from Chelidonium majus, reduces inflammation and catabolism in osteoarthritis (OA) by inhibiting the NF-κB pathway, potentially preventing cartilage degeneration and synovial inflammation.

Immunology
Li M et al (2023).
Braz J Med Biol Res.
DOI:
10.1590/1414-431X2023e12604
PubMed:
37585914

Phytomediated-Assisted Preparation of Cerium Oxide Nanoparticles Using Plant Extracts and Assessment of Their Structural and Optical Properties.

Fifere N et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24108917
PubMed:
37240263

Determination of Selected Isoquinoline Alkaloids from Chelidonium majus, Mahonia aquifolium and Sanguinaria canadensis Extracts by Liquid Chromatography and Their In Vitro and In Vivo Cytotoxic Activity against Human Cancer Cells.

CancerPhytochemistry
Tuzimski T et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24076360
PubMed:
37047332

Relationships between Heavy Metal Concentrations in Greater Celandine (Chelidonium majus L.) Tissues and Soil in Urban Parks.

Rahmonov O et al (2023).
Int J Environ Res Public Health.
DOI:
10.3390/ijerph20053887
PubMed:
36900897

Preliminary outcome of Chelidonium majus (greater celandine) for COVID-19.

COVID-19
Gardin NE and Braga AJ (2023).
Phytother Res.
DOI:
10.1002/ptr.7776
PubMed:
36794596

Investigation of in vitro Cytotoxicity of Chelidonium majus against Leishmania major.

Madjeed Haddao K et al (2022).
Arch Razi Inst.
DOI:
10.22092/ARI.2022.358758.2301
PubMed:
36618311

Species-Specific Plant-Derived Nanoparticle Characteristics.

Viršilė A et al (2022).
Plants (Basel).
DOI:
10.3390/plants11223139
PubMed:
36432868

Chelerythrine-Induced Apoptotic Cell Death in HepG2 Cells Involves the Inhibition of Akt Pathway and the Activation of Oxidative Stress and Mitochondrial Apoptotic Pathway.

Lin Y et al (2022).
Antioxidants (Basel).
DOI:
10.3390/antiox11091837
PubMed:
36139911

The Activity of Chelidonium majus L. Latex and Its Components on HPV Reveal Insights into the Antiviral Molecular Mechanism.

Antimicrobial
Musidlak O et al (2022).
Int J Mol Sci.
DOI:
10.3390/ijms23169241
PubMed:
36012505

Research Status and Hotspots of Anticancer Natural Products Based on the Patent Literature and Scientific Articles.

Cancer
Shen J et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.903239
PubMed:
35784720

Effectiveness of Volatile Natural Deep Eutectic Solvents (VNADESs) for the Green Extraction of Chelidonium majus Isoquinoline Alkaloids.

Phytochemistry
Strzemski M et al (2022).
Molecules.
DOI:
10.3390/molecules27092815
PubMed:
35566166

Chelidonium majus Induces Apoptosis of Human Ovarian Cancer Cells via ATF3-Mediated Regulation of Foxo3a by Tip60.

Cancer
Shen L et al (2022).
J Microbiol Biotechnol.
DOI:
10.4014/jmb.2109.09030
PubMed:
35283423

Preventive Efficiency of Chelidonium majus Ethanolic Extract Against Aflatoxin B(1) Induced Neurochemical Deteriorations in Rats.

Ra Kasem N et al (2022).
Pak J Biol Sci.
DOI:
10.3923/pjbs.2022.234.244
PubMed:
35234014

The Cultivation of Chelidonium majus L. Increased the Total Alkaloid Content and Cytotoxic Activity Compared with Those of Wild-Grown Plants.

Phytochemistry
Krizhanovska V et al (2021).
Plants (Basel).
DOI:
10.3390/plants10091971
PubMed:
34579502

Greater celandine (Chelidonium majus L.) for COVID-19: A twenty-case series.

Summary

This study describes the use of greater celandine (Chelidonium majus L.) to treat 20 COVID-19 outpatients. The patients were treated with Chelidonium majus 10% mother tincture, and symptoms were assessed during and after treatment. The patients had mild symptoms and complete or almost complete clinical improvement occurred within 1-9 days of treatment. No adverse events were reported. This small study suggests that greater celandine may have potential as a treatment for COVID-19 and may inspire further research in this area.

COVID-19
Gardin NE and Braga AJ (2021).
Phytother Res.
DOI:
10.1002/ptr.7085
PubMed:
33778996

Chelidonium majus crude extract induces activation of peripheral blood mononuclear cells and enhances their cytotoxic effect toward HeLa cells.

Popovic A et al (2022).
Int J Environ Health Res.
DOI:
10.1080/09603123.2021.1897534
PubMed:
33706629

Chelidonium majus crude extract inhibits migration and induces cell cycle arrest and apoptosis in tumor cell lines.

Cancer
Deljanin M et al (2016).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2016.06.056
PubMed:
27350008

Chelidonium majus--an integrative review: traditional knowledge versus modern findings.

Review
Gilca M et al (2010).
Forsch Komplementmed.
DOI:
10.1159/000321397
PubMed:
20980763