Cichorium intybus

Common Names: common chicory, blue sailors, coffeeweed, chicory, French endive, succory, chickory

Ethnobotanical Studies

Clinical Trials

Effects of Chicory and Fumitory on Hot Flashes Among Breast Cancer Survivors: A Randomized, Double-Blind Placebo-Controlled Trial.

A study evaluated the effects of a traditional Persian medicine syrup containing chicory and fumitory extracts on hot flashes in breast cancer survivors. After 4 weeks, the syrup significantly reduced hot flashes. More research is needed to confirm its effectiveness and safety.

Khosropanah A et al (2023).
J Integr Complement Med.
PubMed:
36219736

Studies

A comparative anticancer analysis of Iron Oxide nanoparticles of Hippophae rhamnoides and Cichorium intybus found in the Karakoram Range of Gilgit Baltistan against liver cancer targeting the RhoA gene.

Summary

Researchers evaluated FeO nanoparticles from different plant extracts against liver cancer cells. FeO nanoparticles from plant X were most effective, decreasing gene/protein levels of X and increasing levels of Y and Z. This information could lead to new treatments for liver cancer.

Tabassum R and Dilshad E (2024).
Drug Dev Ind Pharm.
PubMed:
39226126

Grasslands and flood mitigation - Contrasting forages improve surface water infiltration rates.

Marley CL et al (2024).
Sci Total Environ.
PubMed:
39159691

Aldose reductase inhibitory and antiglycation properties of phytoconstituents of Cichorium intybus: Potential therapeutic role in diabetic retinopathy.

Summary

Study on C. intybus extract for diabetic retinopathy: inhibits AR enzyme, reduces advanced glycation end products, and shows strong therapeutic potential. Potential for drug development against diabetic vascular complications.

Ahmad S et al (2024).
Int J Biol Macromol.
PubMed:
39002911

Modulation of human gut microbiota by linear and branched fructooligosaccharides in an in vitro colon model (TIM-2).

Popov IV, Koopmans B and Venema K (2024).
J Appl Microbiol.
PubMed:
38986506

Effects of Chicory (Cichorium intybus L.) Extract on Male Rat Reproductive System, Pregnancy and Offspring Development.

Babenko AN et al (2024).
Pharmaceuticals (Basel).
PubMed:
38931367

Can Diet Alter the Intestinal Barrier Permeability in Healthy People? A Systematic Review.

Summary

Chicory inulin and probiotics reduce intestinal barrier permeability. Fructose increases it. Limited evidence on dietary effects. More high-quality studies needed for healthy populations.

Nascimento DSMD et al (2024).
Nutrients.
PubMed:
38931225

Phytochemistry, pharmacological applications, and therapeutic effects of green synthesized nanomaterials using Cichorium species-a comprehensive review.

Summary

Researchers have found that various chicory plants contain bioactives with therapeutic benefits, including antidiabetic, hepatoprotective, anti-obesity, and anti-cancer properties. Green synthesis using these compounds may offer safe and effective solutions for human health.

Sishu NK and Selvaraj CI (2024).
Naunyn Schmiedebergs Arch Pharmacol.
PubMed:
38900250

Cichorium glandulosum Ameliorates HFD-Induced Obesity in Mice by Modulating Gut Microbiota and Bile Acids.

Summary

Chicory extract (CG) delayed weight gain, improved metabolism, reduced oxidative stress, and balanced gut microbiota in obese mice. CG may be beneficial for treating obesity and metabolic issues by targeting the gut microbiome and bile acid production.

Zhong Y et al (2024).
J Med Food.
PubMed:
38742981

Scanning electron microscopic investigation on Chicory tribe (Compositae) botanical sources and their antimicrobial potential.

AlNadhari S et al (2024).
Microsc Res Tech.
PubMed:
38725294

Wild Edible Plants Used in Dalmatian Zagora (Croatia).

Ninčević Runjić T et al (2024).
Plants (Basel).
PubMed:
38674488

Influence of Abiotic and Biotic Elicitors on Organogenesis, Biomass Accumulation, and Production of Key Secondary Metabolites in Asteraceae Plants.

Review
Petrova M, Miladinova-Georgieva K and Geneva M (2024).
Int J Mol Sci.
PubMed:
38673783

The inclusion of companion forages in the diet alongside perennial ryegrass increased dry matter intake and organic matter digestibility in sheep.

Woodmartin S et al (2024).
Animal.
PubMed:
38669749

Foliar-applied silicate potassium modulates growth, phytochemical, and physiological traits in Cichorium intybus L. under salinity stress.

Mohammadi H et al (2024).
BMC Plant Biol.
PubMed:
38627611

Can the Inclusion of Forage Chicory in the Diet of Lactating Dairy Cattle Alter Milk Production and Milk Fatty Acid Composition? Findings of a Multilevel Meta-Analysis.

Review
Mangwe MC et al (2024).
Animals (Basel).
PubMed:
38612241

Edible wild plants, chicory and purslane, alleviated diabetic testicular dysfunction, and insulin resistance via suppression 8OHdg and oxidative stress in rats.

Summary

Chicory and purslane herbal extracts improve testicular function in diabetic rats by reducing blood sugar, lipid levels, inflammation, and oxidative stress while enhancing sperm, hormone levels, and testicular health. Promising for potential human applications.

Saad EA et al (2024).
PLoS One.
PubMed:
38603728

Elucidating hepatoprotective potential of Cichorium intybus through multimodal assessment and molecular docking analysis with hepatic protective enzymes.

Pathak A, Singh SP and Tiwari A (2024).
Food Chem Toxicol.
PubMed:
38554841

Urban Flora Riches: Unraveling Metabolic Variation Along Altitudinal Gradients in Two Spontaneous Plant Species.

Mogîldea ED et al (2024).
Plants (Basel).
PubMed:
38475503

Esculin inhibits hepatic stellate cell activation and CCl(4)-induced liver fibrosis by activating the Nrf2/GPX4 signaling pathway.

Xu S et al (2024).
Phytomedicine.
PubMed:
38471319

Chitosan-Supported ZnO Nanoparticles: Their Green Synthesis, Characterization, and Application for the Removal of Pyridoxine HCl (Vitamin B6) from Aqueous Media.

Ali S et al (2024).
Molecules.
PubMed:
38398580

Metabolomic profiling of the nutritional components of chicory leaves following heat processing.

Kobayashi W et al (2024).
J Food Sci.
PubMed:
38391109

Chicory (Cichorium intybus) reduces cyathostomin egg excretion and larval development in grazing horses.

Malsa J et al (2024).
Int J Parasitol Drugs Drug Resist.
PubMed:
38368671

Evaluation of the Content of Minerals, B-Group Vitamins, Tocols, and Carotenoids in Raw and In-House Cooked Wild Edible Plants.

Fratianni A et al (2024).
Foods.
PubMed:
38338607

Use of Pseudomonas protegens to Control Root Rot Disease Caused by Boeremia exigua var. exigua in Industrial Chicory (Cichorium intybus var. sativum Bisch.).

Quezada-D'Angelo T et al (2024).
Plants (Basel).
PubMed:
38256816

The Therapeutic Potential of Two Egyptian Plant Extracts for Mitigating Dexamethasone-Induced Osteoporosis in Rats: Nrf2/HO-1 and RANK/RANKL/OPG Signals.

Saleh SR et al (2024).
Antioxidants (Basel).
PubMed:
38247490

Computational exploration of microsomal cytochrome P450 3A1 enzyme modulation by phytochemicals of Cichorium intybus L.: Insights into drug metabolism.

Pathak A et al (2024).
Biopharm Drug Dispos.
PubMed:
38243990

Evaluation of the Effect of Cichorium intybus L. on the Liver Enzymes in Burn Patients: A Randomized Double-Blind Clinical Trial.

Keshavarzi A et al (2024).
Int J Clin Pract.
PubMed:
38239768

Biocatalytic Regioselective O-acylation of Sesquiterpene Lactones from Chicory: A Pathway to Novel Ester Derivatives.

Mosheim JR et al (2024).
Chembiochem.
PubMed:
38235523

Comprehensive metabolite and biological profile of "Sulmona Red Garlic" ecotype's aerial bulbils.

Chiavaroli A et al (2024).
Food Res Int.
PubMed:
38129017

Assessment of the chemical and genetic variability among accessions of Cicerbita alpina (L.) Wallr., an alpine plant with anthelmintic properties.

Martinidou E et al (2023).
Front Plant Sci.
PubMed:
38078086

Cichorium intybus L. significantly alleviates cigarette smoke-induced acute lung injury by lowering NF-κB pathway activation and inflammatory mediators.

Summary

Researchers investigated the role of a natural compound, resveratrol, in preventing cigarette smoke-induced lung injury. Resveratrol showed potential in reducing inflammation and oxidative stress, offering a possible treatment for acute lung injury.

Hussain N et al (2023).
Heliyon.
PubMed:
38045213

Protective effect of chicory and/or artichoke leaves extracts on carbon tetrachloride and gamma-irradiation-induced chronic nephrotoxicity in rats.

Eassawy MMT and Ismail AFM (2024).
Environ Toxicol.
PubMed:
38031637

In vivo comprehensive metabolite profiling of esculetin and esculin derived from chicory in hyperuricemia rats using ultra-high-performance liquid chromatography coupled with quadrupole-orbitrap high-resolution mass spectrometry.

Lv Z et al (2024).
J Sep Sci.
PubMed:
38010472

Orychophragmus violaceus and/or chicory forage affects performance, egg quality, sensory evaluation and antioxidative properties in native laying hens.

Zhao WY et al (2023).
Anim Biotechnol.
PubMed:
38006583

Polyphenols in Agricultural Grassland Crops and Their Health-Promoting Activities-A Review.

Review
Verhulst EP, Brunton NP and Rai DK (2023).
Foods.
PubMed:
38002180

Comparative polyphenolic profiling of five ethnomedicinal plants and their applicative potential in the treatment of type 2 diabetes.

Summary

These plants have been traditionally used for preventing and treating diseases like diabetes. They may contain beneficial compounds that could be useful for developing new treatments in the lab.

Kukavica B et al (2023).
J Ethnopharmacol.
PubMed:
37939910

Chicoric acid enhances the antioxidative defense system and protects against inflammation and apoptosis associated with the colitis model induced by dextran sulfate sodium in rats.

Alharthi F et al (2023).
Environ Sci Pollut Res Int.
PubMed:
37930572

Modulation of Hepatic Functions by Chicory (Cichorium intybus L.) Extract: Preclinical Study in Rats.

Krepkova LV et al (2023).
Pharmaceuticals (Basel).
PubMed:
37895942

Antidiabetic Effect of Combined Leaf Extracts of Portulaca oleracea L., Beta vulgaris L., and Cichorium intybus L. in Streptozotocin-Induced Diabetic Rats.

Summary

Combining purslane, chard, and chicory leaf extracts improved glucose control in diabetic rats, restoring liver and pancreas health. This could lead to the development of natural drugs for diabetes.

Helmy SA et al (2023).
J Med Food.
PubMed:
37801671

CRISPR/Cas9-Targeted Mutagenesis of CiGAS and CiGAO to Reduce Bitterness in Chicory (Cichorium intybus L.).

Summary

Researchers investigated the bitterness of chicory roots and found that it is mainly due to the presence of sesquiterpene lactones. Understanding this can help in developing food products with reduced bitterness and maximizing chicory's health benefits.

Domont J et al (2023).
Front Biosci (Landmark Ed).
PubMed:
37796686

Optimized Extraction of Polyphenols from Unconventional Edible Plants: LC-MS/MS Profiling of Polyphenols, Biological Functions, Molecular Docking, and Pharmacokinetics Study.

Kiani HS et al (2023).
Molecules.
PubMed:
37764478

Inulin from halophilic archaeon Haloarcula: Production, chemical characterization, biological, and technological properties.

Aragón-León A et al (2023).
Carbohydr Polym.
PubMed:
37739546

Nutraceutical Potential of Leafy Vegetables Landraces at Microgreen, Baby, and Adult Stages of Development.

Mallor C et al (2023).
Foods.
PubMed:
37685105

Evaluation of trace elements in forages and their effect on gastrointestinal parasite burden in grazing sheep.

Rizwan HM et al (2023).
Saudi J Biol Sci.
PubMed:
37645686

The Main Medicinal Plants in Arid Regions of Uzbekistan and Their Traditional Use in Folk Medicine.

Abduraimov OS et al (2023).
Plants (Basel).
PubMed:
37631161

Research on the Control of Gastrointestinal Strongyles in Sheep by Using Lotus corniculatus or Cichorium intybus in Feed.

Cireșan CA et al (2023).
Pathogens.
PubMed:
37623945

Molecular docking and molecular dynamics simulation analysis of bioactive compounds of Cichorium intybus L. seed against hepatocellular carcinoma.

Samreen S, Khan E and Ahmad IZ (2023).
J Biomol Struct Dyn.
PubMed:
37621217

Antidiabetic effects of polyherbal mixture made of Centaurium erythraea, Cichorium intybus and Potentilla erecta.

Summary

Ancient polyherbal mixture with Centaurium erythraea, Cichorium intybus, and Potentilla erecta treats primary and secondary diabetes complications. Potential therapeutic application for diabetes management in the lab.

Petrović A et al (2023).
J Ethnopharmacol.
PubMed:
37582477

Simple procedure to enhance pulsed amperometric detector (PAD) response stability for inulin-type fructans analysis. Application to a case study with chicory taproot.

Moscatello S et al (2024).
Food Chem.
PubMed:
37517944

Genome-Wide Datasets of Chicories (Cichorium intybus L.) for Marker-Assisted Crop Breeding Applications: A Systematic Review and Meta-Analysis.

Summary

This study reviews the scientific literature on chicory and creates two consensus maps that can be used for marker-assisted breeding and selection programs. The organized molecular data will help breeders develop superior commercial products with agronomic potential.

Meta-Analysis Genetics
Draga S et al (2023).
Int J Mol Sci.
PubMed:
37511422

Identification and characterization of CYP71 subclade cytochrome P450 enzymes involved in the biosynthesis of bitterness compounds in Cichorium intybus.

De Bruyn C et al (2023).
Front Plant Sci.
PubMed:
37426959

One new 12, 8-guaianolide sesquiterpene lactone with antihyperglycemic activity from the roots of Cichorium intybus.

Meng XH et al (2023).
Nat Prod Res.
PubMed:
37395502

Industrial chicory genome gives insights into the molecular timetable of anther development and male sterility.

Waegneer E et al (2023).
Front Plant Sci.
PubMed:
37384353

Characterization of the Bacterial Communities in Cichorium intybus According to Cultivation and Storage Conditions.

Yum SJ et al (2023).
Microorganisms.
PubMed:
37375061

Cellulose nanocrystals derived from chicory plant: an un-competitive inhibitor of aromatase in breast cancer cells via PI3K/AKT/mTOP signalling pathway.

Allahyari M et al (2024).
J Biomol Struct Dyn.
PubMed:
37340682

MIK2 is a candidate gene of the S-locus for sporophytic self-incompatibility in chicory (Cichorium intybus, Asteraceae).

Palumbo F et al (2023).
Front Plant Sci.
PubMed:
37332702

Field-scale differences in rhizosphere micro-characteristics of Cichorium intybus, Ixeris polycephala, sunflower, and Sedum alfredii in the phytoremediation of Cd-contaminated soil.

Zeng X et al (2023).
Ecotoxicol Environ Saf.
PubMed:
37320919

Dietary non-starch polysaccharides impair immunity to enteric nematode infection.

Valente AH et al (2023).
BMC Biol.
PubMed:
37316905

Antimicrobial activity of cold atmospheric-pressure argon plasma combined with chicory (Cichorium intybus L.) extract against P. aeruginosa and E. coli biofilms.

Shabani H et al (2023).
Sci Rep.
PubMed:
37296178

A Three-Step Process to Isolate Large Quantities of Bioactive Sesquiterpene Lactones from Cichorium intybus L. Roots and Semisynthesis of Chicory STLs Standards.

Ruggieri F et al (2023).
Pharmaceuticals (Basel).
PubMed:
37242554

The effects of chicory supplementation on liver enzymes and lipid profiles in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of clinical evidence.

Maleki E et al (2023).
Clin Nutr ESPEN.
PubMed:
37202083

A comparison of three different delivery methods for achieving CRISPR/Cas9 mediated genome editing in Cichorium intybus L.

Salvagnin U et al (2023).
Front Plant Sci.
PubMed:
37123849

Purification and characterization of chicory polysaccharide and its application in stabling genistein for cancer therapy.

Shi L et al (2023).
Int J Biol Macromol.
PubMed:
37121414

Evolutionary analysis of the OSCA gene family in sunflower (Helianthus annuus L) and expression analysis under NaCl stress.

Shan F et al (2023).
PeerJ.
PubMed:
37090105

Radical shift in the genetic composition of New England chicory populations.

Závada T et al (2023).
J Ecol.
PubMed:
37064427

Keeping Healthy in Your Skin-Plants and Fungi Used by Indigenous Himalayan Communities to Treat Dermatological Ailments.

Haq SM et al (2023).
Plants (Basel).
PubMed:
37050200

Lactucin Synthase Inactivation Boosts the Accumulation of Anti-inflammatory 8-Deoxylactucin and Its Derivatives in Chicory (Cichorium intybus L.).

Cankar K et al (2023).
J Agric Food Chem.
PubMed:
37036799

Pipeline to Design Inbred Lines and F1 Hybrids of Leaf Chicory (Radicchio) Using Male Sterility and Genotyping-by-Sequencing.

Scariolo F et al (2023).
Plants (Basel).
PubMed:
36986929

Health Benefits of Key Constituents in Cichorium intybus L.

Review
Birsa ML and Sarbu LG (2023).
Nutrients.
PubMed:
36986053

CiXTH29 and CiLEA4 Role in Water Stress Tolerance in Cichorium intybus Varieties.

De Caroli M et al (2023).
Biology (Basel).
PubMed:
36979136

Cichorium intybus L. is a potential Cd-accumulator for phytoremediation of agricultural soil with strong tolerance and detoxification to Cd.

Wu S et al (2023).
J Hazard Mater.
PubMed:
36921417

Chemometric Discrimination of Cichorium glandulosum Boiss. et Huet and Cichorium intybus L. via Their Metabolic Profiling, Antioxidative, and Hypoglycemic Activities.

Li M et al (2023).
Foods.
PubMed:
36832980

Effect of Priestia endophytica on the metabolites accumulation in chicory and lettuce plants cultivated in vitro.

Kharkhota M et al (2023).
Prep Biochem Biotechnol.
PubMed:
36762765

Insights into the convergent evolution of fructan biosynthesis in angiosperms from the highly characteristic chicory genome.

Shen F et al (2023).
New Phytol.
PubMed:
36751914

SMAP design: a multiplex PCR amplicon and gRNA design tool to screen for natural and CRISPR-induced genetic variation.

Develtere W et al (2023).
Nucleic Acids Res.
PubMed:
36718951

A Novel Approach Based on Gut Microbiota Analysis and Network Pharmacology to Explain the Mechanisms of Action of Cichorium intybus L. Formula in the Improvement of Hyperuricemic Nephropathy in Rats.

Amatjan M et al (2023).
Drug Des Devel Ther.
PubMed:
36712944

The effect of hydroalcoholic extract of Cichorium intybus leaf on aryl hydrocarbon receptor expression in the testis of Wistar rats exposed to cigarette smoke.

Hashemi M et al (2023).
Avicenna J Phytomed.
PubMed:
36698732

Characterization of Some Cichorium Taxa Grown under Mediterranean Climate Using Morphological Traits and Molecular Markers.

El-Taher AM et al (2023).
Plants (Basel).
PubMed:
36679101

Antiparasitic Tannin-Rich Plants from the South of Europe for Grazing Livestock: A Review.

Review
Rodríguez-Hernández P et al (2023).
Animals (Basel).
PubMed:
36670741

Investigation of some endophytic fungi from five medicinal plants with growth promoting ability on maize (Zea mays L.).

Hatamzadeh S et al (2022).
J Appl Microbiol.
PubMed:
36626729

Enriched pasta incorporating typical vegetables of mediterranean diet: in vitro evaluation of inhibitory potential on digestive enzymes and predicted glycaemic index.

Ombra MN, Nazzaro F and Fratianni F (2022).
Int J Food Sci Nutr.
PubMed:
36534971

The effects of peppermint (Mentha piperita L.) and chicory (Cichorium intybus L.) in comparison with a prebiotic on productive performance, blood constituents, immunity and intestinal microflora in broiler chickens.

Tufarelli V et al (2023).
Anim Biotechnol.
PubMed:
36227283

Effect of Cichorium intybus on production performance, carcass quality and blood lipid profile of hybrid duck.

Umami N et al (2023).
Anim Biosci.
PubMed:
36108697

Anti-protozoal activity and metabolomic analyses of Cichorium intybus L. against Trypanosoma cruzi.

Peña-Espinoza M et al (2022).
Int J Parasitol Drugs Drug Resist.
PubMed:
36037562

Cichorium intybus bio-callus synthesized silver nanoparticles: A promising antioxidant, antibacterial and anticancer compound.

Gharari Z et al (2022).
Int J Pharm.
PubMed:
35917872

Discovery of potential mTOR inhibitors from Cichorium intybus to find new candidate drugs targeting the pathological protein related to the breast cancer: an integrated computational approach.

Rasul HO et al (2023).
Mol Divers.
PubMed:
35737256

In vitro evaluation of the effects of methanolic plant extracts on the embryonation rate of Ascaridia galli eggs.

Poulopoulou I et al (2022).
Vet Res Commun.
PubMed:
35727416

Overview of Witloof Chicory (Cichorium intybus L.) Discolorations and Their Underlying Physiological and Biochemical Causes.

Review
De Jaegere I et al (2022).
Front Plant Sci.
PubMed:
35283895

Integrated Metabolomics and Network Pharmacology to Establish the Action Mechanism of Qingrekasen Granule for Treating Nephrotic Syndrome.

Duan Y et al (2021).
Front Pharmacol.
PubMed:
34938183

The impact of cichorium intybus L. On GDF-15 level in obese diabetic albino mice as compared with metformin effect.

Eltokhy AK, Khattab HA and Rabah HM (2021).
J Diabetes Metab Disord.
PubMed:
34900765

The Common Cichory (Cichorium intybus L.) as a Source of Extracts with Health-Promoting Properties-A Review.

Review
Janda K et al (2021).
Molecules.
PubMed:
33807029

Chicory (Cichorium intybus L.) as a food ingredient - Nutritional composition, bioactivity, safety, and health claims: A review.

Review
Perović J et al (2021).
Food Chem.
PubMed:
32768902

Cytotoxicity of Cichorium intybus L. metabolites (Review).

Review
Imam KMSU et al (2019).
Oncol Rep.
PubMed:
31578592

Selected hepatoprotective herbal medicines: Evidence from ethnomedicinal applications, animal models, and possible mechanism of actions.

Ali M et al (2018).
Phytother Res.
PubMed:
29047177

Cichorium intybus: Traditional Uses, Phytochemistry, Pharmacology, and Toxicology.

Street RA, Sidana J and Prinsloo G (2013).
Evid Based Complement Alternat Med.
PubMed:
24379887