Cicuta douglasii

Common Names: Douglas' waterhemlock, water hemlock, western water hemlock

Ethnobotanical Studies

Studies

The non-competitive blockade of GABAA receptors by an aqueous extract of water hemlock (Cicuta douglasii) tubers.

Summary

Water hemlocks are extremely toxic plants due to the presence of cicutoxin. This study investigated the effect of an aqueous extract of water hemlock on GABAA receptors in WSS-1 cells. Noncompetitive blockade of the receptors was observed, indicating the potential mechanisms behind the plant's toxicity. Additionally, researchers found that midazolam could modulate the blockade, which could have implications for treatment options in cases of water hemlock poisoning.

Neuroscience
Green BT et al (2015).
Toxicon.
DOI:
10.1016/j.toxicon.2015.09.015
PubMed:
26415905

Water hemlock (Cicuta douglasii) toxicoses in sheep: pathologic description and prevention of lesions and death.

Panter KE, Baker DC and Kechele PO (1996).
J Vet Diagn Invest.
PubMed:
8953535

Seizures and death on a white river float trip. Report of water hemlock poisoning.

Summary

White water rafting is becoming more popular in the US, but many people are unprepared and may find themselves in dangerous situations without access to medical help. In addition to drowning, there is a risk of poisoning from common plants like Cicuta douglasii. This plant is toxic and can be easily mistaken for wild parsnip or carrot. Physicians and poison control centers should be aware of common poisonous plants in their area to treat cases of poisoning.

Neuroscience
Landers D, Seppi K and Blauer W (1985).
West J Med.
PubMed:
4013278

The convulsive profile of Cicuta douglasii (water hemlock).

Nelson RB and Cole FR (1976).
Proc West Pharmacol Soc.
PubMed:
995987

The influence of biperiden, benztropine, physostigmine and diazepam on the convulsive effects of Cicuta douglasii.

Nelson RB et al (1978).
Proc West Pharmacol Soc.
PubMed:
693490