Cimicifuga racemosa

Common Names: black bugbane, black cohosh, black snakeroot

Ethnobotanical Studies

Clinical Trials

Effects of a combination of botanical actives on skin health and antioxidant status in post-menopausal women: A randomized, double-blind, placebo-controlled clinical trial.

Researchers investigated the use of nutraceuticals with estrogenic and antioxidative effects as an alternative therapy to slow down skin aging in post-menopausal women.

Tumsutti P et al (2022).
J Cosmet Dermatol.
DOI:
10.1111/jocd.14345
PubMed:
34260808

Studies

Transfer of preclinical study data on the influence of cimicifuga racemosaon functional changes in the hippocampus during menopause.

Summary

Black cohosh extract (iCR) may help relieve menopausal symptoms, including hot flashes and cognitive impairments, in women who cannot or prefer not to use hormone replacement therapy. It works by affecting gene expression in the brain, especially in the hippocampus, to regulate various physiological and cognitive functions.

Review EndocrinologyNeuroscience
Stute P, Henneicke-von Zepelin HH and Nicken P (2024).
Gynecol Endocrinol.
DOI:
10.1080/09513590.2024.2360066
PubMed:
38833172

Exploring the Efficacy and Safety of Black Cohosh (Cimicifuga racemosa) in Menopausal Symptom Management.

Review
Hedaoo K et al (2024).
J Midlife Health.
DOI:
10.4103/jmh.jmh_242_23
PubMed:
38764923

AMPK Activation by Cimicifuga racemosa Extract Ze 450 Is Associated with Metabolic Effects and Cellular Resilience against Age-Related Pathologies in Different Tissue Cell Types.

Günther M et al (2024).
Pharmaceutics.
DOI:
10.3390/pharmaceutics16030393
PubMed:
38543287

Harder, better, faster, stronger? Retrospective chart review of adverse events of interactions between adaptogens and antidepressant drugs.

Summary

This study evaluated the prevalence and characteristics of adverse events associated with adaptogen-antidepressant interactions. Adaptogens were involved in 9% of adverse events. Clinicians should monitor these interactions due to the potential for clinically significant adverse events.

Neuroscience
Siwek M et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1271776
PubMed:
37829299

Extract of Cimicifuga racemosa (L.) Nutt protects ovarian follicle reserve of mice against in vitro deleterious effects of dexamethasone.

Summary

CIMI extract counteracts the harmful effects of DEXA on mouse ovaries in vitro, maintaining follicle morphology, stromal cellular density, and gene expression levels of Bax, Bcl-2, and Caspase-3 similar to control. CIMI can protect ovaries from DEXA-induced damage.

Endocrinology
Assis EIT et al (2023).
Braz J Med Biol Res.
DOI:
10.1590/1414-431X2023e12811
PubMed:
37792779

Quality by Design Assisted Optimization and Risk Assessment of Black Cohosh Loaded Ethosomal Gel for Menopause: Investigating Different Formulation and Process Variables.

Endocrinology
Mohapatra S et al (2023).
Pharmaceutics.
DOI:
10.3390/pharmaceutics15020465
PubMed:
36839787

Protective Effect of Cimicifuga racemosa (L.) Nutt Extract on Oocyte and Follicle Toxicity Induced by Doxorubicin during In Vitro Culture of Mice Ovaries.

de Assis EIT et al (2022).
Animals (Basel).
DOI:
10.3390/ani13010018
PubMed:
36611626

Effects of Cimicifuga racemosa (L.) Nutt on sexual function in women receiving tamoxifen for breast cancer.

Review Cancer
Furtado Macruz C and Lima SMRR (2022).
J Obstet Gynaecol.
DOI:
10.1080/01443615.2022.2111517
PubMed:
35993523

A Preliminary Study on the Effects of Black Cohosh Preparations on Bone Metabolism of Rat Models With GnRH-a-Induced Peri-Menopausal Symptoms.

Qin Z et al (2022).
Front Endocrinol (Lausanne).
DOI:
10.3389/fendo.2022.854345
PubMed:
35757412

Treat more than heat-New therapeutic implications of Cimicifuga racemosa through AMPK-dependent metabolic effects.

Review
Drewe J, Boonen G and Culmsee C (2022).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154060
PubMed:
35338990

Benefits of Black Cohosh (Cimicifuga racemosa) for Women Health: An Up-Close and In-Depth Review.

Review
Mohapatra S et al (2022).
Pharmaceuticals (Basel).
DOI:
10.3390/ph15030278
PubMed:
35337076

Systematic Review of Black Cohosh (Cimicifuga racemosa) for Management of Polycystic Ovary Syndrome-Related Infertility.

Endocrinology
Fan CW, Cieri-Hutcherson NE and Hutcherson TC (2022).
J Pharm Pract.
DOI:
10.1177/08971900211012244
PubMed:
33926292

Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms - an update on the evidence.

Meta-Analysis
Castelo-Branco C et al (2021).
Climacteric.
DOI:
10.1080/13697137.2020.1820477
PubMed:
33021111

Black Cohosh.

Review
(2020).
PubMed:
31643322

Black Cohosh.

Review
(2021).
PubMed:
30000840

A review of effective herbal medicines in controlling menopausal symptoms.

Review
Kargozar R, Azizi H and Salari R (2017).
Electron Physician.
DOI:
10.19082/5826
PubMed:
29403626

Black Cohosh.

Wobser RW and Takov V (2022).
PubMed:
29261886

Botanicals and Their Bioactive Phytochemicals for Women's Health.

Review Phytochemistry
Dietz BM et al (2016).
Pharmacol Rev.
PubMed:
27677719

Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings.

Review Endocrinology
Arentz S et al (2014).
BMC Complement Altern Med.
DOI:
10.1186/1472-6882-14-511
PubMed:
25524718

Adverse effects of herbal medicines: an overview of systematic reviews.

Review
Posadzki P, Watson LK and Ernst E (2013).
Clin Med (Lond).
PubMed:
23472485

Pharmacological effects of Cimicifuga racemosa.

Review
Borrelli F, Izzo AA and Ernst E (2003).
Life Sci.
PubMed:
12850238